Usefulness of supplementary ultrasound surveillance in the detection of a second breast cancer in patients with ductal carcinoma in situ
CONCLUSION: In DCIS patients, the rate of second breast cancers was 7.5%. Breast conservation, involved margins after lumpectomy and shortened hormonal therapy were associated with second cancers. Patients with involved margins after lumpectomy have the highest cancer detection rate and minimal unnecessary biopsies and follow-ups. Hence, ipsilateral breast ultrasound surveillance could be personalized for this high-risk group with mammographically dense breasts.PMID:34544658 | DOI:10.1016/j.clbc.2021.08.006 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - September 21, 2021 Category: Cancer & Oncology Authors: Hend Saeed Almalki Annabelle Lim John C Allen Sze Yiun Teo Geok Hoon Lim Source Type: research

Usefulness of supplementary ultrasound surveillance in the detection of a second breast cancer in patients with ductal carcinoma in situ
CONCLUSION: In DCIS patients, the rate of second breast cancers was 7.5%. Breast conservation, involved margins after lumpectomy and shortened hormonal therapy were associated with second cancers. Patients with involved margins after lumpectomy have the highest cancer detection rate and minimal unnecessary biopsies and follow-ups. Hence, ipsilateral breast ultrasound surveillance could be personalized for this high-risk group with mammographically dense breasts.PMID:34544658 | DOI:10.1016/j.clbc.2021.08.006 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 21, 2021 Category: Cancer & Oncology Authors: Hend Saeed Almalki Annabelle Lim John C Allen Sze Yiun Teo Geok Hoon Lim Source Type: research

Magnetic resonance imaging radiomics signatures for predicting endocrine resistance in hormone receptor-positive non-metastatic breast cancer
CONCLUSION: This study developed and validated a pretreatment multiparametric MRI-based radiomic-clinical combined model and showed good performance in predicting endocrine resistance.PMID:34536884 | DOI:10.1016/j.breast.2021.09.005 (Source: Breast)
Source: Breast - September 18, 2021 Category: Cancer & Oncology Authors: Yaping Yang Junwei Li Yajing Liu Ying Zhong Wei Ren Yujie Tan Zifan He Chenchen Li Jie Ouyang Qiugen Hu Yunfang Yu Herui Yao Source Type: research

Menopausal hormone therapy and breast cancer risk
Best Pract Res Clin Endocrinol Metab. 2021 Sep 10:101577. doi: 10.1016/j.beem.2021.101577. Online ahead of print.ABSTRACTThis narrative review analyses the customization of Menopause Hormone Therapy in the context of breast cancer risk in women with premature ovarian insufficiency (POI) and with menopause at a normal age. Women with Idiopathic POI, FMR-1 premutation or Turner syndrome, if left untreated, may have lower breast cancer risk compared to the healthy age-matched female population. These women should be treated with MHT until the age of 50, as the risk of breast cancer is equal to that of normally menstruating wo...
Source: Clinical Breast Cancer - September 18, 2021 Category: Cancer & Oncology Authors: Serge Rozenberg Victoria Di Pietrantonio Jean Vandromme Christine Gilles Source Type: research

Menopausal hormone therapy and breast cancer risk
Best Pract Res Clin Endocrinol Metab. 2021 Sep 10:101577. doi: 10.1016/j.beem.2021.101577. Online ahead of print.ABSTRACTThis narrative review analyses the customization of Menopause Hormone Therapy in the context of breast cancer risk in women with premature ovarian insufficiency (POI) and with menopause at a normal age. Women with Idiopathic POI, FMR-1 premutation or Turner syndrome, if left untreated, may have lower breast cancer risk compared to the healthy age-matched female population. These women should be treated with MHT until the age of 50, as the risk of breast cancer is equal to that of normally menstruating wo...
Source: Clinical Genitourinary Cancer - September 18, 2021 Category: Cancer & Oncology Authors: Serge Rozenberg Victoria Di Pietrantonio Jean Vandromme Christine Gilles Source Type: research

