Hypermetropia (long sighted) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Historic dam removal poses challenge of restoring both river and landscape
Standing on an outcrop of volcanic rock, Joshua Chenoweth looks across the languid waters of California’s Iron Gate Reservoir and imagines the transformation in store for the landscape. In early 2024, operators will open the floodgates on the 49-meter-high dam that blocks the Klamath River, allowing the more than 50 million tons of water it impounds to begin to drain. Once it’s gone, heavy equipment will dismantle the structure. All that will remain of the 11-kilometer-long reservoir that filled the valley for 60 years will be steep-sided slopes coated in gray mud, split once again by a free-flowing river. Within...
Source: Science of Aging Knowledge Environment - October 19, 2023 Category: Geriatrics Source Type: research

News at a glance: Diphtheria vaccine shortage, prisoner release, and iNaturalist ’s growth
CONSERVATION Popular biodiversity app to expand The nonprofit that runs iNaturalist, a popular app and website for identifying species, has received a $10 million grant to expand. The funding from the Gordon and Betty Moore Foundation, announced last week, will allow iNaturalist—whose website is one of the largest generators of crowd-sourced species-occurrence data—to add users, technology, and observations to inform conservation. iNaturalist hopes to grow in nature-rich parts of the world, such as Asia and South America, which have fewer users uploading data. Since iNaturalist’s founding in 20...
Source: Science of Aging Knowledge Environment - September 21, 2023 Category: Geriatrics Source Type: research

Lamb-Shaffer syndrome: 20 Spanish patients and literature review expands the view of neurodevelopmental disorders caused by SOX5 haploinsufficiency
In conclusion, LLS is a rare genetic disorder mostly characterized by a wide range of developmental and neurological symptoms. Early diagnosis would allow to start of care programs, clinical follow up, prospective studies and appropriate genetic counseling, to promote clinical and social improvement to have profound lifelong benefits for patients and their families. Further research is needed to better understand the underlying mechanisms of the syndrome related to SOX5 haploinsufficiency.PMID:37702321 | DOI:10.1111/cge.14423 (Source: Clinical Genetics)
Source: Clinical Genetics - September 13, 2023 Category: Genetics & Stem Cells Authors: Jair Tenorio-Castano Ángela Sánchez-Algaba Gómez M ónica Coronado Pilar Rodr íguez-Martín Alejandro Parra Patricia Pascual Mario Cazalla Natalia Gallego Pedro Arias Aixa V Morales Juli án Nevado Pablo Lapunzina Source Type: research

Sensors, Vol. 23, Pages 7562: Clutter Effect Investigation on Co-Polarized Chipless RFID Tags and Mitigation Using Cross-Polarized Tags, Analytical Model, Simulation, and Measurement
as Kaiser Chipless radio frequency identification (RFID) technology is expected to replace barcode technology due to its ability to read in non-line-of-sight (NLOS) situations, long reading range, and low cost. Currently, there is extensive research being conducted on frequency-coded (FC) co-polarized radar cross-section (RCS)-based tags, which are widely used. However, detecting co-polarized chipless RFID tags in cluttered environments is still a challenge, as confirmed by measuring two co-polarized tags in front of a perfect metal reflector (30.5cm&times;22.5cm). To address this challenge, a realistic mathema...
Source: Sensors - August 31, 2023 Category: Biotechnology Authors: Jahangir Alam Maher Khaliel Feng Zheng Klaus Solbach Thomas Kaiser Tags: Article Source Type: research

Cells with extra genomes may help tissues respond to injuries —and species survive cataclysms
When Vicki Losick got her Ph.D. and joined a fruit fly lab at the Carnegie Institution for Science in 2008, its head announced that he expected his postdocs to launch new fields of inquiry. She chose a then-fashionable focus: stem cells, versatile cells that specialize into other cell types and play critical roles in embryonic development and the renewal of adult tissues. Losick wondered whether they also help in wound repair. So, she and another postdoc, Don Fox, began stabbing fruit flies with a tiny needle, hoping to document stem cells coming to the rescue. Instead, the two postdocs, working independently, saw ot...
Source: Science of Aging Knowledge Environment - August 24, 2023 Category: Geriatrics Source Type: research

Sensors, Vol. 23, Pages 7394: Unveiling LoRa & rsquo;s Oceanic Reach: Assessing the Coverage of the Azores LoRaWAN Network from an Island
In this study, we explore the viability of a low-power, cost-effective wireless communication solution for maritime sensing data. Specifically, we conduct an experimental assessment of the Azorean Long Range Wide Area Network (LoRaWAN) coverage. Our tests involve positioning the gateway at the island&rsquo;s highest point and installing end nodes on medium-sized fishing vessels. Through measurements of received signal strength indicator (RSSI), signal-to-noise ratio (SNR), and lines of sight (LOS), we showcase the potential of LoRaWAN transmissions to achieve communication distances exceeding 130 km in a LOS-free s...
Source: Sensors - August 24, 2023 Category: Biotechnology Authors: Jo ão Pinelo Andr é Dionísio Rocha Miguel Arvana Jo ão Gonçalves Nuno Cota Pedro Silva Tags: Article Source Type: research

