Clinicopathologic and Treatment Features of Long-Term Surviving Brain Metastasis Patients.
CONCLUSION: Most LTS were younger than 60 years old and had a single BM. Many received treatment with surgery or targeted, immune, or hormonal therapy. PMID: 33477698 [PubMed - in process] (Source: Current Oncology)
Source: Current Oncology - January 23, 2021 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Gender-affirming hormone therapy in cystic fibrosis – a case of new pseudomonas infection
Publication date: Available online 21 January 2021Source: Respiratory Medicine Case ReportsAuthor(s): L. Shaffer, K. Bozkanat, M. Lau, P. Sharma, M. Sathe, X. Lopez, R. Jain (Source: Respiratory Medicine Case Reports)
Source: Respiratory Medicine Case Reports - January 22, 2021 Category: Respiratory Medicine Source Type: research

Effectiveness of an Educational Intervention to Improve Medical Student Comfort and Familiarity With Providing Gender-Affirming Hormone Therapy.
CONCLUSIONS: GAHT can be initiated and managed in a primary care setting. There is a push to introduce GAHT in the preclinical years. After participating in a short interactive lecture on GAHT, second-year medical students reported increased comfort and familiarity with GAHT. Inclusion of GAHT in the preclinical curriculum does not require significant teaching time and is important knowledge for all future physicians. PMID: 33471925 [PubMed - as supplied by publisher] (Source: Family Medicine)
Source: Family Medicine - January 21, 2021 Category: Primary Care Tags: Fam Med Source Type: research

The risk of multiple intracranial aneurysm formation in patients with malignant disease undergoing radiation therapy: a case report and literature review.
In conclusion, the risk of multiple intracranial aneurysm formation in patients with breast cancer undergoing radiation therapy is low, but still possible. Long-term follow-up and regular cerebral angiographic check-up studies are necessary in selected malignant patients to decrease such a risk and to evade the worst outcome associated with aneurysm rupture. PMID: 33456125 [PubMed - in process] (Source: Acta Clinica Croatica)
Source: Acta Clinica Croatica - January 21, 2021 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Sexual Dimorphism in Innate Immunity: The Role of Sex Hormones and Epigenetics
Sexual dimorphism refers to differences between biological sexes that extend beyond sexual characteristics. In humans, sexual dimorphism in the immune response has been well demonstrated, with females exhibiting lower infection rates than males for a variety of bacterial, viral, and parasitic pathogens. There is also a substantially increased incidence of autoimmune disease in females compared to males. Together, these trends indicate that females have a heightened immune reactogenicity to both self and non-self-molecular patterns. However, the molecular mechanisms driving the sexually dimorphic immune response are not ful...
Source: Frontiers in Immunology - January 21, 2021 Category: Allergy & Immunology Source Type: research

Natural Compounds in Sex Hormone-Dependent Cancers: The Role of Triterpenes as Therapeutic Agents
Sex hormone-dependent cancers currently contribute to the high number of cancer-related deaths worldwide. The study and elucidation of the molecular mechanisms underlying the progression of these tumors was a double-edged sword, leading to the expansion and development of new treatment options, with the cost of triggering more aggressive, therapy resistant relapses. The interaction of androgen, estrogen and progesterone hormones with specific receptors (AR, ER, PR) has emerged as a key player in the development and progression of breast, ovarian, prostate and endometrium cancers. Sex hormone-dependent cancers share a commo...
Source: Frontiers in Endocrinology - January 21, 2021 Category: Endocrinology Source Type: research

IJERPH, Vol. 18, Pages 917: Multidisciplinary Approach to the Child with Sex Chromosomal Mosaicism Including a Y-Containing Cell Line
ine Cools Children born with sex chromosomal mosaicism including material derived from the Y chromosome may present with a broad phenotypical spectrum. Both boys and girls can present with Turner features and functional health problems typically associated with Turner syndrome, but the presence of Y-chromosomal material can modify some aspects of the condition. We retrospectively analyzed the results of our cohort of 21 individuals (14 boys, 7 girls) with sex chromosomal mosaicism including Y-derived material followed at Ghent University Hospital according to our local multidisciplinary Turner surveillance protocol. Re...
Source: International Journal of Environmental Research and Public Health - January 21, 2021 Category: Environmental Health Authors: Bauke Debo Marlies Van Loocke Katya De Groote Els De Leenheer Martine Cools Tags: Article Source Type: research

