CpG DNA analysis of bacterial STDs

Conclusions: Our results show varying CpG index values between bacterial species, which may help clarify the clinical course of infection, and may help diagnosis.
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research

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In this study, we carried out a screen to identify C. trachomatis genes important for recovery from IFNγ- and/or penicillin-induced stress. We found that ptr, encoding a poorly characterized secreted protease, is required for rapid recovery from IFNγ- but not penicillin-induced stress. Materials and Methods Cell Culture, Infection and C. trachomatis Strains HeLa (CCL-2, ATCC) and Vero cells (CCL-81, ATCC) were cultured in high glucose Dulbecco’s modified Eagle’s medium (Gibco) supplemented with 10% FBS (Natocor) without antibiotics in 5% CO2 at 37°C in a humidified atmosphere. Cells were rout...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Authors: Mao X, Zhao R, Yao R, Guo S, Bao L, Gao Y, Sun J, Bao Y, Shi Y, Cui X Abstract Cervicitis is a common sexually transmitted disease. In recent years, the abuse of antibiotic in the treatment of cervicitis results in the emergence of antibiotic-resistant bacteria; alternative strategies are needed to be developed. In this research, we investigated the effects of Feilin Vaginal Gel (FVG), a Chinese herbal formula, on the treatment of cervicitis. Two cervicitis models were optimized using BALB/c mouse; one in vitro model was established in HeLa cells. In Chlamydia trachomatis-induced cervicitis model, the high...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
AbstractEpididymo-orchitis is a common urological condition in men of all ages, causing a unilateral or bilateral swelling of the epididymis and/or testis. It is frequently caused by sexually transmitted infections,Chlamydia trachomatis andNeisseria gonorrheae, as well as common enteric organisms implicated in urinary tract infections. Men over 35  years old may develop epididymo-orchitis associated with enteric organisms, often associated with functional bladder outlet problems such as benign prostatic hyperplasia or urethral stricture disease. Fluoroquinolones, especially ciprofloxacin, have long been the mainstay o...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
Chlamydia is a prevalent sexually transmitted disease that infects more than 100 million people worldwide. Although most individuals infected with Chlamydia trachomatis are initially asymptomatic, symptoms can arise if left undiagnosed. Long-term infection can result in debilitating conditions such as pelvic inflammatory disease, infertility, and blindness. Chlamydia infection, therefore, constitutes a significant public health threat, underscoring the need for a Chlamydia-specific vaccine. Chlamydia strains express a major outer-membrane protein (MOMP) that has been shown to be an effective vaccine antigen. However, appro...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Membrane Biology Source Type: research
Michael Solomon, Ralf HenkelIndian Journal of Urology 2017 33(3):188-193 The male factor contributes approximately 50% to infertility-related cases in couples with an estimated 12%–35% of these cases attributable to male genital tract infections. Depending on the nature of the infection, testicular sperm production, sperm transport, and sperm function can be compromised. Yet, infections are potentially treatable causes of infertility. Male genital tract infections are increasingly difficult to detect. Moreover, they often remain asymptomatic (“silent”) with the result that they are then passe...
Source: Indian Journal of Urology - Category: Urology & Nephrology Authors: Source Type: research
Conclusions: This review presents key aspects of acute epididymitis, which are increasingly adopted in updated guidelines. PMID: 27123660 [PubMed - as supplied by publisher]
Source: Aktuelle Urologie - Category: Urology & Nephrology Authors: Tags: Aktuelle Urol Source Type: research
In this Medcomic, we’ll visualize three common abnormalities of the prostate.  Let’s meet our new friends. On the left is Burney and he could certainly benefit from a trial of antibiotics and an analgesic. The large fellow in the middle straining to urinate goes by the name of Turp. On the far right is Grampa Addy, currently dealing with the stresses of a slow-growing adenocarcinoma. The normal prostate is a rounded structure with a median sulcus between two lateral lobes. It encircles the urethra just inferior to the bladder. The ducts of the seminal vesicles join that of the ductus deferens to form the e...
Source: Kevin, M.D. - Medical Weblog - Category: Journals (General) Authors: Tags: Conditions Cancer Source Type: blogs
In 2012, a group of UCLA researchers set out to mine thousands of electronic health records for a more accurate and less expensive way to identify people who have undiagnosed Type 2 diabetes. The researchers got much more than they bargained for. Not only did they develop an algorithm with the potential to vastly increase the number of correct diagnoses of the disease by refining the pool of candidates who are put forward for screening; they also uncovered several previously unknown risk factors for diabetes, including a history of sexual and gender identity disorders, intestinal infections and a category of illnesses...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Conclusions HIV-positive MSM infected with S flexneri 3a used social media to meet sexual partners for unprotected sex mainly at sex parties. The potential for the transmission of S flexneri, HIV and other infections is clear. MSM need to be aware of the effect that chemsex drugs have on their health.
Source: Sexually Transmitted Infections - Category: Sexual Medicine Authors: Tags: Editor's choice, Drugs: infectious diseases, HIV/AIDS, HIV / AIDS, Gonorrhoea, HIV infections, Health education Epidemiology Source Type: research
Conclusions Even in antimicrobially pretreated patients, acute epididymitis is mainly of bacterial origin. STIs are not limited to patients aged <35 yr. Viral epididymitis seems a rare condition. Current guideline recommendations on empirical antimicrobial therapy are adequate. Patient summary Patients with acute epididymitis should receive appropriate diagnostics and antimicrobial therapy for safe conservative management. Using state-of-the-art methods, acute epididymitis was detected as a predominant bacterial infection (87%), whereby STIs should be considered in all sexually active patients. Antimicrobial susceptibi...
Source: European Urology - Category: Urology & Nephrology Source Type: research
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