Fight Aging! Newsletter, March 8th 2021
Conclusion
Coupled with the animal data, and the existing human trial data for safety, the results here suggests that someone should run a formal, controlled trial of flagellin immunization in older people, 65 and over. The goal would be to see whether (a) this sort of outcome holds up in a larger group of people, and (b) there is a meaningful impact on chronic inflammation and other parameters of health that are known to be affected by the aging of the gut microbiome.
The Role of Reactive Oxygen Species in Aging is Complex
https://www.fightaging.org/archives/2021/03/the-role-of-reactive-oxygen-species-in-a...
Source: Fight Aging! - March 7, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Physical Exercise and the Resilience of the Brain to Aging
Being active and fit slows the impact of aging on the brain. A diverse set of mechanisms are involved, and, as is often the case in these matters, it is far from clear as to which of these mechanisms are the most important. Fitness helps to maintain the vascular system in a better shape, keep levels of chronic inflammation lower, causes mild stress that makes cells throughout the body undertake greater maintenance activities, ensures that the gut microbiome ages more slowly, better maintaining the production of metabolites that affect neurogenesis. And so forth - the list goes on.
Nowadays, we are constantly bomba...
Source: Fight Aging! - March 1, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Midlife ADHD? Coping strategies that can help
Trouble staying focused and paying attention are two familiar symptoms of attention deficit hyperactivity disorder (ADHD), a common health issue among children and teens. When ADHD persists through early adulthood and on into middle age, it presents many of the same challenges it does in childhood: it’s hard to stay organized, start projects, stay on task, and meet deadlines. But now life is busier, and expectations from work and family often are even higher. Fortunately, there are lots of strategies that can help you navigate this time in your life.
Staying organized
Organizational tools are a must for people with adult...
Source: Harvard Health Blog - February 5, 2021 Category: Consumer Health News Authors: Heidi Godman Tags: Behavioral Health Brain and cognitive health Memory Source Type: blogs
Fight Aging! Newsletter, January 18th 2021
In this study, Desferal, deferoxamine mesylate for injection, which is approved for the treatment of acute iron intoxication and chronic iron overload, was used to explore the beneficial effects on preventing aging-induced bone loss and mitigating dysfunction of aged BMSCs. High-dose Desferal significantly prevented bone loss in aged rats. Compared with controls, the ex vivo experiments showed that short-term Desferal administration could promote the potential of BMSC growth and improve the rebalance of osteogenic and adipogenic differentiation, as well as rejuvenate senescent BMSCs and revise the expression of stemness/se...
Source: Fight Aging! - January 17, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senescent Cells Provoke Excessive Sympathetic Nerve Fiber Growth, with Harmful Consequences
Senescent cells are created constantly throughout life in response to a range of circumstances, but only begin to accumulate in later life, once there is an imbalance between processes of creation (as a response to cell damage, for example) and processes of destruction (such as immune surveillance of senescent cells). Senescent cells secrete a potent mix of signals that, when sustained over time, provokes chronic inflammation and alters nearby cell behavior and tissue structure in detrimental ways. Researchers are only now attempting to catalog exactly how senescent cells cause harm, given the advent of senolytic therapies...
Source: Fight Aging! - January 14, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Using Reddit as a population-level “mental health tracker” during the COVID pandemic
Conclusions: By using a broad set of NLP techniques and analyzing a baseline of prepandemic posts, we uncovered patterns of how specific mental health problems manifest in language, identified at-risk users, and revealed the distribution of concerns across Reddit, which could help provide better resources to its millions of users. We then demonstrated that textual analysis is sensitive to uncover mental health complaints as they appear in real time, identifying vulnerable groups and alarming themes during COVID-19, and thus may have utility during the ongoing pandemic and other world-changing events such as elections and p...
Source: SharpBrains - November 9, 2020 Category: Neuroscience Authors: SharpBrains Tags: Technology & Innovation Uncategorized anxiety machine-learning mental health natural language processing pandemic Source Type: blogs
Fight Aging! Newsletter, November 9th 2020
In this study, young adult mice were submitted to endurance exercise training and the function, differentiation, and metabolic characteristics of satellite cells were investigated in vivo and in vitro.
We found that injured muscles from endurance-exercised mice display improved regenerative capacity, demonstrated through higher densities of newly formed myofibres compared with controls (evidenced by an increase in embryonic myosin heavy chain expression), as well as lower inflammation (evidenced by quantifying CD68-marked macrophages), and reduced fibrosis. Enhanced myogenic function was accompanied by an increased ...
Source: Fight Aging! - November 8, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
RyR2 as a Target to Prevent Alzheimer's Symptoms in a Mouse Model of the Condition
Mouse models of Alzheimer's disease are quite artificial: mice, and indeed most mammals, do not naturally exhibit the relevant mechanisms underlying Alzheimer's disease, such as aggregation of amyloid-β. The details of the model become important in determining whether or not discoveries and interventions are relevant in anything other than the model. Thus one shouldn't become too excited by any small adjustment to cellular metabolism that appears to have profound effects on the progression of the condition in these models. Maybe it will be relevant to the human condition, but the odds are not good, looking at the history ...
