Efficacy and Safety of 177Lu-PSMA-617 Radioligand Therapy in Metastatic Castration-Resistant Prostate Cancer Patients
Conclusions 177Lu-PSMA-617 radionuclide therapy is a safe and effective approach to the treatment of mCRPC patients. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - December 7, 2019 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Case-based discussion on the implications of exogenous estrogens in hemostasis and thrombosis: the hematologist's view.
Authors: Ragni MV Abstract In the childbearing years, hormonal therapy or hormonal changes in the menstrual cycle or the puerperium may be complicated by bleeding or thrombosis; however, among women with congenital disorders of hemostasis and thrombosis, the risk of bleeding or thrombosis may be increased. In women with congenital bleeding disorders, heavy menstrual bleeding is the most common bleeding symptom, and postpartum hemorrhage occurs despite treatment. Given the limitations of current therapy and the associated medical and psychological burden in women with bleeding disorders, better treatment approaches ...
Source: Hematology ASH Education Program - December 7, 2019 Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research

Menopausal hormone therapy: what should be kept in mind for a personalized choice in a shared decision-making
We read with interest the Editorial of Meletios P. Nigdelis (1) and would like to provide some information useful for decision-making. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - December 7, 2019 Category: OBGYN Authors: Gianluca Franceschini, Stefano Lello, Alba Di Leone, Armando Orlandi, Riccardo Masetti Tags: Correspondence Source Type: research

Validity of state cancer registry treatment information for adolescent and young adult women
ConclusionsIn this cohort of young women, population-based cancer registry data on chemotherapy receipt was reasonably accurate and complete in comparison with insurance claims. Radiation and hormone therapy appeared to be less complete. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - December 5, 2019 Category: Cancer & Oncology Source Type: research

Long-Term Hormone Therapy Increases Mortality in Some PSA Patients
No abstract available (Source: Oncology Times)
Source: Oncology Times - December 5, 2019 Category: Cancer & Oncology Tags: News Source Type: research

Case Report: Adenosquamous carcinoma of the prostate with greater than 20 month response to multimodal therapy
We present a case of de novo adenosquamous carcinoma of the prostate treated with a multimodal approach including surgery, androgen-deprivation therapy, chemotherapy, and radiation. (Source: Urology Case Reports)
Source: Urology Case Reports - December 5, 2019 Category: Urology & Nephrology Source Type: research

Gene Expression Assay in the Management of Early Breast Cancer.
Abstract The addition of adjuvant chemotherapy to hormonal therapy is often considered questionable in patients with estrogen receptor-positive early breast cancer. Low risk of disease relapse after endocrine treatment alone and/or a low sensitivity to chemotherapy are reasons behind not all patients benefit from chemotherapy. Most of patients could be exposed to unnecessary treatment-related adverse events and health care costs when treatment decision-making is based only on classical clinical histological features. Gene expression profile has been developed to refine physician decision-making process and to tayl...
Source: Current Medicinal Chemistry - December 5, 2019 Category: Chemistry Authors: Caputo R, Cianniello D, Giordano A, Piezzo M, Riemma M, Trovo M, Berretta M, De-Laurentiis M Tags: Curr Med Chem Source Type: research

New therapeutic approaches for endometriosis besides hormonal therapy.
CONCLUSIONS: Clinical data about most of the non-hormonal agents are not sufficient to support them as options for replacement therapy for endometriosis. In spite of this, a few drugs like pentoxifylline showed strong potential for real clinical application. PMID: 31809322 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - December 5, 2019 Category: General Medicine Authors: Chen FY, Wang X, Tang RY, Guo ZX, Deng YZ, Yu Q Tags: Chin Med J (Engl) Source Type: research

