Weekly Postings
See something of interest? Please share our postings with colleagues in your institutions!
Spotlight
The MAReport: read the Summer/Fall 2018 issue of the MAReport newsletter! Have you had the chance to meet our Health Programming Coordinator? Learn more about the newest member of the MAR team, Michael Balkenhol!
DOCLINE users! Please review the DOCLINE 6.0 Preview Checklist. Questions or concerns? Contact the DOCLINE Coordinating Office (NDCO) via email: DOCLINE@hshsl.umaryland.edu or telephone: (410) 706-4173.
National Network of Libraries of Medicine News
NNLM All of Us Community Engagement Awards: NNLM MAR is accepting...
Source: NN/LM Middle Atlantic Region Blog - November 9, 2018 Category: Databases & Libraries Authors: Hannah Sinemus Tags: Weekly Postings Source Type: news
GOOD WORKS SA: Losing son inspires creation of AugustHeart
Ten years after Bart Koontz's teenage son died, his voice wavers with emotion as he recounts the morning August never woke due to an undetected heart condition called hypertrophic cardiomyopathy.
A few years later, in 2011, Bart and Dore Koontz founded AugustHeart with a bold vision: to establish and fund a rapid, low-cost, scalable cardiovascular screening model. Their goal was a free communitywide cardiac screening program for all teens in Bexar County to minimize the risks of sudden car diac arrest,… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - October 26, 2018 Category: American Health Authors: Andi Rodriguez Source Type: news
Researchers determine how contraction leads to hypertrophic cardiomyopathy
Individual myosin molecules and rod-like filaments inside muscles produce less force and lower velocity of contraction, leading to hypertrophic cardiomyopathy, researcher report in a new study. (Source: Health News - UPI.com)
Source: Health News - UPI.com - October 16, 2018 Category: Consumer Health News Source Type: news
Why heart contractions are weaker in those with hypertrophic cardiomyopathy
(McGill University) Familial hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease in the US and affects an estimated 1 in 500 people around the world. A protein called myosin acts as the molecular motor which makes the muscles in the heart contract. An international team has discovered that in transgenic rabbits with the R403Q mutation,, individual myosin molecules and myofibrils (the basic rod-like filaments inside muscles) produce less force and a lower maximum velocity of contraction than those isolated from healthy hearts. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 16, 2018 Category: International Medicine & Public Health Source Type: news
The man who has died NINE times: 29-year-old's illness regularly makes his heart stop
Jamie Poole, from Australia but living in London, has hypertrophic cardiomyopathy, which means his heart muscle is thickened and weaker, and causes him regular cardiac arrests. (Source: the Mail online | Health)
Source: the Mail online | Health - October 4, 2018 Category: Consumer Health News Source Type: news
Can a common heart condition cause sudden death?
(Gladstone Institutes) About one person out of 500 has a heart condition known as hypertrophic cardiomyopathy (HCM). This condition causes thickening of the heart muscle and results in defects in the heart's electrical system. Under conditions of environmental stress such as exercise, HCM can result in sudden death. In other cases, patients may go undiagnosed, with their heart function declining gradually over decades. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - September 20, 2018 Category: Biology Source Type: news
CHOP researchers highlight advances in pediatric heart disease at 2017 AHA scientific sessions
(Children's Hospital of Philadelphia) Physician-researchers from the Cardiac Center at Children's Hospital of Philadelphia (CHOP) recently presented new findings on pediatric cardiovascular disease at the American Heart Association's Scientific Sessions 2017 in Anaheim, Calif. Among many abstracts presented were research on racial disparities in bystander CPR methods in children with sudden cardiac arrest, and findings that children with hypertrophic cardiomyopathy may be at risk for sudden cardiac death. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 28, 2017 Category: International Medicine & Public Health Source Type: news
When Heart Disease Runs in the Family
Treatment TermsCardiomyopathy
Overview
Anne Goodes knew her heart beat faster than normal, but it wasn ’t until her local cardiologist detected a heart murmur that she discovered she was at risk for sudden cardiac death. At Duke, she learned the cause was hypertrophic cardiomyopathy, a common heart condition that can run in the family. Goodes soon discovered her children may need to take precaution s as well.