Source: Fight Aging! - November 2, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 2nd 2020
In conclusion, the circulating antibody repertoire has increased binding to thousands of peptides in older donors, which can be represented as an immune age. Increased immune age is associated with autoimmune disease, acute inflammatory disease severity, and may be a broadly relevant biomarker of immune function in health, disease, and therapeutic intervention. The immune age has the potential for wide-spread use in clinical and consumer settings.
In Vivo Reprogramming Improves Cognitive Function in Old Mice
https://www.fightaging.org/archives/2020/10/in-vivo-reprogramming-improves-cognitive-function-in-old-mi...
Source: Fight Aging! - November 1, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Towards Restoration of Mitophagy to Reverse Mitochondrial Dysfunction in Alzheimer's Disease
Mitochondria are the power plants of the cell, a herd of bacteria-like organelles responsible for packaging energy store molecules used to power the chemistry of life. With age, mitochondria become dysfunctional throughout the body, for reasons that are not yet fully understood, but which clearly contribute to the onset of age-related declines and diseases. There is certainly stochastic damage to mitochondrial DNA that can lead to a small but significant number of pathological cells dumping oxidizing molecules into the surrounding tissue, but the general malaise of mitochondria is more sweeping than this.
One impor...
Source: Fight Aging! - October 29, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Rabies – a dumb disease
Dog vaccination programs are the most effective way to prevent Rabies
Rabies is endemic to over 150 countries, and according to the World Health Organization, 99% of all transmissions to humans are from dogs, potentially bringing into question the animal’s status as the ‘man’s best friend’.
In Europe, southern Africa, and parts of North America, most cases are acquired from wild carnivores; mongooses, and vampire bats in Latin America and the Caribbean. In more recent years, humans have acquired rabies from inhalation of aerosols in bat caves, ingestion of dogs and cats for food, ticks, cart-scratches...
Source: GIDEON blog - September 28, 2020 Category: Databases & Libraries Authors: Kristina Symes Tags: Epidemiology News Source Type: blogs
Psychology Around the Net: August 8, 2020
This week’s Psychology Around the Net looks at a new study on building strong bonds between children and nature, how Google’s search monopoly is affecting the mental health crisis, research suggesting baby boomers aren’t as mentally sharp as their parents’ generation, and more.
Stay well, friends!
To Bond With Nature, Kids Need Solitary Activities Outdoors: A new study finds that solitary activities (thinking hunting, fishing, and just hiking around and exploring) are perfect for children to build strong bonds with nature. Not only do these kinds of activities help children enjoy being outside, bu...
Source: World of Psychology - August 8, 2020 Category: Psychiatry & Psychology Authors: Alicia Sparks Tags: Psychology Around the Net Adhd Amygdala antitrust anxiety Baby Boomers demntia Depression emotional processing Google Hippocampus kids Loneliness Memory Nature outdoors Source Type: blogs
Children, teens, and the safety of psychotropic medicines
Medicines prescribed for attention deficit/hyperactivity disorder (ADHD), depression, anxiety, and other mood disorders — known as psychotropic drugs — have largely been studied in adults. This concerns many parents whose children take these drugs regularly. Studies have most often looked at the effectiveness of these medicines in teens and children. Now a recent systematic review of multiple studies done in children and adolescents offers new guidance on safety for commonly used medicines.
What did the study look at?
The aim of this study was to comprehensively synthesize current evidence on the safety of four major c...
Source: Harvard Health Blog - August 6, 2020 Category: Consumer Health News Authors: Hyun Jung Kim, MD Tags: Adolescent health Anxiety and Depression Behavioral Health Children's Health Mental Health Parenting Source Type: blogs
Podcast: Debating ‘ Anti-Psychiatry ’ Advocacy
Conclusion, do not visit cardiologists. They will give you heart attacks. No, that’s ridiculous. It’s so mind blowing that anyone even said this, right? It’s just ugh. Obviously, people who are extremely sick and who are at risk of killing themselves get psychiatric care. No kidding. So, yeah, this is, in fact, very dangerous.
Gabe: The word bullshit is not big enough. This is the literal equivalent of me saying that I looked at fifty thousand people who went to the hospital in the last year. And you were much more likely to die if you had a hospital admission. Now, I’m talking physical health now. ...
Source: World of Psychology - July 14, 2020 Category: Psychiatry & Psychology Authors: Not Crazy Podcast Tags: General Mental Health and Wellness Not Crazy Podcast Psychiatry Treatment Source Type: blogs
Beware Websites & Apps Pushing Fake Screening Quiz Results
As the internet grows and people find new ways to make money online, more anonymous websites are being published by companies who have little background or interest in mental health. And sadly, thousands of people flock to these sites every day, unaware that they may be taking a fake mental health test on depression or ADHD.
Google and other search engines are supposed to be able to determine the quality of health websites, supposedly emphasizing and promoting those with good E-A-T — expertise, authoritativeness, and trustworthiness. That’s what they claim.
So it’s a bit of head-scratcher when looking up...
Source: World of Psychology - June 19, 2020 Category: Psychiatry & Psychology Authors: John M. Grohol, Psy.D. Tags: General Mental Health and Wellness Psychology Technology Attention Deficit Hyperactivity Disorder Depression depression screening Source Type: blogs
