QbD Based Formulation Development and Optimisation of Ozenoxacin Topical Nano-Emulgel and Efficacy Evaluation Using Impetigo Mice Model
This study demonstrates the application of QbD methodology for the development and optimization of an effective topical nanoemulgel formulation for the treatment of Impetigo focusing on the selection of appropriate excipients, optimization of formulation and process variables, and characterization of critical quality attributes. BBD was used to study the effect of "% of oil, % of Smix and homogenization speed" on critical quality attributes "globule size and % entrapment efficiency" for the optimisation of Ozenoxacin Nano-emulsion. Ozenoxacin loaded nano-emulgel was characterized for "description, identification, pH, speci...
Source: AAPS PharmSciTech - April 22, 2024 Category: Drugs & Pharmacology Authors: Amarnath Reddy Ramireddy Dilip Kumar Behara Source Type: research
Prevalence and determinants of impetigo in Ghana: a cross-sectional study
Skin diseases such as impetigo pose a significant public health challenge in low resource settings. Despite this, there is a dearth of epidemiological data on the prevalence of this condition in Ghana. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - March 26, 2024 Category: Infectious Diseases Authors: Yaw Ampem Amoako, Dennis Odai Laryea, Abigail Agbanyo, Bernadette Agbavor, Michael Ntiamoah Oppong, Gloria Kyem, Kabiru Mohammed Abass, Renee van Bentum, Richard Odame Phillips and Ymkje Stienstra Tags: Research Source Type: research
Application of Transthoracic Echocardiography for Cardiac Safety Evaluation in the Clinical Development Process of Vaccines Against Streptococcus pyogenes
AbstractSuperficial infections withStreptococcus pyogenes (Strep A), pharyngitis and impetigo can induce acute rheumatic fever, an autoimmune sequela manifesting mostly with arthritis and rheumatic carditis. Valvular heart damage can persist or advance following repeated episodes of acute rheumatic fever, causing rheumatic heart disease. Acute rheumatic fever and rheumatic heart disease disproportionately affect children and young adults in developing countries and disadvantaged communities in developed countries. People living with rheumatic heart disease are at risk of experiencing potentially fatal complications such as...
Source: Drugs in R&D - March 18, 2024 Category: Drugs & Pharmacology Source Type: research
A framework for the analysis of skin sores disease using evolutionary intelligent computing approach
In this study, a neuro-evolutionary global algorithm is introduced to solve the dynamics of nonlinear skin sores disease model (SSDM) with the help of an artificial neural network. The global genetic algorithm is integrated with local sequential quadratic programming (GA-LSQP) to obtain the optimal solution for the proposed model. The designed differential model of skin sores disease is comprised of susceptible (S), infected (I), and recovered (R) categories. An activation function based neural network modeling is exploited for skin sores system through mean square error to achieve best trained weights. The integrated appr...
Source: Computer Methods in Biomechanics and Biomedical Engineering - March 12, 2024 Category: Biomedical Engineering Authors: Muhammad Shoaib Rafia Tabassum Kottakkaran Sooppy Nisar Muhammad Asif Zahoor Raja Source Type: research
A framework for the analysis of skin sores disease using evolutionary intelligent computing approach
In this study, a neuro-evolutionary global algorithm is introduced to solve the dynamics of nonlinear skin sores disease model (SSDM) with the help of an artificial neural network. The global genetic algorithm is integrated with local sequential quadratic programming (GA-LSQP) to obtain the optimal solution for the proposed model. The designed differential model of skin sores disease is comprised of susceptible (S), infected (I), and recovered (R) categories. An activation function based neural network modeling is exploited for skin sores system through mean square error to achieve best trained weights. The integrated appr...
Source: Computer Methods in Biomechanics and Biomedical Engineering - March 12, 2024 Category: Biomedical Engineering Authors: Muhammad Shoaib Rafia Tabassum Kottakkaran Sooppy Nisar Muhammad Asif Zahoor Raja Source Type: research
A framework for the analysis of skin sores disease using evolutionary intelligent computing approach
In this study, a neuro-evolutionary global algorithm is introduced to solve the dynamics of nonlinear skin sores disease model (SSDM) with the help of an artificial neural network. The global genetic algorithm is integrated with local sequential quadratic programming (GA-LSQP) to obtain the optimal solution for the proposed model. The designed differential model of skin sores disease is comprised of susceptible (S), infected (I), and recovered (R) categories. An activation function based neural network modeling is exploited for skin sores system through mean square error to achieve best trained weights. The integrated appr...
Source: Computer Methods in Biomechanics and Biomedical Engineering - March 12, 2024 Category: Biomedical Engineering Authors: Muhammad Shoaib Rafia Tabassum Kottakkaran Sooppy Nisar Muhammad Asif Zahoor Raja Source Type: research
A framework for the analysis of skin sores disease using evolutionary intelligent computing approach
In this study, a neuro-evolutionary global algorithm is introduced to solve the dynamics of nonlinear skin sores disease model (SSDM) with the help of an artificial neural network. The global genetic algorithm is integrated with local sequential quadratic programming (GA-LSQP) to obtain the optimal solution for the proposed model. The designed differential model of skin sores disease is comprised of susceptible (S), infected (I), and recovered (R) categories. An activation function based neural network modeling is exploited for skin sores system through mean square error to achieve best trained weights. The integrated appr...
