Kenya: Kenya At Risk of Poultry Viral Disease

[The Star]Kenya is at risk of influenza A (H7N9) virus common in poultry and other birds. Livestock PS Dr Khadijah Kassachoon said the disease was confirmed in China last year with a total of 139 human cases including 45 deaths.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news

Related Links:

Vaccine. 2021 Nov 15:S0264-410X(21)01470-5. doi: 10.1016/j.vaccine.2021.11.025. Online ahead of print.ABSTRACTBACKGROUND: High vaccination rates are needed to protect against influenza and to end the COVID-19 pandemic. Health authorities need to know if supplementing mass communications with direct correspondence to the community would increase uptake.OBJECTIVES: The primary objective is to determine if sending a single written message directly to individuals increases influenza vaccine uptake, and a secondary objective is to identify any identified content shown to increase influenza vaccine uptake.METHODS: MEDLINE, Embas...
Source: Vaccine - Category: Allergy & Immunology Authors: Source Type: research
Vaccine. 2021 Nov 23:S0264-410X(21)01461-4. doi: 10.1016/j.vaccine.2021.11.016. Online ahead of print.ABSTRACTBACKGROUND: Influenza causes substantial mortality, especially among older persons. Influenza vaccines are rarely more than 50% effective and rarely reach more than half of the US Medicare population, which is primarily an aged population. We wished to estimate the association between vaccination and mortality reduction.METHOD: We used the US Center for Medicare and Medicaid Services (CMS) DataLink Project to determine vaccination status and timing during the 2017-2018 influenza season for more than 26 million Medi...
Source: Vaccine - Category: Allergy & Immunology Authors: Source Type: research
EMBO Mol Med. 2021 Nov 26:e14485. doi: 10.15252/emmm.202114485. Online ahead of print.ABSTRACTSPINK6 was identified in human skin as a cellular inhibitor of serine proteases of the KLK family. Airway serine proteases are required to cleave hemagglutinin (HA) of influenza A viruses (IAVs) to initiate an infection in the human airway. We hypothesized that SPINK6 may inhibit common airway serine proteases and restrict IAV activation. We demonstrate that SPINK6 specifically suppresses the proteolytic activity of HAT and KLK5, HAT- and KLK5-mediated HA cleavage, and restricts virus maturation and replication. SPINK6 constrains ...
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
Contributors : Haley E Randolph ; Jessica K Fiege ; Beth K Thielen ; Mari S Cobb ; Jo ão Batista-Barroso ; Ryan A Langlois ; Luis B BarreiroSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHumans show remarkable variation in susceptibility to infectious diseases as well as chronic inflammatory and autoimmune disorders. This heterogeneity arises partially from variation in the immune response, which is responsible for preventing and controlling infection. To better understand the major factors driving antiviral immune response differences, we used single-cell RNA-sequencing to me...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Conclusions: Two-way messaging and standardized documentation increased rates. Declinations persisted despite education. Reasons included fear of side effects, and rarely leaving home due to the COVID-19 pandemic. Nursing interventions can increase influenza vaccination quality measures for primary care home telehealth patients.
Source: Journal of Nursing Care Quality - Category: Nursing Tags: Articles Source Type: research
H9N2 avian influenza viruses (AIVs) infect avian and mammalian hosts and provide internal genes for new emerging highly pathogenic avian viruses that cause severe pneumonia with high mortality, for which few m...
Source: BMC Complementary and Alternative Medicine - Category: Complementary Medicine Authors: Tags: Research Source Type: research
The objectives of this study were to investigate the prevalence and genetic characteristics of hBoVs detected in patients with ARIs in Bulgaria. From October 2016 to September 2019, nasopharyngeal/oropharyngeal swabs were prospectively collected from 1842 patients of all ages and tested for 12 common respiratory viruses using a real-time RT-PCR. Phylogenetic and amino acid analyses of the hBoV VP1/VP2 gene/protein were performed. HBoV was identified in 98 (5.3%) patients and was the 6th most prevalent virus after respiratory-syncytial virus (20.4%), influenza A(H1N1)pdm09 (11.1%), A(H3N2) (10.5%), rhinoviruses (9.9%), and ...
Source: International Journal of Microbiology - Category: Microbiology Authors: Source Type: research
Mitochondrial dysfunction is a hallmark of IPF and promotes the development of fibrosis. Mitochondrial stress has been shown to activate innate immunity via mitochondrial (mt) DNA sensing. However, whether mitochondrial stress regulates adaptive immune responses is unknown. We here investigated the regulation of MHC I antigen presentation by mitochondrial stress using a chronic mitochondrial dysfunction and an acute mtDNA stress model.Mouse embryonic fibroblasts derived from the PolgA mutator mouse, which represents a system of disturbed mitochondrial function, demonstrated concerted upregulation of the MHC I antigen prese...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Airway cell biology and immunopathology Source Type: research
ger Disease tolerance has emerged as an alternative way, in addition to host resistance, to survive viral-bacterial co-infections. Disease tolerance plays an important role not in reducing pathogen burden, but in maintaining tissue integrity and controlling organ damage. A common co-infection is the synergy observed between influenza virus and Streptococcus pneumoniae that results in superinfection and lethality. Several host cytokines and cells have shown promise in promoting tissue protection and damage control while others induce severe immunopathology leading to high levels of morbidity and mortality. The focus of ...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
Conclusion: A significant and gradually increasing proportion of hospitalized patients, who were not diagnosed with COVID-19 before, demonstrated seropositivity against SARS-CoV-2, indicating wide spread dissemination of COVID-19 infection in the community. Seroposivity was significantly higher in patients coming from states with higher COVID-19 load.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Epidemiology Source Type: research
More News: African Health | Health | Influenza