Therapeutic effect of mesenchymal stem cell on Hashimoto's thyroiditis in a rat model by modulating Th17/Treg cell balance.
In this study, we utilize female SD rats induced HT to evaluated the ability of transplanted MSCs to regulate Th17/Treg interactions in a rat Hashimoto's thyroiditis (HT) model system. The results showed that Rats in the HT model group exhibited increased thyroid autoantibody levels consistent with successful model development, whereas these levels were lower in rats treated with MSCs. There were also fewer thyroid lesions and less lymphoid infiltration of the thyroid in MSC-treated rats relative to HT model rats, as well as fewer Th17 cells and more Treg cells - an observation consistent with the cytokine analyses. All of...
Source: Autoimmunity - December 4, 2019 Category: Allergy & Immunology Tags: Autoimmunity Source Type: research

Quantitative MRI Changes During Weekly Ultra-Hypofractionated Prostate Cancer Radiotherapy With Integrated Boost
Conclusions: Weekly quantitative MRI could identify statistically significant ADC changes in the tumor in patients without hormonal therapy. On a patient level few persistent T2 changes in the tumor were observed. Long-term follow-up is required to relate the persistent T2 and ADC changes to outcome and evaluate the applicability of quantitative MRI for response based treatment adaptation. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - December 4, 2019 Category: Cancer & Oncology Source Type: research

[Research Articles] Targeting cellular heterogeneity with CXCR2 blockade for the treatment of therapy-resistant prostate cancer
Hormonal therapy targeting androgen receptor (AR) is initially effective to treat prostate cancer (PCa), but it eventually fails. It has been hypothesized that cellular heterogeneity of PCa, consisting of AR+ luminal tumor cells and AR– neuroendocrine (NE) tumor cells, may contribute to therapy failure. Here, we describe the successful purification of NE cells from primary fresh human prostate adenocarcinoma based on the cell surface receptor C-X-C motif chemokine receptor 2 (CXCR2). Functional studies revealed CXCR2 to be a driver of the NE phenotype, including loss of AR expression, lineage plasticity, and resistan...
Source: Science Translational Medicine - December 4, 2019 Category: Biomedical Science Authors: Li, Y., He, Y., Butler, W., Xu, L., Chang, Y., Lei, K., Zhang, H., Zhou, Y., Gao, A. C., Zhang, Q., Taylor, D. G., Cheng, D., Farber-Katz, S., Karam, R., Landrith, T., Li, B., Wu, S., Hsuan, V., Yang, Q., Hu, H., Chen, X., Flowers, M., McCall, S. J., Lee, Tags: Research Articles Source Type: research

Muscle strength, size and composition following 12 months of gender-affirming treatment in transgender individuals.
CONCLUSIONS: One year of gender-affirming treatment resulted in robust increases in muscle mass and strength in TM, but modest changes in TW. These findings add new knowledge on the magnitude of changes in muscle function, size and composition with cross-hormone therapy, which could be relevant when evaluating the transgender eligibility rules for athletic competitions. PMID: 31794605 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - December 4, 2019 Category: Endocrinology Authors: Anna W, Lundberg TR, Eric R, Andersson DP, Mats H, Mirko M, Brismar TB, Olof DL, Setareh C, John N F, Stefan A, Thomas G Tags: J Clin Endocrinol Metab Source Type: research

