Serum Levels of Vitamin A and Vitamin D and Their Association With Symptoms in Children With Attention Deficit Hyperactivity Disorder
Conclusion: VA deficiency and VD deficiency in children with ADHD were increased in comparison with that in HCs. VA and VD co-deficiency associated with ADHD symptom severity. Attention should be paid to regular testing of VA levels and VD levels. However, the mechanism of VA and VD in ADHD needs to be further studied. Interventional studies on VA and VD supplementation are recommended to further verify the relationship between VA and VD co-deficiency and ADHD. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - November 23, 2020 Category: Psychiatry Source Type: research

Examining Associations Between Physical Activity and Academic Performance in a Large Sample of Ontario Students: The Role of Inattention and Hyperactivity.
CONCLUSION: Students may experience academic benefits from PA even if they are not meeting the guidelines of exercising daily. These benefits may occur, in part, through reductions in inattention and hyperactivity. Further work is needed to determine the temporality and mechanism of these associations. PMID: 33217724 [PubMed - as supplied by publisher] (Source: Journal of Physical Activity and Health)
Source: Journal of Physical Activity and Health - November 22, 2020 Category: Sports Medicine Tags: J Phys Act Health Source Type: research

Potential disturbance of methylphenidate of gonadal hormones or pubescent development in patients with attention-deficit/hyperactivity disorder: A twelve-month follow-up study
Publication date: Available online 21 November 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Liang-Jen Wang, Ying-Hua Huang, Wen-Jiun Chou, Sheng-Yu Lee, Ching-Shu Tsai, Min-Jing Lee, Miao-Chun Chou (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 22, 2020 Category: Psychiatry Source Type: research

IJERPH, Vol. 17, Pages 8674: Relative Incidence of Office Visits and Cumulative Rates of Billed Diagnoses Along the Axis of Vaccination
mas We performed a retrospective analysis spanning ten years of pediatric practice focused on patients with variable vaccination born into a practice, presenting a unique opportunity to study the effects of variable vaccination on outcomes. The average total incidence of billed office visits per outcome related to the outcomes were compared across groups (Relative Incidence of Office Visit (RIOV)). RIOV is shown to be more powerful than odds ratio of diagnoses. Full cohort, cumulative incidence analyses, matched for days of care, and matched for family history analyses were conducted across quantiles of vaccine uptake....
Source: International Journal of Environmental Research and Public Health - November 22, 2020 Category: Environmental Health Authors: James Lyons-Weiler Paul Thomas Tags: Article Source Type: research

Advancing understanding of the classification of broad autism phenotype and attention ‐deficit/hyperactivity disorder symptom dimensions within the Hierarchical Taxonomy of Psychopathology
AbstractResearch on personality and psychopathology associations has informed the classification of many symptom dimensions within the Hierarchical Taxonomy of Psychopathology (HiTOP). However, classification of symptom dimensions defining autism and attention ‐deficit/hyperactivity disorder (ADHD) within the HiTOP framework remains unclear in many ways. To address this issue, we examined the joint factor structure of (a) measures assessing characteristics relevant to ADHD and autism and (b) normal range personality traits in a sample of 547 adults recr uited from Amazon Mechanical Turk, many of whom reported elevated au...
Source: Personality and Mental Health - November 22, 2020 Category: Psychiatry Authors: Kasey Stanton, Elizabeth A. DeLucia, Matthew F. D. Brown, Christina G. McDonnell Tags: Research Article Source Type: research

Sleep characteristics and problems of 2-year-olds with Williams syndrome: relations with language and behavior
ConclusionsThe relations of nighttime sleep duration, positive screens for SRBD, and excessive daytime sleepiness to language and behavior in toddlers with WS parallel prior findings for typically developing toddlers. These results highlight the importance of screening young children with WS for sleep problems. Studies investigating the efficacy of behavioral strategies for improving sleep in children with WS are warranted. (Source: Journal of Neurodevelopmental Disorders)
Source: Journal of Neurodevelopmental Disorders - November 20, 2020 Category: Neurology Source Type: research

A hybrid AI approach for supporting clinical diagnosis of attention deficit hyperactivity disorder (ADHD) in adults
AbstractAttention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder that includes symptoms such as inattentiveness, hyperactivity and impulsiveness. It is considered as an important public health issue and prevalence of, as well as demand for diagnosis, has increased as awareness of the disease grew over the past years. Supply of specialist medical experts has not kept pace with the increasing demand for assessment, both due to financial pressures on health systems and the difficulty to train new experts, resulting in growing waiting lists. Patients are not being treated quickly enough causing problems...
Source: Health Information Science and Systems - November 20, 2020 Category: Information Technology Source Type: research

