Africa: Viagra Useful to Fight Against Malaria?
[SciDev.Net] The male impotence drug Viagra could also prevent malaria transmission, an in-vitro study demonstrates.
Conditions: Diabetes Mellitus, Type 2; Erectile Dysfunction With Diabetes Mellitus; Drug Interaction Interventions: Drug: Saxagliptin 5mg; Drug: Sildenafil 50 mg Sponsor: Ain Shams University Not yet recruiting
Publication date: 19 November 2019Source: Cell Reports, Volume 29, Issue 8Author(s): Ann Ly, Yang Liao, Halina Pietrzak, Lisa J. Ioannidis, Tom Sidwell, Renee Gloury, Marcel Doerflinger, Tony Triglia, Raymond Z. Qin, Joanna R. Groom, Gabrielle T. Belz, Kim L. Good-Jacobson, Wei Shi, Axel Kallies, Diana S. HansenSummaryDespite the key role that antibodies play in protection, the cellular processes mediating the acquisition of humoral immunity against malaria are not fully understood. Using an infection model of severe malaria, we find that germinal center (GC) B cells upregulate the transcription factor T-bet during infecti...
(Duke University) Engineers at Duke University have developed a microscope that adapts its lighting angles, colors and patterns while teaching itself the optimal settings needed to complete a given diagnostic task. In the initial proof-of-concept study, the microscope simultaneously developed a lighting pattern and classification system that allowed it to quickly identify red blood cells infected by the malaria parasite more accurately than trained physicians and other machine learning approaches.
Clinical manifestation of malaria is mainly due to intra-erythrocytic development of Plasmodium parasites. Plasmodium falciparum merozoites, the invasive form of the blood-stage parasite, invade human erythrocytes in a complex but rapid process. This multi-step progression involves interactions between parasite and human host proteins. Here we show that antibodies against a vaccine antigen, PfGAMA, co-immunoprecipitate with PfMSP10. This interaction was validated as direct by surface plasmon resonance analysis. We then demonstrate that antibodies against PfMSP10 have growth inhibitory activity against cultured parasites, w...
International Journal of Impotence Research, Published online: 20 November 2019; doi:10.1038/s41443-019-0217-9Comment on “Lower urinary tract symptoms and depressive symptoms among patients presenting for distressing early ejaculation”
Condition: Birth Asphyxia Intervention: Drug: Sildenafil Citrate Sponsor: Pia Wintermark Recruiting
ConclusionsThe study showed that over half of the frequently used medicinal plants showed moderate to high mutagenicity before and after metabolism at the concentration of a 100 μg/mL. This may have implications for the safety of those who use them to manage diseases. These findings will suggest the need for an in-depth study of the mutagenic potentials of plants commonly used by indigenous people and more especially for those exhibiting high mutagenicity in this study.Graphical abstract
[Monitor] Many residents of Lira and Alebtong districts have rejected government's national Indoor Residual Spraying (IRS) programme meant for malaria control, claiming it makes men impotent.
[Monitor] Tororo -Residents of Mella Sub-county in Tororo District have rejected a free indoor residual spraying exercise claiming that the chemical used increases the spread of bedbugs and makes men impotent.
Conclusion In this review, the ethnomedicinal uses, phytochemistry, biological activities and toxicity of different extracts and compounds of X. caffra have been summarized. Although many of the ethnomedicinal uses of X. caffra have been validated by phytochemical and pharmacological studies, there are still some gaps where current knowledge could be improved. There are very few to nil experimental animal studies, randomized clinical trials and target-organ toxicity studies involving X. caffra and its derivatives that have been carried out so far. At the present moment, there is not sufficient evidence to interpret the spe...