Breast Cancer Response to Therapy: Can microRNAs Lead the Way?
AbstractBreast cancer (BC) is a leading cause of death among women with malignant diseases. The selection of adequate therapies for highly invasive and metastatic BCs still represents a major challenge. Novel combinatorial therapeutic approaches are urgently required to enhance the efficiency of BC treatment. Recently, microRNAs (miRNAs) emerged as key regulators of the complex mechanisms that govern BC therapeutic resistance and susceptibility. In the present review we aim to critically examine how miRNAs influence BC response to therapies, or how to use miRNAs as a basis for new therapeutic approaches. We summarized rece...
Source: Journal of Mammary Gland Biology and Neoplasia - January 21, 2021 Category: Cancer & Oncology Source Type: research

Efficacy of 125I seed implantation combined with intermittent hormonal therapy on moderate- and high-risk non-metastatic prostate cancer.
CONCLUSIONS: IRF-1/PVT1-214 may markedly boost the oxaliplatin-resistance of CRC, resulting in the late TNM stage and poor survival. These findings suggest that the IRF-1/PVT1-214 axis may be a helpful target for intervention in CRC. PMID: 33455104 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

Therapeutic effect of thalidomide combined with temozolomide and three-dimensional conformal radiotherapy for patients with high-grade gliomas after operation.
Authors: Sui L, Li Y, Xu Z, Shen X Abstract PURPOSE: To explore the efficacy and safety of 125 I radioactive seed implantation combined with intermittent hormonal therapy (IHT) in the clinical treatment of moderate- and high-risk non-metastatic prostate cancer. METHODS: A total of 136 patients were divided into the observation group (n=68) and the control group (n=68). In the observation group, 125I radioactive seed implantation was performed, bicalutamide capsules were taken orally immediately after operation, and leuprorelin was injected from 1 week after operation. In the control group, IHT alone was adminis...
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

circ_NOTCH3 Functions as a Protooncogene Competing With miR-205-5p, Modulating KLF12 Expression and Promoting the Development and Progression of Basal-Like Breast Carcinoma
Breast cancer is the most common type of cancer diagnosed among women, and basal-like breast carcinoma (BLBC) has been associated with a more aggressive histology, poorer prognosis, and non-responsiveness to hormone therapy. In the present study, the role and molecular mechanism of circular (circ)_NOTCH3 in the development and progression for BLBC was identified. circ_RNAs array was used to screen the ectopic expression of hsa_circ_0109177 (circ_NOTCH3) in BLBC. RT-qPCR was conducted to evaluate the circ_NOTCH3 expression in BLBC tissues and paired normal tissues, as well as related cell lines. Cell function changes were a...
Source: Frontiers in Oncology - January 20, 2021 Category: Cancer & Oncology Source Type: research

Factors Associated With Acne Among Transgender Patients Receiving Masculinizing Hormones
This cohort study examines the prevalence of acne in transgender individuals initiating masculinizing hormone therapy. (Source: JAMA Dermatology)
Source: JAMA Dermatology - January 20, 2021 Category: Dermatology Source Type: research

Outpatient oral anticancer agent utilization and costs in Manitoba from 2003 to 2016: a population-based study.
CONCLUSION: We observed an increase in OAA prevalence and the cost of oral targeted chemotherapy is high. Our findings underline the need for addressing these high-cost medications in future developments of a national drug program. PMID: 33471346 [PubMed - as supplied by publisher] (Source: Canadian Journal of Public Health)
Source: Canadian Journal of Public Health - January 20, 2021 Category: International Medicine & Public Health Authors: Leong C, Czaykowski P, Geirnaert M, Katz A, Dragan R, Yogendran M, Raymond C Tags: Can J Public Health Source Type: research

