Propranolol inhibits myocardial infarction-induced brown adipose tissue D2 activation and maintains a low thyroid hormone state in rats.
es EL Abstract Considering the recognized role of thyroid hormones on the cardiovascular system during health and disease, we hypothesized that type 2 deiodinase (D2) activity, the main activation pathway of thyroxine (T4)-to-triiodothyronine (T3), could be an important site to modulate thyroid hormone status, which would then constitute a possible target for β-adrenergic blocking agents in a myocardial infarction (MI) model induced by left coronary occlusion in rats. Despite a sustained and dramatic fall in serum T4 concentrations (60-70%), the serum T3 concentration fell only transiently in the first week p...
Source: Braz J Med Biol Res - October 18, 2019 Category: Research Authors: Seara FAC, Araujo IG, Império GE, Marassi MP, Silva ACM, Mecawi AS, Reis LC, Olivares EL Tags: Braz J Med Biol Res Source Type: research

Practical considerations for the evaluation and management of Attention Deficit Hyperactivity Disorder (ADHD) in adults.
This article aims to provide practical considerations for the management of ADHD and associated disorders in adults, in this particular French context. PMID: 31610922 [PubMed - as supplied by publisher] (Source: L Encephale)
Source: L Encephale - October 17, 2019 Category: Psychiatry Tags: Encephale Source Type: research

Modeling cortical spreading depression induced by the hyperactivity of interneurons
AbstractCortical spreading depression (CSD) is a wave of transient intense neuronal firing leading to a long lasting depolarizing block of neuronal activity. It is a proposed pathological mechanism of migraine with aura. Some forms of migraine are associated with a genetic mutation of the Nav1.1 channel, resulting in its gain of function and implying hyperexcitability of interneurons. This leads to the counterintuitive hypothesis that intense firing of interneurons can cause CSD ignition. To test this hypothesis in silico, we developed a computational model of an E-I pair (a pyramidal cell and an interneuron), in which the...
Source: Journal of Computational Neuroscience - October 17, 2019 Category: Neuroscience Source Type: research

Attention-deficit hyperactivity disorder shares copy number variant risk with schizophrenia and autism spectrum disorder
Translational Psychiatry, Published online: 17 October 2019; doi:10.1038/s41398-019-0599-yAttention-deficit hyperactivity disorder shares copy number variant risk with schizophrenia and autism spectrum disorder (Source: Translational Psychiatry)
Source: Translational Psychiatry - October 17, 2019 Category: Psychiatry Authors: Olafur O. Gudmundsson G. Bragi Walters Andres Ingason Stefan Johansson Tetyana Zayats Lavinia Athanasiu Ida Elken Sonderby Omar Gustafsson Muhammad S. Nawaz Gudbjorn F. Jonsson Lina Jonsson Per-Morten Knappskog Ester Ingvarsdottir Katrin Davidsdottir Srdj Source Type: research

Young Children with Attention-Deficit/Hyperactivity Disorder and/or Disruptive Behavior Disorders Are More Frequently Prescribed Alpha Agonists Than Stimulants
Journal of Child and Adolescent Psychopharmacology, Ahead of Print. (Source: Journal of Child and Adolescent Psychopharmacology)
Source: Journal of Child and Adolescent Psychopharmacology - October 17, 2019 Category: Pediatrics Authors: Shruti Mittal Andrea D. Boan Mary C. Kral Michelle D. Lally Karen van Bakergem Michelle M. Macias Angela LaRosa Source Type: research

How do adolescents with ADHD perceive and experience stress? An interview study.
Conclusions: Stress should be considered among other problems related to ADHD. Psychoeducation about stress, stress managing techniques and coaching should be included in the treatment of adolescents with ADHD. PMID: 31613179 [PubMed - as supplied by publisher] (Source: Nordic Journal of Psychiatry)
Source: Nordic Journal of Psychiatry - October 16, 2019 Category: Psychiatry Tags: Nord J Psychiatry Source Type: research

Crosstalk between S. cerevisiae SAPKs Hog1 and Mpk1 is mediated by glycerol accumulation
In this study, we show that hyperactivation of Mpk1 in a ptp2 ptp3 null mutant is an indirect consequence of Hog1 hyperactivation, which induces accumulation of intracellular glycerol and an attendant hypo-osmotic stress. Mpk1 hyperactivity in the absence of PTP2 and PTP3 was suppressed by a hog1 null mutation, or by restoration of osmotic balance with a constitutive form of the glycerol channel Fps1. We found similarly that activation of Mpk1 in response to zymolyase treatment is partly a consequence of Hog1-driven glycerol accumulation. Thus, we have identified two conditions in which glycerol serves as a mediator of cro...
Source: Fungal Biology - October 16, 2019 Category: Biology Source Type: research

