Is it really possible to kill with insulin without leaving traces? From lifesaver to killer, the issues surrounding the analytical characterization of postmortem insulin illustrated by an exemplary case
J Forensic Sci. 2024 Mar 14. doi: 10.1111/1556-4029.15501. Online ahead of print.ABSTRACTEvidence of an insulin overdose is very complicated in the medico-legal field. The analysis and subsequent interpretation of results is complex, especially when treating postmortem blood samples. The instability of insulin, the special pre-analytical conditions and the absence of specific analytical methods has led most laboratories not to analyze insulin in their routine with a consequent underestimation of cases. This paper aims to assess the difficulties associated with the analytical characterization of insulin by describing a case...
Source: Journal of Forensic Sciences - March 14, 2024 Category: Forensic Medicine Authors: Nadia Arbouche Audrey Farrugia Laurie Gheddar Alice Ameline Adeline Blanchot Jean-S ébastien Raul Pascal Kintz Source Type: research
Is it really possible to kill with insulin without leaving traces? From lifesaver to killer, the issues surrounding the analytical characterization of postmortem insulin illustrated by an exemplary case
J Forensic Sci. 2024 Mar 14. doi: 10.1111/1556-4029.15501. Online ahead of print.ABSTRACTEvidence of an insulin overdose is very complicated in the medico-legal field. The analysis and subsequent interpretation of results is complex, especially when treating postmortem blood samples. The instability of insulin, the special pre-analytical conditions and the absence of specific analytical methods has led most laboratories not to analyze insulin in their routine with a consequent underestimation of cases. This paper aims to assess the difficulties associated with the analytical characterization of insulin by describing a case...
Source: Journal of Forensic Sciences - March 14, 2024 Category: Forensic Medicine Authors: Nadia Arbouche Audrey Farrugia Laurie Gheddar Alice Ameline Adeline Blanchot Jean-S ébastien Raul Pascal Kintz Source Type: research
Is it really possible to kill with insulin without leaving traces? From lifesaver to killer, the issues surrounding the analytical characterization of postmortem insulin illustrated by an exemplary case
J Forensic Sci. 2024 Mar 14. doi: 10.1111/1556-4029.15501. Online ahead of print.ABSTRACTEvidence of an insulin overdose is very complicated in the medico-legal field. The analysis and subsequent interpretation of results is complex, especially when treating postmortem blood samples. The instability of insulin, the special pre-analytical conditions and the absence of specific analytical methods has led most laboratories not to analyze insulin in their routine with a consequent underestimation of cases. This paper aims to assess the difficulties associated with the analytical characterization of insulin by describing a case...
Source: Journal of Forensic Sciences - March 14, 2024 Category: Forensic Medicine Authors: Nadia Arbouche Audrey Farrugia Laurie Gheddar Alice Ameline Adeline Blanchot Jean-S ébastien Raul Pascal Kintz Source Type: research
Pregnancy-associated fulminant type 1 diabetes: a case report and review of the literature
We report a case of PF, review the published literature and consider a cesarean section at the onset of PF. A 39-year-old woman was admitted to our hospital with dyspnea and nausea. The patient was diagnosed with PF. Insulin Lispro and Glargine were administered to control the blood glucose levels. Six hours later, the fetus died. The fetal status due to PF probably worsened during the conservative treatment. No perioperative complications have been reported for cesarean sections under diabetic ketoacidosis due to PF and there have been cases of live birth by emergency cesarean section. Identifying the features of PF and c...
Source: Diabetology International - March 12, 2024 Category: Endocrinology Source Type: research
Error in Table
This article was corrected online. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - October 26, 2023 Category: General Medicine Source Type: research
Tirzepatide vs Insulin Lispro Added to Basal Insulin in Type 2 Diabetes
This study examines the efficacy and safety of tirzepatide vs insulin lispro adjunctive therapy to insulin glargine among those receiving basal insulin with inadequately controlled type 2 diabetes. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - October 3, 2023 Category: General Medicine Source Type: research
Glycaemia in low-premixed insulin analogue type 2 diabetes patients in a real-world setting: are the CGM targets met?