Bruceantin targets HSP90 to overcome resistance to hormone therapy in castration-resistant prostate cancer
Conclusion: Our findings suggest that BCT could serve as a promising therapeutic candidate against CRPC and highlight the potential benefit of targeting AR-FL/AR-V7-HSP90 axis to overcome resistance caused by aberrant AR-FL/AR-V7 signaling. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Sue Jin Moon, Byong Chang Jeong, Hwa Jin Kim, Joung Eun Lim, Hye-Jeong Kim, Ghee Young Kwon, Joshua A. Jackman, Jeong Hoon Kim Tags: Research Paper Source Type: research

Development or exacerbation of hidradenitis suppurativa in two transgender men after initiation of testosterone therapy.
Abstract Transgender individuals are a growing patient population with unique dermatologic needs. Masculinizing hormone therapy (MHT) involves the use of exogenous testosterone to promote masculine and suppress feminine secondary sex characteristics.1 Commonly reported cutaneous effects of MHT include acne vulgaris and androgenic alopecia.2 To our knowledge, there have been no reported cases of hidradenitis suppurativa (HS) among transgender patients receiving MHT. Herein we present two patients, one that developed HS and one with worsening HS symptoms after initiating MHT. PMID: 33448331 [PubMed - as supplie...
Source: The British Journal of Dermatology - January 15, 2021 Category: Dermatology Authors: Buonomo M, Mansh MD, Thorpe D, Goldfarb N Tags: Br J Dermatol Source Type: research

Association of Child Neurology (AOCN) - Indian Epilepsy Society (IES) Consensus Guidelines for the Diagnosis and Management of West Syndrome.
tee Abstract JUSTIFICATION: West syndrome is one of the commonest causes of epilepsy in infants and young children and is a significant contributor to neurodevelopmental morbidity. Multiple regimens for treatment are in use. PROCESS: An expert group consisting of pediatric neurologists and epileptologists was constituted. Experts were divided into focus groups and had interacted on telephone and e-mail regarding their group recommendations, and developed a consensus. The evidence was reviewed, and for areas where the evidence was not certain, the Delphi consensus method was adopted. The final guidelines were ...
Source: Indian Pediatrics - January 15, 2021 Category: Pediatrics Authors: Sharma S, Kaushik JS, Srivastava K, Goswami JN, Sahu JK, Vinayan KP, Mittal R, Association of Child Neurology – Indian Epilepsy Society Expert Committee Tags: Indian Pediatr Source Type: research

Live births and maintenance with levonorgestrel IUD improve disease-free survival after fertility-sparing treatment of atypical hyperplasia and early endometrial cancer.
Abstract OBJECTIVE: Our objectives were to (1) compare different regimens of hormonal therapy (HT) in young women with atypical endometrial hyperplasia (AEH) and early endometrial cancer (EC), (2) assess reproductive and oncologic outcomes and (3) explore possible predictors of complete response (CR) and disease free survival (DFS). METHODS: Reproductive age women with AEH and Grade 1-2 endometrioid EC with no or minimal myometrial invasion on MRI treated with different regimens of HT were prospectively analyzed. Treatment protocols included levonorgestrel intrauterine device (LNG IUD), gonadotropin-releasing...
Source: Gynecologic Oncology - January 15, 2021 Category: Cancer & Oncology Authors: Novikova OV, Nosov VB, Panov VA, Novikova EG, Krasnopolskaya KV, Andreeva YY, Shevchuk AS Tags: Gynecol Oncol Source Type: research

Insights into the theranostic value of precision medicine on advanced radiotherapy to breast cancer.
Authors: Jiang M, Yang J, Li K, Liu J, Jing X, Tang M Abstract Breast cancer is the most common cancer in women worldwide. "Breast cancer" encompasses a broad spectrum of diseases (i.e., subtypes) with significant epidemiological, clinical, and biological heterogeneity. Each of these subtypes has a different natural history and prognostic profile. Although tumour staging (TNM classification) still provides valuable information in the overall management of breast cancer, the current reality is that clinicians must consider other biological and molecular factors that directly influence treatment decision-ma...
Source: International Journal of Medical Sciences - January 14, 2021 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Analysis of Speech Fundamental Frequencies for Different Tasks in Japanese
Speech fundamental frequency (SFF) assessment is essential for all dysphonia patients to effectively evaluate the therapeutic effects of voice therapy, especially in patients with disturbances in their voice pitch due to mutational dysphonia, Reinke's edema, or as side effects of hormone therapy. A standard method of SFF measurement remains unknown. Speech tasks such as sustained vowel phonation, counting, reading passage, and spontaneous speech have generally been used for SFF measurements. Ideally, spontaneous speech best reflects SFF; however, this task has not yet been clearly defined and is limited with regard to its ...
Source: Journal of Voice - January 14, 2021 Category: ENT & OMF Authors: Taisuke Sotome, Takeharu Kanazawa, Ujimoto Konomi, Naoshi Maeara, Kiyoshi Misawa, Satoka Takahashi, Junichi Fukaura, Yusuke Watanabe Source Type: research