SHARP hypofractionated stereotactic radiotherapy for localized prostate cancer: a biochemical response to treatment.
Authors: Rucinska M, Osowiecka K, Kieszkowska Grudny A, Nawrocki S Abstract PURPOSE: The standard treatment for patients with early-stage prostate cancer are operation and radiotherapy. Stereotactic body radiation therapy (SBRT) is one of the new radiotherapy methods. The aim of the study was to analyze tumor control of prostate cancer patients treated with SBRT. METHODS: A prospective single-institution clinical study was conducted among previously untreated patients with histologically confirmed localized prostate cancer. Patients were treated with SBRT: 33.5 Gy in 5 fractions. RESULTS: A total of 68 men ...
Source: Journal of B.U.ON. - December 2, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Lifetime estrogen exposure and cognition in late life: the Cache County Study
Conclusions: Our results suggest that longer EEE and HT use, especially in older women, are associated with higher cognitive status in late life. (Source: Menopause)
Source: Menopause - December 1, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Transrectal high-intensity focused ultrasound (HIFU) for the management of rectosigmoid deep infiltrating endometriosis: results of phase I clinical trial.
CONCLUSIONS: TR-HIFU therapy for posterior DIE is feasible. It could be an interesting minimally invasive alternative to surgery for the treatment of rectosigmoid endometriosis if its efficacy and safety is confirmed. This article is protected by copyright. All rights reserved. PMID: 31788875 [PubMed - as supplied by publisher] (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - December 1, 2019 Category: Radiology Authors: Philip CA, Warembourg S, Dairien M, Lefevre C, Gelet A, Chavrier F, Guillen N, Tonoli H, Maissiat E, Lafon C, Dubernard G Tags: Ultrasound Obstet Gynecol Source Type: research

Tamoxifen inhibits cell proliferation by impaired glucose metabolism in gallbladder cancer.
This study aims to evaluate the antitumour activity of tamoxifen (TAM), a major agent of hormonal therapy for breast cancer, in preclinical GBC model. Quantitative real-time PCR was used to investigate mRNA levels. Protein expression was measured by immunohistochemistry and Western blot. Glycolytic levels were measured by glucose consumption and lactic acid measurement. The antitumour activity of TAM alone or with cisplatin was examined with CCK8 assay, colony formation, flow cytometry and in vivo models. The results revealed that ERɑ expression was higher in GBC tissues and predicted poor clinical outcomes. TAM was showe...
Source: J Cell Mol Med - November 28, 2019 Category: Molecular Biology Authors: Huang S, Wang H, Chen W, Zhan M, Xu S, Huang X, Lin R, Shen H, Wang J Tags: J Cell Mol Med Source Type: research

Importance and Difficulty of Differentiating BMA-induced AFF Prodromal Symptoms from Hormonal Therapy-related Femoral Pain.
Authors: Ota S, Tokizaki T, Sugimoto M, Ochiai R, Haruyama T, Ishihara M, Natsume M, Fukasawa Y, Sakamoto T, Tanzawa S, Usui R, Honda T, Ichikawa Y, Watanabe K, Kawano H, Seki N Abstract We herein report a case of breast cancer in a 74-year-old woman treated with exemestane as fourth-line hormonal therapy and bone-modifying agents for long time. She suddenly developed a right femoral shaft fracture during treatment. Her femoral fracture had a beaking sign on radiogram. Given this finding, her fracture was ultimately diagnosed as atypical femoral fracture (AFF). In this case, it was difficult to recognize the differ...
Source: Internal Medicine - November 27, 2019 Category: Internal Medicine Tags: Intern Med Source Type: research

Risk of Breast Cancer Rises with Duration of Menopausal Hormone Therapy.
Authors: Abstract Elevated risk persists more than a decade after stopping hormone therapy. PMID: 31764035 [PubMed - in process] (Source: The American Journal of Nursing)
Source: The American Journal of Nursing - November 27, 2019 Category: Nursing Tags: Am J Nurs Source Type: research

Type A insulin resistance syndrome misdiagnosed as polycystic ovary syndrome: a case report
ConclusionWe report a case of a young woman with type A insulin resistance syndrome that was misdiagnosed as polycystic ovary syndrome. We discuss the causes, clinical features, diagnosis, and treatment of type A insulin resistance syndrome to improve the recognition of the disease and reduce its misdiagnosis. Female patients with high androgen levels and severe hyperinsulinemia should be considered for the possibility of hereditary insulin resistance syndromes (such as type A insulin resistance syndrome). Gene sequencing helps in making an early diagnosis and developing a targeted treatment strategy. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - November 27, 2019 Category: General Medicine Source Type: research

