Carmat: No problem with artificial heart fundamentals despite death

Carmat says the death of the 2nd patient implanted with its artificial heart was due to a fault with the device's controls but doesn't involve any problems with the device itself. Carmat Inc.News Well, Clinical Trials, Artificial Organs, Cardiac Assist Devicesread more
Source: Mass Device - Category: Medical Equipment Authors: Source Type: news

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In conclusion, senolytic drugs have shown promising results in the elimination of senescent cells and in alleviating various diseases in animal models. However, in patients, there is a paucity in data on the efficacy and safety of senotherapeutics from clinical trials, including systemic effects and side-effects. In this regard it is important to assess the specificity of senolytics in killing targeted senescent cells and their cytotoxic effects, to identify reliable markers for intervention responses, to elucidate interactions with comorbidities and other drugs, and to standardise administration protocols. FOXO3...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Myocardial injury leads to an irreversible loss of cardiomyocytes (CM). The implantation of human engineered heart tissue (EHT) has become a promising regenerative approach. Previous studies exhibited beneficial, dose-dependent effects of human induced pluripotent stem cell (hiPSC)-derived EHT patch transplantation in a guinea pig model in the subacute phase of myocardial injury. Yet, advanced heart failure often results from a chronic remodeling process. Therefore, from a clinical standpoint it is worthwhile to explore the ability to repair the chronically injured heart.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Source Type: research
: Phenotyping chronic lung allograft dysfunction (CLAD) in single lung transplant (SLTX) is challenging, due to the native lung contribution to pulmonary function test (PFT). We aimed to assess the applicability and prognostic performances of ISHLT classification in SLTX.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
Ann Thorac Surg. 2022 Jan 18:S0003-4975(22)00058-3. doi: 10.1016/j.athoracsur.2021.12.055. Online ahead of print.NO ABSTRACTPMID:35063421 | DOI:10.1016/j.athoracsur.2021.12.055
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
Lancet Respir Med. 2022 Jan 18:S2213-2600(21)00503-8. doi: 10.1016/S2213-2600(21)00503-8. Online ahead of print.ABSTRACTBACKGROUND: Progressive fibrosing interstitial lung disease (ILD) is characterised by parenchymal scar formation, leading to high morbidity and mortality. The ability to predict this phenotype remains elusive. We conducted a proteomic analysis to identify novel plasma biomarkers of progressive fibrosing ILD and developed a proteomic signature to predict this phenotype.METHODS: Relative plasma concentrations for 368 biomarkers were determined with use of a semi-quantitative, targeted proteomic platform in ...
Source: Respiratory Care - Category: Respiratory Medicine Authors: Source Type: research
AbstractAimsThe angiotensin receptor –neprilysin inhibitor (ARNI), sacubitril/valsartan, has been shown to be effective in treatment of patients with heart failure (HF), but limited data are available in patients with advanced disease. This retrospective observational study assessed the effects of ARNI treatment in patients with adva nced HF.Methods and resultsWe reviewed medical records of all advanced HF patients evaluated at our centre for unconventional therapies from September 2016 to January 2019. We studied 44 patients who started ARNI therapy and who had a haemodynamic assessment before beginning ARNI and aft...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Article Source Type: research
We present the sequential use of intra-aortic balloon pump, Impella 5.5 ®, and venoarterial extracorporeal membrane oxygenation as a bridge to heart–liver–kidney transplantation. The patient was supported for 78 days on Impella 5.5 and 95 days total temporary MCS. He had an uncomplicated postoperative course after triple-organ transplantation and was stable with no signs of rejection at 1-, 3-, 6-, and 12-month follow-up.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: CASE REPORT Source Type: research
This study aimed to develop and validate a competing risk nomogram for predicting all-cause mortality and heart transplantation (HT) before first appropriate shock in non-ischaemic dilated cardiomyopathy (DCM) patients receiving implantable cardioverter-defibrillators (ICD).Methods and resultsA total of 218 consecutive DCM patients implanted with ICD between 2010 and 2019 at our institution were retrospectively enrolled. Cox proportional hazards model was primarily built to identify variables associated with death and HT. Then, a Fine –Gray model, accounting for the appropriate shock as a competing risk, was construc...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Article Source Type: research
To study the utility of artificial intelligence (AI) –enabled electrocardiograms (ECGs) in patients with Graves disease (GD) in identifying patients at high risk of atrial fibrillation (AF) and heart failure with reduced ejection fraction (HFrEF), and to study whether AI-ECG can reflect hormonal changes and the resulting menstrual changes in GD.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Original article Source Type: research
AbstractHeterotaxy is a complex, multisystem disorder associated with single ventricle heart disease and decreased survival. Ciliary dysfunction is common in heterotaxy and other situs abnormalities (H/SA) and may increase post-operative complications. We hypothesized that patients with H/SA have increased respiratory and renal morbidities and increased in-hospital mortality after Fontan procedure. We queried the Pediatric Health Information System database for hospitalizations with ICD-9/10 codes for Fontan procedure in patients aged 1 through 11  years from 2004 to 2019. H/SA was identified by codes for dextrocardia...
Source: Mammalian Genome - Category: Genetics & Stem Cells Source Type: research
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