Clear Cell Adenocarcinoma in Men: A Series of 15 Cases
Clear cell adenocarcinoma (CCA) is a rare tumor in the genitourinary tract with female predominance and few reports in men. We identified 15 cases of CCA in men evaluated at our institution. Five arose in the bladder, 7 in the prostate or prostatic urethra, 2 in the membranous urethra (1 multifocal in the prostatic and membranous urethra), 1 periprostatic (likely from an embryologic remnant), and 1 between rectum and bladder (likely in a prostatic utricle cyst). No cases showed associated Müllerian structures. One case showed separate foci of nephrogenic adenoma at diagnosis, and 1 case showed urothelial carcinoma in ...
Source: The American Journal of Surgical Pathology - January 13, 2021 Category: Pathology Tags: Original Articles Source Type: research

Sociodemographic and Clinical-pathological Study of Molecular Subtitles of Breast Carcinoma in a Reference Unit of Maranhão
Conclusion It was concluded that in the association of molecular subtypes with sociodemographic and clinical-pathological characteristics, there were no statistically significant results obtained, except for complementary therapy, referring to hormone therapy, and there was a high index of metastasis at diagnosis, which was a worrying factor and indicative of failures in the screening and early diagnosis of this population.Resumo Objetivo Avaliar a distribui ção das principais características sociodemográficas e clínico-patológicas em mulheres com câncer de mama segundo o per...
Source: Revista Brasileira de Ginecologia e Obstetricia - January 11, 2021 Category: OBGYN Source Type: research

Immunotherapy-induced pneumonitis in non-small cell lung cancer patients: current concern in treatment with immune-check-point inhibitors
In this study, we investigated the clinical and CT features of IIP in non-small cell lung cancer (NSCLC) patients treated with ICI.Methods CT images and clinical data of 98 NSCLC patients in our hospital were retrospectively analyzed after ICI therapy, and the incidence, onset time, CT findings, grade, treatment and prognosis of IIP were recorded.Results Nineteen patients developed IIP, which occurred 42 ∼210 days after ICI therapy, and the median time was 97 days. The CT findings for IIP showed multifocal ground-glass opacity (GGO) in 5 cases, patchy shadows in 6 cases, mixed distribution of patchy and strip-like shad...
Source: Investigational New Drugs - January 11, 2021 Category: Drugs & Pharmacology Source Type: research

Racial Disparities and Diagnosis-to-Treatment Time Among Patients Diagnosed with Breast Cancer in South Carolina
ConclusionsTo improve timely receipt of effective BrCA treatments, programs aimed at reducing racial disparities may need to target subgroups of Black breast cancer patients based on their social determinants of health and geographic residence. (Source: Journal of Racial and Ethnic Health Disparities)
Source: Journal of Racial and Ethnic Health Disparities - January 11, 2021 Category: International Medicine & Public Health Source Type: research

Risks of Testosterone for Postmenopausal Women
Transdermal testosterone therapy, dosed within premenopausal physiologic testosterone ranges, used alone or with menopausal hormone therapy for postmenopausal hypoactive sexual desire disorder, has shown short-term efficacy, with few androgenic side effects. After natural or surgical menopause, meaningful improvements include an additional satisfying sexual episode per month; improvement in desire, arousal, orgasm, pleasure, and responsiveness; and a reduction in distress. Long-term data on cardiovascular, cancer, and cognitive safety are lacking. No approved testosterone preparation is available for women. Compounded test...
Source: Endocrinology and Metabolism Clinics of North America - January 11, 2021 Category: Endocrinology Authors: JoAnn V. Pinkerton, Isabella Blackman, Edward Alexander Conner, Andrew M. Kaunitz Source Type: research