Erythrocytosis and thromboembolic events in transgender individuals receiving gender-affirming testosterone
Erythrocytosis is a well-recognized consequence of exogenous testosterone, however its prevalence and contributions to thrombosis remain unknown in the context of gender-affirming hormonal therapy. We undertook a retrospective study of transgender and non-binary (TGNB) adults receiving exogenous testosterone. In the retrospective sample, 923 transgender individuals receiving testosterone were identified with 519 having documented pre- and post-testosterone hemoglobin and hematocrit (Hgb/Hct). The mean peak Hgb/Hct was 15.7  g/dL, and 47.0%. (Source: Thrombosis Research)
Source: Thrombosis Research - September 18, 2021 Category: Hematology Authors: Michael Oakes, Asad Arastu, Catherine Kato, Julia Somers, Hannah D. Holly, Benjamin K. Elstrott, Geolani W. Dy, Tia C.L. Kohs, Rishi R. Patel, Owen J.T. McCarty, Thomas G. DeLoughery, Christina Milano, Vikram Raghunathan, Joseph J. Shatzel Tags: Letter to the Editors-in-Chief Source Type: research

MRI Finding of Prostatic Ductal Adenocarcinoma
We report a 63-year-old male with prostatic ductal adenocarcinoma, presenting as urinary retention and a prostate-specific antigen (PSA) level of 11.71 ng/mL and biopsy-proven prostate cancer (Gleason score 3 + 3). MRI showed 2 hemorrhagic, multilocular cysts projecting into the bladder side from the prostatic inner gland and between the prostate and the right seminal vesicle. The prostate inner gland showed high signal intensity on the T2-weighted image and included tiny hyperintense spots on the fat-suppression T1-weighted image. In the part of the border of the hemorrhagic, multilocular cyst, a solid portion showing sli...
Source: Case Reports in Oncology - September 16, 2021 Category: Cancer & Oncology Source Type: research

Cancers, Vol. 13, Pages 4635: The Impact of Tumor Edema on T2-Weighted 3T-MRI Invasive Breast Cancer Histological Characterization: A Pilot Radiomics Study
Conclusions: radiomic features extracted from tumor edema contribute significantly to predicting tumor histology, increasing the accuracy obtained from the combination of patient clinical characteristics and breast imaging data. (Source: Cancers)
Source: Cancers - September 15, 2021 Category: Cancer & Oncology Authors: Domiziana Santucci Eliodoro Faiella Ermanno Cordelli Alessandro Calabrese Roberta Landi Carlo de Felice Bruno Beomonte Zobel Rosario Francesco Grasso Giulio Iannello Paolo Soda Tags: Article Source Type: research

Neoadjuvant hormonal therapy before radical prostatectomy in high-risk prostate cancer
Nature Reviews Urology, Published online: 15 September 2021; doi:10.1038/s41585-021-00514-9Cancer recurrence after radical prostatectomy for high-risk prostate cancer is common. The addition of neoadjuvant hormonal therapy with the introduction of potent androgen receptor signalling inhibitors has gained interest in the oncological community. However, conclusions of a survival benefit with this therapy cannot currently be made and results of several phase II trials are much anticipated. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - September 15, 2021 Category: Urology & Nephrology Authors: Ga ëtan Devos Wout Devlies Gert De Meerleer Marcella Baldewijns Thomas Gevaert Lisa Moris Daimantas Milonas Hendrik Van Poppel Charlien Berghen Wouter Everaerts Frank Claessens Steven Joniau Source Type: research

Lesion Genotype Modifies High-Fat Diet Effects on Endometriosis Development in Mice
Endometriosis is a chronic, estrogen-dependent gynecologic disorder that affects reproductive-aged women and to a lesser extent, post-menopausal women on hormone therapy. The condition is associated with systemic and local immune dysfunctions. While its underlying mechanisms remain poorly understood, endometriosis has a genetic component and propensity for the disease is subject to environmental, nutritional, and lifestyle influences. Previously, we showed that high-fat diet (HFD) increased ectopic lesion numbers, concurrent with systemic and peritoneal changes in inflammatory and oxidative stress status, in immunocompeten...
Source: Frontiers in Physiology - September 14, 2021 Category: Physiology Source Type: research

