Risk of venous thromboembolism in users of contraception and menopausal hormone therapy during the COVID-19 pandemic
CONCLUSIONS In this scenario, apart from the fundamental orientations of preventive measures, like social isolation and hygiene, it is important that all female health professionals have knowledge of the new rules and adopt safety measures, especially on the prescription of hormonal therapy and contraception.RESUMO OBJETIVOS A pandemia da COVID-19 é um problema de saúde pública emergente e que tem repercussão internacional. As alterações inflamatórias fazem parte da fisiopatologia da COVID-19 e isso pode acarretar um maior risco tromboembólico em mulheres que fazem us...
Source: Revista da Associacao Medica Brasileira - September 22, 2020 Category: General Medicine Source Type: research

Addition of abemaciclib to hormonal therapy for high-risk early breast cancer reduces recurrence by 25%, research suggests
Combining  abemaciclib with hormonal therapy reduces the risk of cancer recurrence by 25% in patients with high-risk early hormone receptor positive (HR+) human epidermal growth factor receptor 2 negative (HER2-) breast cancer, interim analysis of a phase III study has suggested. (Source: The Pharmaceutical Journal)
Source: The Pharmaceutical Journal - September 21, 2020 Category: Drugs & Pharmacology Source Type: research

Health-Related Quality of Life and Survival in Prostate Cancer Patients in a Real-World Setting
Conclusions: Patients receiving hormonal treatment had significantly impaired HRQoL and survival compared with other treatments. Although the number of QALYs experienced was similar in the 3 other treatment lines, there were marked differences between treatment lines on some 15D dimensions.Urol Int (Source: Urologia Internationalis)
Source: Urologia Internationalis - September 21, 2020 Category: Urology & Nephrology Source Type: research

Risk of developing hypertension after hormone therapy for prostate cancer: a nationwide propensity score-matched longitudinal cohort study
This study aimed to investigate the risk of subsequent hypertension in patients undergoing androgen deprivation therapy for prostate cancer.Setting Data of 10,843 patients with prostate cancer were retrospectively collected from the Longitudinal Health Insurance Database of Taiwan. The institutional review board of Kaohsiung Medical University Hospital approved our study.Method In propensity score matching, 3001 patients with prostate cancer aged ≥ 40 years who underwent androgen deprivation therapy were included in the study cohort (androgen deprivation therapy-ever), and 3001 patients wi...
Source: International Journal of Clinical Pharmacy - September 20, 2020 Category: Drugs & Pharmacology Source Type: research

Significance of age-associated quality of life in patients with stage IV breast cancer who underwent endocrine therapy in Japan.
In conclusion, psychological stress was more prominent in younger patients with stage IV breast cancer treated with hormonal therapy compared with elderly patients. Importantly, improving QOL within the 3 months after treatment initiation could lead to longer PFS rate. PMID: 32934747 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - September 18, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

CYP17A1 polymorphism c.-362T & gt;C predicts clinical outcome in metastatic castration-resistance prostate cancer patients treated with abiraterone
ConclusionsThese findings suggest an association between CYP17A1 c.-362T>C  polymorphism and poorer clinical outcome with abiraterone for mCRPC patients. However, further validations on larger cohort of patients are needed to confirm its role as a predictive biomarker for abiraterone resistance. (Source: Cancer Chemotherapy and Pharmacology)
Source: Cancer Chemotherapy and Pharmacology - September 18, 2020 Category: Cancer & Oncology Source Type: research

Worldwide management of donors after neurological death: a systematic review and narrative synthesis of guidelines.
CONCLUSION: Highly inconsistent recommendations for deceased donor care summarized in this review likely reflect the relatively slow emergence of high-quality clinical research in this field, as well as a late uptake of recent validated guideline methodology. Even in this context of few randomized-controlled trials, our group supported the need for new Canadian guidelines for the management of organ donors that follow rigorous recognized methodology and grading of the evidence. TRIAL REGISTRATION: PROSPERO (CRD42018084012); registered 25 February 2016. PMID: 32949008 [PubMed - as supplied by publisher] (Source: C...
Source: Canadian Journal of Anaesthesia - September 18, 2020 Category: Anesthesiology Authors: Frenette AJ, Williamson D, Weiss MJ, Rochwerg B, Ball I, Brindamour D, Serri K, D'Aragon F, Meade MO, Charbonney E Tags: Can J Anaesth Source Type: research