Environmental lead exposure is associated with neurocognitive dysfunction in children with chronic kidney disease
ConclusionsLow-level lead exposure is associated with significantly lower IQ and more inattention in children with CKD, a population already at high risk for neurocognitive dysfunction. Universal screening for elevated BLL should be considered for all children with CKD at age 12 –24 months. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - October 16, 2019 Category: Urology & Nephrology Source Type: research

Impact of video-assisted thoracoscopic sympathectomy and related complications on quality of life according to the level of sympathectomy
Primary hyperhidrosis is defined as excessive sweating of idiopathic aetiology, associated with sympathetic hyperactivity, which greatly impacts patients ’ quality of life (QoL). The definitive treatment for palmar and axillary hyperhidrosis (PAH) is video-assisted thoracic sympathectomy (VATS). (Source: Annals of Vascular Surgery)
Source: Annals of Vascular Surgery - October 16, 2019 Category: Surgery Authors: T.J. Soares, P.G. Dias, S.M. Sampaio Tags: Clinical Research, Basic Science Source Type: research

Rates of Mental Health Symptoms and Associations With Self-Reported Sleep Quality and Sleep Hygiene in Adolescents Presenting for Insomnia Treatment
Conclusions:Health providers should assess for mental health problems in youth presenting with sleep-related concerns. Intervening with both sleep and mental health problems should be considered to most effectively improve functioning.Citation:Van Dyk TR, Becker SP, Byars KC. Rates of mental health symptoms and associations with self-reported sleep quality and sleep hygiene in adolescents presenting for insomnia treatment.J Clin Sleep Med. 2019;15(10):1433–1442. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - October 15, 2019 Category: Sleep Medicine Source Type: research

Obstructive Sleep Apnea in Children With Autism
Conclusions:The absence of demographic or clinical predictors of OSA supports using general indications for PSG in children with ASD.Citation:Tomkies A, Johnson RF, Shah G, Caraballo M, Evans P, Mitchell RB. Obstructive sleep apnea in children with autism.J Clin Sleep Med. 2019;15(10):1469–1476. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - October 15, 2019 Category: Sleep Medicine Source Type: research

Electrophysiological Correlates of Response Time Variability During a Sustained Attention Task
This study aimed to investigate the relationship between brain connectivity, RTV, and levels of ADHD symptoms. Twenty-eight children aged 9–12 years and 49 adolescents aged 15–18 years performed the Sustained Attention to Response Task (SART) while EEG was recorded. The participants’ levels of ADHD symptoms were measured using self- and parent-rated questionnaires. The ex-Gaussian analysis and The Fast Fourier Transform were used to measure multiple aspects of RTV. Functional connectivity between 64 electrodes was computed during task performance, and global efficiency and modularity were calculated, refl...
Source: Frontiers in Human Neuroscience - October 15, 2019 Category: Neuroscience Source Type: research

IJERPH, Vol. 16, Pages 3911: Remarkable Reduction of Cocaine Use in Dual Disorder (Adult Attention Deficit Hyperactive Disorder/Cocaine Use Disorder) Patients Treated with Medications for ADHD
This study supports the validity of the SMH in ADHD patients with co-occurring CUD. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - October 15, 2019 Category: Environmental Health Authors: Corrado Manni Giada Cipollone Alessandro Pallucchini Angelo G. I. Maremmani Giulio Perugi Icro Maremmani Tags: Article Source Type: research

Polygenic Risk Scores for Psychiatric Disorders Reveal Novel Clues About the Genetics of Disordered Gambling.
Abstract Disordered gambling (DG) is a rare but serious condition that results in considerable financial and interpersonal harms. Twin studies indicate that DG is heritable but are silent with respect to specific genes or pathways involved. Existing genomewide association studies (GWAS) of DG have been substantially underpowered. Larger GWAS of other psychiatric disorders now permit calculation of polygenic risk scores (PRSs) that reflect the aggregated effects of common genetic variants contributing risk for the target condition. The current study investigated whether gambling and DG are associated with PRSs for fo...
Source: Twin Research and Human Genetics - October 14, 2019 Category: Genetics & Stem Cells Authors: Piasecki TM, Gizer IR, Slutske WS Tags: Twin Res Hum Genet Source Type: research