Metastatic hormone receptor-positive breast cancer in CDK 4/6 era: An outcome audit
Conclusions: Among patients with HR-positive, advanced breast cancer, hormone therapy is efficacious addition of CDK 4/6 inhibitor improve the efficacy with tolerable side effects. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 14, 2021 Category: Cancer & Oncology Authors: Rajeev Krishnappa Lakkavalli Jitendra Kumar Pehalajani Venkatesh Tirumala Govind K Babu Dassappa Loknatha Linu Abraham Jacob Suresh M C Babu AH Rudresha Lokesh Nagendrappa Kadabur Smitha C Saldanha GV Giri Source Type: research

Factors associated with return to work of breast cancer patients following axillary lymph node dissection
Work. 2021 Sep 5. doi: 10.3233/WOR-213571. Online ahead of print.ABSTRACTBACKGROUND: The identification of factors that are related to return to work after surgery for breast cancer could help healthcare professionals accurately identify patients at risk of return to work-related difficulties in order to provide them with appropriate support during breast cancer management.OBJECTIVE: The aim of this study was to identify factors related to return to work in breast cancer patients three months after axillary lymph node dissection.METHODS: Seventy-three women who were working before the surgery were evaluated. Age, body mass...
Source: Work - September 13, 2021 Category: Occupational Health Authors: Yoshiteru Akezaki Eiji Nakata Masato Kikuuchi Ritsuko Tominaga Hideaki Kurokawa Makiko Hamada Kenjiro Aogi Shozo Ohsumi Shinsuke Sugihara Source Type: research

Can belly dance and mat Pilates be effective for range of motion, self-esteem, and depressive symptoms of breast cancer women?
CONCLUSION: Belly dance and the Mat Pilates can bring positive results in the range of movement of women undergoing adjuvant treatment of breast cancer, with the Pilates method being the one that most contributed to improvements in this variable.PMID:34517217 | DOI:10.1016/j.ctcp.2021.101483 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - September 13, 2021 Category: Cancer & Oncology Authors: Bruna Leite Tatiana de Bem Fretta Leonessa Boing Adriana Coutinho de Azevedo Guimar ães Source Type: research

Can belly dance and mat Pilates be effective for range of motion, self-esteem, and depressive symptoms of breast cancer women?
CONCLUSION: Belly dance and the Mat Pilates can bring positive results in the range of movement of women undergoing adjuvant treatment of breast cancer, with the Pilates method being the one that most contributed to improvements in this variable.PMID:34517217 | DOI:10.1016/j.ctcp.2021.101483 (Source: Complementary Therapies in Clinical Practice)
Source: Complementary Therapies in Clinical Practice - September 13, 2021 Category: Complementary Medicine Authors: Bruna Leite Tatiana de Bem Fretta Leonessa Boing Adriana Coutinho de Azevedo Guimar ães Source Type: research

Can belly dance and mat Pilates be effective for range of motion, self-esteem, and depressive symptoms of breast cancer women?
CONCLUSION: Belly dance and the Mat Pilates can bring positive results in the range of movement of women undergoing adjuvant treatment of breast cancer, with the Pilates method being the one that most contributed to improvements in this variable.PMID:34517217 | DOI:10.1016/j.ctcp.2021.101483 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 13, 2021 Category: Cancer & Oncology Authors: Bruna Leite Tatiana de Bem Fretta Leonessa Boing Adriana Coutinho de Azevedo Guimar ães Source Type: research

Factors associated with return to work of breast cancer patients following axillary lymph node dissection
Work. 2021 Sep 5. doi: 10.3233/WOR-213571. Online ahead of print.ABSTRACTBACKGROUND: The identification of factors that are related to return to work after surgery for breast cancer could help healthcare professionals accurately identify patients at risk of return to work-related difficulties in order to provide them with appropriate support during breast cancer management.OBJECTIVE: The aim of this study was to identify factors related to return to work in breast cancer patients three months after axillary lymph node dissection.METHODS: Seventy-three women who were working before the surgery were evaluated. Age, body mass...
Source: Work - September 13, 2021 Category: Occupational Health Authors: Yoshiteru Akezaki Eiji Nakata Masato Kikuuchi Ritsuko Tominaga Hideaki Kurokawa Makiko Hamada Kenjiro Aogi Shozo Ohsumi Shinsuke Sugihara Source Type: research