Adjuvant radiation therapy alone is associated with improved overall survival compared to hormonal therapy alone in older women with estrogen receptor positive early stage breast cancer
In this cohort study of 130,194 women age ≥65 years with invasive ER+, node negative breast cancer who underwent breast conserving surgery, radiation (RT) with hormonal therapy (HT) was associated with the highest 5 and 10‐year survival rates (90.0% and 64.3%, respectively). Compared to patients receiving HT alone, those receiving RT al one had improved unadjusted and adjusted survival rates. AbstractBackgroundBreast conserving surgery (BCS) and adjuvant hormonal therapy (HT) without radiation therapy (RT) is an acceptable approach for older women with early stage, estrogen receptor (ER) positive breast cancer. Toxici...
Source: Cancer Medicine - September 17, 2020 Category: Cancer & Oncology Authors: Sachin R. Jhawar, Naomi Alpert, Emanuela Taioli, Mutlay Sayan, Jose Bazan, Ko Un Park, Daniel Stover, Mathew Cherian, Julia White, Bruce Haffty, Nisha Ohri Tags: ORIGINAL RESEARCH Source Type: research

Beyond Gender Identity Disorder Diagnoses Codes: An Examination of Additional Methods to Identify Transgender Individuals in Administrative Databases
Conclusion: In the absence of gender identity data, additional data elements beyond GID codes improves the identification of transgender people in large, administrative claims databases. (Source: Medical Care)
Source: Medical Care - September 16, 2020 Category: Health Management Tags: Original Articles Source Type: research

Phase 1 study of TTC-352 in patients with metastatic breast cancer progressing on endocrine and CDK4/6 inhibitor therapy
ConclusionsTTC-352 demonstrates safety and early clinical evidence of antitumor activity against heavily pretreated hormone-refractory breast cancer. Based upon TTC-352 plasma concentrations and tolerability, the 180  mg twice a day is recommended for further testing.(ClinicalTrials.gov Identifier: NCT03201913) (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 16, 2020 Category: Cancer & Oncology Source Type: research

Characterizing the effects of tonic 17 β-estradiol administration on spatial learning and memory in the follicle-deplete middle-aged female rat.
Characterizing the effects of tonic 17β-estradiol administration on spatial learning and memory in the follicle-deplete middle-aged female rat. Horm Behav. 2020 Sep 16;:104854 Authors: Koebele SV, Mennenga SE, Poisson ML, Hewitt LT, Patel S, Mayer LP, Dyer CA, Bimonte-Nelson HA Abstract 17β-estradiol (E2)-containing hormone therapy is a safe, effective way to alleviate unwanted menopause symptoms. Preclinical research has focused upon the role of E2 in learning and memory using a surgically menopausal rodent model whereby the ovaries are removed. Given that most women retain their reproducti...
Source: Hormones and Behavior - September 16, 2020 Category: Endocrinology Authors: Koebele SV, Mennenga SE, Poisson ML, Hewitt LT, Patel S, Mayer LP, Dyer CA, Bimonte-Nelson HA Tags: Horm Behav Source Type: research

Identification of risk factors for falls in postmenopausal women: a systematic review and meta-analysis
AbstractThe purpose of this study was to identify risk factors for falls in postmenopausal women and provide evidence for the primary prevention of falls in postmenopausal women. The protocol for this meta-analysis is registered with PROSPERO (CRD42020170927). We searched PubMed, the Cochrane Library and EMBASE for observational studies on the risk factors for falls in postmenopausal women. Review Manager 5.3 was used to calculate the relative risk (RR) or weighted mean difference (WMD) of potential risk factors related to falls. STATA 14.0 was used for the quantitative evaluation of publication bias. Eleven studies with 4...
Source: Osteoporosis International - September 15, 2020 Category: Orthopaedics Source Type: research

