Rationale and protocol for a prospective cohort study of respiratory viral infections in patients admitted from emergency departments of community hospitals: Effect of respiratory Virus infection on EmeRgencY admission (EVERY) study
Introduction
Respiratory syncytial virus (RSV) is a causative virus for the common cold worldwide and can result in hospitalisations and even death in patients with high-risk conditions and older adults. However, the relationship between RSV or other incidental respiratory infections and acute exacerbations of underlying conditions has not been well investigated. The primary objective of this study is to estimate RSV prevalence, risk factors for adverse outcomes or hospitalisation and their effect on the hospital course of patients with acute respiratory symptoms admitted from emergency departments. Furthermore, we evaluat...
Source: BMJ Open - April 15, 2024 Category: General Medicine Authors: Morimoto, T., Morikawa, T., Imura, H., Nezu, M., Hamazaki, K., Sakuma, M., Chaumont, A., Moitinho de Almeida, M., Moreno, V. P., Ho, Y., Harrington, L., Matsuki, T., Nakamura, T. Tags: Open access, Health services research Source Type: research
The N-LVA Study: effectiveness and cost-effectiveness of lymphaticovenous anastomosis (LVA) for patients with cancer who suffer from chronic peripheral lymphoedema - study protocol of a multicentre, randomised sham-controlled trial
The objective of this study is to evaluate whether LVA is effective and cost-effective compared with sham surgery in improving the HRQoL.
Methods and analysis
A multicentre, double-blind, randomised sham-controlled trial conducted in three university hospitals in the Netherlands. The study population comprises 110 patients over the age of 18 years with unilateral, peripheral cancer-related lymphoedema, including 70 patients with upper limb lymphoedema and 40 patients with lower limb lymphoedema. A total of 55 patients will undergo the LVA operation, while the remaining 55 will undergo sham surgery. The follow-up will be a...
Source: BMJ Open - April 15, 2024 Category: General Medicine Authors: Kleeven, A., Jonis, Y. M. J., Tielemans, H., van Kuijk, S., Kimman, M., van der Hulst, R., Vasilic, D., Hummelink, S., Qiu, S. S. Tags: Open access, Surgery Source Type: research
Artificial intelligence-based prediction of diabetic retinopathy evolution (EviRed): protocol for a prospective cohort
Introduction
An important obstacle in the fight against diabetic retinopathy (DR) is the use of a classification system based on old imaging techniques and insufficient data to accurately predict its evolution. New imaging techniques generate new valuable data, but we lack an adapted classification based on these data. The main objective of the Evaluation Intelligente de la Rétinopathie Diabétique, Intelligent evaluation of DR (EviRed) project is to develop and validate a system assisting the ophthalmologist in decision-making during DR follow-up by improving the prediction of its evolution.
Methods and anal...
Source: BMJ Open - April 15, 2024 Category: General Medicine Authors: Tadayoni, R., Massin, P., Bonnin, S., Magazzeni, S., Lay, B., Le Guilcher, A., Vicaut, E., Couturier, A., Quellec, G., Investigators, E. Tags: Open access, Ophthalmology Source Type: research
Effects of a therapeutic lifestyle modification intervention on cardiometabolic health, sexual functioning and health-related quality of life in perimenopausal Chinese women: protocol for a randomised controlled trial
Introduction
Perimenopause is a critical transitional period in reproductive ageing. A set of physiological and psychological changes can affect perimenopausal women’s quality of life and further threaten their older adult health conditions. In China, less than one-third of midlife women with menopausal symptoms have actively sought professional healthcare. Regarding the public health significance of comprehensive menopause management, the current study aims to investigate the effects of a therapeutic lifestyle modification (TLM) intervention on cardiometabolic health, sexual functioning and health-related quality of...