Can belly dance and mat Pilates be effective for range of motion, self-esteem, and depressive symptoms of breast cancer women?
CONCLUSION: Belly dance and the Mat Pilates can bring positive results in the range of movement of women undergoing adjuvant treatment of breast cancer, with the Pilates method being the one that most contributed to improvements in this variable.PMID:34517217 | DOI:10.1016/j.ctcp.2021.101483 (Source: Complementary Therapies in Clinical Practice)
Source: Complementary Therapies in Clinical Practice - September 13, 2021 Category: Complementary Medicine Authors: Bruna Leite Tatiana de Bem Fretta Leonessa Boing Adriana Coutinho de Azevedo Guimar ães Source Type: research

Factors associated with return to work of breast cancer patients following axillary lymph node dissection
Work. 2021 Sep 5. doi: 10.3233/WOR-213571. Online ahead of print.ABSTRACTBACKGROUND: The identification of factors that are related to return to work after surgery for breast cancer could help healthcare professionals accurately identify patients at risk of return to work-related difficulties in order to provide them with appropriate support during breast cancer management.OBJECTIVE: The aim of this study was to identify factors related to return to work in breast cancer patients three months after axillary lymph node dissection.METHODS: Seventy-three women who were working before the surgery were evaluated. Age, body mass...
Source: Work - September 13, 2021 Category: Occupational Health Authors: Yoshiteru Akezaki Eiji Nakata Masato Kikuuchi Ritsuko Tominaga Hideaki Kurokawa Makiko Hamada Kenjiro Aogi Shozo Ohsumi Shinsuke Sugihara Source Type: research

Can belly dance and mat Pilates be effective for range of motion, self-esteem, and depressive symptoms of breast cancer women?
CONCLUSION: Belly dance and the Mat Pilates can bring positive results in the range of movement of women undergoing adjuvant treatment of breast cancer, with the Pilates method being the one that most contributed to improvements in this variable.PMID:34517217 | DOI:10.1016/j.ctcp.2021.101483 (Source: Complementary Therapies in Clinical Practice)
Source: Complementary Therapies in Clinical Practice - September 13, 2021 Category: Complementary Medicine Authors: Bruna Leite Tatiana de Bem Fretta Leonessa Boing Adriana Coutinho de Azevedo Guimar ães Source Type: research

Factors associated with return to work of breast cancer patients following axillary lymph node dissection
Work. 2021 Sep 5. doi: 10.3233/WOR-213571. Online ahead of print.ABSTRACTBACKGROUND: The identification of factors that are related to return to work after surgery for breast cancer could help healthcare professionals accurately identify patients at risk of return to work-related difficulties in order to provide them with appropriate support during breast cancer management.OBJECTIVE: The aim of this study was to identify factors related to return to work in breast cancer patients three months after axillary lymph node dissection.METHODS: Seventy-three women who were working before the surgery were evaluated. Age, body mass...
Source: Work - September 13, 2021 Category: Occupational Health Authors: Yoshiteru Akezaki Eiji Nakata Masato Kikuuchi Ritsuko Tominaga Hideaki Kurokawa Makiko Hamada Kenjiro Aogi Shozo Ohsumi Shinsuke Sugihara Source Type: research

Can belly dance and mat Pilates be effective for range of motion, self-esteem, and depressive symptoms of breast cancer women?
CONCLUSION: Belly dance and the Mat Pilates can bring positive results in the range of movement of women undergoing adjuvant treatment of breast cancer, with the Pilates method being the one that most contributed to improvements in this variable.PMID:34517217 | DOI:10.1016/j.ctcp.2021.101483 (Source: Complementary Therapies in Clinical Practice)
Source: Complementary Therapies in Clinical Practice - September 13, 2021 Category: Complementary Medicine Authors: Bruna Leite Tatiana de Bem Fretta Leonessa Boing Adriana Coutinho de Azevedo Guimar ães Source Type: research

Factors associated with return to work of breast cancer patients following axillary lymph node dissection
Work. 2021 Sep 5. doi: 10.3233/WOR-213571. Online ahead of print.ABSTRACTBACKGROUND: The identification of factors that are related to return to work after surgery for breast cancer could help healthcare professionals accurately identify patients at risk of return to work-related difficulties in order to provide them with appropriate support during breast cancer management.OBJECTIVE: The aim of this study was to identify factors related to return to work in breast cancer patients three months after axillary lymph node dissection.METHODS: Seventy-three women who were working before the surgery were evaluated. Age, body mass...
Source: Work - September 13, 2021 Category: Occupational Health Authors: Yoshiteru Akezaki Eiji Nakata Masato Kikuuchi Ritsuko Tominaga Hideaki Kurokawa Makiko Hamada Kenjiro Aogi Shozo Ohsumi Shinsuke Sugihara Source Type: research