β-Adrenoceptor blockade prevents carotid body hyperactivity and elevated vascular sympathetic nerve density induced by chronic intermittent hypoxia.
This study evaluated whether beta-blocker treatment with propranolol (Prop) prevented the development of CB hyperactivity, vascular sympathetic nerve growth and hypertension caused by CIH. Adult male Wistar rats were assigned into 1 of 4 groups: Control (N), N + Prop, CIH and CIH + Prop. The CIH paradigm consisted of 8 cycles h-1, 8 h day-1, for 3 weeks. Propranolol was administered via drinking water to achieve a dose of 40 mg kg-1 day-1. Immunohistochemistry revealed the presence of both β1 and β2-adrenoceptor subtypes on the CB type I cell. CI...
Source: Pflugers Archiv : European Journal of Physiology - November 19, 2020 Category: Physiology Authors: Alzahrani AA, Cao LL, Aldossary HS, Nathanael D, Fu J, Ray CJ, Brain KL, Kumar P, Coney AM, Holmes AP Tags: Pflugers Arch Source Type: research

Tracking Inhibitory Control in Youth With ADHD: A Multi-Modal Neuroimaging Approach
ConclusionsWe identified potential white matter tracts related to deficient inhibitory control, elucidating the brain mechanisms of an important cognitive deficit in ADHD. These findings could be integrated into future endophenotypic biomarker studies, incorporating altogether brain structure, function, and behavior for future studies of ADHD and other psychiatric conditions that exhibit this deficit. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - November 19, 2020 Category: Psychiatry Source Type: research

Early childhood infections, antistreptococcal and basal ganglia antibodies in adult ADHD: a preliminary study
To explore the relationship between adult Attention Deficit/ Hyperactivity Disorder (ADHD), antistreptococcal titers, ABGA, and recurrent infections during early childhood. (Source: BMC Psychiatry)
Source: BMC Psychiatry - November 18, 2020 Category: Psychiatry Authors: Francesco Oliva, Giulia di Girolamo, Francesca Malandrone, Noemi Iaia, Fiorella Biasi and Giuseppe Maina Tags: Research article Source Type: research

[Research Articles] Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19
Patients with COVID-19 are at high risk for thrombotic arterial and venous occlusions. Lung histopathology often reveals fibrin-based blockages in the small blood vessels of patients who succumb to the disease. Antiphospholipid syndrome is an acquired and potentially life-threatening thrombophilia in which patients develop pathogenic autoantibodies targeting phospholipids and phospholipid-binding proteins (aPL antibodies). Case series have recently detected aPL antibodies in patients with COVID-19. Here, we measured eight types of aPL antibodies in serum samples from 172 patients hospitalized with COVID-19. These aPL antib...
Source: Science Translational Medicine - November 18, 2020 Category: Biomedical Science Authors: Zuo, Y., Estes, S. K., Ali, R. A., Gandhi, A. A., Yalavarthi, S., Shi, H., Sule, G., Gockman, K., Madison, J. A., Zuo, M., Yadav, V., Wang, J., Woodard, W., Lezak, S. P., Lugogo, N. L., Smith, S. A., Morrissey, J. H., Kanthi, Y., Knight, J. S. Tags: Research Articles Source Type: research

Severe COVID-19: understanding the role of immunity, endothelium, and coagulation in clinical practice
Resumo O SARS-CoV-2 é o responsável pela pandemia da COVID-19. O sistema imunológico é fator determinante no combate à infecção viral e, quando atua equilibrada e eficientemente, a doença é autolimitada e benigna. Uma parcela significativa da população, porém, apresenta resposta imune exacerbada. Os indiví duos diabéticos, hipertensos, obesos e com doenças cardiovasculares, infectados pelo vírus, apresentam maior chance de progredir para formas graves. Essas doenças estão relacionadas a processos in...
Source: Jornal Vascular Brasileiro - November 17, 2020 Category: Surgery Source Type: research