A Prospective Open-Label Trial of Long-Acting Liquid Methylphenidate for the Treatment of Attention Deficit/Hyperactivity Disorder in Intellectually Capable Adults with Autism Spectrum Disorder.
Abstract Objectives: This treatment trial is aimed at assessing the short-term tolerability and efficacy of liquid-formulation extended-release methylphenidate (MPH-ER) for the treatment of ADHD in adults with high-functioning autism spectrum disorder (HF-ASD). Methods: Six-week open-label trial (ClinicalTrials.gov: NCT02096952) was conducted in 15 HF-ASD adults (mean age: 24.9 ± 4.6; male: 12 [80%]) suffering from moderate-severe ADHD. MPH-ER was administered based on a flexible titration schedule. Efficacy was assessed on clinician- and self-rated measures. Tolerability was assessed by docum...
Source: The World Journal of Biological Psychiatry - October 14, 2019 Category: Psychiatry Authors: Joshi G, DiSalvo M, Wozniak J, Ceranoglu TA, Yule A, Surman C, Fried R, Galdo M, Hoskova B, Belser A, Biederman J Tags: World J Biol Psychiatry Source Type: research

A review on the effects of new anti-diabetic drugs on platelet function.
CONCLUSION: GLP-1RA and DPP-4i drugs have antiplatelet properties beyond their primary hypoglycemic effects. Whilst we have little direct evidence for the antiplatelet effects of SGLT2 inhibitors, some studies have shown that these agents may inhibit platelet aggregation and reduce the risk of thrombotic events in diabetes. PMID: 31612835 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 14, 2019 Category: Endocrinology Authors: Yaribeygi H, Atkin SL, Jamialahmadi T, Sahebkar A Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

The association between subcortical and cortical fMRI and lifetime noise exposure in listeners with normal hearing thresholds
Publication date: 1 January 2020Source: NeuroImage, Volume 204Author(s): Rebecca S. Dewey, Susan T. Francis, Hannah Guest, Garreth Prendergast, Rebecca E. Millman, Christopher J. Plack, Deborah A. HallAbstractIn animal models, exposure to high noise levels can cause permanent damage to hair-cell synapses (cochlear synaptopathy) for high-threshold auditory nerve fibers without affecting sensitivity to quiet sounds. This has been confirmed in several mammalian species, but the hypothesis that lifetime noise exposure affects auditory function in humans with normal audiometric thresholds remains unconfirmed and current evidenc...
Source: NeuroImage - October 13, 2019 Category: Neuroscience Source Type: research

Non-pharmacological interventions for cognitive difficulties in ADHD: A systematic review and meta-analysis
This study highlights the positive effect of psychological interventions on ADHD cognitive symptomology and supports the inclusion of non-pharmacological interventions in conjunction with the commonly used pharmacological treatments. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - October 12, 2019 Category: Psychiatry Source Type: research

Exposure to valproic acid during middle to late-stage corticogenesis induces learning and social behavioral abnormalities with attention deficit/hyperactivity in adult mice.
Abstract Single prenatal exposure to valproic acid (VPA) in rodents is a widely used preclinical model of autism spectrum disorder (ASD). Continuous prenatal VPA exposure has been recently proposed as a new ASD model that closely captures the neuropathological features of ASD, including increases in cerebral cortex volume and the number of cortical upper layer neurons. We investigated the influence of prenatal VPA exposure on the behavior of adult offspring of pregnant dams that received intraperitoneal injections of VPA twice on one day during the genesis of cortical upper layer neurons. Mice exposed to VPA at E1...
Source: Biomed Res - October 12, 2019 Category: Research Authors: Sakade Y, Yamanaka K, Soumiya H, Furukawa S, Fukumitsu H Tags: Biomed Res Source Type: research

Management of Attention-Deficit/Hyperactivity Disorder in Primary Care
This article examines risk factors and treatment considerations in the United States for evidence-informed care, with a focus on affordable and readily accessible treatment in primary care settings. (Source: Nursing Clinics of North America)
Source: Nursing Clinics of North America - October 12, 2019 Category: Nursing Authors: Kathleen T. McCoy, Kirsten Pancione, Linda Sue Hammonds, Christine B. Costa Source Type: research