Can belly dance and mat Pilates be effective for range of motion, self-esteem, and depressive symptoms of breast cancer women?
CONCLUSION: Belly dance and the Mat Pilates can bring positive results in the range of movement of women undergoing adjuvant treatment of breast cancer, with the Pilates method being the one that most contributed to improvements in this variable.PMID:34517217 | DOI:10.1016/j.ctcp.2021.101483 (Source: Complementary Therapies in Clinical Practice)
Source: Complementary Therapies in Clinical Practice - September 13, 2021 Category: Complementary Medicine Authors: Bruna Leite Tatiana de Bem Fretta Leonessa Boing Adriana Coutinho de Azevedo Guimar ães Source Type: research

Factors associated with return to work of breast cancer patients following axillary lymph node dissection
Work. 2021 Sep 5. doi: 10.3233/WOR-213571. Online ahead of print.ABSTRACTBACKGROUND: The identification of factors that are related to return to work after surgery for breast cancer could help healthcare professionals accurately identify patients at risk of return to work-related difficulties in order to provide them with appropriate support during breast cancer management.OBJECTIVE: The aim of this study was to identify factors related to return to work in breast cancer patients three months after axillary lymph node dissection.METHODS: Seventy-three women who were working before the surgery were evaluated. Age, body mass...
Source: Work - September 13, 2021 Category: Occupational Health Authors: Yoshiteru Akezaki Eiji Nakata Masato Kikuuchi Ritsuko Tominaga Hideaki Kurokawa Makiko Hamada Kenjiro Aogi Shozo Ohsumi Shinsuke Sugihara Source Type: research

Can belly dance and mat Pilates be effective for range of motion, self-esteem, and depressive symptoms of breast cancer women?
CONCLUSION: Belly dance and the Mat Pilates can bring positive results in the range of movement of women undergoing adjuvant treatment of breast cancer, with the Pilates method being the one that most contributed to improvements in this variable.PMID:34517217 | DOI:10.1016/j.ctcp.2021.101483 (Source: Complementary Therapies in Clinical Practice)
Source: Complementary Therapies in Clinical Practice - September 13, 2021 Category: Complementary Medicine Authors: Bruna Leite Tatiana de Bem Fretta Leonessa Boing Adriana Coutinho de Azevedo Guimar ães Source Type: research

Associations Between Hyperphagia, Symptoms of Sleep Breathing Disorder, Behaviour Difficulties and Caregiver Well-Being in Prader-Willi Syndrome: A Preliminary Study
This study used data collected in the Australasian PWS Registry (n = 50, mean age 11.2 years) to evaluate associations between child behaviours and caregiver mental well-being. Symptoms of sleep-related breathing disorder, child depression and social difficulties were associated with poorer caregiver mental and physical well-being. Growth hormone therapy use was associated with better caregiver mental and physical well-being. Optimising management of problematic behaviours and sleep disturbances have the potential to support caregivers who are the most vital network of support for individuals affected by PWS.PMID:34498151 ...
Source: Journal of Autism and Developmental Disorders - September 9, 2021 Category: Psychiatry Authors: Jessica Mackay Gillian M Nixon Antony R Lafferty Geoff Ambler Nitin Kapur Philip B Bergman Cara Schofield Chris Seton Andrew Tai Elaine Tham Komal Vora Patricia Crock Charles Verge Yassmin Musthaffa Greg Blecher Daan Caudri Helen Leonard Peter Jacoby Andr Source Type: research

