Structure characterization and protective effect against UVB irradiation of polysaccharides isolated from the plateau plant Gentiana dahurica Fisch
Int J Biol Macromol. 2024 Apr 13:131551. doi: 10.1016/j.ijbiomac.2024.131551. Online ahead of print.ABSTRACTGentiana dahurica Fisch. (G. dahurica) is one of the legitimate sources of Qinjiao in Traditional Chinese Medicine (TCM) and grows on high-altitude plateaus. Plants develop unique biochemical accumulations to resist plateau conditions, especially the strong UV irradiation. Thus, this study aimed to investigate the polysaccharide of G. dahurica (GDP), its structure and its activity against UVB irradiation. Four GDPs were isolated and two of them were subjected to structural elucidation. The results suggested that GDP-...
Source: International Journal of Biological Macromolecules - April 15, 2024 Category: Biochemistry Authors: Wen Ji Cuiyin Qian Xiaopeng Su Xiang Li Zhenqing Zhang Yonggui Ma Mingjin Zhang Duxin Li Source Type: research
Molecules, Vol. 29, Pages 1793: Saponins of Paris polyphylla for the Improvement of Acne: Anti-Inflammatory, Antibacterial, Antioxidant and Immunomodulatory Effects
g
Quan An
Acne is a chronic inflammatory skin disease with a recurring nature that seriously impacts patients’ quality of life. Currently, antibiotic resistance has made it less effective in treating acne. However, Paris polyphylla (P. polyphylla) is a valuable medicinal plant with a wide range of chemical components. Of these, P. polyphylla saponins modulate the effects in vivo and in vitro through antibacterial, anti-inflammatory, immunomodulatory, and antioxidant effects. Acne is primarily associated with inflammatory reactions, abnormal sebum function, micro-ecological disorders, hair follicle hyper...
Source: Molecules - April 15, 2024 Category: Chemistry Authors: Luyao Li Jiachan Zhang Wenjing Cheng Feiqian Di Changtao Wang Quan An Tags: Review Source Type: research
Molecules, Vol. 29, Pages 1791: Obacunone, a Promising Phytochemical Triterpenoid: Research Progress on Its Pharmacological Activity and Mechanism
e Wang
Rong Shi
Obacunone, a natural triterpenoid, is an active component of the herbs Dictamnus dasycarpus Turcz. and Phellodendron amurense Rupr, and an indicator of the herbs’ quality. Owing to its multiple health benefits, several studies have investigated the multi-targeting potential action mechanisms of obacunone. To summarize recent developments on the pharmacological actions of obacunone and focus on the underlying molecular mechanisms and signaling networks, we searched PubMed, Europe PMC, Wiley Online Library, Web of Science, Google Scholar, Wanfang Medical Network, and China National Knowled...
Source: Molecules - April 15, 2024 Category: Chemistry Authors: Yuyang Zhou Jifeng Gu Jiahui Li Huishan Zhang Mei Wang Yuanyuan Li Tianming Wang Jiajie Wang Rong Shi Tags: Review Source Type: research
Metabolomic profiling of wild rooibos (Aspalathus linearis) ecotypes and their antioxidant-derived phytopharmaceutical potential
AbstractIntroductionAspalathus linearis (commonly known as rooibos) is endemic to the Cape Floristic Region of South Africa and is a popular herbal drink and skin phytotherapeutic ingredient, with health benefits derived primarily from its unique phenolic content. Several, seemingly habitat-specific ecotypes from the Cederberg (Western Cape) and Northern Cape have morphological, ecological, genetic and biochemical differences.Objectives and methodsDespite the commercial popularity of the cultivated variety, the uncultivated ecotypes are largely understudied. To address gaps in knowledge about the biochemical constituency, ...
Source: Metabolomics - April 14, 2024 Category: Biology Source Type: research
Integrated analyses for identification of a three-gene signature associated with Chaihu Shugan San formula for hepatocellular carcinoma treatment
In conclusion, CSS may regulate the activity of immune-related factors in the tumour microenvironment, reverse immune escape, enhance immune responses through AKT1, MAPK3, and CASP3, and synergistically alleviate HCC. The co-administration of sorafenib with CSS has a strong clinical outlook against HCC.PMID:38613352 | PMC:PMC11015397 | DOI:10.1111/jcmm.18211 (Source: Molecular Medicine)
Source: Molecular Medicine - April 13, 2024 Category: Molecular Biology Authors: Jia-Heng Xing Ru-Xue Tan Fei-Er Huang Nan Tian Source Type: research
Irpexols A-C, xanthone derivatives from the endophyte fungus Irpex laceratus A878
Fitoterapia. 2024 Apr 11:105952. doi: 10.1016/j.fitote.2024.105952. Online ahead of print.ABSTRACTThree new xanthone derivatives irpexols A-C (1-3) and five known xanthones including three dimeric ones were successfully isolated from Irpex laceratus A878, an endophytic fungus of the family Irpicaceae from the medicinal plant Pogostemon cablin (Blanco) Bentham (Lamiaceae). The structures of these compounds were elucidated by extensive spectroscopic analyses includingultraviolet-visible spectroscopy (UV), infrared spectroscopy (IR), mass spectrometry (MS), and nuclear magnetic resonance (NMR). All of the three new compounds ...
