Hyperactivity Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Perinatal compromise affects development, form, and function of the hippocampus part one; clinical studies
Pediatr Res. 2024 Mar 22. doi: 10.1038/s41390-024-03105-7. Online ahead of print.ABSTRACTThe hippocampus is a neuron-rich specialised brain structure that plays a central role in the regulation of emotions, learning and memory, cognition, spatial navigation, and motivational processes. In human fetal development, hippocampal neurogenesis is principally complete by mid-gestation, with subsequent maturation comprising dendritogenesis and synaptogenesis in the third trimester of pregnancy and infancy. Dendritogenesis and synaptogenesis underpin connectivity. Hippocampal development is exquisitely sensitive to perturbations du...
Source: Pediatric Research - March 23, 2024 Category: Pediatrics Authors: Tegan A White Suzanne L Miller Amy E Sutherland Beth J Allison Emily J Camm Source Type: research

Continuity of mental disorders in children with chronic physical illness
We examined the prevalence and predictors of homotypic and heterotypic continuity of mental disorder in children with CPI. A sample of 263 children aged 2 –16 years with physician-diagnosed CPI were recruited from outpatient clinics (e.g., dermatology, respiratory) at a Canadian pediatric academic hospital and followed for 24 months. Parent and child-reported mental disorders (mood, anxiety, behavioral, attention-deficit hyperactivity disorder [ADHD ]) were assessed using the Mini International Neuropsychiatric Interview for Children and Adolescents at baseline, 6, 12, and 24 months. Marginal regression models were compu...
Source: European Child and Adolescent Psychiatry - March 23, 2024 Category: Psychiatry Source Type: research

mTOR hyperactivity and RICTOR amplification as targets for personalized treatments in malignancies
Pathol Oncol Res. 2024 Mar 7;30:1611643. doi: 10.3389/pore.2024.1611643. eCollection 2024.ABSTRACTThe increasing knowledge of molecular alterations in malignancies, including mutations and regulatory failures in the mTOR (mechanistic target of rapamycin) signaling pathway, highlights the importance of mTOR hyperactivity as a validated target in common and rare malignancies. This review summarises recent findings on the characterization and prognostic role of mTOR kinase complexes (mTORC1 and mTORC2) activity regarding differences in their function, structure, regulatory mechanisms, and inhibitor sensitivity. We have recent...
Source: Pathology Oncology Research - March 22, 2024 Category: Pathology Authors: D ániel Sztankovics Dorottya Moldvai G ábor Petővári Titanilla Dank ó Fatime Szalai Risa Miyaura Vikt ória Varga No émi Nagy Gerg ő Papp Judit P ápay Ildik ó Krencz Anna Sebesty én Source Type: research

mTOR hyperactivity and RICTOR amplification as targets for personalized treatments in malignancies
Pathol Oncol Res. 2024 Mar 7;30:1611643. doi: 10.3389/pore.2024.1611643. eCollection 2024.ABSTRACTThe increasing knowledge of molecular alterations in malignancies, including mutations and regulatory failures in the mTOR (mechanistic target of rapamycin) signaling pathway, highlights the importance of mTOR hyperactivity as a validated target in common and rare malignancies. This review summarises recent findings on the characterization and prognostic role of mTOR kinase complexes (mTORC1 and mTORC2) activity regarding differences in their function, structure, regulatory mechanisms, and inhibitor sensitivity. We have recent...
Source: Cell Research - March 22, 2024 Category: Cytology Authors: D ániel Sztankovics Dorottya Moldvai G ábor Petővári Titanilla Dank ó Fatime Szalai Risa Miyaura Vikt ória Varga No émi Nagy Gerg ő Papp Judit P ápay Ildik ó Krencz Anna Sebesty én Source Type: research

 Have you been paying attention? : Adult-onset attention-deficit hyperactivity disorder
Aust N Z J Psychiatry. 2024 Mar 22:48674241240591. doi: 10.1177/00048674241240591. Online ahead of print.NO ABSTRACTPMID:38516810 | DOI:10.1177/00048674241240591 (Source: The Australian and New Zealand Journal of Psychiatry)
Source: The Australian and New Zealand Journal of Psychiatry - March 22, 2024 Category: Psychiatry Authors: Shuichi Suetani Kannan Kallapiran James G Scott Source Type: research

Tinnitus-related increases in single-unit activity in awake rat auditory cortex correlate with tinnitus behavior
Hear Res. 2024 Mar 16;445:108993. doi: 10.1016/j.heares.2024.108993. Online ahead of print.ABSTRACTTinnitus is known to affect 10-15 % of the population, severely impacting 1-2 % of those afflicted. Canonically, tinnitus is generally a consequence of peripheral auditory damage resulting in maladaptive plastic changes in excitatory/inhibitory homeostasis at multiple levels of the central auditory pathway as well as changes in diverse nonauditory structures. Animal studies of primary auditory cortex (A1) generally find tinnitus-related changes in excitability across A1 layers and differences between inhibitory neuronal subty...
Source: Hearing Research - March 22, 2024 Category: Audiology Authors: Rui Cai Lynne Ling Madan Ghimire Kevin A Brownell Donald M Caspary Source Type: research