Jazz spending spree has ups and downs

Aerial sells Jazz rights to sleeping sickness drug but Gentium shareholders put brakes on earlier deal
Source: Chemistry World | Latest News - Category: Chemistry Authors: Source Type: research

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iro M Abstract Quinolines are nitrogen heterocyclic compounds ubiquitous in nature and largely used as a structural component of dyes, solvent for resins, terpenes as well as during the production of several other chemical stuffs, including pesticides. Quinolines, such as quinine and chloroquine, exhibit various pharmacological properties, acting as antimalarial drugs, antiparasitic, antibacterial, antiviral, antifungal, and anticancer agents, besides being in clinical use for autoimmune diseases. Presently, a brief review is present regarding the biological effect and clinical use of quinolines and derivatives up...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
ntino de Sousa Trypanosomiases are diseases caused by parasitic protozoan trypanosomes of the genus Trypanosoma. In humans, this includes Chagas disease and African trypanosomiasis. There are few therapeutic options, and there is low efficacy to clinical treatment. Therefore, the search for new drugs for the trypanosomiasis is urgent. This review describes studies of the trypanocidal properties of essential oils, an important group of natural products widely found in several tropical countries. Seventy-seven plants were selected from literature for the trypanocidal activity of their essential oils. The main chemical co...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
Sleeping sickness is caused by a eukaryotic unicellular parasite known to infect wild animals, cattle, and humans. It causes a fatal disease that disrupts many rhythmic physiological processes, including daily rhythms of hormonal secretion, temperature regulation, and sleep, all of which are under circadian (24-h) control. In this review, we summarize research on sleeping sickness parasite biology and the impact it has on host health. We also consider the possible evolutionary advantages of sleep and circadian deregulation for the parasite.
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
The objective set by WHO to reach elimination of human African trypanosomiasis (HAT) as a public health problem by 2020 is being achieved. The next target is the interruption of gambiense-HAT transmission in humans by 2030. To monitor progress towards this target, in areas where specialized local HAT control capacities will disappear, is a major challenge. Test specimens should be easily collectable and safely transportable such as dried blood spots (DBS). Monitoring tests performed in regional reference centres should be reliable, cheap and allow analysis of large numbers of specimens in a high-throughput format. The aim ...
Source: Experimental Parasitology - Category: Parasitology Authors: Tags: Exp Parasitol Source Type: research
Human African Trypanosomiasis &Heart. Expert Rev Cardiovasc Ther. 2020 Sep 23;: Authors: Ortiz HIA, Farina JM, Saldarriaga C, Mendoza I, Sosa Liprandi A, Wyss F, Burgos LM, Alexander B, Baranchuk A Abstract INTRODUCTION: Human African Trypanosomiasis is a neglected tropical disease resulting from the infection with the parasite Trypanosoma brucei. Neurological compromise often dominates, and the impact of cardiovascular involvement has not been fully investigated. Recently, publications indicate that cardiovascular compromise is more frequent than previously thought. Early detection of cardiac comp...
Source: Expert Review of Cardiovascular Therapy - Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research
This study aimed to evaluate if a community-led vector control programme was feasible in the context of DRC’s g-HAT elimination programme. In 2017, a community-led intervention was implemented in three villages in the Kwilu province of DRC. This interventio n was evaluated through an Action Research with qualitative data collected through 21 focus group discussions and 289 hours of observation. Also the geographical location and quality of each Tiny Targets were collected (total number deployed = 2429). This research revealed that community-based appro ach largely worked: people were motivated and proactive, showed a...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Background: Hunting activities play an important role in the survival and subsistence of the population. During hunting activities, trappers go into the bush and end up in the same biotopes with wild animals and flies, vectors of various diseases; they can accidentally get involved in the wild transmission cycle of diseases maintained by vectors and wild animal, potential reservoir hosts. Many researchers reported a tight link between hunting activities and the emergence of some infectious diseases in forest areas.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 0636 Source Type: research
by H élène Clémentine Margareta Baudouin, Laura Pfeiffer, Torsten OchsenreiterTrypanosoma brucei is a single celled eukaryotic parasite and the causative agent of human African trypanosomiasis and nagana in cattle. Aside from its medical relevance,T.brucei has also been key to the discovery of several general biological principles including GPI-anchoring, RNA-editing and trans-splicing. The parasite contains a single mitochondrion with a singular genome. Recent studies have identified several molecular components of the mitochondrial genome segregation machinery (tripartite attachment complex, TAC), wh...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
ConclusionThis description illustrates the complexity of detecting the last HAT cases due to complex diagnosis and the progressive disinterest and unawareness by both health professionals and the population. It confirms the need of implementing passive surveillance in combination with continued sensitization and health staff training.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
The West African nation of Togo has eliminated human African trypanosomiasis or “sleeping sickness” as a public health problem, becoming the first in the continent to achieve the milestone, the UN World Health Organization (WHO) has said. 
Source: UN News Centre - Health, Poverty, Food Security - Category: International Medicine & Public Health Source Type: news
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