Risk of Breast Cancer Rises with Duration of Menopausal Hormone Therapy
Elevated risk persists more than a decade after stopping hormone therapy. (Source: AJN)
Source: AJN - November 25, 2019 Category: Nursing Tags: In the News Source Type: research

Bipolar Disorder in the Menopausal Transition
AbstractPurpose of ReviewWe review recent data on bipolar disorder in menopausal-aged women, particularly in women undergoing the menopausal transition (MT). We discuss evidence on the severity of symptoms in bipolar women during the MT. Moreover, we address two factors in bipolar disorder and menopausal research: standardized menopausal staging and women ’s conceptualization of their menopausal and bipolar symptoms.Recent FindingsWhile there are few studies within the last 5  years on bipolar women undergoing the MT, new evidence suggest that mood symptoms in women worsen with progression through the MT. Consis...
Source: Current Psychiatry Reports - November 25, 2019 Category: Psychiatry Source Type: research

Molecular evaluation of PROGINS mutation in Progesterone Receptor gene and determination of its frequency, distribution pattern and association with Breast Cancer susceptibility in Saudi Arabia.
Abstract Experimental and clinical evidence demonstrate that progesterone hormone and its nuclear receptor, the Progesterone Receptor (PR), play critical role in controlling mammary gland tumorigenesis and breast cancer development. Hormonal therapy (Tomaxifen) is the frontline treatment for hormone-dependent breast cancers .Progesterone hormone induces its action on the target cells by binding with its Progesterone receptor (PgR) therefore any genetic variations, which might induce alienation in the progesterone receptor, can result to an increased susceptibility to gynecological cancers. Alu insertion (PROGINS) ...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - November 25, 2019 Category: Endocrinology Authors: Albalawi IA, Rashid M, Abu-Duhier FM Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Mortality of Pregnancy Following Breast Cancer Diagnoses in Taiwanese Women.
CONCLUSION: Our nationwide retrospective analysis revealed that pregnancy after BC diagnosis was associated with lower mortality than that of nonpregnant patients with BC at a similar age, year at diagnosis, and clinical characteristics. IMPLICATIONS FOR PRACTICE: This article provides high-level evidence based on an Asian population for pregnancy counseling after a breast cancer diagnosis, including for patients with estrogen receptor-positive cancers. The study also revealed the optimal time for patients who would like to become pregnant after breast cancer. PMID: 31767794 [PubMed - as supplied by publisher] (S...
Source: The Oncologist - November 25, 2019 Category: Cancer & Oncology Authors: Chuang SC, Lin CH, Lu YS, Hsiung CA Tags: Oncologist Source Type: research

DNA methylation profiling to explore colorectal tumor differences according to menopausal hormone therapy use in women
Epigenomics, Ahead of Print. (Source: Future Medicine: Epigenomics)
Source: Future Medicine: Epigenomics - November 23, 2019 Category: Genetics & Stem Cells Authors: Sonja Neumeyer Odilia Popanda Katja Butterbach Dominic Edelmann Hendrik Bl äker Csaba Toth Wilfried Roth Esther Herpel Cornelia J äkel Peter Schmezer Axel Benner Barbara Burwinkel Michael Hoffmeister Hermann Brenner Jenny Chang-Claude Source Type: research

Acquired neuro-secretory defect in growth hormone secretion due to Imatinib mesylate and the efficacy of growth hormone therapy in children with chronic myeloid leukemia
. (Source: Pediatric Hematology and Oncology)
Source: Pediatric Hematology and Oncology - November 21, 2019 Category: Pediatrics Authors: Rama Walia Anuradha Aggarwal Anil Bhansali Anshita Aggarwal Neelam Varma Naresh Sachdeva Niranjan Khandelwal Deepak Bansal Source Type: research