Degree centrality of key brain regions of attention networks in children with primary nocturnal enuresis: A resting-state functional magnetic resonance imaging study.
Abstract Primary nocturnal enuresis (PNE) is always associated with attention impairment, some of which even could develop to attention deficit hyperactivity disorder. The mechanism of attention impairment is not clear, especially lacking of objective indicators of neuroimaging. The aim of this study is to explore the possible functional imaging mechanism of impaired attention in PNE children. A total of 26 PNE children and 26 age-matched normal controls were recruited. Resting-state functional magnetic resonance imaging (rs-fMRI) was performed on these children. Degree centrality (DC) of key brain regions of DAN ...
Source: International Journal of Developmental Neuroscience - October 12, 2019 Category: Neuroscience Authors: Jiang K, Yi Y, Ding L, Li H, Li Y, Yang M, Zheng A Tags: Int J Dev Neurosci Source Type: research

X-linked adrenoleukodystrophy in brazil: a case series
Conclusions: All phenotypes of X-linked adrenoleukodystrophy, except for myelopathy in women, were presented in the studied population, which mainly consisted of children and adolescents. Prevalent signs and symptoms registered in the literature were observed. Most of the patients with cerebral demyelinating inflammatory adrenoleukodystrophy were not diagnosed in time for hematopoietic stem cell transplantation.RESUMO Objetivo: Descrever pacientes com diferentes formas de adrenoleucodistrofia ligada ao X: pr é-sintomática, adrenoleucodistrofia inflamatória desmielinizante cerebral, adrenomieloneuropati...
Source: Revista Paulista de Pediatria - October 11, 2019 Category: Pediatrics Source Type: research

Risk Factors for Prolonged Postoperative Opioid Use After Spinal Fusion for Adolescent Idiopathic Scoliosis
Background: Opioids are commonly used after posterior spinal instrumented fusion (PSIF) for adolescent idiopathic scoliosis (AIS). Prescription opioids use can potentially lead to misuse, abuse, dependence, and overdose death. Prolonged opioid use has not been extensively studied in the postoperative AIS population. The purpose of this study is to identify risk factors associated with prolonged opioid use after PSIF for AIS. Methods: A large insurance database was queried for AIS patients undergoing PSIF. Patients with prolonged postoperative opioid use were defined as those receiving new prescriptions for an opioid m...
Source: Journal of Pediatric Orthopaedics - October 11, 2019 Category: Orthopaedics Tags: Scoliosis Source Type: research

Reliability and validation of Swedish translation of Beliefs about Medication Specific (BMQ-Specific) and Brief Illness Perception Questionnaire (B-IPQ) for use in adolescents with attention-deficit hyperactivity disorder.
Conclusions: The present results prove the Swedish translation of BMQ-Specific and B-IPQ to be valid and reliable for utilization in adolescents with ADHD. The PCA confirmed the original components for BMQ-Specific and the recent findings of two main B-IPQ components describing emotional and cognitive implications versus the capability for self-care maintenance of ADHD. PMID: 31596161 [PubMed - as supplied by publisher] (Source: Nordic Journal of Psychiatry)
Source: Nordic Journal of Psychiatry - October 11, 2019 Category: Psychiatry Tags: Nord J Psychiatry Source Type: research

Evaluation of a new model for assessment and treatment of uncomplicated ADHD - effect, patient satisfaction and costs.
Authors: Wernersson R, Johansson J, Andersson M, Jarbin H Abstract Aim: Attention-deficit/hyperactivity disorder (ADHD) is the most common diagnosis within child- and adolescent psychiatry. Waiting lists and delayed care are major issues. The aim was to evaluate if standardized care (SC) for assessment and treatment of uncomplicated ADHD would reduce resource utilization and increase satisfaction with preserved improvement within the first year of treatment. Method: Patients 6-12 years with positive screen for uncomplicated ADHD at the brief child and family phone interview (BCFPI), a routine clinical proced...
Source: Nordic Journal of Psychiatry - October 11, 2019 Category: Psychiatry Tags: Nord J Psychiatry Source Type: research

The Puzzle of Emotion Regulation: Development and Evaluation of the Tangram Emotion Coding Manual for Children
In this study, we investigated the interrater and intrarater reliability, construct validity, and content validity of a new observational method for evaluating children’s emotion regulation abilities (a complex puzzle task) in a sample of 62 children without psychiatric disorders and 23 children with attention-deficit/hyperactivity disorder (ADHD) aged 7–12, using intra-class correlation coefficients for the reliability analyses and Spearman’s rank-order correlations for analyses of convergent and discriminant validity. A panel of experts examined the content validity of the test, and Mann–Whitney U...
Source: Frontiers in Psychiatry - October 11, 2019 Category: Psychiatry Source Type: research

