Twist of fate: What happens when a top Parkinson ’s researcher gets the disease?
SEVERAL YEARS AGO , Tim Greenamyre, a neuroscientist and physician who directs the Pittsburgh Institute for Neurodegenerative Diseases at the University of Pittsburgh (Pitt), began to notice unsettling symptoms in his own body. He couldn’t smell things. He was constipated. He was shouting and kicking in his sleep. His left arm didn’t swing when he walked. In July 2021, Greenamyre turned to a neurologist colleague to confirm the diagnosis he already suspected. He had Parkinson’s disease, an illness he has devoted himself to treating and trying to cure. Over the course of his long and productive career, the ...
Source: Science of Aging Knowledge Environment - May 4, 2023 Category: Geriatrics Source Type: research

2200-year-old pile of excrement provides window into condors ’ past
High on a northern Patagonian cliffside sits a pile of poo with a view. Measuring multiple meters across, the densely layered ring is the product of thousands of years’ worth of condor excrement. Now, researchers have dug deep into this pile, scientifically speaking. The result, reported today in the Proceedings of the Royal Society B , offers an unprecedented look at the history of the Andean condor —Earth’s largest bird of prey—including a peek at how the giant scavengers responded when volatile volcanoes decimated the region. It's a “fascinating” study, says Kathryn Hargan, a ...
Source: Science of Aging Knowledge Environment - May 2, 2023 Category: Geriatrics Source Type: research

A variation of foveal morphology in a group of children with hypermetropia
ConclusionWider and flattened foveal pits described here represent a newly defined variation in healthy hypermetropic children. Although a correlation with visual acuity was not evident, these changes in foveal profile are shown to be related with macular microvascular changes in deep capillary plexus. Awareness of these morphologic changes will help clinicians in the differential diagnosis of macular pseudohole. (Source: International Ophthalmology)
Source: International Ophthalmology - April 20, 2023 Category: Opthalmology Source Type: research

Marking time: Cosmic ray storms can pin precise dates on history from ancient Egypt to the Vikings
One thousand years ago, according to Viking sagas, intrepid seafarers sailed west from Greenland to a coast they called Vinland. There they set up camps, harvested wild grapes, and skirmished with local people. At an archaeological site in a coastal town in Newfoundland called L’Anse aux Meadows, remnants of structures laid out like Viking longhouses and artifacts such as a bronze cloak pin and iron nails record their presence—likely the first Europeans to set foot in North America. Yet pinning down exactly when Vikings came to Vinland was impossible, until researchers discovered a kind of cosmic timestamp preceding th...
Source: Science of Aging Knowledge Environment - April 13, 2023 Category: Geriatrics Source Type: research

Dwindling sea ice may speed melting of Antarctic glaciers
In February, on an icebreaker off the coast of West Antarctica, Robert Larter, a marine geophysicist with the British Antarctic Survey (BAS), came on deck to a startling sight: open gray water as far as the eye could see. There was no ice at all for the ship to break. The next day, satellite surveys would find sea ice around the continent hitting a record low. Unlike fast-shrinking Arctic sea ice, the sea ice ringing Antarctica seemed more resistant to climate change—until recently. But now a long-term decline may have set in, and it could have unexpected and ominous domino effects, according to several recent stud...
Source: Science of Aging Knowledge Environment - April 11, 2023 Category: Geriatrics Source Type: research

Phage defense origin of animal immunity
Curr Opin Microbiol. 2023 Apr 1;73:102295. doi: 10.1016/j.mib.2023.102295. Online ahead of print.ABSTRACTThe innate immune system is the first line of defense against microbial pathogens. Many of the features of eukaryotic innate immunity have long been viewed as lineage-specific innovations, evolved to deal with the challenges and peculiarities of multicellular life. However, it has become increasingly apparent that in addition to evolving their own unique antiviral immune strategies, all lifeforms have some shared defense strategies in common. Indeed, critical fixtures of animal innate immunity bear striking resemblance ...
Source: Current Opinion in Microbiology - April 3, 2023 Category: Microbiology Authors: Benjamin R Morehouse Source Type: research

Phage defense origin of animal immunity
Curr Opin Microbiol. 2023 Apr 1;73:102295. doi: 10.1016/j.mib.2023.102295. Online ahead of print.ABSTRACTThe innate immune system is the first line of defense against microbial pathogens. Many of the features of eukaryotic innate immunity have long been viewed as lineage-specific innovations, evolved to deal with the challenges and peculiarities of multicellular life. However, it has become increasingly apparent that in addition to evolving their own unique antiviral immune strategies, all lifeforms have some shared defense strategies in common. Indeed, critical fixtures of animal innate immunity bear striking resemblance ...
Source: Current Opinion in Microbiology - April 3, 2023 Category: Microbiology Authors: Benjamin R Morehouse Source Type: research

Phage defense origin of animal immunity
Curr Opin Microbiol. 2023 Apr 1;73:102295. doi: 10.1016/j.mib.2023.102295. Online ahead of print.ABSTRACTThe innate immune system is the first line of defense against microbial pathogens. Many of the features of eukaryotic innate immunity have long been viewed as lineage-specific innovations, evolved to deal with the challenges and peculiarities of multicellular life. However, it has become increasingly apparent that in addition to evolving their own unique antiviral immune strategies, all lifeforms have some shared defense strategies in common. Indeed, critical fixtures of animal innate immunity bear striking resemblance ...
Source: Current Opinion in Microbiology - April 3, 2023 Category: Microbiology Authors: Benjamin R Morehouse Source Type: research