Hero Image2017_anne_heart_596.jpg
Preview Image
Content Blocks
Header
Learning to Live with Hypertrophic Cardiomyopathy
ContentHypertrophic cardiomyopathy affects the cells that make up the heart mus...
Source: dukehealth.org: Duke Health News - November 27, 2017 Category: Consumer Health News Authors: dg62 at duke.edu Source Type: news
MRI discovers heart damage among male triathletes
Using late gadolinium-enhanced MRI scans, German researchers found myocardial...Read more on AuntMinnie.comRelated Reading:
Some cardiac MRI findings predict future heart events
Stress cardiac MR matches 320-row CCTA results
Study shows feasibility of cardiac PET/MRI -- with caveats
Cardiac MR tops ECG in finding hidden myocardial infarctions
Late MRI enhancement predicts death risk in hypertrophic cardiomyopathy (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - November 21, 2017 Category: Radiology Source Type: news
Fruit fly muscles with a hypertrophic cardiomyopathy mutation don't relax properly
(Johns Hopkins Medicine) Using fruit flies, Johns Hopkins researchers have figured out why a particular inherited human heart condition that is almost always due to genetic mutations causes the heart to enlarge, thicken and fail. They found that one such mutation interferes with heart muscle's ability to relax after contracting, and prevents the heart from fully filling with blood and pumping it out. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 9, 2017 Category: International Medicine & Public Health Source Type: news
Preventing sudden death in hypertrophic cardiomyopathy: ESC guidelines (HCM-EVIDENCE)
(European Society of Cardiology) A large study conducted across North America, Europe, the Middle East and Asia has validated the ESC recommendations for predicting and preventing sudden cardiac death (SCD) in patients with hypertrophic cardiomyopathy (HCM). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 29, 2017 Category: International Medicine & Public Health Source Type: news
MyoKardia ’s Phase II trial for oHCM drug meets endpoints
MyoKardia has reported positive top-line results from the first cohort of its Phase II PIONEER-HCM clinical trial of mavacamten in patients with symptomatic, obstructive hypertrophic cardiomyopathy (oHCM). (Source: Drug Development Technology)
Source: Drug Development Technology - August 7, 2017 Category: Pharmaceuticals Source Type: news
Researchers successfully edit 1st human embryo with CRISPR
Scientists have successfully edited genes in a human embryo, correcting a disease-causing mutation to prevent the defect from being inherited.
The groundbreaking process, covered in a paper published yesterday in Nature, was confirmed last week by the Oregon Health and Science University, which collaborated with the Salk Institute and Korea’s Institute for Basic Science on the task.
To edit the genetic mutation, in this case for hypertrophic cardiomyopathy, researchers used a technique known as CRISPR-Cas9. The CRISPR-Cas9 technique operates as a sort of ‘molecular scissors’ which can trim away unwanted parts of a ge...
Source: Mass Device - August 3, 2017 Category: Medical Devices Authors: Fink Densford Tags: Biotech Research & Development Source Type: news
Gene editing used to repair diseased genes in embryos
Conclusion
Currently, genetically-inherited conditions like hypertrophic cardiomyopathy cannot be cured, only managed to reduce the risk of sudden cardiac death. For couples where one partner carries the mutated gene, the only option to avoid passing it onto their children is pre-implantation genetic diagnosis. This involves using IVF to create embryos, then testing a cell of the embryo to see whether it carries the healthy or mutated version of the gene. Embryos with healthy versions of the gene are then selected for implantation in the womb.
Problems arise if too few or none of the embryos have the correct version of the...
Source: NHS News Feed - August 3, 2017 Category: Consumer Health News Tags: Genetics/stem cells Source Type: news