Source: BMJ Open - April 15, 2024 Category: General Medicine Authors: Wang, Y., Miao, X., Viwattanakulvanid, P. Tags: Open access, Obstetrics & Gynaecology Obstetrics and gynaecology Source Type: research
Discovery of palmatine derivatives as potent neuroprotective agents
. (Source: Journal of Asian Natural Products Research)
Source: Journal of Asian Natural Products Research - April 15, 2024 Category: Complementary Medicine Authors: Shuo PangNa ChenZhuo LiZhuo-Hui LuoWei DongShan GaoNing LiuShuo PanLian-Feng ZhangJun ChenYa-Jun Yanga The Laboratory of Neurological Disorders and Brain Cognition, Beijing Pediatric Research Institute, Beijing Children ’s Hospital, Capital Medical Univ Source Type: research
Repression of YEATS2 induces cellular senescence in hepatocellular carcinoma and inhibits tumor growth
. (Source: Cell Cycle)
Source: Cell Cycle - April 15, 2024 Category: Cytology Authors: Qi WuQuan ZhengLei YuanDandan GaoYabing HuXinqing JiangQiaocheng ZhaiMing LiuLifeng XuHeng XuJinlin YeFeng Zhanga Department of Hepatobiliary Surgery, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, Chinab The Joint Innovation Center Source Type: research
Preoperative Serum Thyroglobulin Levels Predict Radioiodine Therapy
Outcome in Papillary Thyroid Microcarcinoma Patients
Horm Metab Res DOI: 10.1055/a-2291-0340Our previous study showed that elevated preoperative thyroglobulin (pre-Tg) level
predicted the risk of developing radioiodine refractory in PTC patients. In the
present study, we aimed to evaluate the prognostic value of pre-Tg in papillary
thyroid microcarcinoma (PTMC). After a specific inclusion and exclusion criteria
were applied, a total of 788 PTMCs were enrolled from Jiangyuan Hospital
affiliated to Jiangsu Institute of Nuclear Medicine between Jan 2015 and Dec
2019. Among them, 107 PTMCs were treated with radioiodine ...
Source: Hormone and Metabolic Research - April 15, 2024 Category: Endocrinology Authors: Cheng, Xian Fan, Yijun Ye, Wanzhong Xu, Shichen Wu, Jing Gao, Wenjing Bao, Jiandong Yu, Huixin Zhang, Li Tags: Original Article: Endocrine Care Source Type: research
Is pulmonary hypertension protective against cardiac tamponade? A systematic review
AbstractThe presence of pulmonary hypertension (PH) may affect whether cardiac tamponade physiology develops from a pericardial effusion. Specifically, the increased intracardiac pressure and right ventricular hypertrophy associated with PH would seemingly increase the intrapericardial pressure threshold at which the right-sided chambers collapse. In this systematic review, we examined the impact of PH on the incidence, in-hospital and long-term mortality, and echocardiographic findings of patients with cardiac tamponade. Using the PRISMA guideline, a systematic search was conducted in PubMed, Academic Search Premier, Web ...
Source: Internal and Emergency Medicine - April 15, 2024 Category: Emergency Medicine Source Type: research
Molecular epidemiology and resistance mechanisms of tigecycline-non-susceptible Acinetobacter baumannii isolated from a tertiary care hospital in Chongqing, China
AbstractWe studied 34 isolates of Tigecycline-Non-SusceptibleA. baumannii (TNAB) obtained from clinical specimens at a large tertiary care hospital in Chongqing, China. These 34 strains belonged to 8 different clones including ST195 (35.3%) and ST208 (17.7%). EBURST analysis found that these 8 ST types belonged to the Clonal Complex 92. Tigecycline resistance-associated genesadeR, adeS, adeL, adeN, rrf, rpsJ, and trm were detected in most strains. The expression level of the resistance-nodulation-cell division (RND) efflux pumps in TNAB strains was higher than the reference strain ATCC19606. 58.8% of strains had a decrease...