Clinicopathologic features of single bone metastasis in breast cancer
In conclusion, the risk of developing single bone metastasis is likely in non-metastatic patients with Stage III tumors and possibly in mixed type tumors. Knowing this risk, especially in patients with mixed type tumors, may be instrumental in taking measures with different adjuvant therapies in future studies. Among these, treatment modalities such as prolonged hormone therapy and addition of bisphosphonates to the adjuvant treatments of stage III and mixed breast cancer patients may be considered. (Source: Medicine)
Source: Medicine - January 8, 2021 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Clinicopathologic features and clinical outcomes of intravenous leiomyomatosis of the uterus: A case series
Rationale: Intravenous leiomyomatosis (IVL) is a rare and special type of smooth muscle tumor originating in the uterus. It is classified as a benign disease according to its histological features but shows the behavioral characteristics of a malignant tumor. It is easily misdiagnosed and recurrent. The purpose of this study was to retrospectively analyze clinicopathological data of 25 cases of IVL in order to enhance clinicians’ understanding of this rare disease. Patient concerns: We screened and identified 25 cases of IVL at our hospital from October 2013 to January 2020. Five patients had tumors. Di...
Source: Medicine - January 8, 2021 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

The Adrenal Cortex, an Underestimated Site of SARS-CoV-2 Infection
ConclusionWe demonstrate that ACE2 and TMPRSS2 are colocalized in adrenocortical cells, and that the cortisol levels are lower in critically ill patients with COVID-19 as compared to those of non-COVID-19 critically ill patients. Based on our findings, we recommend measuring plasma cortisol level to guide hormonal therapy. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - January 8, 2021 Category: Endocrinology Source Type: research

No Venous Thromboembolism Increase Among Transgender Female Patients Remaining on Estrogen for Gender Affirming Surgery.
CONCLUSIONS: Peri-operative VTE was not a significant risk in a large, homogenously treated cohort of TGNB patients independent of whether or not hormone therapy was suspended prior to surgery. PMID: 33417686 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 8, 2021 Category: Endocrinology Authors: Kozato A, Fox GWC, Yong PC, Shin SJ, Avanessian BK, Ting J, Ling Y, Karim S, Safer JD, Pang JH Tags: J Clin Endocrinol Metab Source Type: research

Transgender adults, gender-affirming hormone therapy and blood pressure: a systematic review
Conclusion: There is currently insufficient data to advise the impact of GHT on BP in transgender individuals. Better quality research is essential to elucidate whether exogenous sex hormones modulate BP in transgender people and whether this putative alteration infers poorer cardiovascular outcomes. (Source: Journal of Hypertension)
Source: Journal of Hypertension - January 7, 2021 Category: Cardiology Tags: SYSTEMATIC REVIEWS AND META-ANALYSES Source Type: research

Bioidentical hormones.
Abstract After the results of the Women's Health Initiative trials were published, patient and clinician interest in potential alternatives to conventional hormone therapy (HT) has grown. A commonly used alternative therapy involves custom-compounded steroid hormone preparations, formulated by compounding pharmacies. Many postmenopausal women consider the hormones as natural or bioidentical, in contrast to hormones used in conventional HT, which they consider synthetic. In actuality, the chemical structures of many of the hormones used in bioidentical HT (BHT) are the same as those used in conventional HT. To cust...
Source: Climacteric - January 6, 2021 Category: Geriatrics Authors: Stanczyk FZ, Matharu H, Winer SA Tags: Climacteric Source Type: research

The Specialized Donor Care Facility (SDCF) Model and Advances in Management of Thoracic Organ Donors.
CONCLUSIONS: Lack of high-quality prospective evidence results in conflicting practices across organ procurement organizations and best practices remain controversial. Future studies should focus on prospective, randomized investigations to evaluate donor management strategies. The SDCF model fosters a collaborative environment that encourages academic inquiry and is an ideal setting for these investigations. PMID: 33421385 [PubMed - as supplied by publisher] (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - January 6, 2021 Category: Cardiovascular & Thoracic Surgery Authors: Bery A, Marklin G, Itoh A, Kreisel D, Takahashi T, Meyers BF, Nava R, Kozower BD, Shepherd H, Patterson GA, Puri V Tags: Ann Thorac Surg Source Type: research

