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What is the cause of central cyanosis in Osler-Weber-Rendu syndrome?
Central cyanosis in Osler-Weber-Rendu syndrome is due to pulmonary arteriovenous fistula. Those with Osler-Weber-Rendu syndrome or hereditary hemorrhagic telangiectasia have multiple capillary hemangiomas on skin, lips, mucosa of nose, upper and lower respiratory tract and gastrointestinal tract. Central cyanosis can occur when there are multiple pulmonary arteriovenous fistulae with significant right to left shunt allowing desaturated blood to reach the systemic circulation. (Source: Cardiophile MD)
Source: Cardiophile MD - November 5, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

TXA a Late Bloomer in Bleeding Management
Tranexamic acid (TXA) was invented by a Japanese husband-and-wife research team in the 1960s. Years earlier, this same research team had discovered epsilon-aminocaproic acid, a derivative and an analogue of the amino acid lysine. In their search for a more potent antifibrinolytic agent, they discovered tranexamic acid, a synthetic analog of the amino acid lysine. Tranexamic acid is eight to 10 times more powerful than epsilon-aminocaproic acid.The antifibrinolytic actions of TXA result from the binding of four or five lysine receptor sites on plasminogen. This binding prevents plasmin from binding to and degrading fibri...
Source: M2E Too! Mellick's Multimedia EduBlog - February 1, 2019 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs

Rare Cancer are Subsets of Common Cancers
In June, 2014, my book, entitled Rare Diseases and Orphan Drugs: Keys to Understanding and Treating the Common Diseases was published by Elsevier. The book builds the argument that our best chance of curing the common diseases will come from studying and curing the rare diseases. One of the key ideas developed in the book is that each common diseases is actually an aggregate of cellular processes that are present, individually, in rare diseases. In the case of the common cancers, we can find specific rare diseases that are subsets of the common diseases. Here is an excerpt from Chapter 8: 8.3.3 Inherited syndromes that...
Source: Specified Life - July 9, 2014 Category: Pathologists Tags: cancer syndromes carcinogenesis common cancers common disease familial cancer syndromes genetic disease orphan disease orphan drugs rare cancers rare disease Source Type: blogs