Better efficacy and lower recurrence rate with guselkumab treatment for generalized pustular psoriasis: A prospective cohort study from China
Clin Immunol. 2024 Jan 5:109899. doi: 10.1016/j.clim.2024.109899. Online ahead of print.ABSTRACTGeneralized pustular psoriasis (GPP) is a severe and uncommon form of psoriasis, for which treatment options are limited. There is an urgent need to expand the treatment options for GPP. Currently, adalimumab, secukinumab, and guselkumab are considered effective for GPP, but there is a lack of prospective direct comparative studies on their efficacy for GPP. We conducted a prospective, single-center, observational study on 50 GPP patients to compare the efficacy, safety, and recurrence rates of these three biologics. Adalimumab,...
Source: Clinical Immunology - January 7, 2024 Category: Allergy & Immunology Authors: Jiajing Lu Dawei Huang Nan Yang Hui Qin Yingyuan Yu Xiaoyuan Zhong Luyang Kong Yuxiong Jiang Jing Zhou Yuling Shi Source Type: research
Better efficacy, lower recurrence rate and decreased CD8 < sup > + < /sup > T < sub > RM < /sub > with guselkumab treatment for generalized pustular psoriasis: A prospective cohort study from China
Clin Immunol. 2024 Feb;259:109899. doi: 10.1016/j.clim.2024.109899. Epub 2024 Jan 5.ABSTRACTGeneralized pustular psoriasis (GPP) is a severe and uncommon form of psoriasis, for which treatment options are limited. There is an urgent need to expand the treatment options for GPP. Currently, adalimumab, secukinumab, and guselkumab are considered effective for GPP, but there is a lack of prospective direct comparative studies on their efficacy for GPP. We conducted a prospective, single-center, observational study on 50 GPP patients to compare the efficacy, safety, and recurrence rates of these three biologics. Adalimumab, sec...
Source: Clinical Immunology - January 7, 2024 Category: Allergy & Immunology Authors: Jiajing Lu Dawei Huang Nan Yang Hui Qin Yingyuan Yu Xiaoyuan Zhong Luyang Kong Yuxiong Jiang Jing Zhou Yuling Shi Source Type: research
Development of an in-line Raman analytical method for commercial-scale CHO cell culture process monitoring: Influence of measurement channels and batch number on model performance
In this study, an in-line Raman analytical method was developed for monitoring glucose, lactate, and viable cell density (VCD) in the Chinese hamster ovary (CHO) cell culture process during commercial production of biosimilar adalimumab (1500 L). The influence of different Raman measurement channels was considered to determine whether to merge data from different channels for model development. Raman calibration models were developed and optimized, with minimum root mean square error of prediction of 0.22 g L-1 for glucose in the range of 1.66-3.53 g L-1 , 0.08 g L-1 for lactate in the range of 0.15-1.19 g L-1 , 0.31 E6 ce...
Source: Biotechnology Journal - January 5, 2024 Category: Biotechnology Authors: Xu Yan Xiaoxiao Dong Yuxiang Wan Dong Gao Zhenhua Chen Ying Zhang Zhilong Zheng Kaifeng Chen Jingyu Jiao Yan Sun Zhuohong He Lei Nie Xiaohui Fan Haibin Wang Haibin Qu Source Type: research
Bibliometric analysis and visualisation of research hotspots and frontiers in Takayasu's arteritis
CONCLUSIONS: Although the area of TAK research is growing rapidly, intensive institutional and author collaboration has to be fostered in the future to fuel TAK research and information dissemination. Future research on TAK may revolve around cytokines, disease activity evaluation and clinical trials.PMID:38179700 | DOI:10.55563/clinexprheumatol/akl7x6 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 5, 2024 Category: Rheumatology Authors: Xiufang Kong Xiao Huang Wei Wang Source Type: research
Development of an in-line Raman analytical method for commercial-scale CHO cell culture process monitoring: Influence of measurement channels and batch number on model performance
In this study, an in-line Raman analytical method was developed for monitoring glucose, lactate, and viable cell density (VCD) in the Chinese hamster ovary (CHO) cell culture process during commercial production of biosimilar adalimumab (1500 L). The influence of different Raman measurement channels was considered to determine whether to merge data from different channels for model development. Raman calibration models were developed and optimized, with minimum root mean square error of prediction of 0.22 g L-1 for glucose in the range of 1.66-3.53 g L-1 , 0.08 g L-1 for lactate in the range of 0.15-1.19 g L-1 , 0.31 E6 ce...