Identification of glycyrrhizin metabolites in humans and of a potential biomarker of liquorice-induced pseudoaldosteronism: a multi-centre cross-sectional study.
Abstract Liquorice [main ingredient, glycyrrhizin (GL)] is widely used as a food sweetener and herbal medicine. Occasionally, liquorice consumption causes pseudoaldosteronism as a side effect which causes oedema, hypokalaemia, and hypertension due to hyperactivity of mineral corticoid receptor. We aimed to detect GL metabolites in human blood and urine samples and to determine the pathological relationship between GL metabolites and pseudoaldosteronism. For this multi-centre, retrospective, cross-sectional study, we recruited patients who had visited Center for Kampo Medicine in Keio University Hospital, Departmen...
Source: Archives of Toxicology - October 11, 2019 Category: Toxicology Authors: Takahashi K, Yoshino T, Maki Y, Ishiuchi K, Namiki T, Ogawa-Ochiai K, Minamizawa K, Makino T, Nakamura T, Mimura M, Watanabe K Tags: Arch Toxicol Source Type: research

Hyperactive behavioral phenotypes and an altered brain monoaminergic state in male offspring mice with perinatal hypothyroidism
Publication date: Available online 7 October 2019Source: Toxicology ReportsAuthor(s): Toyoshi Umezu, Taizo Kita, Masatoshi MoritaAbstractThyroid hormone (TH) is essential for normal brain development. TH insufficiency during early stages of development may increase the risk for attention deficit/hyperactivity disorder, in which malfunction of brain monoaminergic systems is likely involved. However, little is known about the effects of perinatal hypothyroidism on behaviors and brain monoaminergic systems in offspring mice. The present study examined in mice (1) whether perinatal hypothyroidism causes hyperactive behavioral ...
Source: Toxicology Reports - October 10, 2019 Category: Toxicology Source Type: research

Altered Regional Cerebral Blood Flow Associated with Mood and Sleep in Shift Workers: Cerebral Perfusion Magnetic Resonance Imaging Study.
CONCLUSIONS: SW experience considerably more insomnia and mood disturbances than do DW, and this is significantly related to perfusion changes in multiple brain areas. PMID: 31591830 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - October 10, 2019 Category: Neurology Tags: J Clin Neurol Source Type: research

Potential Contribution of Carotid Body-Induced Sympathetic and Renin-Angiotensin System Overflow to Pulmonary Hypertension in Intermittent Hypoxia
AbstractPurpose of ReviewObstructive sleep apnea (OSA), featured by chronic intermittent hypoxia (CIH), is an independent risk for systemic hypertension (HTN) and is associated with pulmonary hypertension (PH). The precise mechanisms underlying pulmonary vascular remodeling and PH in OSA are not fully understood. However, it has been suggested that lung tissue hypoxia, oxidative stress, and pro-inflammatory mediators following CIH exposure may contribute to PH.Recent FindingsNew evidences obtained in preclinical OSA models support that an enhanced carotid body (CB) chemosensory reactiveness to oxygen elicits sympathetic an...
Source: Current Hypertension Reports - October 10, 2019 Category: Primary Care Source Type: research

IJERPH, Vol. 16, Pages 3822: Executive Function and Attention Performance in Children with ADHD: Effects of Medication and Comparison with Typically Developing Children
aacute;romy Balázs The emerging literature reports that children with Attention-Deficit/Hyperactivity Disorder (ADHD) show deficits in executive functioning. To date, the combination of drug therapy with certain evidence-based non-medication interventions has been proven to be the most effective treatment for ADHD. There is a gap in the literature regarding comparing the executive functions (EF) of treatment naïve and medicated children with ADHD with both each other and typically developing children. Altogether, 50 treatment naïve and 50 medicated children with ADHD and 50 typically...
Source: International Journal of Environmental Research and Public Health - October 10, 2019 Category: Environmental Health Authors: Mikl ós Fut ó Kom áromy Bal ázs Tags: Article Source Type: research

Systematic Review: Overlap Between Eating, Autism Spectrum, and Attention-Deficit/Hyperactivity Disorder
Conclusions: Studies on the prevalence rates of EDs in ADHD and ASD and vice versa are heterogeneous, but they indicate frequent association. While there is growing evidence of clinical overlaps between the three disorders, it remains difficult to determine whether overlapping characteristics (e.g., social withdrawal) are due to common comorbidities (e.g., depression) or are instead primarily associated with EDs and neurodevelopmental disorders. Furthermore, prospective studies are required to better understand how these disorders are related and whether ADHD and ASD could be either specific or nonspecific predisposing fac...
Source: Frontiers in Psychiatry - October 10, 2019 Category: Psychiatry Source Type: research

