Temporal patterns of sleep latency in central hypersomnia and attention deficit hyperactivity disorder: a cluster analysis exploration using Multiple Sleep Latency Test
ConclusionsOur study highlights the value of time-course clustering in understanding sleep latency patterns of patients with central hypersomnia. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - March 13, 2024 Category: Psychiatry Source Type: research

Post-COVID central hypersomnia, a treatable trait in long COVID: 4 case reports
ConclusionWe highlight the importance of identifying cases of post-COVID central hypersomnia, as it may be a treatable trait of a post-COVID condition. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 14, 2024 Category: Neurology Source Type: research

Association between idiopathic hypersomnia and a genetic variant in the PER3 gene
J Sleep Res. 2024 Jan 22:e14146. doi: 10.1111/jsr.14146. Online ahead of print.ABSTRACTWe aim to identify genetic markers associated with idiopathic hypersomnia, a disabling orphan central nervous system disorder of hypersomnolence that is still poorly understood. In our study, DNA was extracted from 79 unrelated patients diagnosed with idiopathic hypersomnia with long sleep time at the National Reference Center for Narcolepsy-France according to very stringent diagnostic criteria. Whole exome sequencing on the first 30 patients with idiopathic hypersomnia (25 females and 5 males) allowed the single nucleotide variants to ...
Source: Journal of Sleep Research - January 22, 2024 Category: Sleep Medicine Authors: Yoan Cherasse Yuki Taira Anna Laura Rassu Lucie Barateau Elisa Evangelista Masafumi Muratani Hiromasa Funato Masashi Yanagisawa Yves Dauvilliers Source Type: research

Single sessions of transcranial direct current stimulation and transcranial random noise stimulation exert no effect on sleepiness in patients with narcolepsy and idiopathic hypersomnia
ConclusionWe could not demonstrate any clinically relevant effects of single sessions of tDCS or tRNS on objective or subjective measures of sleepiness in patients with hypersomnia. However, we cannot exclude that repeated sessions of tES may affect vigilance or sleepiness in hypersomniac patients. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - December 11, 2023 Category: Psychiatry Source Type: research

New insights and potential clinical implications of the odds ratio product
The odds ratio product (ORP) is a continuous metric of sleep depth that ranges from 0 (very deep sleep) to 2. 5 (full wakefulness). Its advantage over the conventional method recommended by AASM is that it discloses different levels of stage wake (sleep propensity) and different sleep depths within the same sleep stage. As such, it can be used to identify differences in sleep depth between subjects, and in the same subjects under different circumstances, when differences are not discernible by conventional staging. It also identifies different sleep depths within stage rapid-eye-movement sleep, with possible implications t...
Source: Frontiers in Neurology - October 9, 2023 Category: Neurology Source Type: research

Manage idiopathic hypersomnia with a combination of non-pharmacological and pharmacological treatments
AbstractIdiopathic hypersomnia (IH) is a rare sleeping disorder that is difficult to diagnose, and little is known about its pathophysiology. A defining symptom of IH is excessive daytime sleepiness, which can manifest as narcolepsy-like episodes or as continuous sleepiness. Other symptoms of IH includes sleep inertia and cognitive impairment. Currently, calcium, magnesium, potassium and sodium oxybates is the only FDA approved pharmacological treatment option in the management of IH. Off-label treatment options are recommended by guidelines, with many also being used for the management of narcolepsy. (Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - October 3, 2023 Category: Drugs & Pharmacology Source Type: research

Skin temperature as a predictor of on-the-road driving performance in people with central disorders of hypersomnolence
J Sleep Res. 2023 Sep 18:e14045. doi: 10.1111/jsr.14045. Online ahead of print.ABSTRACTExcessive daytime sleepiness is the core symptom of central disorders of hypersomnolence (CDH) and can directly impair driving performance. Sleepiness is reflected in relative alterations in distal and proximal skin temperature. Therefore, we examined the predictive value of skin temperature on driving performance. Distal and proximal skin temperature and their gradient (DPG) were continuously measured in 44 participants with narcolepsy type 1, narcolepsy type 2 or idiopathic hypersomnia during a standardised 1-h driving test. Driving pe...
Source: Journal of Sleep Research - September 18, 2023 Category: Sleep Medicine Authors: Veronique E C Vael Denise Bijlenga Mink S Schinkelshoek Nick N J J M van der Sluiszen Aniek Remmerswaal Sebastiaan Overeem Johannes G Ramaekers Annemiek Vermeeren Gert Jan Lammers Rolf Fronczek Source Type: research