Source: Biotechnology Journal - January 5, 2024 Category: Biotechnology Authors: Xu Yan Xiaoxiao Dong Yuxiang Wan Dong Gao Zhenhua Chen Ying Zhang Zhilong Zheng Kaifeng Chen Jingyu Jiao Yan Sun Zhuohong He Lei Nie Xiaohui Fan Haibin Wang Haibin Qu Source Type: research
Bibliometric analysis and visualisation of research hotspots and frontiers in Takayasu's arteritis
CONCLUSIONS: Although the area of TAK research is growing rapidly, intensive institutional and author collaboration has to be fostered in the future to fuel TAK research and information dissemination. Future research on TAK may revolve around cytokines, disease activity evaluation and clinical trials.PMID:38179700 | DOI:10.55563/clinexprheumatol/akl7x6 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 5, 2024 Category: Rheumatology Authors: Xiufang Kong Xiao Huang Wei Wang Source Type: research
Development of an in-line Raman analytical method for commercial-scale CHO cell culture process monitoring: Influence of measurement channels and batch number on model performance
In this study, an in-line Raman analytical method was developed for monitoring glucose, lactate, and viable cell density (VCD) in the Chinese hamster ovary (CHO) cell culture process during commercial production of biosimilar adalimumab (1500 L). The influence of different Raman measurement channels was considered to determine whether to merge data from different channels for model development. Raman calibration models were developed and optimized, with minimum root mean square error of prediction of 0.22 g L-1 for glucose in the range of 1.66-3.53 g L-1 , 0.08 g L-1 for lactate in the range of 0.15-1.19 g L-1 , 0.31 E6 ce...
Source: Biotechnology Journal - January 5, 2024 Category: Biotechnology Authors: Xu Yan Xiaoxiao Dong Yuxiang Wan Dong Gao Zhenhua Chen Ying Zhang Zhilong Zheng Kaifeng Chen Jingyu Jiao Yan Sun Zhuohong He Lei Nie Xiaohui Fan Haibin Wang Haibin Qu Source Type: research
Bibliometric analysis and visualisation of research hotspots and frontiers in Takayasu's arteritis
CONCLUSIONS: Although the area of TAK research is growing rapidly, intensive institutional and author collaboration has to be fostered in the future to fuel TAK research and information dissemination. Future research on TAK may revolve around cytokines, disease activity evaluation and clinical trials.PMID:38179700 | DOI:10.55563/clinexprheumatol/akl7x6 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 5, 2024 Category: Rheumatology Authors: Xiufang Kong Xiao Huang Wei Wang Source Type: research
Development of an in-line Raman analytical method for commercial-scale CHO cell culture process monitoring: Influence of measurement channels and batch number on model performance
In this study, an in-line Raman analytical method was developed for monitoring glucose, lactate, and viable cell density (VCD) in the Chinese hamster ovary (CHO) cell culture process during commercial production of biosimilar adalimumab (1500 L). The influence of different Raman measurement channels was considered to determine whether to merge data from different channels for model development. Raman calibration models were developed and optimized, with minimum root mean square error of prediction of 0.22 g L-1 for glucose in the range of 1.66-3.53 g L-1 , 0.08 g L-1 for lactate in the range of 0.15-1.19 g L-1 , 0.31 E6 ce...
Source: Biotechnology Journal - January 5, 2024 Category: Biotechnology Authors: Xu Yan Xiaoxiao Dong Yuxiang Wan Dong Gao Zhenhua Chen Ying Zhang Zhilong Zheng Kaifeng Chen Jingyu Jiao Yan Sun Zhuohong He Lei Nie Xiaohui Fan Haibin Wang Haibin Qu Source Type: research
Bibliometric analysis and visualisation of research hotspots and frontiers in Takayasu's arteritis
CONCLUSIONS: Although the area of TAK research is growing rapidly, intensive institutional and author collaboration has to be fostered in the future to fuel TAK research and information dissemination. Future research on TAK may revolve around cytokines, disease activity evaluation and clinical trials.PMID:38179700 | DOI:10.55563/clinexprheumatol/akl7x6 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 5, 2024 Category: Rheumatology Authors: Xiufang Kong Xiao Huang Wei Wang Source Type: research
Development of an in-line Raman analytical method for commercial-scale CHO cell culture process monitoring: Influence of measurement channels and batch number on model performance
In this study, an in-line Raman analytical method was developed for monitoring glucose, lactate, and viable cell density (VCD) in the Chinese hamster ovary (CHO) cell culture process during commercial production of biosimilar adalimumab (1500 L). The influence of different Raman measurement channels was considered to determine whether to merge data from different channels for model development. Raman calibration models were developed and optimized, with minimum root mean square error of prediction of 0.22 g L-1 for glucose in the range of 1.66-3.53 g L-1 , 0.08 g L-1 for lactate in the range of 0.15-1.19 g L-1 , 0.31 E6 ce...