Glycogen synthase kinase 3 β hyperactivity in urinary exfoliated cells predicts progression of diabetic kidney disease.
Burgeoning evidence points to glycogen synthase kinase (GSK)3 β as a key player in diverse kidney diseases. However, as a pivotal transducer of the insulin signaling pathway, the role of GSK3β in diabetic kidney disease remains uncertain. In db/db mice, renal expression of total and activated GSK3β was increasingly elevated. This preceded the development of diabetic kidney disease, and correlated with the progression of signs of diabetic kidney injury, including albuminuria and extracellular matrix accumulation in glomeruli and tubulointerstitia. (Source: Kidney International)
Source: Kidney International - October 10, 2019 Category: Urology & Nephrology Authors: Xianhui Liang, Pei Wang, Bohan Chen, Yan Ge, Athena Y. Gong, Bryce Flickinger, Deepak K. Malhotra, Li Juan Wang, Lance Dworkin, Zhangsuo Liu, Rujun Gong Tags: Clinical Investigation Source Type: research

Intracerebroventricular injection of deltamethrin increases locomotion activity and causes spatial working memory and dopaminergic pathway impairment in rats.
Abstract Deltamethrin (DM) is widely used in agriculture, veterinary medicine and control of domestic pests. Epidemiological studies suggest that DM exposure is a risk factor for neurodegenerative disorders such as Parkinson's (PD) and Alzheimer diseases; however the mechanisms are elusive. In the present study we evaluated the effects of intracerebroventricular (i.c.v.) administration of DM on locomotion activity, spatial working memory and dopaminergic pathway in the rat. Middle-aged male Wistar rats received three i.c.v. injections of DM 0.5 μg, DM 5 μg or vehicle, every other day. Across th...
Source: Brain Research Bulletin - October 10, 2019 Category: Neurology Authors: Souza MF, Medeiros KAAL, Lins LCRF, Bispo JMM, Gois AM, Freire MAM, Marchioro M, Santos JR Tags: Brain Res Bull Source Type: research

[Emotionality and temperament in attention deficit disorder with or without hyperactivity].
CONCLUSIONS: The confluence of poor self-regulation skills, emotion awareness and autonomy, and a temperament profile with a higher novelty seeking and lower persistence increase the risk of children diagnosed with ADHD for the development of a series of adjustment and adaptation problems in childhood and adolescence. PMID: 31588988 [PubMed - in process] (Source: Revista de Neurologia)
Source: Revista de Neurologia - October 9, 2019 Category: Neurology Authors: Alberdi-Paramo I, Pelaz-Antolin A Tags: Rev Neurol Source Type: research

Early Detection and Outcome in Borderline Personality Disorder
Borderline personality disorder (BPD) is a severe and heterogeneous mental disorder that is known to have the onset in young age, often in adolescence. For this reason, it is of fundamental importance to identify clinical conditions of childhood and adolescence that present a high risk to evolve in BPD. Investigations indicate that early borderline pathology (before 19 years) predict long-term deficits in functioning, and a higher percentage of these patients continue to present some BPD symptoms up to 20 years. There is a general accordance among investigators that good competence in both childhood and early adulthood is ...
Source: Frontiers in Psychiatry - October 9, 2019 Category: Psychiatry Source Type: research

Correction: The effect of methylphenidate on social cognition and oxytocin in children with attention deficit hyperactivity disorder
Neuropsychopharmacology, Published online: 09 October 2019; doi:10.1038/s41386-019-0533-2Correction: The effect of methylphenidate on social cognition and oxytocin in children with attention deficit hyperactivity disorder (Source: Neuropsychopharmacology)
Source: Neuropsychopharmacology - October 9, 2019 Category: Neurology Authors: Orit Levi-Shachar Hila Z. Gvirts Yiftach Goldwin Yuval Bloch Simone Shamay-Tsoory Orna Zagoory-Sharon Ruth Feldman Hagai Maoz Source Type: research