Skin temperature as a predictor of on-the-road driving performance in people with central disorders of hypersomnolence
J Sleep Res. 2023 Sep 18:e14045. doi: 10.1111/jsr.14045. Online ahead of print.ABSTRACTExcessive daytime sleepiness is the core symptom of central disorders of hypersomnolence (CDH) and can directly impair driving performance. Sleepiness is reflected in relative alterations in distal and proximal skin temperature. Therefore, we examined the predictive value of skin temperature on driving performance. Distal and proximal skin temperature and their gradient (DPG) were continuously measured in 44 participants with narcolepsy type 1, narcolepsy type 2 or idiopathic hypersomnia during a standardised 1-h driving test. Driving pe...
Source: Journal of Sleep Research - September 18, 2023 Category: Sleep Medicine Authors: Veronique E C Vael Denise Bijlenga Mink S Schinkelshoek Nick N J J M van der Sluiszen Aniek Remmerswaal Sebastiaan Overeem Johannes G Ramaekers Annemiek Vermeeren Gert Jan Lammers Rolf Fronczek Source Type: research

Idiopathic hypersomnia and Kleine-Levin syndrome
Rev Neurol (Paris). 2023 Sep 6:S0035-3787(23)01008-1. doi: 10.1016/j.neurol.2023.08.010. Online ahead of print.ABSTRACTIdiopathic hypersomnia (IH) and Kleine-Levin syndrome (KLS) are rare disorders of central hypersomnolence of unknown cause, affecting young people. However, increased sleep time and excessive daytime sleepiness (EDS) occur daily for years in IH, whereas they occur as relapsing/remitting episodes associated with cognitive and behavioural disturbances in KLS. Idiopathic hypersomnia is characterized by EDS, prolonged, unrefreshing sleep at night and during naps, and frequent morning sleep inertia, but rare sl...
Source: Revue Neurologique - September 8, 2023 Category: Neurology Authors: I Arnulf P Dodet S Leu-Semenescu J B Maranci Source Type: research

Idiopathic hypersomnia years after the diagnosis
J Sleep Res. 2023 Aug 12:e14011. doi: 10.1111/jsr.14011. Online ahead of print.ABSTRACTLittle attention has been paid to the long-term development of idiopathic hypersomnia symptoms and idiopathic hypersomnia comorbidities. The aim of this study was to describe the general health of patients with idiopathic hypersomnia years after the initial diagnosis, focusing on current subjective hypersomnolence and the presence of its other possible causes. Adult patients diagnosed with idiopathic hypersomnia ≥ 3 years ago at sleep centres in Prague and Kosice were invited to participate in this study. A total of 60 patients were ex...
Source: Journal of Sleep Research - August 12, 2023 Category: Sleep Medicine Authors: Karel Šonka Eva Feketeov á So ňa Nevšímalová Eszter Maurovich Horvat Iva P říhodová Simona Dost álová Karol ína Galušková Martin Milata Jitka Bu šková Marek Susta Source Type: research

Idiopathic hypersomnia years after the diagnosis
J Sleep Res. 2023 Aug 12:e14011. doi: 10.1111/jsr.14011. Online ahead of print.ABSTRACTLittle attention has been paid to the long-term development of idiopathic hypersomnia symptoms and idiopathic hypersomnia comorbidities. The aim of this study was to describe the general health of patients with idiopathic hypersomnia years after the initial diagnosis, focusing on current subjective hypersomnolence and the presence of its other possible causes. Adult patients diagnosed with idiopathic hypersomnia ≥ 3 years ago at sleep centres in Prague and Kosice were invited to participate in this study. A total of 60 patients were ex...
Source: Journal of Sleep Research - August 12, 2023 Category: Sleep Medicine Authors: Karel Šonka Eva Feketeov á So ňa Nevšímalová Eszter Maurovich Horvat Iva P říhodová Simona Dost álová Karol ína Galušková Martin Milata Jitka Bu šková Marek Susta Source Type: research

Idiopathic hypersomnia: the long journey from classification to an efficacious drug
Journal of Clinical Sleep Medicine, Ahead of Print. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - August 9, 2023 Category: Sleep Medicine Authors: Geert Mayer Andrea Rodenbeck 1Department of Neurology Philipps-Universit ät Marburg, Marburg, Germany 2Evangelisches Krankenhaus Göttingen-Weende, Göttingen, Germany Source Type: research

Long-term efficacy and safety of low-sodium oxybate in an open-label extension period of a placebo-controlled, double-blind, randomized withdrawal study in adults with idiopathic hypersomnia
Journal of Clinical Sleep Medicine, Ahead of Print. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - July 6, 2023 Category: Sleep Medicine Authors: Anne Marie Morse Yves Dauvilliers Isabelle Arnulf Michael J. Thorpy Nancy Foldvary-Schaefer Patricia Chandler Abby Chen Luke Hickey Jed Black Richard K. Bogan 1Janet Weis Children ’s Hospital, Geisinger, Danville, PA 2Sleep and Wake Disorders Centre, De Source Type: research