Nonhormonal Treatment for Endometriosis Focusing on Redox Imbalance
In conclusion, this review summarizes the following 2 points: superoxide anion generation by methemoglobin is enhanced in endometriosis, resulting in redox imbalance; and some compounds and natural substances that can suppress free radicals may be effective in endometriosis-related pain. Further randomized clinical trials based on larger series are mandatory to confirm the promising role of antioxidants in the nonhormonal management of endometriosis.Gynecol Obstet Invest (Source: Gynecologic and Obstetric Investigation)
Source: Gynecologic and Obstetric Investigation - January 4, 2021 Category: OBGYN Source Type: research

Breast cancer risk factors by mode of detection among screened women in the Cancer Prevention Study-II
ConclusionsDifferences in risk factors for symptom-detected vs. screen-detected breast cancer were observed and most notably, use of combined and estrogen-only HT and a history of benign breast disease were associated with increased risk of symptomatic detected breast cancer.ImpactIf confirmed, these data suggest that such women may benefit from more intensive screening to facilitate early detection. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 4, 2021 Category: Cancer & Oncology Source Type: research

Breast Cancer Risk and Screening in Transgender Individuals
AbstractPurpose of ReviewThere are over 1.4 million individuals who identify as transgender in the USA, and these individuals are frequently treated with cross-sex hormonal therapy (CSH) to acquire their desired phenotype. Simultaneously, breast cancer is one of the most common cancers in the USA, and there are mixed data on how CSH may influence breast cancer development in transgender individuals. Here, we review the barriers that exist to health access in this population, the current evidence of breast cancer risk in transgender individuals, and breast cancer screening guidelines for both transgender women and men.Recen...
Source: Current Breast Cancer Reports - January 4, 2021 Category: Cancer & Oncology Source Type: research

Hypertensive disorders of pregnancy and menopausal symptoms: a cross-sectional study from the data registry on experiences of aging, menopause, and sexuality
Conclusions: In this large cross-sectional study, a history of hypertensive disorders of pregnancy was associated with more bothersome menopausal symptoms. Additional study is needed to determine the strength of this association, underlying mechanisms of the association, and clinical implications for cardiovascular risk prediction in women. (Source: Menopause)
Source: Menopause - January 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Long-term resveratrol supplementation improves pain perception, menopausal symptoms, and overall well-being in postmenopausal women: findings from a 24-month randomized, controlled, crossover trial
Objective: Following concerns about hormone therapy, postmenopausal women need alternative options to manage menopause-related symptoms and improve their well-being. A 14-week pilot study has shown that supplementation with resveratrol, a phytoestrogen with circulatory benefits, can improve aspects of well-being including chronic pain, which is a common complaint in postmenopausal women. We aimed to confirm these benefits in a larger, long-term study. Methods: The Resveratrol for Healthy Ageing in Women study, a 24-month randomized, double-blind, placebo-controlled, two-period crossover intervention trial of res...
Source: Menopause - January 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Onset of the climacteric phase by the mid-forties associated with impaired insulin sensitivity: a birth cohort study
Objective: To investigate whether the early-onset menopausal transition is associated with deteriorated glucose tolerance in women in their mid-forties. Methods: A cross-sectional analysis of a cohort study including 2,632 women of the Northern Finland Birth Cohort 1966. The participants were divided into two groups by their menstrual history and follicle-stimulating hormone values at age 46: climacteric and preclimacteric women. Glucose and insulin parameters, as well as mathematical indices derived from them to evaluate insulin sensitivity, were compared between the groups. The results were adjusted for measur...
Source: Menopause - January 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Migraine and menopause - a narrative review
Discussion and conclusion: Many women are informed that their migraines will disappear postmenopause; there are some data to support this, but a specific time frame has not been evidenced. Stroke risk in women with migraine with aura is small in absolute terms, but important at the population level, because migraine is so prevalent. The risk becomes clinically important in the context of additional stroke risk factors, which increase with aging such as hypertension. Estrogen in combined hormonal contraception increases the risk of an ischemic stroke, however, the lower amount of estrogen in HT may not contribute to a m...
Source: Menopause - January 1, 2021 Category: OBGYN Tags: Review Articles Source Type: research