Perioperative Use of Antiestrogen Therapies in Breast Reconstruction: A Systematic Review and Treatment Recommendations
Background Patients with hormone receptor-positive breast tumors receive hormonal therapy with either selective estrogen receptor modulators (SERMs) (eg, tamoxifen) or aromatase inhibitors (AIs) (eg, anastrozole) for 5 to 10 years. Patients are using these therapies frequently during breast reconstruction. Literature investigating the effects of hormonal modulators on breast reconstruction outcomes demonstrates conflicting results. We sought to perform a systematic evaluation to assess the effects of hormonal therapy on breast reconstruction outcomes and to guide perioperative management of antiestrogen therapies. Metho...
Source: Annals of Plastic Surgery - September 15, 2020 Category: Cosmetic Surgery Tags: Review Paper Source Type: research

Upregulation of G Protein-Coupled Estrogen Receptor by Chrysin-Nanoparticles Inhibits Tumor Proliferation and Metastasis in Triple Negative Breast Cancer Xenograft Model
Triple-negative breast cancer (TNBC) is associated with a high mortality rate among women globally. TNBC shows a high rate of recurrence and distant metastasis. Particularly, the chemotherapy is limited because hormone therapy of breast cancer is ineffective. Thus, an effective chemotherapeutic agent is needed for tumor suppression. Chrysin-nanoparticles (chrysin-NPs) were investigated for their inhibitory effect on a MDA-MB-231-derived xenograft model. To gain insight into the underlying mechanisms, we conducted human matrix metalloproteinase (MMP) array, western blot, and immunohistochemistry analysis. Furthermore, in vi...
Source: Frontiers in Endocrinology - September 15, 2020 Category: Endocrinology Source Type: research

Impact of adjuvant chemotherapy or tamoxifen-alone on the ovarian reserve of young women with breast cancer
AbstractPurposeTo determine the longitudinal impact of adjuvant chemotherapy and tamoxifen-only treatments on the reproductive potential of women with breast cancer by using a sensitive ovarian reserve marker anti-Mullerian hormone (AMH) as a surrogate.MethodsOne-hundred-and-forty-two women with a primary diagnosis of breast cancer were prospectively followed with serum AMH assessments before the initiation, and 12, 18 and 24  months after the completion of adjuvant chemotherapy or the start of tamoxifen-only treatment. The chemotherapy regimens were classified into Anthracycline-Cyclophosphamide-based (AC-based) and ...
Source: Breast Cancer Research and Treatment - September 15, 2020 Category: Cancer & Oncology Source Type: research

Women ’s views about physical activity as a treatment for vasomotor menopausal symptoms: a qualitative study
Women commonly seek medical advice about menopausal symptoms. Although menopausal hormone therapy is the most effective treatment, many women prefer non-pharmacological treatments, such as physical activity. T... (Source: BMC Women's Health)
Source: BMC Women's Health - September 14, 2020 Category: OBGYN Authors: Ad èle Thomas and Amanda J. Daley Tags: Research article Source Type: research

Over-diagnosed prostate cancer in solid organ recipients: lessons from the last 3 decades
ConclusionSystematic screening in male SOTR after 50  years old could not be recommended. In the last 3 decades, we diagnosed too many low-risk prostate cancers strongly increasing the SIR but failing to decrease prostate cancer related mortality. SOTR should undergo individual screening with prior MRI when PSA rates are high. Management should not b e different from that of the general population. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - September 14, 2020 Category: Urology & Nephrology Source Type: research

Evaluation of endocrine therapy and patients preferences in early breast cancer: results of Elena study
ConclusionsThis is a large study of patient preferences on HT. Compared with other studies with similar design, the patients included in the present study required larger benefits to make adjuvant therapy worthwhile. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 14, 2020 Category: Cancer & Oncology Source Type: research

Prostate re-irradiation: current concerns and future perspectives.
Authors: Cuccia F, Mazzola R, Nicosia L, Giaj-Levra N, Figlia V, Ricchetti F, Rigo M, Vitale C, Corradini S, Alongi F Abstract INTRODUCTION: To date, the optimal management of locally relapsed prostate cancer patients after an initial course of radiotherapy, remains a matter of debate. In recent years, local approaches have been proposed as a therapeutic option, which may potentially delay the initiation of hormone therapy. In the case of external beam radiotherapy (EBRT), re-irradiation has been supported by growing evidence in the literature, mostly represented by extreme hypofractionated schedules delivered with...
Source: Expert Review of Anticancer Therapy - September 13, 2020 Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research