Differences in the prevalence of childhood adversity by geography in the 2017-18 National Survey of Children's Health.
CONCLUSIONS: This analysis demonstrates a higher ACE burden in rural compared to suburban children. These findings underscore the importance of ACE screening and suggest investment of healthcare resources in the historically underserved rural population. PMID: 33218713 [PubMed - as supplied by publisher] (Source: Child Abuse and Neglect)
Source: Child Abuse and Neglect - November 17, 2020 Category: Child Development Authors: Calthorpe LM, Pantell MS Tags: Child Abuse Negl Source Type: research

The role of top-down attentional control and attention-deficit/hyperactivity disorder symptoms in predicting future motor vehicle crash risk.
Conclusions: The driving risks associated with ADHD appear to be conveyed in part by impairments in the top-down, voluntary control of attention, rather than by difficulties sustaining attention over time or inhibiting impulses, as is often assumed. (PsycInfo Database Record (c) 2020 APA, all rights reserved) (Source: Neuropsychology)
Source: Neuropsychology - November 16, 2020 Category: Neurology Source Type: research

The Role of Decision-Making in Psychological Wellbeing and Risky Behaviours in Autistic Adolescents Without ADHD: Longitudinal Evidence from the UK Millennium Cohort Study.
This study examined the development of decision-making and its association with psychological wellbeing and risky behaviours in adolescents with and without autism. Participants included 270 autistic and 9,713 typically developing adolescents. In both samples, those with a diagnosis of attention-deficit/hyperactivity disorder (ADHD) were excluded. Data came from the Millennium Cohort Study, a nationally representative population-based birth cohort. Decision-making was assessed using the Cambridge Gambling Task at ages 11 and 14. Psychological wellbeing (happiness, self-esteem, depressive symptoms and self-harm) and risky/a...
Source: Journal of Autism and Developmental Disorders - November 16, 2020 Category: Psychiatry Authors: Hosozawa M, Mandy W, Cable N, Flouri E Tags: J Autism Dev Disord Source Type: research

Effectiveness of Pharmacological Agents and Validation of Diagnostic Scales for the Management of Paroxysmal Sympathetic Hyperactivity in Hispanics
The identification and treatment of paroxysmal sympathetic hyperactivity (PSH) still present a significant challenge. We assessed the efficacy of pharmacological agents in treating PSH symptoms and the validity of the diagnostic scales in a cohort of Hispanic patients. A retrospective chart review of cases from a single hospital was conducted in 464 records. Exclusion criteria included underlying conditions such as severe infection. Only nine patients remained in the cohort after examining their clinical records, corresponding to the following diagnoses: traumatic brain injury, subdural hemorrhage, anoxic or ischemic encep...
Source: Frontiers in Neurology - November 16, 2020 Category: Neurology Source Type: research

ADHD in Children: Common Questions and Answers.
Abstract Attention-deficit/hyperactivity disorder (ADHD) is a multidimensional chronic neurodevelopmental condition that affects 8.4% of U.S. children between two and 17 years of age and may pose long-term morbidity if untreated. The evaluation for ADHD begins when parents or caregivers present to primary care physicians with concerns about behavior problems or poor school or social function. A comprehensive history and physical examination should assess for comorbid or other conditions that can mimic ADHD. The combination of Diagnostic and Statistical Manual of Mental Disorders, 5th ed., criteria and validated sc...
Source: American Family Physician - November 14, 2020 Category: Primary Care Authors: Chang JG, Cimino FM, Gossa W Tags: Am Fam Physician Source Type: research

Impairments of interpersonal synchrony evident in attention deficit hyperactivity disorder (ADHD).
Abstract In addition to well-known attention deficiencies, attention deficit hyperactivity disorder (ADHD) is accompanied by deficiencies in social cognition. Both intentional and spontaneous interpersonal synchrony have been found to be an essential part of successful human interaction. Here, we used a novel paradigm to assess intentional and spontaneous interpersonal synchrony in adults with and without ADHD. Our data indicate that intentional interpersonal synchrony is reduced in ADHD, whereas spontaneous interpersonal synchrony remains intact. These results suggest that a dysfunctional pattern of interpersonal...
Source: Acta Psychologica - November 14, 2020 Category: Psychiatry & Psychology Authors: Gvirts Problovski HZ, Lavi D, Yozevitch R, Sherman M, Hagay Y, Dahan A Tags: Acta Psychol (Amst) Source Type: research

