KPC-2-producing Enterobacterales from ready-to-eat food to hospitalized patients
Infect Genet Evol. 2024 Apr 19:105596. doi: 10.1016/j.meegid.2024.105596. Online ahead of print.ABSTRACTFoodstuffs are a well-documented source of multidrug-resistant bacteria, and hospitalized patients are usually susceptible to hospital infections owing to their immune status. Therefore, this study aimed to investigate the presence of beta-lactamase-producing Enterobacterales in ready-to-eat foods consumed by hospitalized patients. For this purpose, 51 vegetable and meat samples were collected over 2 months and analyzed. Enterobacterales isolates were identified and subjected to antimicrobial susceptibility testing, foll...
Source: Infection, Genetics and Evolution - April 21, 2024 Category: Genetics & Stem Cells Authors: Bianca Lara Ven âncio de Godoy Marlon do Valle Barroso Yasmin Fontoura de Azeredo Louren ção Let ícia Kellen de Andrade Vit ória Gabriela Tosta Rodrigues Caroline Atu í Ana Caroline do Valle Ta ís Paulino Ferreira Mara Corr êa Lelles Nogueira Tiag Source Type: research
Identifying co-morbidities and risk in people with epilepsy: The Maltese experience
DISCUSSION: Patient outcomes may be improved with increasing rates of personalized epilepsy care plans, appropriate nocturnal surveillance and reducing the prescription of antipsychotic medication as it is associated with greater risk of mortality. Issues such as stigma and shame appear to play a significant role in small communities and their access to care.PMID:38643661 | DOI:10.1016/j.yebeh.2024.109795 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - April 21, 2024 Category: Neurology Authors: Adrian Pace Lance Watkins Daniel Fiott Paul Bassett Richard Laugharne Christopher James Rohit Shankar Source Type: research
Psychoneuroimmunology in multiple myeloma and autologous hematopoietic stem cell transplant: Opportunities for research among patients and caregivers
Brain Behav Immun. 2024 Apr 19:S0889-1591(24)00366-0. doi: 10.1016/j.bbi.2024.04.019. Online ahead of print.ABSTRACTMultiple myeloma (MM) is an incurable cancer and is the leading indication for autologous hematopoietic stem cell transplantation (HSCT). To be eligible for HSCT, a patient must have a caregiver, as caregivers play a central role in HSCT preparation and recovery. MM patients remain on treatment indefinitely, and thus patients and their caregivers face long-term challenges including the intensity of HSCT and perpetual therapy after transplant. Importantly, both patients and their caregivers show heightened dep...
Source: Brain, Behavior, and Immunity - April 21, 2024 Category: Neurology Authors: Lisa M Christian Janice K Kiecolt-Glaser Steve W Cole Christin E Burd Annelise A Madison Stephanie J Wilson Ashley E Rosko Source Type: research
HELLP Syndrome at 20 Gestational Weeks Managed Using the Mississippi Protocol: A Case Report
This report indicates that early and intensive treatment of patients with HELLP syndrome occurring before 22 GWs according to the Mississippi protocol may enable clinicians to complete pregnancy termination without maternal complications and provide useful information to clinical practitioners in perinatal medicine.PMID:38644297 | DOI:10.24546/0100488386 (Source: Kobe J Med Sci)
Source: Kobe J Med Sci - April 21, 2024 Category: General Medicine Authors: Naohisa Masuko Kenji Tanimura Masayuki Tanaka Akiko Uchida Ryosuke Takahashi Hitomi Imafuku Masashi Deguchi Yoshito Terai Source Type: research
Latent safety threats in a pediatric emergency department: Using in situ simulation to test a new trauma room concept
DISCUSSION: With the help of this study, it could be shown that the implementation of in situ simulation before the commissioning of new clinical premises and the introduction of new processes can contribute to the detection of latent safety threats in an interdisciplinary German pediatric emergency department.PMID:38644149 | DOI:10.1016/j.zefq.2024.03.005 (Source: Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen)
Source: Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen - April 21, 2024 Category: Health Management Authors: Anja Gro ße Lordemann Dirk Sommerfeldt Lukas Mileder Source Type: research
Antimicrobial resistance and carbapenemase dissemination in < em > Pseudomonas aeruginosa < /em > isolates from Libyan hospitals: a call for surveillance and intervention
This study aimed to assess resistance of clinical isolates from Libyan hospitals to antipseudomonal antibiotics, the prevalence of selected extended-spectrum β-lactamases and carbapenemase genes among these isolates, and the microorganisms' capacity for alginate and biofilm production. Forty-five isolates were collected from four hospitals in Benghazi and Derna, Libya. Antimicrobial susceptibility was determined using agar disc diffusion. The presence of resistance genes (blaCTXM, blaTEM, blaSHV-1, blaGES-1, blaKPC, and blaNDM) was screened using PCR. Biofilm formation was quantified via the crystal violet assay, while al...