Associations Between Hyperphagia, Symptoms of Sleep Breathing Disorder, Behaviour Difficulties and Caregiver Well-Being in Prader-Willi Syndrome: A Preliminary Study
This study used data collected in the Australasian PWS Registry (n = 50, mean age 11.2 years) to evaluate associations between child behaviours and caregiver mental well-being. Symptoms of sleep-related breathing disorder, child depression and social difficulties were associated with poorer caregiver mental and physical well-being. Growth hormone therapy use was associated with better caregiver mental and physical well-being. Optimising management of problematic behaviours and sleep disturbances have the potential to support caregivers who are the most vital network of support for individuals affected by PWS.PMID:34498151 ...
Source: Journal of Autism and Developmental Disorders - September 9, 2021 Category: Psychiatry Authors: Jessica Mackay Gillian M Nixon Antony R Lafferty Geoff Ambler Nitin Kapur Philip B Bergman Cara Schofield Chris Seton Andrew Tai Elaine Tham Komal Vora Patricia Crock Charles Verge Yassmin Musthaffa Greg Blecher Daan Caudri Helen Leonard Peter Jacoby Andr Source Type: research

Cancers, Vol. 13, Pages 4502: Potential of Bioactive Food Components against Gastric Cancer: Insights into Molecular Mechanism and Therapeutic Targets
Ko Bonglee Kim Gastric cancer, also known as stomach cancer, is a cancer that develops from the lining of the stomach. Accumulated evidence and epidemiological studies have indicated that bioactive food components from natural products play an important role in gastric cancer prevention and treatment, although its mechanism of action has not yet been elucidated. Particularly, experimental studies have shown that natural bioactive food products display a protective effect against gastric cancer via numerous molecular mechanisms, such as suppression of cell metastasis, anti-angiogenesis, inhibition of cell proliferati...
Source: Cancers - September 7, 2021 Category: Cancer & Oncology Authors: Seog Young Kang Dongwon Hwang Soyoung Shin Jinju Park Myoungchan Kim MD. Hasanur Rahman Md. Ataur Rahman Seong-Gyu Ko Bonglee Kim Tags: Review Source Type: research

Unresectable bulky chest wall recurrent breast cancer controlled with CT-guided interstitial high-dose-rate brachytherapy and external beam radiotherapy with adjuvant hormonal therapy - case report
CONCLUSIONS: CT-guided HDR ISBT boost can be a useful modality in individualizing treatment strategies for breast cancer patients with unresectable bulky chest wall recurrence.PMID:34484361 | PMC:PMC8407259 | DOI:10.5114/jcb.2021.108600 (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - September 6, 2021 Category: Cancer & Oncology Authors: Hiroaki Kunogi I-Chow Hsu Keisuke Sasai Source Type: research

Use of oral estradiol plus vaginal progesterone in healthy postmenopausal women
Data strongly suggest that estrogen replacement therapy is associated with beneficial effects on cardiovascular disease (CVD) when initiated within 10 years of the menopause [1, 2]. Growing evidence for the timing hypothesis supports the effects of postmenopausal estrogen therapy on atherosclerosis and CVD depending on the timing of the initiation of hormone therapy (HT) relative to menopause, age, or both [3-5]. Estrogen hormone replacement most effectively slows atherosclerosis when underlying vascular tissue is healthy and maintains up-regulated estrogen receptors [5-8]. (Source: Maturitas)
Source: Maturitas - September 5, 2021 Category: Primary Care Authors: Intira Sriprasert, Melissa Mert, Wendy J. Mack, Howard N. Hodis, Donna Shoupe Source Type: research

Climacteric symptoms more severe in 2010 than in 2000 – experience of Finnish women aged 52-56 years not now or previously on menopausal hormone therapy
The intensity and prevalence of climacteric symptoms at different stages of menopause have been examined in several epidemiological and healthcare studies [1-4]. Most menopausal women have climacteric symptoms, such as sweating and hot flushes or sleeping problems, but some women experience only mild symptoms, whereas others experience moderate or severe symptoms [1,4-6]. There is still limited knowledge on whether the experience of climacteric symptoms differs across birth cohorts, i.e., if the experience of climacteric symptoms differs between generations of women. (Source: Maturitas)
Source: Maturitas - September 5, 2021 Category: Primary Care Authors: Maija Lipasti, Jaana Jalava-Broman, Lauri Sillanm äki, Juha Mäkinen, Päivi Rautava Source Type: research