Effects of inspiratory muscle training intensity on cardiovascular control in amateur cyclists.
This study aims at evaluating chronic effects of different IMT intensities on cardiovascular control in amateur cyclists. A longitudinal, randomized, controlled, blind study was performed on 30 recreational male cyclists undergoing IMT for 11 weeks. Participants were randomly allocated into sham-trained group (SHAM, n=9), trained group at 60% of the maximal inspiratory pressure (MIP60, n=10), and trained group at critical inspiratory pressure (CIP, n=11). Electrocardiogram, finger arterial pressure and respiratory movements were recorded before (PRE) and after (POST) training at rest in supine position (REST) and during ac...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - October 9, 2019 Category: Physiology Authors: Martins de Abreu R, Porta A, Rehder-Santos P, Cairo B, Donisete da Silva C, De Favari Signini É, Sakaguchi CA, Catai AM Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Molecules, Vol. 24, Pages 3620: Anti-Platelet Properties of Phenolic Extracts from the Leaves and Twigs of Elaeagnus rhamnoides (L.) A. Nelson
This study is the first to demonstrate that extracts from sea buckthorn leaves and twigs are a source of bioactive compounds which may be used for the prophylaxis and treatment of cardiovascular pathologies associated with blood platelet hyperactivity. Both leaf and twig extracts were found to display anti-platelet activity in vitro. Moreover, the twig extract (rich in proanthocyanidins) displayed better anti-platelet potential than the leaf extract or aronia extract. (Source: Molecules)
Source: Molecules - October 8, 2019 Category: Chemistry Authors: Bartosz Skalski Bogdan Kontek Agata Rolnik Beata Olas Anna Stochmal Jerzy Żuchowski Tags: Article Source Type: research

The norepinephrine transporter gene modulates intrinsic brain activity, visual memory, and visual attention in children with attention-deficit/hyperactivity disorder
Molecular Psychiatry, Published online: 08 October 2019; doi:10.1038/s41380-019-0545-7The norepinephrine transporter gene modulates intrinsic brain activity, visual memory, and visual attention in children with attention-deficit/hyperactivity disorder (Source: Molecular Psychiatry)
Source: Molecular Psychiatry - October 8, 2019 Category: Psychiatry Authors: Chi-Yung Shang Hsiang-Yuan Lin Susan Shur-Fen Gau Source Type: research

Saccade eye movement in children with attention deficit hyperactivity disorder.
Conclusions: The results suggest that children with ADHD have the following difficulties: precise oculomotor control, oculomotor response inhibition function and basic visual attention. PMID: 31581925 [PubMed - as supplied by publisher] (Source: Nordic Journal of Psychiatry)
Source: Nordic Journal of Psychiatry - October 6, 2019 Category: Psychiatry Tags: Nord J Psychiatry Source Type: research

Case Study Of Massage And Reflexology Use In A 15-Year-Old With Paroxysmal Sympathetic Hyperactivity (PSH) (Also Known As Sympathetic Storming (SS)) Following Surgery For Post Fossa Tumour Removal In Paediatric Intensive Care (PICU) In Order To Reduce Symptoms And Improve Patient’s Quality Of Life (Qol) Following Sub-Dural Bleed Intraoperatively
Publication date: November 2019Source: European Journal of Surgical Oncology, Volume 45, Issue 11Author(s): Gabrielle Bignell, Gabriele Avery, Suzanne Ruggles, Sebastian Elanko, Afsana Elanko (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - October 5, 2019 Category: Surgery Source Type: research

Erucic acid from Isatis indigotica Fort. Suppresses influenza A virus replication and inflammation in vitro and in vivo through modulation of NF-κB and p38 MAPK pathway
Publication date: Available online 4 October 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Xiaoli Liang, Yuan Huang, Xiping Pan, Yanbing Hao, Xiaowei Chen, Haiming Jiang, Jing Li, Beixian Zhou, Zifeng YangAbstractIsatis indigotica Fort. (Ban-Lan-Gen) is an herbal medicine prescribed for influenza treatment. However, its active components and mode of action remain mostly unknown. In the present study, erucic acid was isolated from Isatis indigotica Fort., and subsequently its underlying mechanism against influenza A virus (IAV) infection was investigated in vitro and in vivo. Our results demonstrated that erucic ...
Source: Journal of Pharmaceutical Analysis - October 5, 2019 Category: Drugs & Pharmacology Source Type: research

Pediatric moyamoya disease presenting as attention deficit hyperactivity disorder: Time to pay attention.
Authors: Patra S, Patnaik A PMID: 31579158 [PubMed] (Source: Indian Journal of Psychiatry)
Source: Indian Journal of Psychiatry - October 4, 2019 Category: Psychiatry Tags: Indian J Psychiatry Source Type: research

