BCAR4 Expression as a Predictive Biomarker for Endocrine Therapy Resistance in Breast Cancer
CONCLUSION: This study expands on previous findings by demonstrating that BCAR4 expression is associated with resistance to newer therapies. The identification of patients with intrinsic resistance to hormone therapy is crucial to avoid ineffective treatment strategies. These findings contribute to our understanding of endocrine therapy resistance in breast cancer and could potentially guide the development of more effective treatment strategies.PMID:38443227 | DOI:10.1016/j.clbc.2024.02.007 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - March 5, 2024 Category: Cancer & Oncology Authors: Muheng Liao Jace Webster Emily M Coonrod Katherine N Weilbaecher Christopher A Maher Nicole M White Source Type: research
BCAR4 Expression as a Predictive Biomarker for Endocrine Therapy Resistance in Breast Cancer
CONCLUSION: This study expands on previous findings by demonstrating that BCAR4 expression is associated with resistance to newer therapies. The identification of patients with intrinsic resistance to hormone therapy is crucial to avoid ineffective treatment strategies. These findings contribute to our understanding of endocrine therapy resistance in breast cancer and could potentially guide the development of more effective treatment strategies.PMID:38443227 | DOI:10.1016/j.clbc.2024.02.007 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 5, 2024 Category: Cancer & Oncology Authors: Muheng Liao Jace Webster Emily M Coonrod Katherine N Weilbaecher Christopher A Maher Nicole M White Source Type: research
The role of modern parameters and their relationship with recurrence risk as assessed by Oncotype DX: real-world evidence
In this study, we aimed to identify classical clinical-pathological factors associated with high RS in a local population, including modern parameters such as current abemaciclib treatment recommendations, HER2-low status, different Ki-67 cutoff values, and samples obtained from secondary primary tumours. This is a retrospective single-institution study that analysed a total of 215 tumour samples. Among lymph node-negative patients (n = 179), age, Ki67 values, and progesterone receptor status predicted RS after multivariate analysis. HER2-low status was not associated with RS differences (p = 0.41). Among lymph node-positi...
Source: Ecancermedicalscience - March 5, 2024 Category: Cancer & Oncology Authors: Dana Narvaez Jorge Nadal Adrian Nervo Victoria Costanzo Claudio Paletta Fernando Petracci Sergio Rivero Alexis Ostinelli Federico Col ó Loza Mart ín Veronica Fabiano Luciana Sabatini Azul Perazzolo Mora Amat Matias Chacon Federico Waisberg Source Type: research