Source: Biotechnology Journal - January 5, 2024 Category: Biotechnology Authors: Xu Yan Xiaoxiao Dong Yuxiang Wan Dong Gao Zhenhua Chen Ying Zhang Zhilong Zheng Kaifeng Chen Jingyu Jiao Yan Sun Zhuohong He Lei Nie Xiaohui Fan Haibin Wang Haibin Qu Source Type: research
Development of an in-line Raman analytical method for commercial-scale CHO cell culture process monitoring: Influence of measurement channels and batch number on model performance
In this study, an in-line Raman analytical method was developed for monitoring glucose, lactate, and viable cell density (VCD) in the Chinese hamster ovary (CHO) cell culture process during commercial production of biosimilar adalimumab (1500 L). The influence of different Raman measurement channels was considered to determine whether to merge data from different channels for model development. Raman calibration models were developed and optimized, with minimum root mean square error of prediction of 0.22 g L-1 for glucose in the range of 1.66-3.53 g L-1 , 0.08 g L-1 for lactate in the range of 0.15-1.19 g L-1 , 0.31 E6 ce...
Source: Biotechnology Journal - January 5, 2024 Category: Biotechnology Authors: Xu Yan Xiaoxiao Dong Yuxiang Wan Dong Gao Zhenhua Chen Ying Zhang Zhilong Zheng Kaifeng Chen Jingyu Jiao Yan Sun Zhuohong He Lei Nie Xiaohui Fan Haibin Wang Haibin Qu Source Type: research
Development of an in-line Raman analytical method for commercial-scale CHO cell culture process monitoring: Influence of measurement channels and batch number on model performance
In this study, an in-line Raman analytical method was developed for monitoring glucose, lactate, and viable cell density (VCD) in the Chinese hamster ovary (CHO) cell culture process during commercial production of biosimilar adalimumab (1500 L). The influence of different Raman measurement channels was considered to determine whether to merge data from different channels for model development. Raman calibration models were developed and optimized, with minimum root mean square error of prediction of 0.22 g L-1 for glucose in the range of 1.66-3.53 g L-1 , 0.08 g L-1 for lactate in the range of 0.15-1.19 g L-1 , 0.31 E6 ce...
Source: Biotechnology Journal - January 5, 2024 Category: Biotechnology Authors: Xu Yan Xiaoxiao Dong Yuxiang Wan Dong Gao Zhenhua Chen Ying Zhang Zhilong Zheng Kaifeng Chen Jingyu Jiao Yan Sun Zhuohong He Lei Nie Xiaohui Fan Haibin Wang Haibin Qu Source Type: research
Development of an in-line Raman analytical method for commercial-scale CHO cell culture process monitoring: Influence of measurement channels and batch number on model performance
In this study, an in-line Raman analytical method was developed for monitoring glucose, lactate, and viable cell density (VCD) in the Chinese hamster ovary (CHO) cell culture process during commercial production of biosimilar adalimumab (1500 L). The influence of different Raman measurement channels was considered to determine whether to merge data from different channels for model development. Raman calibration models were developed and optimized, with minimum root mean square error of prediction of 0.22 g L-1 for glucose in the range of 1.66-3.53 g L-1 , 0.08 g L-1 for lactate in the range of 0.15-1.19 g L-1 , 0.31 E6 ce...
Source: Biotechnology Journal - January 5, 2024 Category: Biotechnology Authors: Xu Yan Xiaoxiao Dong Yuxiang Wan Dong Gao Zhenhua Chen Ying Zhang Zhilong Zheng Kaifeng Chen Jingyu Jiao Yan Sun Zhuohong He Lei Nie Xiaohui Fan Haibin Wang Haibin Qu Source Type: research