Letter to the Editor in Response to Paul Katz et  al: “Raising the Bar for Physicians Practicing in Nursing Homes: Is Specialty Status the Answer?”
Our current health care system is failing to meet the needs of our population, particularly with regard to chronic illness and post-acute and long-term care (PA-LTC). Despite widespread dissatisfaction, major reforms are not in sight. (Source: Journal of the American Medical Directors Association)
Source: Journal of the American Medical Directors Association - March 31, 2023 Category: Health Management Authors: Mark E. Williams Tags: Letter to the Editor Source Type: research

Challenges and management of childhood non-infectious chronic uveitis
Expert Rev Clin Immunol. 2023 Mar 30. doi: 10.1080/1744666X.2023.2198210. Online ahead of print.ABSTRACTINTRODUCTION: Childhood uveitis is a sight-threatening condition, because if not properly recognized and treated can lead to several ocular complications and blindness. It represents a real challenge not only from an etiologic/diagnostic point of view, but also for management and therapy.AREAS COVERED: In this review we will discuss the main etiologies, the diagnostic approach, risk factors associated to childhood non-infectious uveitis (cNIU), and the difficulties in eye examination in childhood. Moreover, we will discu...
Source: Expert Review of Clinical Immunology - March 30, 2023 Category: Allergy & Immunology Authors: Ilaria Maccora Edoardo Marrani Ilaria Pagnini Maria Vincenza Mastrolia Cinzia de Libero Roberto Caputo Gabriele Simonini Source Type: research

Sensors, Vol. 23, Pages 3046: Coseismic Deformation Field and Fault Slip Distribution Inversion of the 2020 Jiashi Ms 6.4 Earthquake: Considering the Atmospheric Effect with Sentinel-1 Data Interferometry
This study, therefore, proposes an inversion method of coseismic deformation field and fault slip distribution, taking atmospheric effect into account to address this issue. First, an improved inverse distance weighted (IDW) interpolation tropospheric decomposition model is utilised to accurately estimate the turbulence component in tropospheric delay. Using the joint constraints of the corrected deformation fields, the geometric parameters of the seismogenic fault and the distribution of coseismic slip are then inverted. The findings show that the coseismic deformation field (long axis strike was nearly east&ndash...
Source: Sensors - March 11, 2023 Category: Biotechnology Authors: Xuedong Zhang Jiaojie Li Xianglei Liu Ziqi Li Nilufar Adil Tags: Article Source Type: research

News at a glance: Hubble interlopers, an ocean-drilling gap, and a near-sighted astronomer
ASTRONOMY Satellite swarms spoil Hubble’s view Images from the iconic Hubble Space Telescope are increasingly marred by the tracks of passing satellites in higher orbits , a threat that could balloon as companies vie to build “megaconstellations” for global internet services. The rocket company SpaceX has launched more than 3500 of its Starlink satellites out of a planned 12,000; Amazon and the Chinese government have similar plans. Ground-based observatories are already seeing images spoiled, so researchers wanted to know how badly Hubble was affected. They enlisted members of the p...
Source: Science of Aging Knowledge Environment - March 9, 2023 Category: Geriatrics Source Type: research

Suffering in silence: Caring for research animals can take a severe mental toll
Conner Sessions’s decision to combine his love of science and animals nearly destroyed him. Growing up in rural Washington state, he spent his early life surrounded by cows, horses, cats, and dogs. He cared about all of them and considered a career in veterinary medicine. But after graduating with a bachelor’s degree in biochemistry from the University of Washington (UW), Seattle, in 2016, he saw a job ad that changed his mind. The school needed an animal technician, someone to clean and feed mice, pigs, dogs, and other creatures used in biomedical research. “I wanted to get involved with science, and working w...
Source: Science of Aging Knowledge Environment - March 9, 2023 Category: Geriatrics Source Type: research

Shape detection beyond the visual field using a visual-to-auditory sensory augmentation device
In this study, we aimed to use the EyeMusic for the blind areas of sighted individuals. We use it in this initial proof-of-concept study to test the ability of sighted subjects to combine visual information with surrounding auditory sonification representing visual information. Participants in this study were tasked with recognizing and adequately placing the stimuli, using sound to represent the areas outside the standard human visual field. As such, the participants were asked to report shapes’ identities as well as their spatial orientation (front/right/back/left), requiring combined visual (90° frontal) and auditory...
Source: Frontiers in Human Neuroscience - March 2, 2023 Category: Neuroscience Source Type: research

Sensors, Vol. 23, Pages 2534: A 2D-Lidar-Equipped Unmanned Robot-Based Approach for Indoor Human Activity Detection
tsuki Monitoring the activities of elderly people living alone is of great importance since it allows for the detection of when hazardous events such as falling occur. In this context, the use of 2D light detection and ranging (LIDAR) has been explored, among others, as a way to identify such events. Typically, a 2D LIDAR is placed near the ground and collects measurements continuously, and a computational device classifies these measurements. However, in a realistic environment with home furniture, it is hard for such a device to operate as it requires a direct line of sight (LOS) with its target. Furniture will block...
Source: Sensors - February 24, 2023 Category: Biotechnology Authors: Mondher Bouazizi Alejandro Lorite Mora Tomoaki Ohtsuki Tags: Article Source Type: research