Cytology positive pleural aspirations: sufficient to guide treatment?
Conclusion: Pleural cytology is sufficient to guide oncological treatments in over half malignant pleural effusion (MPE) cases, and appears more likely to be sufficient in lung and haematological cancers. In cases of recurrent breast and pelvic cancers, cytology may be sufficient, but in new breast or gynaecological cancers, histological samples appear to be necessary. This data may have implications for early use of invasive diagnostic methods in MPE according to likely primary source. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Varatharajah, R., Shepherd, G., Mercer, R., Thanayanandan, A., Lu, Q., Tsikrika, M., Mccracken, D., Asciak, R., Bedawi, E., Hassan, M., Rahman, N. Tags: Pleural and mediastinal malignancies Source Type: research

[When to introduce hormone therapy after total prostatectomy with positive lymph nodes? Study of the factors influencing the time of introduction of hormone therapy].
Authors: Duquesne I, Champy C, Klap J, Chahwan C, Vordos D, de la Taille A, Salomon L Abstract INTRODUCTION: Adjuvant hormone therapy is the standard treatment after total prostatectomy with positive lymph node. However, this treatment has side effects and at the time of the PSA era and extensive lymph node dissection, this principle is questioned. The aim of this study is to describe the oncological characteristics of patients that may explain the delay in introducing hormone therapy in patients with positive lymph node. METHODS: Monocentric, retrospective study of 161 patients from November 1988 to February 2...
Source: Progres en Urologie - November 20, 2019 Category: Urology & Nephrology Tags: Prog Urol Source Type: research

In Regard to Buszek et  al
The recent report by Buszek et  al reassuringly reveals equivalent 5-year overall survival among older patients with breast cancer who have undergone lumpectomy and are receiving adjuvant monotherapy, whether with radiation therapy (RT) or hormone therapy (HT).1 This contribution is consistent with prior efforts in favorable sub populations for which disease-specific outcomes are excellent, remaining life expectancy is limited, and the survival benefit of any adjuvant treatment remains notoriously elusive. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - November 18, 2019 Category: Radiology Authors: Lior Z. Braunstein Tags: Comment Source Type: research

Update on Menopausal Hormone Therapy for Fracture Prevention
AbstractPurpose of ReviewThe goal of the review is to assess the appropriateness of menopausal hormone therapy (MHT) for the primary prevention of bone loss in women at elevated risk in the early years after menopause.Recent FindingsEstrogen alone or combined with progestin to protect the uterus from cancer significantly reduces the risk of osteoporosis-related fractures. MHT increases type 1 collagen production and osteoblast survival and maintains the equilibrium between bone resorption and bone formation by modulating osteoblast/osteocyte and T cell regulation of osteoclasts. Estrogens have positive effects on muscle an...
Source: Current Osteoporosis Reports - November 18, 2019 Category: Orthopaedics Source Type: research

Effect of CIMicifuga racemosa on metaBOLIC parameters in women with menopausal symptoms: a retrospective observational study (CIMBOLIC)
ConclusionMenopausal symptoms improved significantly in both groups (MHT and CR), while serum metabolic parameters and body weight did not change in MHT- or CR-treated women. (Source: Archives of Gynecology and Obstetrics)
Source: Archives of Gynecology and Obstetrics - November 16, 2019 Category: OBGYN Source Type: research

Predicting Optimal Combination LT4 + LT3 Therapy for Hypothyroidism Based on Residual Thyroid Function
Objective: To gain insight into the mixed results of reported combination therapy studies conducted with levothyroxine (LT4) and liothyronine (LT3) between 1999 and 2016.Methods: We defined trial success as improved clinical outcome measures and/or patient preference for added LT3. We hypothesized that success depends strongly on residual thyroid function (RTF) as well as the LT3 added to sufficient LT4 dosing to normalize serum T4 and TSH, all rendering T3 levels to at least middle-normal range. The THYROSIM app was used to simulate “what-if” experiments in patients and study designs corresponding to the study...
Source: Frontiers in Endocrinology - November 15, 2019 Category: Endocrinology Source Type: research