Hallucinogenic potential: a review of psychoplastogens for the treatment of opioid use disorder
The United States is entering its fourth decade of the opioid epidemic with no clear end in sight. At the center of the epidemic is an increase in opioid use disorder (OUD), a complex condition encompassing physical addiction, psychological comorbidities, and socioeconomic and legal travails associated with the misuse and abuse of opioids. Existing behavioral and medication-assisted therapies show limited efficacy as they are hampered by lack of access, strict regimens, and failure to fully address the non-pharmacological aspects of the disease. A growing body of research has indicated the potential of hallucinogens to eff...
Source: Frontiers in Pharmacology - August 22, 2023 Category: Drugs & Pharmacology Source Type: research

LncRNA-edited biomimetic nanovaccines combined with anti-TIM-3 for augmented immune checkpoint blockade immunotherapy
J Control Release. 2023 Aug 15:S0168-3659(23)00519-9. doi: 10.1016/j.jconrel.2023.08.022. Online ahead of print.ABSTRACTT-cell immunoglobulin mucin (TIM)-3 blockade ameliorates T cell exhaustion and triggers dendritic cell (DC) inflammasome activation, showing great potential in immune checkpoint blockade (ICB) immunotherapy. However, pharmacokinetic profile and T cell/DC infiltration in tumor microenvironment is still undesired. Here, we develop a long noncoding RNA (lncRNA)-edited biomimetic nanovaccine combined with anti-TIM-3 to mediate dual-effect antigen cross-presentation and dampen T cell immunosuppression for rein...
Source: Cancer Control - August 17, 2023 Category: Cancer & Oncology Authors: Yang Zhang Feng Liu Lulu Tan Xin Li Zheng Dai Qian Cheng Jia Liu Yang Wang Lei Huang Lin Wang Zheng Wang Source Type: research

The ‘Great Indian Desert’ could disappear within a century
It’s as constant as the sunrise: Each year, the South Asian monsoon deluges the verdant east of India and leaves the west, where India and Pakistan share a border, bone-dry. That asymmetry, between the Himalayan rainforests and the “Great Indian Desert”—the most populated in the world—has shaped civilizations. But as climate change heats up, the monsoon is moving farther west into this region. Within a century, a new study suggests, the desert could disappear completely. “This is going to affect a billion people,” says Shang-Ping Xie, a climate scientist at the Scripps Institution of Oceanography who wa...
Source: Science of Aging Knowledge Environment - August 11, 2023 Category: Geriatrics Source Type: research

Advances in multimodal imaging for diagnosis of pigmented ocular fundus lesions
We describe key diagnostic features using multimodal imaging modalities of ultra-widefield fundus photography, fundus autofluorescence, optical coherence tomography (OCT), enhanced-depth imaging OCT, ultrasonography, fluorescein angiography, indocyanine green angiography, and OCT angiography (OCTA), with particular attention to diagnostic features that could be missed on fundus examination alone. Finally, we review what is on the horizon, including applications of artificial intelligence. Through skilled application of current and emerging imaging technologies, earlier detection of sight- and life-threatening melanocytic o...
Source: Canadian Journal of Ophthalmology - July 22, 2023 Category: Opthalmology Authors: Sara Verbeek Lauren A Dalvin Source Type: research

Novel sights on therapeutic, prognostic, and diagnostics aspects of non-coding RNAs in glioblastoma multiforme
AbstractGlioblastoma Multiforme (GBM) is the primary brain tumor and accounts for 200,000 deaths each year worldwide. The standard therapy includes surgical resection followed by temozolomide (TMZ)-based chemotherapy and radiotherapy. The survival period of GBM patients is only 12 –15 months. Therefore, novel treatment modalities for GBM treatment are urgently needed. Mounting evidence reveals that non-coding RNAs (ncRNAs) were involved in regulating gene expression, the pathophysiology of GBM, and enhancing therapeutic outcomes. The combinatory use of ncRNAs, chemotherape utic drugs, and tumor suppressor gene expressio...
Source: Metabolic Brain Disease - July 21, 2023 Category: Neurology Source Type: research

Ocular manifestations of congenital anomalies of the kidney and urinary tract (CAKUT)
This study reviewed diseases associated with the Genomics England CAKUT-associated gene panel for ocular anomalies. In addition, each gene was examined for expression in the human retina and an ocular phenotype in mouse model s using the Human Protein Atlas and Mouse Genome Informatics databases, respectively. Thirty-four (54%) of the 63 CAKUT-associated genes (55 ‘green’ and 8 ‘amber’) had a reported ocular phenotype. Five of the 6 most common CAKUT-associated genes (PAX2,EYA1,SALL1,GATA3,PBX1) that represent 30% of all diagnoses had ocular features. The ocular abnormalities found with most CAKUT-associated genes...
Source: Pediatric Nephrology - July 20, 2023 Category: Urology & Nephrology Source Type: research

Novel sights on therapeutic, prognostic, and diagnostics aspects of non-coding RNAs in glioblastoma multiforme
AbstractGlioblastoma Multiforme (GBM) is the primary brain tumor and accounts for 200,000 deaths each year worldwide. The standard therapy includes surgical resection followed by temozolomide (TMZ)-based chemotherapy and radiotherapy. The survival period of GBM patients is only 12 –15 months. Therefore, novel treatment modalities for GBM treatment are urgently needed. Mounting evidence reveals that non-coding RNAs (ncRNAs) were involved in regulating gene expression, the pathophysiology of GBM, and enhancing therapeutic outcomes. The combinatory use of ncRNAs, chemotherape utic drugs, and tumor suppressor gene expressio...
Source: Metabolic Brain Disease - July 15, 2023 Category: Neurology Source Type: research