Clinical Reports Adult acampomelic campomelic dysplasia and disorders of sex development due to a reciprocal translocation involving chromosome 17q24.3 upstream of the SOX9 gene
We report on a female patient with a reciprocal translocation of t(11; 17) (p15.4; q24.3), who was diagnosed with acampomelic campomelic dysplasia. The 34-year-old Japanese patient presented with distinct skeletal abnormalities, profound intellectual disability, and female phenotype despite the presence of Y chromosome and the sex determining region Y (SRY) gene. Her menarche started at 33 years and 4 months after hormone therapy of estrogen therapy followed by estrogen progesterone therapy. By conducting whole genome sequencing followed by Sanger sequencing validation, we determined the precise breakpoint positions of the...
Source: European Journal of Medical Genetics - September 4, 2021 Category: Genetics & Stem Cells Authors: Takako Takano Hideomi Ota Hajime Ohishi Kenichiro Hata Rieko Furukawa Kazuhiko Nakabayashi Source Type: research

Successful Treatment with Hepatic Arterial Infusion Chemotherapy in a Breast Cancer Patient with Multiple Liver Metastases Who Declined Systemic Therapy
We describe a MBC patient with predominant LMs treated with hepatic arterial infusion chemotherapy (HAIC) who declined ST. Moreover, we assessed general health status during treatment using C-reactive protein (CRP)/albumin ratio (CAR) and peripheral platelet count × CRP multiplier (P-CRP), well-known indicators of systemic inflammatory response. A 64-year-old woman who underwent a total mastectomy with axillary lymph node dissection for an HR-positive, HER2-negative infiltrating ductal BC developed multiple liver, lung, lymph node, and bone metastases. She r eceived ST including paclitaxel plus the anti-vascular endo...
Source: Case Reports in Oncology - September 3, 2021 Category: Cancer & Oncology Source Type: research

Health-related needs and barriers in transgender populations: a systematic review study
In this study, health-related needs and barriers to satisfy them were categorized from the viewpoint of TG populations and health policymakers around the world, which may influence future decisions to provide services to TG populations. The results of this systematic review can help to develop different strategies by considering all TGs from individual, family and social aspects to better provide services for this group. However, given the dynamics and changes in the existing communities and the limited studies on gender minorities in developing countries, further research is required to comprehensively address the subject...
Source: International Journal of Human Rights in Healthcare - September 3, 2021 Category: International Medicine & Public Health Authors: Yousef Moradi Marzieh Mahboobi Ghobad Moradi Source Type: research

Validating Data-Driven Methods for Identifying Transgender Individuals in the Veterans Health Administration of the US Department of Veterans Affairs
Am J Epidemiol. 2021 Sep 1;190(9):1928-1934. doi: 10.1093/aje/kwab102.ABSTRACTWe sought to operationalize and validate data-driven approaches for identifying transgender individuals in the Veterans Health Administration (VHA) of the US Department of Veterans Affairs (VA) through a retrospective analysis using VA administrative data from 2006-2018. Besides diagnoses of gender identity disorder (GID), a combination of non-GID data elements was used to identify potentially transgender veterans, including 1) an International Classification of Diseases (Ninth or Tenth Revision) code of endocrine disorder, unspecified or not oth...
Source: Am J Epidemiol - September 1, 2021 Category: Epidemiology Authors: Hill L Wolfe Joel I Reisman Samuel S Yoon John R Blosnich Jillian C Shipherd Varsha G Vimalananda Sowmya R Rao Leila Hashemi Dan Berlowitz Michael Goodman Nicholas A Livingston Scott G Reece Guneet K Jasuja Source Type: research

Validating Data-Driven Methods for Identifying Transgender Individuals in the Veterans Health Administration of the US Department of Veterans Affairs
Am J Epidemiol. 2021 Sep 1;190(9):1928-1934. doi: 10.1093/aje/kwab102.ABSTRACTWe sought to operationalize and validate data-driven approaches for identifying transgender individuals in the Veterans Health Administration (VHA) of the US Department of Veterans Affairs (VA) through a retrospective analysis using VA administrative data from 2006-2018. Besides diagnoses of gender identity disorder (GID), a combination of non-GID data elements was used to identify potentially transgender veterans, including 1) an International Classification of Diseases (Ninth or Tenth Revision) code of endocrine disorder, unspecified or not oth...
Source: Am J Epidemiol - September 1, 2021 Category: Epidemiology Authors: Hill L Wolfe Joel I Reisman Samuel S Yoon John R Blosnich Jillian C Shipherd Varsha G Vimalananda Sowmya R Rao Leila Hashemi Dan Berlowitz Michael Goodman Nicholas A Livingston Scott G Reece Guneet K Jasuja Source Type: research