Assessing Fine-Granularity Structural and Functional Connectivity in Children With Attention Deficit Hyperactivity Disorder
Attention deficit hyperactivity disorder (ADHD) was considered to be a disorder with high heterogeneity, as various abnormalities were found across widespread brain regions in recent neuroimaging studies. However, remarkable individual variability of cortical structure and function may have partially contributed to these discrepant findings. In this work, we applied the Dense Individualized and Common Connectivity-Based Cortical Landmarks (DICCCOL) method to identify fine-granularity corresponding functional cortical regions across different subjects based on the shape of a white matter fiber bundle and measured functional...
Source: Frontiers in Human Neuroscience - November 13, 2020 Category: Neuroscience Source Type: research

Chronic modafinil administration to preadolescent rats impairs social play behavior and dopaminergic system.
ute;rate R, Cruz G, Renard GM Abstract Some clinical trials are investigating modafinil (Mod) as a treatment for attentional deficit and hyperactivity disorder (ADHD) in children and adolescents. Mod increases dopamine (DA) levels in the reward system by blocking dopamine transporter (DAT). Social interactions are rewarding behaviors and evidence reveals the importance of reward circuitry in social interactions. Chronic psychostimulant treatments alter DA neurotransmission and associated behaviors. The aim of this work was to evaluate the effects of chronic Mod treatment during preadolescence on social play behavi...
Source: Neuropharmacology - November 13, 2020 Category: Drugs & Pharmacology Authors: Cid-Jofré V, Gárate-Pérez M, Clark PJ, Valero-Jara V, España RA, Sotomayor-Zárate R, Cruz G, Renard GM Tags: Neuropharmacology Source Type: research

Clinical Reptile Behavior
Reptile behavior varies widely among the approximately 11,000 species of this class. The authors' objective is to allow practitioners to discriminate between normal and abnormal behaviors in reptiles. Some of the most common reasons for presentation of behavioral issues are discussed, including hyperactivity, self-mutilation, biting, repetitive behaviors, and postural abnormalities. Medical problems and suboptimal husbandry causing abnormal behaviors should be ruled out by attending veterinarians. Addressing behavior issues involves determining a differential diagnosis through a systematic approach, which then allows imple...
Source: Veterinary Clinics of North America: Exotic Animal Practice - November 12, 2020 Category: Veterinary Research Authors: Lionel Schilliger, Claire Vergneau-Grosset, Marion R. Desmarchelier Source Type: research

Childhood Atopic Dermatitis is Associated with Cognitive Dysfunction A NHIS study from 2008-2018.
Abstract BACKGROUND: Atopic dermatitis (AD) is a common inflammatory skin disease in children and adults. Little is known about the association of childhood AD with cognitive dysfunction. OBJECTIVE: To examine the association of AD and cognitive dysfunction, including memory impairment and developmental delays, in US children (age
Source: Annals of Allergy, Asthma and Immunology - November 12, 2020 Category: Allergy & Immunology Authors: Jackson-Cowan L, Cole EF, Silverberg JI, Lawley LP Tags: Ann Allergy Asthma Immunol Source Type: research

Neural Basis of Increased Cognitive Control of Impulsivity During the Mid-Luteal Phase Relative to the Late Follicular Phase of the Menstrual Cycle
In conclusion, our results suggest that cyclical gonadal hormones affect cognitive control of impulsive behavior in a periodic manner, possibility via DS-dlPFC circuitry. (Source: Frontiers in Human Neuroscience)
Source: Frontiers in Human Neuroscience - November 12, 2020 Category: Neuroscience Source Type: research

Neurobiology of Attention Deficit Hyperactivity Disorder in moya moya disease.
Authors: Suravi P, Ashis P PMID: 33165360 [PubMed] (Source: Indian Journal of Psychiatry)
Source: Indian Journal of Psychiatry - November 11, 2020 Category: Psychiatry Tags: Indian J Psychiatry Source Type: research

Network and pathway enrichment analysis of Attention Deficit/Hyperactivity Disorder candidate genes.
Conclusion: Functional enrichment analysis revealed regulation of dopamine and behavioral fear response pathways. These pathways have been assumed to play a central role in the ADHD within the selected candidate genes. PMID: 33165377 [PubMed] (Source: Indian Journal of Psychiatry)
Source: Indian Journal of Psychiatry - November 11, 2020 Category: Psychiatry Tags: Indian J Psychiatry Source Type: research

More evidence and attention are needed to clarify the correlation between moyamoya disease and attention deficit hyperactivity disorder.
Authors: Yu J, Zhang J, Chen J PMID: 33165378 [PubMed] (Source: Indian Journal of Psychiatry)
Source: Indian Journal of Psychiatry - November 11, 2020 Category: Psychiatry Tags: Indian J Psychiatry Source Type: research