Source: European Journal of Clinical Microbiology and Infectious Diseases - April 15, 2024 Category: Microbiology Source Type: research
Interventional Radiologists and OBLs: An Excellent Match
This article addresses the value interventional radiologists (IRs) can bring to the OBL, with primary impacts being the ability to impact a larger proportion of the population than is traditionally cared for in most hospital settings, the ability to positively influence multidisciplinary care teams and the financial leverage inherent in procedural diversification not readily afforded by other specialists working in the OBL space. (Source: Techniques in Vascular and Interventional Radiology)
Source: Techniques in Vascular and Interventional Radiology - April 15, 2024 Category: Radiology Authors: Kavi K. Devulapalli Source Type: research
Do pulmonary rehabilitation programmes improve outcomes in patients with COPD posthospital discharge for exacerbation: a systematic review and meta-analysis
Discussion
Pulmonary rehabilitation delivered posthospital discharge for exacerbation of COPD results in a reduction in hospital re-admissions and improvements in exercise capacity, health-related quality of life and dyspnoea in the absence of any intervention-related adverse events.
Trial registration number
CRD42023406397. (Source: Thorax)
Source: Thorax - April 15, 2024 Category: Respiratory Medicine Authors: Jenkins, A. R., Burtin, C., Camp, P. G., Lindenauer, P., Carlin, B., Alison, J. A., Rochester, C., Holland, A. E. Tags: Thorax Rehabilitation Source Type: research
Journal club
This study was undertaken at 11 hospitals in the UK and one in Australia. 142 patients were randomised 1:1 to the IPC or chest drain. The primary outcome... (Source: Thorax)
Source: Thorax - April 15, 2024 Category: Respiratory Medicine Authors: Iqbal, B. Tags: Thorax Journal club Source Type: research
Comparison of the safety and efficacy of robotic natural orifice specimen extraction surgery and conventional robotic colorectal cancer resection: a propensity score matching study
AbstractRobotic resection is widely used to treat colorectal cancer. Although the novel natural orifice specimen extraction surgery (NOSES) results in less trauma, its safety and effectiveness are relatively unknown. In the present study, we used propensity score matching to compare the effectiveness and safety of NOSES and robotic resection for treating colorectal cancer. Present retrospective cohort study included patients who underwent robotic colon and rectal cancer surgery between January 2016 and December 2019 at the Department of Gastrointestinal Surgery, the Second Xiangya Hospital of Central South University. The ...
Source: Journal of Robotic Surgery - April 15, 2024 Category: Surgery Source Type: research
RSV Vaccination —The Juice Is Worth the Squeeze
In this issue of JAMA Internal Medicine, Woodruff et al present a cross-sectional study of patients 50 years and older who were hospitalized and tested positive for respiratory syncytial virus (RSV), reporting that 22% experienced an acute cardiac event, including acute exacerbation of heart failure or myocardial injury. The already high in-hospital mortality rate of 5% for older adults with RSV-associated hospitalizations was doubled among those experiencing a concurrent acute cardiac event. (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - April 15, 2024 Category: Internal Medicine Source Type: research
IJERPH, Vol. 21, Pages 484: Insights into the Impact of Organizational Factors and Burnout on the Employees of a For-Profit Psychiatric Hospital during the Third Wave of the COVID-19 Pandemic
eely
In this paper, we provide insights into the interplay among the organizational, job, and attitudinal factors and employees’ intentions to resign during the third wave of the COVID-19 pandemic at a mental health hospital. We point out shortcomings in the relationship dynamics between executive administration and operational staff and propose a pathway to develop more effective leadership frameworks to increase job satisfaction. We integrate qualitative data from case information and open-ended questions posed to employees at a mental health hospital and quantitative data from a small-scale survey (n =...
Source: International Journal of Environmental Research and Public Health - April 15, 2024 Category: Environmental Health Authors: Michael Seyffert Chunyi Wu G ülru F. Özkan-Seely Tags: Article Source Type: research
