Fatal rituximab‐associated lung injury syndrome in a patient treated with rituximab for recurrence of post‐transplant nephrotic syndrome
Abstract Rituximab (anti‐B CD20 ab.) in recently widely used in renal transplantation. Case history: A 10‐yr‐old patient with end‐stage renal failure due to multidrug‐resistant NS was transplanted with renal graft from deceased donor and presented immediate recurrence of NS. PF was started on day 3 and patient received MP pulses, however with no effect. Rituximab (4 × 375 mg/m2) was administered. Chest radiographs taken at that time were normal. Partial remission was achieved and the patient was discharged in good condition. Sequential recurrence appeared two wk afterward. Twelve sessions of PF were performed and six pulses of MP were given, effecting a partial remission. Three months after the last dose of rituximab, patient was admitted with increasing respiratory failure, requiring mechanical ventilation. Infectious background, including CMV, BKV, mycoplasma, and pneumocystis, was not confirmed. The patient was treated with MP pulses, IVIG, and a variety of antibiotics. Ground‐glass opacity was confirmed on lung CT images. Respiratory failure worsened, despite aggressive ventilation and patient passed away after three wk at ICU. A destruction of alveolar epithelium and extended pulmonary fibrosis was confirmed in the autopsy report. The case represents a fatal RALI.
The mounting NHS staffing crisis and long waiting times will become permanent unless the government brings in a game-changing retention package, with an inflation-busting pay rise at its heart, say health unions today (Monday). In evidence to the independent NHS pay review body (NHSPRB), the 14 unions – representing 1.2 million health staff in England – are calling on ministers to act urgently with a significant wage boost. They say this would help halt the growing exodus of exhausted staff from the NHS. The unions warn that without a decent pay rise this year, the NHS will continue to lose ...
Bone Marrow Transplantation, Published online: 24 January 2022; doi:10.1038/s41409-021-01554-wOutcomes of CD19 chimeric antigen receptor T cell followed by haploidentical hematopoietic stem-cell transplantation in relapsed/refractory B-cell acute lymphoblastic leukemia with IKZF1 deletion
We present a rare case of bilateral compression-sided basicervical femoral neck stress fractures in a non-compliant osteoporotic patient who was treated with cannulated screws. The postoperative course was complicated by bilateral subtrochanteric stress riser fractures requiring revision fixation, which could have been prevented with use of a different implant.
ConclusionsIn order to predict possible hemodynamic instability of the corona mortis following pubic ramus fractures, it is of clinical significance to precisely establish the anatomical position of the corona mortis on the anteroposterior and inlet views.
This study highlights the clinical impact of preformed donor-specific antibodies (DSA) in living donor liver transplantation. We interestingly showed that the graft volume is an important risk factor in highly DSA-mean fluorescence intensity (MFI) cases. An appropriate graft selection should be carefully considered in high-risk case with preformed DSA in living donor liver transplantation AbstractIntroductionThe roles of preformed anti-HLA donor-specific antibodies (DSAs) in liver transplantation remain controversial. We evaluated the impact of preformed DSAs in living donor liver transplantation.MethodsAdults who underwen...
In conclusion, senolytic drugs have shown promising results in the elimination of senescent cells and in alleviating various diseases in animal models. However, in patients, there is a paucity in data on the efficacy and safety of senotherapeutics from clinical trials, including systemic effects and side-effects. In this regard it is important to assess the specificity of senolytics in killing targeted senescent cells and their cytotoxic effects, to identify reliable markers for intervention responses, to elucidate interactions with comorbidities and other drugs, and to standardise administration protocols. FOXO3...
Contributors : Sethuraman Subramanian ; Clara J Busch ; Julien Maurizio ; Hassiba Belahbib ; B érengère de Laval ; Michael H SiewekeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusHere we show that alveolar macrophage (AM) identity were conserved through culture expansion as determined by the analysis of epigenetic chromatin accessibility of core AM specific transcription markers and surface markers. Further, the adaptations to the culture environment were transient, reversible and fully restored to the in vivo status upon transplantation into the alveolar niche.
Contributors : Sethuraman Subramanian ; Clara J Busch ; Kaaweh Molawi ; Laufey Geirsdottir ; Stephanie Vargas-Aguilar ; Julien Maurizio ; Hassiba Belahbib ; Gimenez Gregory ; Michael H SiewekeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHere we show that alveolar macrophages maintain their core AM transcriptomic identity through culture expansion but show adaptations during culture expansion that are transient, reversible and fully restored upon transplantation into the alveolar niche.
Bone Marrow Transplantation, Published online: 23 January 2022; doi:10.1038/s41409-021-01412-9Long-term follow-up of patients with ATL after autologous stem cell transplantation
Bone Marrow Transplantation, Published online: 23 January 2022; doi:10.1038/s41409-021-01553-xAllogeneic hematopoietic cell transplantation in patients with myeloid/lymphoid neoplasm with FGFR1-rearrangement: a study of the Chronic Malignancies Working Party of EBMT