Norovirus vaccine may not be cost effective in Peru

Source: PharmacoEconomics and Outcomes News - Category: Drugs & Pharmacology Source Type: news

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nkataram Prasad Human norovirus (HuNoV) infection is a global health and economic burden. Currently, there are no licensed HuNoV vaccines or antiviral drugs available. The protease encoded by the HuNoV genome plays a critical role in virus replication by cleaving the polyprotein and is an excellent target for developing small-molecule inhibitors. The current strategy for developing HuNoV protease inhibitors is by targeting the enzyme’s active site and designing inhibitors that bind to the substrate-binding pockets located near the active site. However, subtle differential conformational flexibility in response to...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
Lisa C. Lindesmith Acute gastroenteritis (AGE) is a major cause of morbidity and mortality worldwide, resulting in an estimated 440,571 deaths of children under age 5 annually. Rotavirus, norovirus, and sapovirus are leading causes of childhood AGE. A successful rotavirus vaccine has reduced rotavirus hospitalizations by more than 50%. Using rotavirus as a guide, elucidating the determinants, breath, and duration of serological antibody immunity to AGE viruses, as well as host genetic factors that define susceptibility is essential for informing development of future vaccines and improving current vaccine candidates...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
AbstractNoroviruses are significant etiological agents of acute gastroenteritis (AGE) across all age groups, especially in children under 5 years of age. Although the prevalence of norovirus infection is known to have increased in various countries, in India there are few reports pertaining to the norovirus disease burden. We investigated the epidemiology and molecular characteristics of noroviruses in children seeking health care at two hospitals in Kolkata, Eastern India. Faecal specimens were collected between January 2018 and December 2019 from 2812 children under 5 years of age with acute gastroenteritis. Noroviruses ...
Source: Archives of Virology - Category: Virology Source Type: research
Viruses, Vol. 13, Pages 1961: Norovirus Epidemiology and Genetic Diversity in Leipzig, Germany during 2013–2017 Viruses doi: 10.3390/v13101961 Authors: Nora Ennuschat Sabine Härtel Corinna Pietsch Uwe G. Liebert Globally and in all age groups, noroviruses are a main cause of gastroenteritis. To assess their local epidemiology and genetic diversity, stool samples of 7509 inpatients with gastrointestinal complaints from all age groups were analyzed. After detection of norovirus genogroup I and II RNA by real-time RT-PCR, viral capsids were genotyped by partial nucleic acid sequencing. In the case of ...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Noroviruses are a major cause of epidemic and sporadic acute non-bacterial gastroenteritis worldwide. Unfortunately, the development of an effective norovirus vaccine has proven difficult and no prophylactic v...
Source: Microbial Cell Factories - Category: Microbiology Authors: Tags: Research Source Type: research
With its oral vaccines for Covid-19 and norovirus heading into mid-stage clinical trials, Vaxart Inc. will add nearly 25,000 square feet in South San Francisco as it hires more people. The company (NASDAQ: VXRT) inked a lease for 24,544 square feet at 310 Utah Ave. — space being vacated by Sutro Biopharma Inc. as it moves into the former Five Prime Therapeutics headquarters at The Cove development off Oyster Point Boulevard in South San Francisco. Vaxart also will rent 24,606 square feet at 170…
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news
Uirusu. 2020;70(2):117-128. doi: 10.2222/jsv.70.117.ABSTRACTNoroviruses commonly cause infectious gastroenteritis and massive food poisoning. There is an urgent need to elucidate the infection mechanism of noroviruses and to develop vaccines and therapeutic drugs. In addition to human disease, noroviruses have been implicated in animal disease. Noroviruses that cause murine diseases can be propagated in strained cultured cells, and for many years, murine norovirus has been used as a model for human noroviruses that could not be propagated in cultured cells. That model and advances in technology have been instrumental in ba...
Source: Uirusu. Journal of Virology - Category: Virology Authors: Source Type: research
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