Source: Libyan Journal of Medicine - April 21, 2024 Category: General Medicine Authors: Nasrin K Gadaime Randa N Haddadin Asem A Shehabi Intisar N Omran Source Type: research
Multi-omics study reveals different pathogenesis of the generation of skin lesions in SLE and IDLE patients
J Autoimmun. 2024 Apr 20;146:103203. doi: 10.1016/j.jaut.2024.103203. Online ahead of print.ABSTRACTLupus erythematosus (LE) is a heterogeneous, antibody-mediated autoimmune disease. Isolate discoid LE (IDLE) and systematic LE (SLE) are traditionally regarded as the two ends of the spectrum, ranging from skin-limited damage to life-threatening multi-organ involvement. Both belong to LE, but IDLE and SLE differ in appearance of skin lesions, autoantibody panels, pathological changes, treatments, and immunopathogenesis. Is discoid lupus truly a form of LE or is it a completely separate entity? This question has not been full...
Source: Journal of Autoimmunity - April 21, 2024 Category: Allergy & Immunology Authors: Qianwen Li Chen Jia Wenjing Pan Hongmei Liu Congli Tang Daniel Weber Kaili Chen Hai Long Miranda L Byrne-Steele Jian Han Nongyue He Rong Xiao Ming Zhao Nan Che Qing Guo Guangji Gui Shanshan Li Henan Si Shuping Guo Hongye Liu Gang Wang Guannan Zhu Bin Yang Source Type: research
The influence of psychological resilience and nursing practice environment on nurses' moral courage: A cross ‐sectional study
AbstractAimTo determine the relationship between psychological resilience, nursing practice environment, and moral courage of clinical nurses and also the factors influencing moral courage.DesignCross-sectional study.Methods586 nurses from a general hospital were selected by convenience sampling method in January 2023. The general information questionnaire, Nurses' Moral Courage Scale (NMCS), Resilience Scale, and Practice Environment Scale (PES) were measured. Hierarchical linear regression analysis was used to explore the influencing factors of clinical nurses' moral courage.ResultsNurses' average moral courage score was...
Source: Nursing Open - April 21, 2024 Category: Nursing Authors: Zhang Ruixin,
He Shan,
Tang Yongli,
Jie Chen,
Chen Qianzhu,
Wang Xue Tags: EMPIRICAL RESEARCH QUANTITATIVE Source Type: research
H4K20me3, H3K4me2 and H3K9me2 mediate the effect of ER on prognosis in breast cancer
Volume 19, Issue 1, December 2024 . (Source: Epigenetics)
Source: Epigenetics - April 21, 2024 Category: Genetics & Stem Cells Authors: Cheng-Kun XiaoYuexiang RenQianxin ChenYuanzhong YangLuying TangLin XuZefang Rena School of Public Health, Sun Yat-sen University, Guangzhou, Chinab The Sun Yat-Sen University Cancer Center, Guangzhou, Chinac The Third Affiliated Hospital, Sun Yat-Sen Univ Source Type: research
Management and confusion in an elderly trauma patient
As the UK population continues to age, healthcare providers encounter a growing number of geriatric patients in most medical and surgical specialties. In the realm of orthopaedic care, this demographic shift presents distinctive challenges, with delirium emerging as a prominent complicating factor of many orthopaedic admissions. Acute confusion or delirium frequently complicates the treatment of older trauma patients, significantly influencing hospital stays, requiring tailored interventions, an d negatively impacting overall recovery. (Source: Surgery (Medicine Publishing))
Source: Surgery (Medicine Publishing) - April 21, 2024 Category: Surgery Authors: Claire Eastick, Ivan Aganin, Samson Thongs-George, Andrew Oswell Tags: Orthopaedics: Spine, pelvis and general trauma Source Type: research
Corrigendum to ‘Hospital Revenue, Cost, and Contribution Margin in Inpatient Versus Outpatient Primary Total Joint Arthroplasty’ [The Journal of Arthroplasty 38 (2023) 203-208]
The Authors regret that the “Results” section in the Abstract of this manuscript does not match the results reported in the body of the work. During manuscript revisions, the body of the work was updated as a response to reviewer comments, but the abstract was not updated. The online article has been updated and the correc t Results section of the Abstract is also given here: (Source: The Journal of Arthroplasty)