Source: Computer Methods in Biomechanics and Biomedical Engineering - March 12, 2024 Category: Biomedical Engineering Authors: Muhammad Shoaib Rafia Tabassum Kottakkaran Sooppy Nisar Muhammad Asif Zahoor Raja Source Type: research
A framework for the analysis of skin sores disease using evolutionary intelligent computing approach
In this study, a neuro-evolutionary global algorithm is introduced to solve the dynamics of nonlinear skin sores disease model (SSDM) with the help of an artificial neural network. The global genetic algorithm is integrated with local sequential quadratic programming (GA-LSQP) to obtain the optimal solution for the proposed model. The designed differential model of skin sores disease is comprised of susceptible (S), infected (I), and recovered (R) categories. An activation function based neural network modeling is exploited for skin sores system through mean square error to achieve best trained weights. The integrated appr...
Source: Computer Methods in Biomechanics and Biomedical Engineering - March 12, 2024 Category: Biomedical Engineering Authors: Muhammad Shoaib Rafia Tabassum Kottakkaran Sooppy Nisar Muhammad Asif Zahoor Raja Source Type: research
A framework for the analysis of skin sores disease using evolutionary intelligent computing approach
In this study, a neuro-evolutionary global algorithm is introduced to solve the dynamics of nonlinear skin sores disease model (SSDM) with the help of an artificial neural network. The global genetic algorithm is integrated with local sequential quadratic programming (GA-LSQP) to obtain the optimal solution for the proposed model. The designed differential model of skin sores disease is comprised of susceptible (S), infected (I), and recovered (R) categories. An activation function based neural network modeling is exploited for skin sores system through mean square error to achieve best trained weights. The integrated appr...
Source: Computer Methods in Biomechanics and Biomedical Engineering - March 12, 2024 Category: Biomedical Engineering Authors: Muhammad Shoaib Rafia Tabassum Kottakkaran Sooppy Nisar Muhammad Asif Zahoor Raja Source Type: research
A framework for the analysis of skin sores disease using evolutionary intelligent computing approach
In this study, a neuro-evolutionary global algorithm is introduced to solve the dynamics of nonlinear skin sores disease model (SSDM) with the help of an artificial neural network. The global genetic algorithm is integrated with local sequential quadratic programming (GA-LSQP) to obtain the optimal solution for the proposed model. The designed differential model of skin sores disease is comprised of susceptible (S), infected (I), and recovered (R) categories. An activation function based neural network modeling is exploited for skin sores system through mean square error to achieve best trained weights. The integrated appr...
Source: Computer Methods in Biomechanics and Biomedical Engineering - March 12, 2024 Category: Biomedical Engineering Authors: Muhammad Shoaib Rafia Tabassum Kottakkaran Sooppy Nisar Muhammad Asif Zahoor Raja Source Type: research
Identification, characterisation and in silico ADMET prediction of ozenoxacin and its degradation products using high-performance liquid chromatography-photodiode array and liquid chromatography-quadrupole time-of-flight-tandem mass spectrometry
CONCLUSION: The drug was found to be stable in neutral, acidic, basic and oxidative degradation conditions with hydrogen peroxide. Liquid chromatography-electrospray ionisation-quadrupole time-of-flight-tandem mass spectrometry- was employed in positive ionisation mode to analyse both the drug and the mass of the identified DP. The mechanism and the pathway of mass fragmentation have been proposed. The developed method was accurate, repeatable, linear and selective for further research. The ADMET Predictor software was applied to predict the in silico toxicity of the drugs and its DPs as well as their physicochemical chara...
Source: Rapid Communications in Mass Spectrometry : RCM - January 11, 2024 Category: Chemistry Authors: Ashwinkumar Matta Raja Sundararajan Source Type: research
Autoinflammatory Keratinization Diseases —The Concept, Pathophysiology, and Clinical Implications
AbstractRecent advances in medical genetics elucidated the background of diseases characterized by superficial dermal and epidermal inflammation with resultant aberrant keratosis. This led to introducing the term autoinflammatory keratinization diseases encompassing entities in which monogenic mutations cause spontaneous activation of the innate immunity and subsequent disruption of the keratinization process. Originally, autoinflammatory keratinization diseases were attributed to pathogenic variants ofCARD14 (generalized pustular psoriasis with concomitant psoriasis vulgaris, palmoplantar pustulosis, type V pityriasis rub...
Source: Clinical Reviews in Allergy and Immunology - December 16, 2023 Category: Allergy & Immunology Source Type: research
Clinical and Laboratory Diagnosis of Exanthems Among Japanese Children Younger Than 6 Years Old in the Post-Measles-Rubella Vaccine Era
CONCLUSIONS: The most common causes of pediatric exanthems were noninfectious diseases and viral exanthema. PCR assay was instrumental for etiological diagnosis of nonspecific exanthems.PMID:37963264 | DOI:10.1097/INF.0000000000004175 (Source: Herpes)
Source: Herpes - November 14, 2023 Category: Infectious Diseases Authors: Masato Yasuda Kensuke Shoji Keiichi Tomita Yoshiko Uchida Satoko Uematsu Kazue Yoshida Naoko Kono Motoki Funatsu Isao Miyairi Source Type: research
Clinical and Laboratory Diagnosis of Exanthems Among Japanese Children Younger Than 6 Years Old in the Post-Measles-Rubella Vaccine Era
CONCLUSIONS: The most common causes of pediatric exanthems were noninfectious diseases and viral exanthema. PCR assay was instrumental for etiological diagnosis of nonspecific exanthems.PMID:37963264 | DOI:10.1097/INF.0000000000004175 (Source: Herpes)
Source: Herpes - November 14, 2023 Category: Infectious Diseases Authors: Masato Yasuda Kensuke Shoji Keiichi Tomita Yoshiko Uchida Satoko Uematsu Kazue Yoshida Naoko Kono Motoki Funatsu Isao Miyairi Source Type: research
Rapid remission of severe impetigo herpetiformis following combined treatment with secukinumab and corticosteroids
(Source: European Journal of Dermatology)
Source: European Journal of Dermatology - November 1, 2023 Category: Dermatology Source Type: research