The role of prostate-specific antigen in light of new scientific evidence: An update in 2020.
CONCLUSIONS: We present new data about the current role of PSA in the management of patients treated for BPH and/or prostate cancer that should be implemented into routine clinical practice, with special emphasis on the relevant role of this biomarker in the screening and follow-up of prostate cancer, as well as in the progression of BPH in dutasteride treatment. PMID: 33408046 [PubMed - in process] (Source: Actas Urologicas Espanolas)
Source: Actas Urologicas Espanolas - January 1, 2021 Category: Urology & Nephrology Authors: Cózar JM, Hernández C, Miñana B, Morote J, Alvarez-Cubero MJ Tags: Actas Urol Esp Source Type: research

Association of Retinal Vascular Occlusion With Women Filling a Prescription for Female Hormone Therapy
This study investigates whether filling a prescription of female hormone therapy (FHT) is associated with an increased risk of retinal artery occlusion (RAO) or retinal vein occlusions (RVO). (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - January 1, 2021 Category: Opthalmology Source Type: research

Incidence of Cancer and Premalignant Lesions in Surgical Specimens of Transgender Patients
Conclusions: Gender-affirming surgery is increasingly more common given the increase in access to care. The authors’ review of routine pathologic specimens generated from gender-affirming surgery yielded a 6.4 percent rate of finding atypical lesions requiring further evaluation. The authors advocate that all specimens be sent for pathologic evaluation. (Source: Plastic and Reconstructive Surgery)
Source: Plastic and Reconstructive Surgery - December 29, 2020 Category: Cosmetic Surgery Tags: Reconstructive: Trunk: Special Topic Source Type: research

Bipolar androgen therapy sensitizes castration-resistant prostate cancer to subsequent androgen receptor ablative therapy
Cyclical, high-dose testosterone administration, termed bipolar androgen therapy (BAT), can induce clinical responses and restore sensitivity to androgen signalling inhibition in patients with previously treated castration-resistant prostate cancer (PCa) (CRPC). This trial evaluated whether BAT is a safe and effective first-line hormonal therapy for patients with CRPC. (Source: European Journal of Cancer)
Source: European Journal of Cancer - December 29, 2020 Category: Cancer & Oncology Authors: Laura A. Sena, Hao Wang, Su J. Lim ScM, Irina Rifkind, Nduku Ngomba, John T. Isaacs, Jun Luo, Caroline Pratz, Victoria Sinibaldi, Michael A. Carducci, Channing J. Paller, Mario A. Eisenberger, Mark C. Markowski, Emmanuel S. Antonarakis, Samuel R. Denmeade Tags: Original Research Source Type: research

Cancer survivorship: Reproductive health outcomes should be included in standard toxicity assessments
It is well established that cancer and its treatment, whether by chemotherapy, radiotherapy, hormone therapy,  or surgery, can adversely impact reproductive function in both women and men. The effects of cancer treatment on reproductive function in both sexes may lead to loss of fertility, sexual desire and function, and hormone deficiency, which results in additional long-term morbidity in more than a th ird of patients. Given the importance of reproductive function to most people, and the often devastating effect of cancer treatment on it, we propose that proactive assessment of the functional and endocrin...
Source: European Journal of Cancer - December 29, 2020 Category: Cancer & Oncology Authors: Richard A. Anderson, Florian Clatot, Isabelle Demeestere, Matteo Lambertini, Adrienne Morgan, Scott M. Nelson, Fedro Peccatori, David Cameron Tags: Current Perspective Source Type: research

[French ccAFU guidelines - update 2020-2022: prostate cancer].
CONCLUSION: - These updated french guidelines will contribute to increase the level of urological care for the diagnosis and treatment for prostate cancer. PMID: 33349424 [PubMed - in process] (Source: Progres en Urologie)
Source: Progres en Urologie - December 24, 2020 Category: Urology & Nephrology Tags: Prog Urol Source Type: research