Clinical features and suicidal behavior in major depression with comorbid attention-deficit hyperactivity disorder.
Authors: Menon V, Biyyala D, Mukherjee MP PMID: 33165340 [PubMed] (Source: Indian Journal of Psychiatry)
Source: Indian Journal of Psychiatry - November 11, 2020 Category: Psychiatry Tags: Indian J Psychiatry Source Type: research

Description of neurodevelopmental phenotypes associated with ten genetic neurodevelopmental disorders: A scoping review.
This article is protected by copyright. All rights reserved. PMID: 33179249 [PubMed - as supplied by publisher] (Source: Clinical Genetics)
Source: Clinical Genetics - November 11, 2020 Category: Genetics & Stem Cells Authors: Hanly C, Shah H, Au PYB, Murias K Tags: Clin Genet Source Type: research

Papaverine ameliorates prenatal alcohol-induced experimental attention deficit hyperactivity disorder by regulating neuronal function, inflammation, and oxidative stress.
Abstract Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder with complex aetiology and phenotypes. Phosphodiesterase-10A (PDE10A) has been shown to provide benefits in various brain conditions. We investigated the role of papaverine, a selective PDE10A inhibitor on core phenotypes in prenatal alcohol exposure (PAE) model of ADHD. In order to identify probable mechanisms involved, the effects on several protein markers of neuronal function such as, neuronal survival-BDNF, neuronal transcription factor-pCREB, brain inflammation (IL-6, IL-10 and TNF-α) and brain oxidative stress (T...
Source: International Journal of Developmental Neuroscience - November 11, 2020 Category: Neuroscience Authors: Sharma N, Dhiman N, Golani LK, Sharma B Tags: Int J Dev Neurosci Source Type: research

Prevalence of cocaine use and cocaine use disorder among adult patients with attention-deficit/hyperactivity disorder: a systematic review and meta-analysis.
Publication date: Available online 9 November 2020Source: Journal of Psychiatric ResearchAuthor(s): F. Oliva, C. Mangiapane, G. Nibbio, P. Berchialla, N. Colombi, F.D. Vigna-Taglianti (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - November 10, 2020 Category: Psychiatry Source Type: research

Lessons From the 1918 Flu Pandemic: A Novel Etiologic Subtype of ADHD?
In 2009, Dr. A. Fauci stated “The 1918-1919 influenza pandemic was a defining event in the history of public health.”1 In 2020, a popular medical website suggested the 1918 pandemic may offer “lasting lessons for the world in the grip of COVID-19.”2 One lesson from the 1918 pandemic relates to residual long-term effects . In his influential 1971 book, Minimal Brain Dysfunction in Children,3 Dr. P. Wender reviewed historical accounts of the 1918 pandemic and suggested viral infection had selective brain effects on catecholamine nuclei, and behavioral sequelae in some children emerged and overlapped w...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - November 10, 2020 Category: Psychiatry Authors: James M. Swanson, Nora D. Volkow Tags: Letter to the Editor Source Type: research

Bullying Perpetration and Narcissistic Personality Traits across Adolescence: Joint Trajectories and Childhood Risk Factors
Conclusions: Findings suggest adolescence is a time when personality and bullying reflect dynamic and heterogeneous development. Early intervention of childhood risk factors may help prevent a high-risk developmental course of bullying and narcissistic personality traits across adolescence. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - November 10, 2020 Category: Psychiatry Source Type: research

Using the drug repositioning approach to develop a novel therapy, tipepidine hibenzate sustained-release tablet (TS-141), for children and adolescents with attention-deficit/hyperactivity disorder
Asverin ® (tipepidine hibenzate) has been used as an antitussive for> 50 years in Japan. Studies revealed that tipepidine modulates monoamine levels, by inhibiting G-protein-activated inwardly rectifying potas... (Source: BMC Psychiatry)
Source: BMC Psychiatry - November 10, 2020 Category: Psychiatry Authors: Takuya Saito, Yushiro Yamashita, Akemi Tomoda, Takashi Okada, Hideo Umeuchi, Saki Iwamori, Satoru Shinoda, Akiko Mizuno-Yasuhira, Hidetoshi Urano, Izumi Nishino and Kazuhiko Saito Tags: Research article Source Type: research

