VaNoLaH trial: a study protocol--a multinational randomised controlled trial including two identical substudies comparing vaginal versus vNOTES (vaginal natural orifice transluminal surgery) hysterectomy or laparoscopic versus vNOTES hysterectomy
Introduction
Hysterectomy is one of the most common surgeries performed in women. Minimally invasive methods are on the rise globally as they have been shown to decrease surgical morbidity compared with abdominal hysterectomy. Hysterectomy by vaginal natural orifice transluminal endoscopic surgery (vNOTES) is the latest innovation. It combines the vaginal approach and endoscopy via the vagina. Large pragmatic randomised controlled trials (RCTs) are lacking comparing outcomes after vNOTES, vaginal hysterectomy (VH) and laparoscopic hysterectomy (LH).
Methods
Multicentre pragmatic RCT aiming to recruit 1000 women aged 18&nd...
Source: BMJ Open - April 23, 2024 Category: General Medicine Authors: Baekelandt, J. F., Stuart, A., Wagenius, J., Laenen, A., Mol, B. W., Deprest, J., Bosteels, J. J. A. Tags: Open access, Obstetrics & Gynaecology Obstetrics and gynaecology Source Type: research
Regional Nerve Blocks and Opiate Usage in Patients Undergoing Laparoscopic Hysterectomy
Journal of Gynecologic Surgery, Ahead of Print. (Source: Journal of Gynecologic Surgery)
Source: Journal of Gynecologic Surgery - April 22, 2024 Category: OBGYN Authors: Sara M. Drayer Kiley Hunkler Jennifer Bergstrom Source Type: research
Robotic-assisted total hysterectomy with transilluminating uterine manipulator - The guiding green light of the firefly mode
Asian J Surg. 2024 Apr 20:S1015-9584(24)00682-1. doi: 10.1016/j.asjsur.2024.03.205. Online ahead of print.NO ABSTRACTPMID:38643055 | DOI:10.1016/j.asjsur.2024.03.205 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 20, 2024 Category: Surgery Authors: Harald Krentel Antoine Naem Gaby Moawad Rudy Leon De Wilde Source Type: research
Benign metastasizing fumarate hydratase (FH)-deficient uterine leiomyomas: clinicopathological and molecular study with first documentation of multi-organ metastases
AbstractLeiomyoma is the most prevalent benign tumor of the female reproductive system. Benign metastasizing leiomyoma (BML) is a rare phenomenon that presents at distant sites, typically the lungs, exhibiting histopathological features similar to the primary uterine tumor in the absence of malignancy features in both. Fumarate hydratase-deficient uterine leiomyoma (FH-d UL) is an uncommon subtype among uterine smooth muscle tumors (0.5 –2%), showing distinctive histomorphology andFH inactivation. The majority of FH-d ULs are sporadic, caused by somaticFH inactivation, while a minority of cases occur in the context of th...
Source: Virchows Archiv - April 20, 2024 Category: Pathology Source Type: research
Factors Associated with Maternal Morbidity among Black Women in the United States
Conclusion The three factors most associated with SMM among NHBP are potentially avoidable or modifiable by aggressive screening, prevention, and treatment of preeclampsia and preterm birth as well as reducing cesarean rates in this population.
Key Points
[...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - April 19, 2024 Category: Perinatology & Neonatology Authors: Ibrahim Sous, Catrine Moravec, William DeFranco, Emily Kelly, Elizabeth A. Rossi, Robert M. Tags: Original Article Source Type: research
Regional practice variation in hysterectomy and the implementation of less invasive surgical procedures: A register ‐based study in the Netherlands
ConclusionsRegional variation exists in the rates of hysterectomy and minimally invasive techniques. The absence of a significant substitution effect provides no clear evidence that minimally invasive techniques have replaced hysterectomy in clinical practice. However, although the result was not significant, embolization could be an exception based on its stronger negative association. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - April 18, 2024 Category: OBGYN Authors: Maarten D. H. Vink,
France R. M. Portrait,
Wouter J. K. Hehenkamp,
Tim van Wezep,
Xander Koolman,
Marlies Y. Bongers,
Eric J. E. van der Hijden Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Estrogen-Only Hormone Therapy and Dementia
This article has several limitations that should be considered when interpreting the study ’s findings. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 18, 2024 Category: General Medicine Source Type: research
Estrogen-Only Hormone Therapy and Dementia —Reply
In Reply The Letters about our study suggest that the observed positive association between estrogen-only hormone therapy and dementia could have been influenced by (1) potential confounding by indication of hysterectomy-induced early menopause among estrogen-only hormone therapy users or (2) potential late estrogen-only hormone therapy initiation distant from menopause, previously linked to increased risk of dementia. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 18, 2024 Category: General Medicine Source Type: research
vNOTES Radical Hysterectomy: A New Approach To Cervical Cancer
To demonstrate how a radical hysterectomy with sentinel node resection for cervical cancer can be performed via vaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES). (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - April 18, 2024 Category: OBGYN Authors: Jan Baekelandt Tags: Video Article Source Type: research
Caveolin-1's dual impact on endometrioid endometrial carcinoma: a histopathological and immunohistochemical study
The objectives of this study are to evaluate caveolin-1 expression in endometrioid endometrial cancer and its correlation with clinicopathological parameters. Forty-four cases of endometrioid endometrial carcinomas underwent radical hysterectomy. The archived paraffin sections that were stained for caveolin-1 by immunohistochemistry, caveolin-1 expression were detected in cancerous epithelial cells in 18.2% of the cases, and stromal caveolin-1 was detected in 65.9% of the cases. Caveolin-1 expression in the epithelium showed a significant positive association with the T stage and the FIGO stage. Positive caveolin-1 express...
Source: Journal of Immunoassay and Immunochemistry - April 17, 2024 Category: Biochemistry Authors: Rania Mohamed Sabry Samira Abdallah Mahmoud Mona SalahEldin Abdelmagid Somia Abdellatif Mahmoud Yasmine Yassin Ahmed Source Type: research
Same-Day Discharge is Safe, Feasible Following Vaginal Hysterectomy with Apical Suspension
(Source: International Journal of Womens Health)
Source: International Journal of Womens Health - April 17, 2024 Category: OBGYN Tags: International Journal of Women's Health Source Type: research
vNOTES retroperitoneal sentinel lymph node dissection for endometrial cancer staging: First multicenter, prospective case series
ConclusionsThis prospective multicenter case series demonstrates the feasibility of the vNOTES approach for identifying and removing sentinel lymph nodes in women with endometrial carcinoma successfully and safely. vNOTES allows sole transvaginal access with exposure of the entire retroperitoneal space, following the natural lymph trajectory caudally to cranially, and without the need for a Trendelenburg position. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - April 16, 2024 Category: OBGYN Authors: Jan Baekelandt,
Astrid Jespers,
Daniela Huber,
Levon Badiglian ‐Filho,
Andrea Stuart,
Linus Chuang,
Oudai Ali,
Alexander Burnett Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Histology Findings after Two Years of Cytology/HPV Co-Testing in Germany
CONCLUSION: More CIN lesions were found with co-testing, but the increase in histology findings of low-grade or no dysplasia was far greater than findings of CIN3. Lesions not requiring treatment accounted for 94.4% of biopsy results in 2020/21. The use of computer-assisted LBC with progression markers could reduce this.PMID:38618577 | PMC:PMC11006558 | DOI:10.1055/a-2265-3578 (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - April 15, 2024 Category: OBGYN Authors: Arjola Xhaja Andr é Ahr Ilona Zeiser Hans Ikenberg Source Type: research