Treatment interruption and discontinuation  of hormonal therapy in hormone receptor-positive breast cancer patients
ConclusionsThis study showed that HT interruptions and discontinuation were common, often associated with HT-related symptoms. Clinicians caring for breast cancer patients on HT should monitor closely for treatment-emergent symptoms, especially women with pre-existing disorders, and support them to continue therapy through aggressive symptom management and other patient-centered approaches. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 12, 2020 Category: Cancer & Oncology Source Type: research

Do the intervals in growth hormone therapy positively affect the growth velocity?
CONCLUSIONS: Re-introduction of rhGH treatment after short-term therapy cessation leads to the re-occurrence of catch- up growth in patients with GHD. PMID: 32901467 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 11, 2020 Category: Endocrinology Authors: Kędzia A, Majewska K, Korcz M Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Knowledge and awareness toward menopause and hormone therapy among premenopausal women in Jordan.
CONCLUSIONS: The findings suggest that premenopausal females in Jordan are knowledgeable about various aspects of menopause. Nevertheless, there is still a need to develop educational programs and implement proper counseling to improve young females' awareness about menopause, particularly its health implications and treatment options. PMID: 32914657 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - September 11, 2020 Category: Geriatrics Authors: Alshogran OY, Mahmoud FM, Alkhatatbeh MJ Tags: Climacteric Source Type: research

Mitochondrial nanotargeting in malignancies (Review).
Authors: Tomşa AM, Picoş A, Picoş AM, Răchişan AL Abstract Malignancies represent a burden for the health system worldwide. Treating them represents a challenge through the prism of the cancer cell behaviour and the serious systemic side effects that usually occur. Both traditional (chemotherapy, radiotherapy and surgery) and associated therapies (immunotherapy and hormone therapy) have reached a plateau. The new trend for the management of malignancies includes nanoparticles (NPs) which are studied for both their diagnostic and therapeutical use. NPs can be designed in various ways, many of them targeting mit...
Source: Experimental and Therapeutic Medicine - September 10, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Gaps or links between hormonal therapy and schizophrenia? (Review).
Authors: Trifu SC, Istrate D, Miruna DA Abstract Schizophrenia is considered the most severe and debilitating psychiatric disorder. During the 80's, first reports on abnormalities of the schizophrenic brain which could be objectively observed on MRI, CT scans and other imagistic techniques were published. This showed that schizophrenia is a disorder that goes beyond the functional aspect of the symptomatology. The ties between psychiatry and endocrinology are easily observed, even empirically, by any mental health practitioner, and mirrored by endocrinology specialists. Disorders related to menstruation phase of th...
Source: Experimental and Therapeutic Medicine - September 10, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Factors Associated With Serum Estradiol Levels Among Postmenopausal Women Using Hormone Therapy.
Abstract OBJECTIVE: To identify factors associated with serum estradiol (E2) levels among healthy postmenopausal women using hormone therapy (HT). METHODS: This is an unplanned post hoc analysis of data from ELITE (Early versus Late Intervention Trial with Estradiol), a randomized controlled trial of 1 mg oral E2 with or without vaginal progesterone in healthy early compared with late (
Source: Obstetrics and Gynecology - September 10, 2020 Category: OBGYN Authors: Sriprasert I, Kono N, Karim R, Hodis HN, Stanczyk FZ, Shoupe D, Mack WJ Tags: Obstet Gynecol Source Type: research

Cancers, Vol. 12, Pages 2568: Evaluation of Cognitive Function in Trials Testing New-Generation Hormonal Therapy in Patients with Prostate Cancer: A Systematic Review
ssimo Di Maio In patients with prostate cancer, earlier use and longer duration of new-generation hormonal therapy (NGHT), added to androgen deprivation therapy, requires careful evaluation of cognitive function. The aim of this systematic review is to describe the evidence about cognitive function in all the randomized trials (RCTs) testing NGHT (abiraterone, enzalutamide, apalutamide, darolutamide). We assessed the availability of both investigator-assessed cognitive impairment and disorders and patient-reported evaluation of cognitive function. Nineteen RCTs (17,617 patients) were included. The investigator-based ev...
Source: Cancers - September 9, 2020 Category: Cancer & Oncology Authors: Laura Marandino Francesca Vignani Consuelo Buttigliero Teresa Gamba Andrea Necchi Marcello Tucci Massimo Di Maio Tags: Review Source Type: research