Non-invasive Brain Stimulation for the Treatment of Gilles de la Tourette Syndrome
Gilles de la Tourette Syndrome is a multifaceted neuropsychiatric disorder typically commencing in childhood and characterized by motor and phonic tics. Its pathophysiology is still incompletely understood. However, there is convincing evidence that structural and functional abnormalities in the basal ganglia, in cortico-striato-thalamo-cortical circuits, and some cortical areas including medial frontal regions and the prefrontal cortex as well as hyperactivity of the dopaminergic system are key findings. Conventional therapeutic approaches in addition to counseling comprise behavioral treatment, particularly habit reversa...
Source: Frontiers in Neurology - November 10, 2020 Category: Neurology Source Type: research

Compensatory Movement Patterns Are Based on Abnormal Activity of the Biceps Brachii and Posterior Deltoid Muscles in Patients with Symptomatic Rotator Cuff Tears.
CONCLUSION: Patients with a symptomatic rotator cuff tear show compensatory movement patterns based on abnormal activity of the biceps brachii and posterior deltoid muscles when compared with age-matched controls. The posterior deltoid functions less in conjunction with the other deltoid muscles, and lower coactivation was seen in the remaining intact rotator cuff muscles in the rotator cuff tear group than the control group. CLINICAL RELEVANCE: This study supports the potential benefit of addressing the long head biceps tendon in the treatment of patients with a symptomatic rotator cuff tear. Moreover, clinicians mig...
Source: Clinical Orthopaedics and Related Research - November 9, 2020 Category: Orthopaedics Authors: Veen EJD, Koorevaar CT, Verdonschot KHM, Sluijter TE, de Groot T, van der Hoeven JH, Diercks RL, Stevens M Tags: Clin Orthop Relat Res Source Type: research

Configural processing of emotional bodies and faces in patients with attention deficit hyperactivity disorder
. (Source: Journal of Clinical and Experimental Neuropsychology)
Source: Journal of Clinical and Experimental Neuropsychology - November 9, 2020 Category: Psychiatry & Psychology Authors: Patrizia Thoma Denise Soria Bauser Marc-Andreas Edel Georg Juckel Boris Suchan Source Type: research

Shared and anxiety-specific pediatric psychopathology dimensions manifest distributed neural correlates
Imaging research has not yet delivered reliable psychiatric biomarkers. One challenge, particularly among youth, is high comorbidity. This challenge might be met through canonical correlation analysis (CCA) designed to model mutual dependencies between symptom dimensions and neural measures. We map the multivariate associations that intrinsic functional connectivity manifests with pediatric symptoms of anxiety, irritability, and attention-deficit/hyperactivity disorder (ADHD) as common, impactful, co-occurring problems. (Source: Biological Psychiatry)
Source: Biological Psychiatry - November 9, 2020 Category: Psychiatry Authors: Julia O. Linke, Rany Abend, Katharina Kircanski, Michal Clayton, Caitlin Stavish, Brenda E. Benson, Melissa A. Brotman, Olivier Renaud, Stephen M. Smith, Thomas E. Nichols, Ellen Leibenluft, Anderson M. Winkler, Daniel S. Pine Tags: Archival Report Source Type: research

Propofol but not dexmedetomidine produce locomotor sensitization via nitric oxide in rats
ConclusionsOur results suggest that propofol but not dexmedetomidine produced a significant locomotor sensitization via central nitrergic system. Dexmedetomidine may have a lesser psychostimulant type addictive potential than propofol. Sensitization development by propofol implies that this drug might be effective on the neuroadaptive processes associated with a stimulant type of dependence. (Source: Psychopharmacology)
Source: Psychopharmacology - November 9, 2020 Category: Psychiatry Source Type: research

Sensors, Vol. 20, Pages 6386: Attention-Deficit/Hyperactivity Disorder (ADHD): Integrating the MOXO-dCPT with an Eye Tracker Enhances Diagnostic Precision
ssovsky Clinical decision-making may be enhanced when combining psychophysiological sensors with computerized neuropsychological tests. The current study explored the utility of integrating an eye tracker with a commercially available continuous performance test (CPT), the MOXO-dCPT. As part of the study, the performance of adult attention-deficit/hyperactivity disorder (ADHD) patients and healthy controls (n = 43, n = 42, respectively) was compared in the integrated system. More specifically, the MOXO-dCPT has four stages, which differ in their combinations of ecological visual and auditory dynamic distractors. By exp...
Source: Sensors - November 9, 2020 Category: Biotechnology Authors: Tomer Elbaum Yoram Braw Astar Lev Yuri Rassovsky Tags: Article Source Type: research