Source: The Journal of Arthroplasty - April 21, 2024 Category: Orthopaedics Authors: Thomas H. Christensen, Thomas Bieganowski, Alex W. Malarchuk, Roy I. Davidovitch, Joseph A. Bosco, Ran Schwarzkopf, William B. Macaulay, James D. Slover, Claudette M. Lajam Tags: Corrigendum Source Type: research
A case of insulinoma misidentified as schizophrenia due to its manifestation in neuropsychiatric symptoms
AbstractInsulinomas can present with neuroglycopenic symptoms suggesting neuropsychiatric disorders, delaying diagnosis and treatment. We recently treated a 65-year-old woman with insulinoma who was misdiagnosed at her nearby psychiatric clinic as having schizophrenia because of personality changes and memory impairment; she was treated with brexpiprazole, which was discontinued due to persistence of the symptoms. Despite her relatively low casual plasma glucose (70 mg/dL), the physician at the psychiatric clinic did not investigate the possibility of hypoglycemia, partly because her HbA1c level (5.2%) was within normal ...
Source: Diabetology International - April 21, 2024 Category: Endocrinology Source Type: research
Comparison of the PADUA and IMPROVE scores in assessing venous thromboembolism risk in 42,257 medical inpatients in China
The objective of this study is to compare the efficacy of the Padua and IMPROVE scoring models for assessing VTE risk in Chinese medical inpatients. We conducted a retrospective analysis of the clinical characteristics and thrombotic risk of 42,257 medical inpatients at a tertiary hospital in Guangdong, China, between 2021 and 2022. Logistic regression was used to assess thrombotic risk factors. The Receiver Operating Characteristic (ROC) curves, Area Under the Curve (AUC), sensitivity, and specificity were employed to evaluate the performance of the two models. Of the 42,257 patients included, 948 (2.24%) experienced VTE ...
Source: Journal of Thrombosis and Thrombolysis - April 21, 2024 Category: Hematology Source Type: research
Assessing the Variability in Interpretation of the Catholic Directives Pertaining to Reproductive Health Services: An Exploratory Qualitative Study of Two Hospitals on the American East Coast
This study aims to research a potential source of variability in interpretation and application of the directives through interviewing ethics committee members. Participants were recruited from two different hospitals on the east coast with a total sample size of eight. Ethics committee members were asked questions regarding their personal approach to ethics, their hospital ’s approach to ethics, and the permissibility of specific family planning methods at their hospital. Most ethics committee members stated that the Catholic faith and/or directives were important in their hospitals’ approach to ethics. Most participa...
Source: Journal of Religion and Health - April 21, 2024 Category: Medical Ethics Source Type: research
Molecules, Vol. 29, Pages 1888: Dragon & rsquo;s Blood-Loaded Mesoporous Silica Nanoparticles for Rapid Hemostasis and Antibacterial Activity
In this study, different amounts of DB were loaded on mesoporous silica nanoparticles (MSNs) to prepare a series of DB-MSN composites (5DB-MSN, 10DB-MSN, and 20DB-MSN). DB-MSN could quickly release DB and activate the intrinsic blood coagulation cascade simultaneously by DB and MSN. Hemostasis tests demonstrated that DB-MSN showed superior hemostatic effects than either DB or MSNs alone, and 10DB-MSN exhibited the best hemostatic effect. In addition, the antibacterial activities of DB-MSN against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) improved with the increase in DB. Furthermore, the hemolysis as...
Source: Molecules - April 21, 2024 Category: Chemistry Authors: Cuiyun Yin Yihang Li Jing Yu Zhaoyou Deng Shifang Liu Xuanchao Shi Deying Tang Xi Chen Lixia Zhang Tags: Article Source Type: research