Ovarian, breast, and metabolic changes induced by androgen treatment in transgender men
Gender-affirming hormone therapy (GAHT) is often provided to transgender people. In this review of the literature, the current knowledge of ovarian, breast, and metabolic changes (body composition, insulin resistance, bone density, cardiovascular risk factors such as lipids, blood pressure, and hematocrit) observed following GAHT in adult transgender men is discussed.A body of literature concurs to describe that long-term androgen therapy in transgender men exerts atrophic effects on the breast. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2021 Category: Reproduction Medicine Authors: Paul Pirtea, Jean Marc Ayoubi, Stephanie Desmedt, Guy T ’Sjoen Tags: Views and reviews Source Type: research

Cell-free DNA comparative analysis of the genomic landscape of first-line hormone receptor-positive metastatic breast cancer from the US and China
ConclusionThe differential prevalence of ctDNA-based alterations such asFGFR1,AKT1, andCDH1 was observed in initially HR+/HER2 − MBC patients in the US vs. CN. In addition, the association ofPTEN deletions with shorter PFS was found in the CN but not the US cohort. The differential genomic landscapes across the two ethnic groups may reflect biologic differences and clinical implications. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 1, 2021 Category: Cancer & Oncology Source Type: research

Fifteen-Year Experience with the Ghent Technique of Penile Inversion Vaginoplasty
Conclusions: Vaginoplasty is possible in all trans women, with most patients being able to engage in penetrative intercourse and reach an orgasm. To reach the desired depth of 14 cm, the neovaginal vault is usually lined with full-thickness skin grafts from the scrotum and/or abdomen. Diabetes was the only independent risk factor for revision surgery. Rectal tears are a rare complication and can usually be managed conservatively. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV. (Source: Plastic and Reconstructive Surgery)
Source: Plastic and Reconstructive Surgery - August 31, 2021 Category: Cosmetic Surgery Tags: Reconstructive: Trunk: Original Articles Source Type: research

Cancers, Vol. 13, Pages 4375: Targeting Amino Acid Metabolic Reprogramming via L-Type Amino Acid Transporter 1 (LAT1) for Endocrine-Resistant Breast Cancer
Takanori Ishida Hironobu Sasano The PI3K/Akt/mTOR pathway has been well known to interact with the estrogen receptor (ER)-pathway and to be also frequently upregulated in aromatase inhibitor (AI)-resistant breast cancer patients. Intracellular levels of free amino acids, especially leucine, regulate the mammalian target of rapamycin complex 1 (mTORC1) activation. L-type amino acid transporters such as LAT1 and LAT3 are associated with the uptake of essential amino acids. LAT1 expression could mediate leucine uptake, mTORC1 signaling, and cell proliferation. Therefore, in this study, we explored amino acid metabolism,...
Source: Cancers - August 30, 2021 Category: Cancer & Oncology Authors: Haruhiko Shindo Narumi Harada-Shoji Akiko Ebata Miku Sato Tomoyoshi Soga Minoru Miyashita Hiroshi Tada Masaaki Kawai Shinkichi Kosaka Koji Onuki Shin Usami Shozo Furumoto Shinichi Hayashi Takaaki Abe Takashi Suzuki Takanori Ishida Hironobu Sasano Tags: Article Source Type: research

Breast imaging in transgender women: a review
Clin Imaging. 2021 Aug 9;80:283-289. doi: 10.1016/j.clinimag.2021.07.031. Online ahead of print.ABSTRACTTransgender women are increasingly evaluated in breast imaging centers. Radiologists should be familiar with a range of imaging findings related to feminizing hormone therapy and breast augmentations as well as benign and malignant lesions seen in this population. A growing body of literature has suggested that feminizing hormone therapy may increase the risk of breast cancer, prompting professional organizations to develop screening guidelines. The aim of this paper is to review common breast imaging findings in transge...
Source: Clinical Genitourinary Cancer - August 29, 2021 Category: Cancer & Oncology Authors: Thomas Lienhoop Lauren Green Source Type: research