Neonatal phencyclidine and social isolation in the rat: effects of clozapine on locomotor activity, social recognition, prepulse inhibition, and executive functions deficits
ConclusionThe PCP-SI model presents enduring and robust deficits (hyperactivity and social recognition impairment) associated with positive symptoms and cognitive/social deficits of schizophrenia, respectively. These deficits are normalized by chronic treatment with clozapine, thereby confirming the predictive validity of this animal model. (Source: Psychopharmacology)
Source: Psychopharmacology - November 9, 2020 Category: Psychiatry Source Type: research

Bipolar disorder: Treatment strategies for women of childbearing age
ConclusionsDifferential diagnoses for bipolar disorder include depressive disorders, anxiety disorders, trauma ‐related disorders, attention‐deficit/hyperactivity disorder, and personality disorders. Pharmacotherapeutic options for the treatment of bipolar disorder include lithium, anti‐epileptic medications, and atypical antipsychotics. In regard to women of childbearing age, consideration of risks, b enefits, and alternative therapies is needed before initiating therapy.Practice ImplicationsCaring for patients with bipolar disorder, particularly women of childbearing age, requires careful differentiation of bipolar...
Source: Perspectives in Psychiatric Care - November 8, 2020 Category: Psychiatry Authors: Brayden N. Kameg Tags: ORIGINAL ARTICLE Source Type: research

Utility of medical record diagnostic codes to ascertain attention-deficit/hyperactivity disorder and learning disabilities in populations of children
To develop and evaluate machine learning algorithms to ascertain attention-deficit/hyperactivity (ADHD) and learning disability (LD) using diagnostic codes in the medical record. (Source: BMC Pediatrics)
Source: BMC Pediatrics - November 7, 2020 Category: Pediatrics Authors: Yu Shi, Phillip J. Schulte, Andrew C. Hanson, Michael J. Zaccariello, Danqing Hu, Sheri Crow, Randall P. Flick and David O. Warner Tags: Research article Source Type: research

Transforming pediatric neuropsychology through video-based teleneuropsychology: an innovative private practice model pre-COVID-19.
CONCLUSION: Video-based TeleNP benefits the consumer as it can reduce wait times, decrease family financial burden (i.e., travel and parent time off work), expedite referrals for interventions, and provide geographically under-served populations access to providers who are linguistically and culturally responsive. For providers, this model revealed improvements with direct implications for cost-saving, thereby facilitating long-term economic sustainability within a private practice healthcare marketplace. PMID: 33159508 [PubMed - as supplied by publisher] (Source: Archives of Clinical Neuropsychology)
Source: Archives of Clinical Neuropsychology - November 7, 2020 Category: Psychiatry & Psychology Authors: Salinas CM, Bordes Edgar V, Berrios Siervo G, Bender HA Tags: Arch Clin Neuropsychol Source Type: research

Differences in the activity of the shoulder girdle and lower back muscles owing to postural alteration while using a smartphone.
Authors: Adachi G, Oshikawa T, Akuzawa H, Kaneoka K Abstract The purpose of this study was to clarify the influence of different postures on the activity of the shoulder girdle and lower back muscles while using a smartphone. Sixteen healthy male participants maintained two postures while using a smartphone : a good posture in which the tragus and acromion were closer to the vertical line passing through the greater trochanter, and a poor posture in which the tragus and acromion were farther from the vertical line passing through the greater trochanter. The target muscles were the rhomboid major (Rhom), upper t...
Source: Journal of Medical Investigation - November 6, 2020 Category: General Medicine Tags: J Med Invest Source Type: research

Neural Correlates of Theory of Mind in Autism Spectrum Disorder, Attention-Deficit/Hyperactivity Disorder, and the Comorbid Condition
Theory of mind (ToM) or mentalizing difficulties is reported in attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), but the mechanism underpinning these apparently shared deficits is relatively unknown. Eighty-three young adult males, 19 with ASD alone, 21 with ADHD alone, 18 with dual diagnosis of ASD and ADHD, and 25 typically developing (TD) controls completed the functional magnetic resonance imaging version of the Frith-Happé animated-triangle ToM task. We compared neural function during ToM with two non-ToM conditions, random and goal directed motions, using whole-brain and regi...
Source: Frontiers in Psychiatry - November 6, 2020 Category: Psychiatry Source Type: research