CONCLUSIONS: Most of our type 2 diabetes patients, treated with low-premixed insulin, did not meet the recommended TBR target for older/high-risk patients while meeting the TIR and TAR targets. Nevertheless, the time spent in (total and nocturnal) hypoglycemia was short. The study indicates that the general type 2 diabetes population targets would mostly be met for TBR and %CV in our patients but not the TIR and TAR targets. CGM appears to be a useful clinical tool in these patients.PMID:36882852 | DOI:10.1186/s40001-023-01081-y (Source: Molecular Medicine)
Source: Molecular Medicine - March 7, 2023 Category: Molecular Biology Authors: Mitja Krajnc Nika Aleksandra Kravos Tram šek Source Type: research
Glycaemia in low-premixed insulin analogue type 2 diabetes patients in a real-world setting: are the CGM targets met?
ConclusionsMost of our type 2 diabetes patients, treated with low-premixed insulin, did not meet the recommended TBR target for older/high-risk patients while meeting the TIR and TAR targets. Nevertheless, the time spent in (total and nocturnal) hypoglycemia was short. The study indicates that the general type 2 diabetes population targets would mostly be met for TBR and %CV in our patients but not the TIR and TAR targets. CGM appears to be a useful clinical tool in these patients. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - March 7, 2023 Category: Research Source Type: research
Identification, measurement, and evaluation of blood concentrations of insulin glargine and insulin lispro by UPLC-MS-MS in a dead body suspected of insulin overdose
J Forensic Sci. 2023 Feb 10. doi: 10.1111/1556-4029.15219. Online ahead of print.ABSTRACTInsulin preparations, which are drug treatments for diabetes, cause fatal hypoglycemia when an overdose is administered. Cases of homicide and suicide using these preparations have been reported and are of great forensic interest. However, there are few reports assessing the postmortem concentration of insulin preparations, and it is often difficult to determine the cause of death. In the present study, we report a case of a suspected insulin glargine and insulin lispro overdose for suicide. A woman in her 30s had a history of mental i...
Source: Journal of Forensic Sciences - February 10, 2023 Category: Forensic Medicine Authors: Sayaka Nagasawa Rutsuko Yamaguchi Fumiko Chiba Suguru Torimitsu Hirotaro Iwase Source Type: research
Identification, measurement, and evaluation of blood concentrations of insulin glargine and insulin lispro by UPLC-MS-MS in a dead body suspected of insulin overdose
J Forensic Sci. 2023 Feb 10. doi: 10.1111/1556-4029.15219. Online ahead of print.ABSTRACTInsulin preparations, which are drug treatments for diabetes, cause fatal hypoglycemia when an overdose is administered. Cases of homicide and suicide using these preparations have been reported and are of great forensic interest. However, there are few reports assessing the postmortem concentration of insulin preparations, and it is often difficult to determine the cause of death. In the present study, we report a case of a suspected insulin glargine and insulin lispro overdose for suicide. A woman in her 30s had a history of mental i...
Source: Journal of Forensic Sciences - February 10, 2023 Category: Forensic Medicine Authors: Sayaka Nagasawa Rutsuko Yamaguchi Fumiko Chiba Suguru Torimitsu Hirotaro Iwase Source Type: research
Identification, measurement, and evaluation of blood concentrations of insulin glargine and insulin lispro by UPLC-MS-MS in a dead body suspected of insulin overdose
J Forensic Sci. 2023 Feb 10. doi: 10.1111/1556-4029.15219. Online ahead of print.ABSTRACTInsulin preparations, which are drug treatments for diabetes, cause fatal hypoglycemia when an overdose is administered. Cases of homicide and suicide using these preparations have been reported and are of great forensic interest. However, there are few reports assessing the postmortem concentration of insulin preparations, and it is often difficult to determine the cause of death. In the present study, we report a case of a suspected insulin glargine and insulin lispro overdose for suicide. A woman in her 30s had a history of mental i...
Source: Journal of Forensic Sciences - February 10, 2023 Category: Forensic Medicine Authors: Sayaka Nagasawa Rutsuko Yamaguchi Fumiko Chiba Suguru Torimitsu Hirotaro Iwase Source Type: research
Mass Casualty Incident Involving Rapid Acting Insulin
We report on an unusual prehospital incident involving the inadvertent administration of short-acting insulin among a group of high school students. Sixteen students iatrogenically received 10 units of insulin lispro intradermally instead of tuberculin purified protein derivative (PPD), resulting in several students experiencing symptomatic hypoglycemia. A mass casualty incident was declared and the local poison center consulted. An incident command system, with the support of on-scene EMS physicians, was established to track, treat, and transport the involved patients.PMID:36595597 | DOI:10.1080/10903127.2022.2162649 (Sou...
Source: Prehospital Emergency Care - January 3, 2023 Category: Endocrinology Authors: M Liao T Fulks J Garner M Supples N Glober Source Type: research