Short Communication:Transgender Women on Feminizing Hormone Therapy Demonstrate a Distinct Rectal Mucosal Transcriptome from Cisgender Men
AIDS Research and Human Retroviruses,Volume 36, Issue 9, Page 771-774, September 2020. (Source: AIDS Research and Human Retroviruses)
Source: AIDS Research and Human Retroviruses - September 8, 2020 Category: Infectious Diseases Authors: Cassie G. Ackerley James M. Billingsley Gregory K. Tharp Praveen K. Amancha Vin Tangpricha S. Abigail Smith Rama Amara Steven E. Bosinger Colleen F. Kelley Source Type: research

Uterine bleeding with hormone therapies in menopausal women: a  systematic review.
Uterine bleeding with hormone therapies in menopausal women: a systematic review. Climacteric. 2020 Sep 07;:1-9 Authors: Pickar JH, Archer DF, Goldstein SR, Kagan R, Bernick B, Mirkin S Abstract Uterine bleeding is a common reason why women discontinue menopausal hormone therapy (HT). This systematic review compared bleeding profiles reported in studies for continuous-combined HT approved in North America and Europe for moderate to severe vasomotor symptoms in postmenopausal women with a uterus. Non-head-to-head studies showed that uterine bleeding varies by formulation and administration route, ...
Source: Climacteric - September 7, 2020 Category: Geriatrics Authors: Pickar JH, Archer DF, Goldstein SR, Kagan R, Bernick B, Mirkin S Tags: Climacteric Source Type: research

Orbital metastasis: Clinical presentation and survival in a series of 11 cases.
CONCLUSIONS: In the series presented, 27% of the cases established the clinical debut of the malignant neoplasm. The ophthalmologist plays an essential role when this condition is suspected, diagnosing it, and proposing its management together with the Oncology Service. PMID: 32873479 [PubMed - as supplied by publisher] (Source: Archivos de la Sociedad Espanola de Oftalmologia)
Source: Archivos de la Sociedad Espanola de Oftalmologia - September 4, 2020 Category: Opthalmology Tags: Arch Soc Esp Oftalmol Source Type: research

Comparison of effect of preoperative dienogest and gonadotropin-releasing hormone agonist administration on laparoscopic cystectomy for ovarian endometriomas
AbstractPurposeTo compare the effects of preoperative dienogest (DNG) and gonadotropin-releasing hormone (GnRH) agonist administration on the improvement of preoperative symptoms and surgical outcomes in patients who underwent laparoscopic cystectomy for ovarian endometriomas.MethodsSeventy patients who were scheduled for laparoscopic surgery were enrolled in the study. They were divided into two groups: 35 patients who received DNG for 4  months preoperatively (group D) and 35 patients who received low-dose sustained-release goserelin acetate for 4 months preoperatively (group G). Preoperative outcomes, includin...
Source: Archives of Gynecology and Obstetrics - September 4, 2020 Category: OBGYN Source Type: research

Racial differences in genomic testing and receipt of endocrine therapy in early-stage breast cancer
AbstractPurposeGenomic testing in early-stage hormone-positive breast cancer is the standard of care. However, decisions based on genomic testing results are predicated on the assumption that patients receive endocrine treatment. We sought to investigate racial differences in genomic testing and adjuvant treatment in breast cancer.MethodsA retrospective, population-based hospital registry study using the National Cancer Database. Participants included women with stages I –II, ER + breast cancer between 2010 and 2014. Sociodemographic factors were analyzed. Primary outcomes were the utilization of genomi...
Source: Breast Cancer Research and Treatment - September 4, 2020 Category: Cancer & Oncology Source Type: research

Postmenopausal exogenous hormone therapy and Melanoma risk in women: A systematic review and time-response meta-analysis
Publication date: Available online 2 September 2020Source: Pharmacological ResearchAuthor(s): Xiaoling Tang, Hongcan Zhang, Ying Cui, Liqin Wang, Zhu Wang, Yajing Zhang, Jinzhi Huo, Jinfeng Cai, Giulia Rinaldi, Akshaya Srikanth Bhagavathula, Pengying Xiao (Source: Pharmacological Research)
Source: Pharmacological Research - September 3, 2020 Category: Drugs & Pharmacology Source Type: research