Abiraterone acetate and acute leukemia: a casual association?
We present the case of a 70-year-old patient affected by metastatic castration-resistant prostate cancer. He underwent radical prostatectomy in 2007 and subsequent adjuvant radiotherapy and hormonal therapy for 2 years. In 2011, he developed bilateral lung metastases, and therefore he received chemotherapy (eight cycles of docetaxel 75 mg/sqm every 3 weeks) with partial remission; rechallenge with the same drug was performed 7 months later due to recurrence of lung metastases. In August 2013, abiraterone acetate was started for progression of lung metastases. The patient received abiraterone for almost 5 years with stabili...
Source: Anti-Cancer Drugs - December 23, 2020 Category: Cancer & Oncology Tags: Case Reports Source Type: research

Cardiovascular Complications of Prostate Cancer Treatment
This article provides a unique and comprehensive overview of the prevalence and possible mechanisms of cardiovascular toxicities of all PC therapies, including state-of-the-art antineoplastic agents. Additionally, this article summarizes available recommendations regarding screening and prevention of the most common cardiac complications among patients with advanced cancer disease. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 22, 2020 Category: Drugs & Pharmacology Source Type: research

The impact of xenoestrogens on effectiveness of treatment for hormone-dependent breast cancer - current state of knowledge and perspectives for research.
CONCLUSIONS: Confirmation in clinical trials of the results obtained in vitro and in vivo tests, would enable the creation of specific recommendations for patients undergoing breast cancer treatment, especially hormone therapy. An area requiring further research is the analysis of the effects of xenoestrogens other than phytoestrogens, e.g. metalloestrogens, on the effects of drugs used in the treatment of breast cancer. PMID: 33356056 [PubMed - in process] (Source: Annals of Agricultural and Environmental Medicine : AAEM)
Source: Annals of Agricultural and Environmental Medicine : AAEM - December 22, 2020 Category: Environmental Health Authors: Boszkiewicz K, Sawicka E, Piwowar A Tags: Ann Agric Environ Med Source Type: research

Urinary Incontinence and Overactive Bladder Symptoms in Women with Breast Cancer Being Treated with Oral Hormone Therapy
Conclusion: The present study showed a high prevalence of urinary symptoms, such as urinary incontinence and OAB, associated with low/medium adherence and older age in women with BC being treated with oral hormone therapy. Health professionals should be alert to these symptoms since it could influence life quality and adherence to treatment.Resumo Objetivo: O objetivo do presente estudo foi observar a frequ ência e a gravidade dos sintomas urinários em mulheres com câncer de mama em uso de terapia hormonal oral, associando estes com a adesão ao tratamento. Métodos: As pacientes foram entrev...
Source: Revista Brasileira de Ginecologia e Obstetricia - December 21, 2020 Category: OBGYN Source Type: research

Pain and Spirituality Outcomes Among Women With Advanced Breast Cancer Participating in a Foot Reflexology Trial.
Abstract OBJECTIVES: To examine pain and spirituality, demographic and clinical factors associated with pain and spirituality, the contribution of spirituality to experiences of pain over time, and how pain and spirituality relate to engagement with a caregiver-delivered intervention. SAMPLE & SETTING: Women with advanced breast cancer (N = 256) enrolled in a home-based randomized controlled trial of foot reflexology. METHODS & VARIABLES: Secondary analyses were conducted with baseline and postintervention data. Stepwise model building, linear mixed-effects modeling, and negative binomial...
Source: Oncology Nursing Forum - December 20, 2020 Category: Nursing Authors: Miller M, Xu D, Lehto R, Moser J, Wu HS, Wyatt G Tags: Oncol Nurs Forum Source Type: research

‘A little bubble of utopia’: constructions of a primary care-based pilot clinic providing gender affirming hormone therapy
. (Source: Health Sociology Review)
Source: Health Sociology Review - December 20, 2020 Category: International Medicine & Public Health Authors: Alex Ker Gloria Fraser Theresa Fleming Cathy Stephenson Anny da Silva Freitas Richard Carroll Thomas K. Hamilton Antonia C. Lyons Source Type: research