Restless sleep disorder in children with attention deficit-hyperactivity disorder
Journal of Clinical Sleep Medicine, Ahead of Print. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - November 6, 2020 Category: Sleep Medicine Authors: Vidhi KapoorRaffaele FerriMark A. SteinChris RuthJennifer ReedLourdes M. DelRosso1University of Washington, Seattle, Washington2Sleep Research Centre, Oasi Research Institute - IRCCS, Troina, Italy3Seattle Children ’s Hospital, Seattle, Washington Source Type: research

A Post Hoc Comparison of Prior ADHD Medication Dose and Optimized Delayed-release and Extended-release Methylphenidate Dose in a Pivotal Phase III Trial.
Abstract PURPOSE: HLD200 is the first evening-dosed, delayed-release and extended-release methylphenidate (DR/ER-MPH) designed to delay initial release of MPH and provide treatment effects throughout the day and into the evening for individuals with attention-deficit/hyperactivity disorder (ADHD). Because DR/ER-MPH is uniquely absorbed in the colon, it cannot be substituted for other ADHD medications on a milligram-per-milligram basis. To provide clinicians with a target dose range for DR/ER-MPH when transitioning patients from a prior ADHD medication, dose conversion ratios (DCRs) between prior medication do...
Source: Clinical Therapeutics - November 6, 2020 Category: Drugs & Pharmacology Authors: Childress AC, Uchida CL, Po MD, DeSousa NJ, Incledon B Tags: Clin Ther Source Type: research

Genetic Correlation Analysis and Transcriptome-wide Association Study Suggest the Overlapped Genetic Mechanism between Gout and Attention-deficit Hyperactivity Disorder: L'analyse de corr élation génétique et l'étude d'association à l'échelle du transcriptome suggèrent un mécanisme génétique superposé entre la goutte et le trouble de déficit de l'attention avec hyperactivité.
Genetic Correlation Analysis and Transcriptome-wide Association Study Suggest the Overlapped Genetic Mechanism between Gout and Attention-deficit Hyperactivity Disorder: L'analyse de corrélation génétique et l'étude d'association à l'échelle du transcriptome suggèrent un mécanisme génétique superposé entre la goutte et le trouble de déficit de l'attention avec hyperactivité. Can J Psychiatry. 2020 Nov 06;:706743720970844 Authors: Kafle OP, Wang X, Cheng S, Ding M, Li P, Cheng B, Liang X, Liu L, Du Y, Ma M, Zhang L, Zhao ...
Source: Canadian Journal of Psychiatry - November 6, 2020 Category: Psychiatry Authors: Kafle OP, Wang X, Cheng S, Ding M, Li P, Cheng B, Liang X, Liu L, Du Y, Ma M, Zhang L, Zhao Y, Wen Y, Zhang F Tags: Can J Psychiatry Source Type: research

Reviewing the role of emerging therapies in the ADHD armamentarium.
Authors: Childress AC, Beltran N, Supnet C, Weiss MD Abstract Introduction: Attention-deficit/hyperactivity disorder (ADHD) is a common neurobehavioral disorder that can be treated with both pharmacologic and nonpharmacologic modalities. Effective drug treatments for ADHD have been available for more than six decades. However, initial treatments had limitations in duration of effect, need for multiple daily doses, requirement for patients to swallow intact tablets, adverse effects and risk for abuse and diversion. During the past 20 years, more than two dozen stimulant and nonstimulant drugs have been developed. No...
Source: Expert Opinion on Emerging Drugs - November 5, 2020 Category: Drugs & Pharmacology Tags: Expert Opin Emerg Drugs Source Type: research

Effects of vehicular whole-body vibration on focus measured by a mobile app for brain training: A pilot study on the influence of gender and attention deficit hyperactivity disorder.
CONCLUSION: It could be concluded that the group with ADHD had a small but positive influence on the results for most of the tests, indicating that they are less affected by the presence of WBV. Since many students and workers have ADHD, this may be considered an important finding. It was shown that objective results should not be the only measures to use, as the subjective evaluation may explain the results better. PMID: 33164973 [PubMed - as supplied by publisher] (Source: Work)
Source: Work - November 5, 2020 Category: Occupational Health Authors: Duarte MLM, Zerbini Costal G, Martinelli SF, Barbosa Neves JA Tags: Work Source Type: research