Insomnia and menopause: a narrative review on mechanisms and treatments.
Abstract The menopausal transition is associated with an increased frequency of sleep disturbances. Insomnia represents one of the most reported symptoms by menopausal women. According to its pathogenetic model (3-P Model), different predisposing factors (i.e. a persistent condition of past insomnia and aging per se) increase the risk of insomnia during menopause. Moreover, multiple precipitating and perpetuating factors should favor its occurrence across menopause, including hormonal changes, menopausal transition stage symptoms (i.e. hot flashes, night sweats), mood disorders, poor health and pain, other sleep d...
Source: Climacteric - September 3, 2020 Category: Geriatrics Authors: Proserpio P, Marra S, Campana C, Agostoni EC, Palagini L, Nobili L, Nappi RE Tags: Climacteric Source Type: research

Darolutamide as a second-generation Androgen receptor inhibitor in the treatment of prostate cancer.
Abstract Prostate cancer (PC) is known as the most frequent cancer among men in the world. Androgen Deprivation Therapy (ADT) is one of the initial treatment approaches in the PC therapy and various drugs can be used in routine Hormonal therapy for PC therapy. Nevertheless, PC cells can survive and continue their growth via different mechanisms which lead to their resistance to common treatments i.e., Enzalutamide. Darolutamide (ODM-201) is a second-generation androgen receptor (AR) inhibitor with a new chemical structure and has a high affinity to the AR. Darolutamide doesn't cross the bloodbrain barrier, for thi...
Source: Current Molecular Medicine - September 3, 2020 Category: Molecular Biology Authors: Abbasi A, Movahedpour A, Amiri A, Najaf MS, MostafaviPour Z Tags: Curr Mol Med Source Type: research

Melatonin: A Potential Therapeutic Option for Breast Cancer.
Abstract Melatonin has significant inhibitory effects in numerous cancers, especially breast cancer. In estrogen receptor (ER)-positive human breast cancer, the oncostatic actions of melatonin are mainly achieved by suppressing ER mRNA expression and ER transcriptional activity via the MT1 receptor. Melatonin also regulates the transactivation of nuclear receptors, estrogen-metabolizing enzymes, and the expression of related genes. Furthermore, melatonin suppresses tumor aerobic glycolysis, critical cell-signaling pathways relevant to cell proliferation, survival, metastasis, and overcomes drug resistance. Studies...
Source: Trends in Endocrinology and Metabolism: TEM - September 3, 2020 Category: Endocrinology Authors: Kong X, Gao R, Wang Z, Wang X, Fang Y, Gao J, Reiter RJ, Wang J Tags: Trends Endocrinol Metab Source Type: research

Patient Messaging Content Associated with Initiating Hormonal Therapy after a Breast Cancer Diagnosis.
Authors: Yin Z, Warner JL, Chen Q, Malin BA Abstract Hormonal therapy is an effective, but challenging, long-term treatment for patients with hormone-receptor-positive breast cancer. Raising the rate of patients who initiate therapy may be possible by characterizing the factors that influence a patient's decision. We hypothesized that online patient portal messages convey such factors. To investigate this hypothesis, we focused on breast cancer patients who were prescribed hormonal therapy at Vanderbilt University Medical Center and sent messages through the portal between diagnosis and therapy initiation. We first...
Source: AMIA Annual Symposium Proceedings - September 2, 2020 Category: Bioinformatics Tags: AMIA Annu Symp Proc Source Type: research

Summary of Expert Opinion on the Management of Children With Chronic Kidney Disease and Growth Failure With Human Growth Hormone
Conclusions: Despite current guidelines for the management of children with CKD and growth failure, its use varies widely between centers and rhGH is prescribed in a relatively small number of patients and rarely after kidney transplantation. Several raised issues are not taken into account by international guidelines and a multidisciplinary approach with mutual collaboration between specialists will improve patient care based on their unmet needs. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - September 2, 2020 Category: Endocrinology Source Type: research