Prevalence and correlates of non-tissue prostate cancer diagnosis in the United States
ConclusionsNon-tissue diagnosis of prostate cancer, while rare, is not outside normal clinical practice and is strongly associated with advanced patient age, higher clinical stage, multiple comorbidities, and very high PSA levels. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - November 14, 2019 Category: Cancer & Oncology Source Type: research

[Hypertension and menopausal hormone therapy].
Abstract Can menopausal hormone therapy (HT) be used in hypertensive women? The group of experts of the French Society of Hypertension has carried out a review of the recent literature in order to answer this question, based on the most recent scientific publications. If use of oral HT is associated with a discreet increase in blood pressure, the transdermal route seems to be safer. The first results of major randomized trials of HT had alerted to an increase in cardiovascular events and breast cancer with the use of oral HT, generally, tipping the benefit-risk balance of the deleterious side. Complementary analyz...
Source: Presse Medicale - November 14, 2019 Category: General Medicine Authors: Mounier-Vehier C, Angoulvant T, Boivin JM, Plu-Bureau G Tags: Presse Med Source Type: research

Cost-utility analysis of 21-gene assay for node-positive early breast cancer.
Conclusions: Use of the 21-gene rs assay could be a cost-effective strategy for Ontario patients with estrogen receptor-positive, her2-negative early bca and 1-3 positive lns. PMID: 31708649 [PubMed - in process] (Source: Current Oncology)
Source: Current Oncology - November 13, 2019 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Correction to: Thyroid hormone therapy: past, present, and future
An amendment to this paper has been published and can be accessed via a link at the top of the paper. (Source: Endocrine)
Source: Endocrine - November 13, 2019 Category: Endocrinology Source Type: research

Topiramate as an Adjunct in the Management of West Syndrome
ConclusionsThe study observed poor effectiveness of topiramate therapy, which is partially due to a long treatment lag and a high proportion of structural etiology. (Source: Indian Journal of Pediatrics)
Source: Indian Journal of Pediatrics - November 13, 2019 Category: Pediatrics Source Type: research

[Post-menopausal hypertension: Detecting, treating, accompany, prevent].
Abstract Menopause is associated with a significant increase in arterial and metabolic risk. Systolic hypertension is common in post-menopausal women. Measurement of blood pressure should be repeated systematically at each visit. Ambulatory blood pressure measurements should be encouraged, especially to detect nocturnal hypertension and to prevent more efficiently women at risk. Self-testing of hypertension by home blood pressure should be encouraged at menopause. Antihypertensive treatment should be initiated after ambulatory blood pressure monitoring in association with reinforced lifestyle. Furthermore, global ...
Source: Presse Medicale - November 11, 2019 Category: General Medicine Authors: Mounier-Vehier C, Madika AL Tags: Presse Med Source Type: research

Long-term clinical outcomes of 538 prostate carcinoma patients treated with combination high-dose-rate brachytherapy and external beam radiotherapy
ConclusionCombined HDR-B/EBRT for the treatment of clinically localized prostate cancer provides superb clinical outcomes with excellent 5-year bRFS, dMFS, OS, and late GI/GU toxicity rates. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - November 9, 2019 Category: Cancer & Oncology Source Type: research

A prospective clinical cohort study of women at increased risk for endometrial cancer.
CONCLUSIONS: Well-established EC risk factors may have less discriminatory accuracy in high-risk populations. Future analyses will integrate risk factor assessment with biomarker testing for EC detection. PMID: 31718832 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - November 9, 2019 Category: Cancer & Oncology Authors: Clarke MA, Long BJ, Sherman ME, Lemens MA, Podratz KC, Hopkins MR, Ahlberg LJ, Mc Guire LJ, Laughlin-Tommaso SK, Wentzensen N, Bakkum-Gamez JN Tags: Gynecol Oncol Source Type: research

