Hydroxychloroquine no more effective than placebo in preventing COVID-19
(University of Pennsylvania School of Medicine) Clinical trial with COVID-19 testing of participants shows health care workers in contact with coronavirus patients who took hydroxychloroquine each day did not reduce their rate of infection. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - September 30, 2020 Category: Infectious Diseases Source Type: news

Efficacy, safety of hydroxychloroquine vs placebo to prevent SARS-CoV-2 infection among health care
(JAMA Network) In this randomized clinical trial, daily hydroxychloroquine didn't prevent SARS-CoV-2 infection among hospital-based health care workers, although the trial was terminated early. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - September 30, 2020 Category: Infectious Diseases Source Type: news

Trump-touted hydroxychloroquine shows no benefit in COVID-19 prevention: Study
The study largely confirms results from a clinical trial in June that showed hydroxychloroquine was ineffective in preventing infection among people exposed to the new coronavirus. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - September 29, 2020 Category: Pharmaceuticals Source Type: news

A New Look at Safety With Hydroxychloroquine in COVID-19 A New Look at Safety With Hydroxychloroquine in COVID-19
While a precipitous drop in use may make it almost moot, new data show only ' modest ' increases in QT prolongation and no arrhythmic deaths directly attributable to treatment.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - September 29, 2020 Category: Cardiology Tags: Cardiology News Source Type: news

Hydroxychloroquine Tied to Heart Problems Prior to Pandemic
MONDAY, Sept. 28, 2020 -- Real-world, pre-COVID-19 adverse events data show hydroxychloroquine (HCQ) and chloroquine (CQ) are associated with cardiovascular adverse events (CVAEs), according to a study published online Sept. 22 in the British... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - September 28, 2020 Category: Pharmaceuticals Source Type: news

Where Docs, Nurses Stand on COVID Emergency Use Authorizations Where Docs, Nurses Stand on COVID Emergency Use Authorizations
Medscape polled clinicians on their thoughts after questions were raised about evidence the FDA used to grant emergency authorizations for hydroxychloroquine, convalescent plasma, and remdesivir.Medscape Medical News (Source: Medscape Internal Medicine Headlines)
Source: Medscape Internal Medicine Headlines - September 25, 2020 Category: Internal Medicine Tags: Infectious Diseases News Source Type: news

Extracorporeal treatment for chloroquine, hydroxychloroquine, and quinine poisoning: systematic review and recommendations from the EXTRIP Workgroup - Berling I, King JD, Shepherd G, Hoffman RS, Alhatali B, Lavergne V, Roberts DM, Gosselin S, Wilson G, Nolin TD, Ghannoum M, EXTRIP workgroup.
BACKGROUND: Although chloroquine, hydroxychloroquine, and quinine are used for a range of medical conditions, recent research suggested a potential role in treating COVID-19. The resultant increase in prescribing was accompanied by an increase in adverse e... (Source: SafetyLit)
Source: SafetyLit - September 25, 2020 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Cardiovascular adverse events associated with hydroxychloroquine and chloroquine: A comprehensive pharmacovigilance analysis of preCOVID19 reports
This analysis of the FAERS database found use of hydroxychloroquine and chloroquine was associated with a higher reporting rate of major CV adverse events, including cardiomyopathy (reporting OR 29.0), QT prolongation (4.5), cardiac arrhythmias (2.2) and heart failure (2.2). (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 24, 2020 Category: Consumer Health News Source Type: news

Discontinuation of Hydroxychloroquine in Older SLE Patients Discontinuation of Hydroxychloroquine in Older SLE Patients
Hydroxychloroquine is an effective treatment for SLE, but long-term use may increase the risk for adverse events. At what point should discontinuation be considered?Arthritis Research & Therapy (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 23, 2020 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

Analysis reveals heart-related side effects of hydroxychloroquine and chloroquine
(Wiley) As the antimalarial drugs hydroxychloroquine and chloroquine have drawn attention as potential therapies for COVID-19 and are being widely used off-label, it's now more important than ever to have a thorough assessment of the safety of these medications. A recent analysis published in the British Journal of Clinical Pharmacology provides new insights. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 23, 2020 Category: International Medicine & Public Health Source Type: news

COVID-19: Analysis reveals heart-related side effects of hydroxychloroquine, chloroquine
In the analysis of real-world data from the Food and Drug Administration Adverse Events Reporting System, a global database of post-marketing safety reports, hydroxychloroquine and chloroquine were associated with higher rates of various cardiovascular problems, including life-threatening heart rhythm events, heart failure, and damage to the heart muscle itself (termed cardiomyopathy). (Source: The Economic Times)
Source: The Economic Times - September 22, 2020 Category: Consumer Health News Source Type: news

The Lancet changes editorial policy after hydroxychloroquine Covid study retraction
New policy comes after serious quality control questions were raised about the data relied on by a study in the medical journalOne of the world ’s leading medical journals, the Lancet, has reformed its editorial policies following a shocking case of apparent research misconduct involving the study of hydroxychloroquine as a treatment for Covid-19.In May, the Lancet published a peer-reviewed study about the controversial drug hydroxychloroquine, which concluded Covid-19 patients who received the drug were dying at higher rates and experiencing more heart-related complications than other virus patients.Continue reading... ...
Source: Guardian Unlimited Science - September 22, 2020 Category: Science Authors: Melissa Davey Tags: Coronavirus outbreak Medical research Infectious diseases Microbiology Health Source Type: news

We Need a COVID-19 Vaccine. We Also Need Transparency About Its Development
The authorization of an effective vaccine will mark perhaps the biggest turning point in the battle against coronavirus, but only if enough people are willing to get vaccinated. There have been substantial declines in public willingness to get vaccinated against COVID-19, despite immense, unprecedented public investments in vaccine development. In one survey, barely half of Americans said they would get the vaccine as soon as it was available, numbers that will undermine the benefits of even a highly effective vaccine. It is no mystery why trust in a potential vaccine has plummeted. Operation Warp Speed, the Trump Administ...
Source: TIME: Health - September 18, 2020 Category: Consumer Health News Authors: Dr. Ashish K. Jha Tags: Uncategorized COVID-19 Source Type: news

COVID-19 prevention and treatment: A critical analysis of chloroquine and hydroxychloroquine clinical pharmacology, PLOS Medicine
Review states large RCTs with appropriate monitoring are required to determine if chloroquine and hydroxychloroquine have preventive or treatment efficacy in COVID-19 and acceptable safety; and their use outside of clinical trials is not justified at this time. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 16, 2020 Category: Consumer Health News Source Type: news

Hydroxychloroquine and Chloroquine in COVID-19 Hydroxychloroquine and Chloroquine in COVID-19
How often are rheumatologists prescribing hydroxychloroquine and chloroquine for COVID-19 prophylaxis or treatment? A new survey provides insight.Journal of Clinical Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 15, 2020 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news