Factors Relating to the Presence and Modifiability of Self-Perceptual Bias Among Children with ADHD.
Abstract Past research raises concerns about whether the presence of self-perceptual biases among children with attention-deficit/hyperactivity disorder (ADHD) interferes with accurate assessment and/or diminishes treatment response. Yet, it remains unclear whether self-perceptual bias is a construct that can be modified. The current study examines individual differences in how children with ADHD (n = 178) display and modify their self-perceptions of competence in the presence of an external motivator for self-perceptual accuracy. Participants were grouped based on the presence and modifiability of t...
Source: Child Psychiatry and Human Development - October 4, 2019 Category: Child Development Authors: Martin CP, Shoulberg EK, Hoza B, Vaughn A, Waschbusch DA Tags: Child Psychiatry Hum Dev Source Type: research

Effects of 24 CYP2D6 variants found in Chinese population on the metabolism of clonidine in vitro
ConclusionWe comprehensively evaluated the effect of 22 novel CYP2D6 variants on the metabolism of clonidine for the first time and hoped corresponding data provide a reference for metabolism of clonidine for further studies in vivo, and extend our understanding of the clinical drug toxicity or ineffectiveness by CYP2D6 genetic polymorphism. (Source: Chemico Biological Interactions)
Source: Chemico Biological Interactions - October 3, 2019 Category: Biochemistry Source Type: research

Exploring genetic variation that influences brain methylation in attention-deficit/hyperactivity disorder
Translational Psychiatry, Published online: 03 October 2019; doi:10.1038/s41398-019-0574-7Exploring genetic variation that influences brain methylation in attention-deficit/hyperactivity disorder (Source: Translational Psychiatry)
Source: Translational Psychiatry - October 3, 2019 Category: Psychiatry Authors: Laura Pineda-Cirera Anu Shivalikanjli Judit Cabana-Dom ínguez Ditte Demontis Veera M. Rajagopal Anders D. B ørglum Stephen V. Faraone Bru Cormand No èlia Fernàndez-Castillo Source Type: research

Hippocampal Pathology in Clinical High-Risk Patients and the Onset of Schizophrenia
We examined neuroimaging-derived hippocampal biomarkers in subjects at clinical high-risk (CHR) for psychosis to further characterize the pathophysiology of early psychosis. We hypothesized that glutamate hyperactivity reflected by increased metabolic activity derived from fMRI in the CA1 hippocampal subregion, and 1HMRS-derived hippocampal levels of GLX (glutamate/glutamine) represents early hippocampal dysfunction in CHR, and is predictive of conversion to syndromal psychosis. (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 3, 2019 Category: Psychiatry Authors: Frank A. Provenzano, Jia Guo, Melanie M. Wall, Xinyang Feng, Hannah C. Sigmon, Gary Brucato, Michael B. First, Douglas L. Rothman, Ragy R. Girgis, Jeffrey A. Lieberman, Scott A. Small Tags: Archival Report Source Type: research

Individualized Neurofeedback Training May Help Achieve Long-Term Improvement of Working Memory in Children With ADHD.
Abstract Background. Children with attention deficit hyperactivity disorder (ADHD) may suffer from working memory deficits, which can adversely affect their academic performance. Neurofeedback training may enhance working memory and provide a solution to this problem. Aim. To investigate the effect of frequency-neurofeedback on working memory in children with ADHD and to check if the effect is long-lasting. Method. Forty-eight children with ADHD (aged 6-12 years) were randomly assigned either to a neurofeedback with training parameters chosen to take into account each child's peak alpha frequency (PAF) or to a wai...
Source: Clinical EEG and Neuroscience - October 3, 2019 Category: Neuroscience Authors: Dobrakowski P, Łebecka G Tags: Clin EEG Neurosci Source Type: research

NS-Pten adult knockout mice display both quantitative and qualitative changes in urine-induced ultrasonic vocalizations.
Abstract The NS-Pten knockout (KO) mouse exhibits hyperactivity of the mammalian target of rapamycin (mTOR) and is a model of autism spectrum disorder (ASD). ASD presents with marked deficits in communication which can be elucidated by investigating their counterpart in mice, ultrasonic vocalizations (USVs). While USVs have been found to be altered in NS-Pten KO pups, no study has assessed whether this communication deficit persists into adulthood. In the present study, we investigate female urine-induced USVs, scent marking behavior, and open field activity in NS-Pten KO and wildtype (WT) adult male mice. Results...
Source: Behavioural Brain Research - October 3, 2019 Category: Neurology Authors: Binder MS, Jones DG, Hodges SL, Lugo JN Tags: Behav Brain Res Source Type: research