Perinatal Exposure to Polychlorinated Biphenyls (PCBs) and Child Neurodevelopment: A Comprehensive Systematic Review of Outcomes and Methodological Approaches
CONCLUSIONS: Significant methodological, clinical and statistical heterogeneity existed in the included studies. Adverse effects on cognitive development and attention were observed in middle childhood. Inconclusive evidence prevailed regarding other neurodevelopmental aspects due to limited studies. Future research could further explore sex-specific associations and evaluate associations at lower exposure levels post-PCB ban in the US. It should also consider OH-PCB metabolites, co-pollutants, mixtures, and their potential interactions.PMID:38615789 | DOI:10.1016/j.envres.2024.118912 (Source: Environmental Research)
Source: Environmental Research - April 14, 2024 Category: Environmental Health Authors: Arin A Balalian Jeanette A Stingone Linda G Kahn Julie B Herbstman Richard I Graeve Steven D Stellman Pam Factor-Litvak Source Type: research
Comparison of developmental toxicity of graphene oxide and graphdiyne to zebrafish larvae
In this study, we compared with developmental toxicity of GO and GDY to zebrafish larvae. It was shown that exposure of zebrafish embryos from 5 h post fertilization to GO and GDY for up to 5 days decreased hatching rate and induced morphological deformity. Behavioral tests indicated that GO and GDY treatment led to hyperactivity of larvae. However, blood flow velocity was not significantly affected by GO or GDY. RNA-sequencing data revealed that both types of NMs altered gene expression profiles as well as gene ontology terms and KEGG pathways related with metabolism. We further confirmed that the NMs altered the expressi...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 14, 2024 Category: Biochemistry Authors: Wanyan Wu Weichao Zhao Chaobo Huang Yi Cao Source Type: research
Input-output specific orchestration of aversive valence in lateral habenula during stress dynamics
J Zhejiang Univ Sci B. 2024 Apr 7:1-11. doi: 10.1631/jzus.B2300933. Online ahead of print.ABSTRACTStress has been considered as a major risk factor for depressive disorders, triggering depression onset via inducing persistent dysfunctions in specialized brain regions and neural circuits. Among various regions across the brain, the lateral habenula (LHb) serves as a critical hub for processing aversive information during the dynamic process of stress accumulation, thus having been implicated in the pathogenesis of depression. LHb neurons integrate aversive valence conveyed by distinct upstream inputs, many of which selectiv...
Source: J Zhejiang Univ Sci ... - April 14, 2024 Category: Science Authors: Taida Huang Xiaonan Guo Xiaomin Huang Chenju Yi Yihui Cui Yiyan Dong Source Type: research
Comparison of developmental toxicity of graphene oxide and graphdiyne to zebrafish larvae
In this study, we compared with developmental toxicity of GO and GDY to zebrafish larvae. It was shown that exposure of zebrafish embryos from 5 h post fertilization to GO and GDY for up to 5 days decreased hatching rate and induced morphological deformity. Behavioral tests indicated that GO and GDY treatment led to hyperactivity of larvae. However, blood flow velocity was not significantly affected by GO or GDY. RNA-sequencing data revealed that both types of NMs altered gene expression profiles as well as gene ontology terms and KEGG pathways related with metabolism. We further confirmed that the NMs altered the expressi...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 14, 2024 Category: Biochemistry Authors: Wanyan Wu Weichao Zhao Chaobo Huang Yi Cao Source Type: research
Input-output specific orchestration of aversive valence in lateral habenula during stress dynamics
J Zhejiang Univ Sci B. 2024 Apr 7:1-11. doi: 10.1631/jzus.B2300933. Online ahead of print.ABSTRACTStress has been considered as a major risk factor for depressive disorders, triggering depression onset via inducing persistent dysfunctions in specialized brain regions and neural circuits. Among various regions across the brain, the lateral habenula (LHb) serves as a critical hub for processing aversive information during the dynamic process of stress accumulation, thus having been implicated in the pathogenesis of depression. LHb neurons integrate aversive valence conveyed by distinct upstream inputs, many of which selectiv...
Source: J Zhejiang Univ Sci ... - April 14, 2024 Category: Science Authors: Taida Huang Xiaonan Guo Xiaomin Huang Chenju Yi Yihui Cui Yiyan Dong Source Type: research
Broad Perspectives of the Experience of Romantic Relationships and Sexual Education in Neurodivergent Adolescents and Young Adults
AbstractNeurodivergent young people tend to struggle with building and maintaining their romantic relationships. Despite this, there appears to be a lack of appropriate sexuality education delivered to them. This review aims to present and discuss the most current literature (conducted between 2015 and current) on romantic relationships and sexuality education in young people with Autism Spectrum Disorder (ASD), Attention-Deficit/Hyperactivity Disorder (ADHD), and ASD co-occurring with ADHD. Six internet-based bibliographic databases were used for the present review that followed the Preferred Reporting Items for Systemati...