Pediatric growth hormone therapy in Greece: analysis of the Hellenic cohort of the GeNeSIS study.
CONCLUSIONS: In the Greek cohort of GeNeSIS, GHD is the most frequent indication for GH treatment, followed by TS. While the latter is diagnosed somewhat earlier, GH treatment is not as efficacious as for patients with GHD. No major safety issues were reported during follow-up. The results, which are in accordance with the international literature, should be interpreted in the context of observational studies. PMID: 31696446 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - November 8, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Anti-androgen hormonal therapy for cancer and other diseases.
Abstract The development of targeted therapies has been a consistent goal for hormone-related diseases treatment. As a result of increased knowledge of the role of androgens in different diseases, anti-androgen treatment is becoming increasingly important in targeted therapy. Androgens play an important role in different disorders, therefore, androgen receptor signalling is a crucial factor in pathological conditions. The androgen receptor is a transcription factor activated by the testosterone metabolite 5α-dihydrotestosterone and regulates the expression of genes related to sexual differentiation, growth a...
Source: European Journal of Pharmacology - November 8, 2019 Category: Drugs & Pharmacology Authors: Student S, Hejmo T, Poterała-Hejmo A, Leśniak A, Bułdak R Tags: Eur J Pharmacol Source Type: research

The Combination of MK-2206 and WZB117 Exerts a Synergistic Cytotoxic Effect Against Breast Cancer Cells
Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer death in women. Hormone receptor-positive breast cancer is usually subjected to hormone therapy, while triple-negative breast cancer is more formidable and poses a therapeutic challenge. Glucose transporters are potential targets for the development of anticancer drugs. In search of anticancer agents whose effect could be enhanced by a GLUT1 inhibitor WZB117, we found that MK-2206, a potent allosteric Akt inhibitor, when combined with WZB117, showed a synergistic effect on growth inhibition and apoptosis induction in breast cancer ce...
Source: Frontiers in Pharmacology - November 6, 2019 Category: Drugs & Pharmacology Source Type: research

An Update on Clinical and Surgical Interventions to Reduce Sperm DNA Fragmentation in Infertile Men
ConclusionCurrent evidence supports interventional therapy as a means to alleviate sperm DNA damage. Identification of the conditions associated with SDF remains important to enable treatment to potentially improve pregnancy outcomes but given the limited data further research is needed to determine the exact role of specific interventional therapy for subfertile men with impaired sperm chromatin. (Source: Andrology)
Source: Andrology - November 6, 2019 Category: Urology & Nephrology Authors: Sandro C. Esteves, Daniele Santi, Manuela Simoni Tags: REVIEW ARTICLE Source Type: research

Alteration of ACTH and Cortisol Levels After Estradiol Valerate Treatment in a Male Subject With Gender Dysphoria: A Case Report
Conclusions: We should bear in mind the possibility of elevation in plasma ACTH and serum cortisol levels when we start estradiol valerate injection in subjects with gender dysphoria. In addition, we may need to check ACTH and cortisol levels when we use estrogen replacement therapy for a long period of time in subjects with gender dysphoria. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - November 5, 2019 Category: Endocrinology Source Type: research

Cancers, Vol. 11, Pages 1719: Plasma Androgen Receptor in Prostate Cancer
ngione Mario Pulvirenti Antonino Romeo Ugo De Giorgi The therapeutic landscape of prostate cancer has expanded rapidly over the past 10 years, and there is now an even greater need to understand the biological mechanisms of resistance and to develop noninvasive biomarkers to guide treatment. The androgen receptor (AR) is known to be involved in the pathogenesis and progression of prostate cancer. Recently, highly sensitive next-generation sequencing and PCR-based methods for analyzing androgen receptor gene (AR) copy numbers (CN) and mutations in plasma were established in cell-free DNA (cfDNA) of patients with c...
Source: Cancers - November 4, 2019 Category: Cancer & Oncology Authors: Vincenza Conteduca Giorgia Gurioli Nicole Brighi Cristian Lolli Giuseppe Schepisi Chiara Casadei Salvatore Luca Burgio Stefania Gargiulo Giorgia Ravaglia Lorena Rossi Amelia Altavilla Alberto Farolfi Cecilia Menna Sarah Pia Colangione Mario Pulvirenti Ant Tags: Review Source Type: research