Review of the bone mineral density data in the meta-analysis about the effects of exercise on physical outcomes of breast cancer survivors receiving hormone therapy
This study concludes that exercise has possible effects on bone mineral density (BMD) in breast cancer survivors despite the absence of statistically significant results in this regard. Furthermore, as the authors point out, the results show an enormous heterogeneity that makes their interpretation almost unfeasible. Despite the possible sources of heterogeneity detected by the authors, there are others that do not seem to have been discussed and that we believe should be considered. (Source: Maturitas)
Source: Maturitas - September 2, 2020 Category: Primary Care Authors: Antonio S ánchez-Fernández, Jose M. Moran, María Canal-Macías Tags: Letter to the Editor Source Type: research

Degarelix as a neoadjuvant hormonal therapy for acute urinary tract toxicity associated with external beam radiotherapy for intermediate- and high-risk prostate cancer: a propensity score matched analysis.
CONCLUSIONS: Luteinizing hormone-releasing hormon antagonists may reduce acute urinary tract toxicity during prostate cancer external beam radiotherapy compared with luteinizing hormone-releasing hormon agonists, in particular in patients with moderate to severe symptoms at the start of treatment. PMID: 32875317 [PubMed - as supplied by publisher] (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - September 2, 2020 Category: Cancer & Oncology Authors: Hata S, Shin T, Abe S, Kawano K, Sato R, Kai T, Shibuya T, Ando T, Mimata H Tags: Jpn J Clin Oncol Source Type: research

Vaginal Health: Insights, Views & Attitudes survey in Latin America (VIVA-LATAM): focus on Brazil.
CONCLUSION: Postmenopausal women in Brazil are likely to benefit from increased awareness of the symptoms of vaginal atrophy. Health-care providers can potentially improve outcomes by helping women to understand the chronic nature of the condition and available treatment options. Women may be open to education pre menopause, before symptoms occur. PMID: 32869682 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - September 1, 2020 Category: Geriatrics Authors: Pompei LM, Wender MCO, de Melo NR, Kulak J, Pardini D, Machado RB, Fernandes CE, Palacios S, Nappi RE Tags: Climacteric Source Type: research

Relation between oral health and the use of aromatase inhibitors in women with breast cancer
We present an integrative review, with a search conducted using the descriptors "breast cancer"; "oral health"; "aromatase inhibitor"; and the Boolean operators "E" and "OU"; "AND"; and "OR"; in SciELO and PubMed, using English and Portuguese idioms, since 2014. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - September 1, 2020 Category: ENT & OMF Authors: ELLEN MARCELLA FREIRE PADILHA, SHYRLENE SANTANA SANTOS NOBRE, DIEGO FIGUEIREDO N ÓBREGA, RODOLFO TIBéRIO FERREIRA SILVA, KEVAN GUILHERME NóBREGA BARBOSA, KRISTIANA CERQUEIRA MOUSINHO Tags: 20190304 Source Type: research

The 2020 genitourinary syndrome of menopause position statement of The North American Menopause Society
Conclusions: Clinicians can resolve many distressing genitourinary symptoms and improve sexual health and the quality of life of postmenopausal women by educating women about, diagnosing, and appropriately managing GSM. Choice of therapy depends on the severity of symptoms, the effectiveness and safety of treatments for the individual patient, and patient preference. Nonhormone therapies available without a prescription provide sufficient relief for most women with mild symptoms. Low-dose vaginal estrogens, vaginal DHEA, systemic estrogen therapy, and ospemifene are effective treatments for moderate to severe GSM. When l...
Source: Menopause - August 28, 2020 Category: OBGYN Tags: NAMS Position Statement Source Type: research

Blood pressure and cardiovascular risk factors in women treated for climacteric symptoms with acupuncture, phytoestrogens, or hormones
Objective: To evaluate the response of cardiovascular risk factors to the treatment of climacteric symptoms. Methods: In this prospective study, women reporting climacteric symptoms were randomized to 3 months of treatment with either acupuncture (n = 19), phytoestrogens (75 mg soy isoflavones, BID; n = 22), or low-dose hormone therapy (HT; 0.3 mg conjugated equine oestrogens plus 1.5 mg medroxyprogesterone acetate; n = 20). Greene's climacteric scale, blood pressure (BP), lipids, glucose, insulin, and homeostatic model assessment of insulin resistance were assessed before and after treatment. Observ...
Source: Menopause - August 28, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Adherence to oral anticancer chemotherapies and estimation of the economic burden associated with unused medicines
Conclusions Our data showed that overall adherence to oral anticancer medicines was above the acceptable limit of adherence of 80% with a marked graduation in values between cytotoxic agents, hormonal and targeted therapies. These statistical significant differences in medication possession ratio could be related to the intrinsic toxicity of the three subclasses of molecules, their tolerance and adverse effects. To limit the cost associated with unused medicines, interventions such as dispensing expensive oral anticancer chemotherapies per unit over shorter periods and not only on monthly intervals could be implement. (Sou...
Source: International Journal of Clinical Pharmacy - August 28, 2020 Category: Drugs & Pharmacology Source Type: research