Source: Sexuality and Disability - April 12, 2024 Category: Disability Source Type: research
Music and Movement Therapy Improves Quality of Life and Attention and Associated Electroencephalogram Changes in Patients with Attention-Deficit/Hyperactivity Disorder
Attention-deficit/hyperactivity disorder (ADHD) is the most common neurobehavioral disorder. Treatments for ADHD include pharmacological and nonpharmacological therapy. However, pharmacological treatments have side effects such as poor appetite, sleep disturbance, and headache. Moreover, nonpharmacological treatments are not effective in ameliorating core symptoms and are time-consuming. Hence, developing an alternative and effective treatment without (or with fewer) side effects is crucial. Music therapy has long been used to treat numerous neurological diseases. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - April 12, 2024 Category: Perinatology & Neonatology Authors: Mei-Wen Lee, Ni-Jung Yang, Hin-Kiu Mok, Rei-Cheng Yang, Yi-Hung Chiu, Lung-Chang Lin Source Type: research
Psychosis with use of amphetamine drugs, methylphenidate and atomoxetine in adolescent and adults
Conclusion
Our study suggests that amphetamine use is associated with a higher reporting of psychotic symptoms, compared with methylphenidate use.
Clinical implications
The prescription of psychostimulants should consider this potential adverse effect when assessing the benefit–risk balance. (Source: Evidence-Based Mental Health)
Source: Evidence-Based Mental Health - April 12, 2024 Category: Psychiatry & Psychology Authors: Hamard, J., Rousseau, V., Durrieu, G., Garcia, P., Yrondi, A., Sommet, A., Revet, A., Montastruc, F. Tags: Open access Pharmacological treatments Source Type: research
More Than 1 in 10 US Children Diagnosed With ADHD
About 11% of US children aged 5 to 17 years have been diagnosed with attention-deficit/hyperactivity disorder (ADHD), based on data from the National Health Interview Survey conducted between 2020 and 2022. This survey confirms estimates from earlier reports. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 12, 2024 Category: General Medicine Source Type: research
Costs associated with adverse events during treatment episodes for adult attention-deficit/hyperactivity disorder
Conclusions: This study found that AEs occurring during ADHD treatment episodes are associated with significant healthcare costs. This highlights the potential of treatments with favorable safety profiles to alleviate the burden experienced by patients and the healthcare system.PMID:38602691 | DOI:10.1080/13696998.2024.2342749 (Source: Journal of Medical Economics)
Source: Journal of Medical Economics - April 11, 2024 Category: Health Management Authors: Jeff Schein Martin Cloutier Rebecca Bungay Marjolaine Gauthier-Loiselle Ann Childress Source Type: research
The role of personal strengths in the relationship between adult attention-de ficit/hyperactivity symptoms and perceived stress
DISCUSSION: Our results suggest that ADHD symptoms may be associated with a deficit in personal strengths, which may contribute to negative outcomes. Psychotherapeutic interventions that support the recognition, cultivation and mobilization of strengths may be useful in the treatment of adults diagnosed with ADHD.PMID:38603551 (Source: Neuropsychopharmacologia Hungarica)
Source: Neuropsychopharmacologia Hungarica - April 11, 2024 Category: Psychiatry Authors: Stella Ol áh Vivien Nagy M ónika Miklósi Source Type: research
Costs associated with adverse events during treatment episodes for adult attention-deficit/hyperactivity disorder
Conclusions: This study found that AEs occurring during ADHD treatment episodes are associated with significant healthcare costs. This highlights the potential of treatments with favorable safety profiles to alleviate the burden experienced by patients and the healthcare system.PMID:38602691 | DOI:10.1080/13696998.2024.2342749 (Source: Journal of Medical Economics)
Source: Journal of Medical Economics - April 11, 2024 Category: Health Management Authors: Jeff Schein Martin Cloutier Rebecca Bungay Marjolaine Gauthier-Loiselle Ann Childress Source Type: research
The role of personal strengths in the relationship between adult attention-de ficit/hyperactivity symptoms and perceived stress
DISCUSSION: Our results suggest that ADHD symptoms may be associated with a deficit in personal strengths, which may contribute to negative outcomes. Psychotherapeutic interventions that support the recognition, cultivation and mobilization of strengths may be useful in the treatment of adults diagnosed with ADHD.PMID:38603551 (Source: Neuropsychopharmacologia Hungarica)
Source: Neuropsychopharmacologia Hungarica - April 11, 2024 Category: Psychiatry Authors: Stella Ol áh Vivien Nagy M ónika Miklósi Source Type: research
