Angola: Over 100,000 Cattle Await Vaccine

[ANGOP] Sumbe -At least 126,800 head of cattle will be vaccinated in central Cuanza Sul province under an anthrax immunisation drive between July and September this year.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news

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Condition:   Anthrax Interventions:   Biological: BW-1010: 50 µg - sprayer - IN;   Biological: BW-1010: 50 µg - pipette - IN;   Biological: BW-1010: 100 µg - sprayer - IN;   Biological: BW-1010: 100 µg - pipette - IN;   Biological: Saline (Placebo) - sprayer - IN;   Biological: Saline (Pl acebo) - pipette - IN;   Biological: BioThrax (positive contr...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
We examined the efficacy of fucoidan-N-(2-hydroxy-3-trimethylammonium)propylchitosan nanoparticles (FUC-HTCC NPs) as adjuvants for anthrax vaccine adsorbed (AVA). Positively and negatively surface-charged FUC-HTCC NPs were prepared via polyelectrolyte complexation by varying the mass ratio of FUC and HTCC. When cultured with L929 cells or JAWS II dendritic cells, both charged NPs showed high cell viability and low cytotoxicity, observed via MTT assay and lactate dehydrogenase release assay, respectively. In addition, we have monitored excellent NPs uptake efficacy by dendritic cells and observed that combining FUC-HTCC NPs...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Protective antigen domain 4 of Bacillus anthracis as a candidate for use as vaccine for anthrax. Ann Agric Environ Med. 2019 Sep 19;26(3):392-395 Authors: Żakowska D, Graniak G, Rutyna P, Naylor K, Głowacka P, Niemcewicz M Abstract Existing research for using the protective antigen (PA) of Bacillus anthracis as a vaccine component shows that protection against anthrax may be obtained using fragments of this protein. The aim of the research is to check whether the selected protein fragment of the protective antigen (domain 4) encoded by an appropriate nucleotide sequence of gene pag of B. anthra...
Source: Annals of Agricultural and Environmental Medicine : AAEM - Category: Environmental Health Authors: Tags: Ann Agric Environ Med Source Type: research
Genome editing is an effective tool for the functional examination of bacterial genes and for live attenuated vaccine construction. Here, we report a method to edit the genomic DNA of Bacillus anthracis and Bacillus cereus using the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas)9 system. Using two prophages in B. anthracis as targets, large-fragment deletion mutants were achieved with rates of 100% or 20%. In B. cereus, we successfully introduced precise point mutations into plcR, with phenotypic assays showing that the resulting mutants lost hemolytic and phospholipase e...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Condition:   Anthrax Interventions:   Drug: Ciprofloxacin 500Mg Tablet;   Drug: Doxycycline 100Mg Tablet;   Biological: AV7909 Sponsors:   Emergent Product Development Gaithersburg, Inc.;   Biomedical Advanced Research and Development Authority Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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