IJERPH, Vol. 16, Pages 4273: Fatty Acid Profile of Postmenopausal Women Receiving, and Not Receiving, Hormone Replacement Therapy
eta Grochans Menopause, the permanent cessation of the menstrual cycle, marks the end of a woman’s reproductive lifespan. Menopausal hormonal therapy (MHT) can potentially skew the fatty acid profile increasing the risk for developing metabolic diseases and disorders of skeletal, gastrointestinal, and nervous systems. The aim of this study was to investigate the fatty acid profile of postmenopausal women receiving, and not receiving, hormone replacement therapy. A total of 156 healthy women with a mean age of 60 participated in this cross-sectional study. Gas chromatography with an Agilent Technologies 78...
Source: International Journal of Environmental Research and Public Health - November 4, 2019 Category: Environmental Health Authors: Anna Maria Cybulska Karolina Skonieczna- Żydecka Arleta Drozd Kamila Rachubi ńska Jolanta Pawlik Ewa Stachowska Anna Jurczak El żbieta Grochans Tags: Article Source Type: research

The Effects of Adjuvant Tamoxifen Use on Macula Pigment Epithelium Optical Density, Visual Acuity and Retinal Thickness in Patients with Breast Cancer.
Conclusions: Patients in care of oral tamoxifen therapy were found to have significantly reduced macular pigment optical density. In addition, higher drug use duration correlated significantly with reduced macular pigment optical density, suggesting that the poor long-term effects may play a role in macular pigment absorption and incorporation in the retinal tissue. PMID: 31684771 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - November 4, 2019 Category: Opthalmology Authors: Bicer T, Imamoglu GI, Caliskan S, Bicer BK, Gurdal C Tags: Curr Eye Res Source Type: research

Risk factors for early postoperative psychological problems in breast cancer patients after axillary lymph node dissection.
In this study, a Distress and Impact Thermometer was used to classify patients with adjustment disorders, depression, or major depression and suicidal ideation into a group with psychological problems and the remaining patients into a group with no psychological problems. RESULTS: Logistic regression analysis showed that only DASH was statistically significantly associated with psychological conditions (p 
Source: Breast Cancer - November 2, 2019 Category: Cancer & Oncology Authors: Akezaki Y, Nakata E, Kikuuchi M, Tominaga R, Kurokawa H, Hamada M, Aogi K, Ohsumi S, Sugihara S Tags: Breast Cancer Source Type: research

Evidence map of ductal carcinoma in situ management options
Conclusions: The evidence map provides an overview of DCIS research showing the range of management options and remaining decisional dilemmas that follow a diagnosis of DCIS. It maps the evidence in accessible tools to guide practice and future research. Video Summary:http://links.lww.com/MENO/A448. (Source: Menopause)
Source: Menopause - November 1, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Effects of perimenopausal transdermal estradiol on self-reported sleep, independent of its effect on vasomotor symptom bother and depressive symptoms
Conclusions: We extend existing research by demonstrating that hormone therapy (HT) in subjective sleep cannot be fully explained by improvements in VMS bother or depressive symptoms. Research to examine the mechanism (s) underlying HT's effects on sleep would have public health significance for perimenopausal women and also advance our general understanding of the pathophysiology of impaired sleep. (Source: Menopause)
Source: Menopause - November 1, 2019 Category: OBGYN Tags: Brief Report Source Type: research