Effect of menopausal hormone therapy on proteins associated with senescence and inflammation
This study determined the effects of menopausal hormone treatments on circulating levels of markers of cell senescence.MethodsGrowth differentiation factor 15 (GDF15), tumor necrosis factor receptor 1 (TNFR1), FAS, and macrophage inflammatory protein 1 α (MIP1α) were measured in serum using multiplexed bead‐based assays and compared among menopausal women participating in the Kronos Early Estrogen Prevention Study randomized to either placebo (n = 38), oral conjugated equine estrogen (oCEE,n = 37), or transdermal 17β‐estradiol (tE2,n = 34). Serum levels of the senescent ma...
Source: Physiological Reports - August 28, 2020 Category: Physiology Authors: Laura Faubion, Thomas A. White, Brett J. Peterson, Jennifer R. Geske, Nathan K. LeBrasseur, Marissa J. Schafer, Michelle M. Mielke, Virginia M. Miller Tags: ORIGINAL RESEARCH Source Type: research

PROACTA: a survey on the actual attitude of the Italian radiation oncologists in the management and prescription of hormonal therapy in prostate cancer patients
ConclusionOur survey established the prescription attitude of ADT and new hormonal agents (abiraterone, enzalutamide, apalutamide) by Italian Radiation Oncologists and highlighted the importance of expertise in global PC management. (Source: La Radiologia Medica)
Source: La Radiologia Medica - August 27, 2020 Category: Radiology Source Type: research

Loss of bone density and bone strength following premenopausal risk –reducing bilateral salpingo-oophorectomy: a prospective controlled study (WHAM Study)
AbstractSummaryProphylactic oophorectomy is recommended for women at high risk for ovarian cancer, but the associated impact on bone health is of clinical concern. This prospective, controlled study demonstrated substantial loss of bone density and bone strength following surgical menopause. Postoperative hormone therapy alleviated, but not fully prevented, spinal bone loss.IntroductionThis prospective study investigated bone health in women following premenopausal oophorectomy.MethodsDual-energy x-ray absorptiometry (DXA), peripheral quantitative computed tomography (pQCT), and pQCT-based finite element analysis (pQCT-FEA...
Source: Osteoporosis International - August 27, 2020 Category: Orthopaedics Source Type: research

Implementing SSO-ASTRO Margin Guidelines to Reduce Reoperations After Lumpectomy for Early Breast Cancer
Breast-conserving surgery (BCS) and mastectomy for early breast cancer have equivalent survival rates, with a local recurrence rate of 14.3% after 20 years of follow-up in a study. Adequate margin status after BCS is an important determinant of local recurrence. The definition of adequate surgical margins is controversial. The National Surgical Adjuvant Breast and Bowel Project B-06 trial was the only trial that defined no ink on margin as an adequate margin. Subsequent studies on margin status after BCS led to the recommendation of 2 mm as the ideal margin width for optimal local control. However, local recurrence is also...
Source: JAMA Surgery - August 26, 2020 Category: Sports Medicine Source Type: research

Constipation and Fecal Incontinence in the Elderly
AbstractPurpose of ReviewTo review the epidemiology, pathogenesis, clinical features, and management of primary constipation and fecal incontinence in the elderly.Recent FindingsAmong elderly people, 6.5%, 1.7%, and 1.1% have functional constipation, constipation-predominant IBS, and opioid-induced constipation. In elderly people, the number of colonic enteric neurons and smooth muscle functions is preserved; decreased cholinergic function with unopposed nitrergic relaxation may explain colonic motor dysfunction. Less physical activity or dietary fiber intake and postmenopausal hormonal therapy are risk factors for fecal i...
Source: Current Gastroenterology Reports - August 24, 2020 Category: Gastroenterology Source Type: research