Source: Fitoterapia - April 13, 2024 Category: Biochemistry Authors: Yuchan Chen Nuoyi Wang Weipeng Ma Wei Gu Zihuan Sang Haibo Tan Weimin Zhang Hongxin Liu Source Type: research
Integrated analyses for identification of a three-gene signature associated with Chaihu Shugan San formula for hepatocellular carcinoma treatment
In conclusion, CSS may regulate the activity of immune-related factors in the tumour microenvironment, reverse immune escape, enhance immune responses through AKT1, MAPK3, and CASP3, and synergistically alleviate HCC. The co-administration of sorafenib with CSS has a strong clinical outlook against HCC.PMID:38613352 | PMC:PMC11015397 | DOI:10.1111/jcmm.18211 (Source: Molecular Medicine)
Source: Molecular Medicine - April 13, 2024 Category: Molecular Biology Authors: Jia-Heng Xing Ru-Xue Tan Fei-Er Huang Nan Tian Source Type: research
Thymol Enhances 5-Fluorouracil Cytotoxicity by Reducing Migration and Increasing Apoptosis and Cell Cycle Arrest in Esophageal Cancer Cells: An In-vitro Study
AbstractEsophageal cancer (EC) is a common cancer globally and has a low survival rate because it is often diagnosed at a late-stage, and is frequently chemotherapy resistant. Thymol is found in the herb thyme and has been reported to have potential anticancer properties. We aimed to explore the effects of thymol on the efficacy of 5-Fluorouracil (5-FU) treatment in an in vitro model of EC. We evaluated the synergistic effects of thymol with 5-FU using cell viability, apoptosis, cell cycle analysis, scratch wound healing assay, gelatin zymography, as well as reactive oxygen species (ROS) generation aproaches. The results...
Source: Indian Journal of Clinical Biochemistry - April 13, 2024 Category: Biochemistry Source Type: research
Pararorine A, isoindolinone alkaloid from the endophytic fungus Paramyrothecium roridum and its anti-tumor activity
Fitoterapia. 2024 Apr 10;175:105931. doi: 10.1016/j.fitote.2024.105931. Online ahead of print.ABSTRACTPararorine A, a new isoindolinone alkaloid was isolated from Paramyrothecium roridum, an endophytic fungus from the medicinal plant Gynochthodes officinalis (F.C. How) Razafim. & B. Bremer. The structure of this compound was elucidated by extensive spectroscopic (UV, IR, MS, and NMR) analyses. In addition, the antitumor activity of pararorine A was evaluated against SF-268, MCF-7, HepG2, and A549 tumor cell lines. The results revealed that pararorine A exhibited potent antitumor activities with the IC50 values ranging ...
Source: Fitoterapia - April 12, 2024 Category: Biochemistry Authors: Yuchan Chen Hongxin Liu Nuoyi Wang Haibo Tan Weimin Zhang Source Type: research
Merging total synthesis and NMR technology for deciphering the realistic structure of natural 2,6-dideoxyglycosides
Sci Adv. 2024 Apr 12;10(15):eadn1305. doi: 10.1126/sciadv.adn1305. Epub 2024 Apr 12.ABSTRACTThe structural identification and efficient synthesis of bioactive 2,6-dideoxyglycosides are daunting challenges. Here, we report the total synthesis and structural revision of a series of 2,6-dideoxyglycosides from folk medicinal plants Ecdysanthera rosea and Chonemorpha megacalyx, which feature pregnane steroidal aglycones bearing an 18,20-lactone and glycans consisting of 2,6-dideoxy-3-O-methyl-β-pyranose residues, including ecdysosides A, B, and F and ecdysantheroside A. All the eight possible 2,6-dideoxy-3-O-methyl-β-pyranosi...
Source: Adv Data - April 12, 2024 Category: Epidemiology Authors: Zhaolun Zhang Renjie Wu Shen Cao Jiaji Li Guangen Huang Haoyu Wang Tao Yang Wei Tang Peng Xu Biao Yu Source Type: research
Enhanced Sun Protection Factor Of Octocrylene With Green Tea And Bhringraj Extracts
Cutan Ocul Toxicol. 2024 Apr 12:1-27. doi: 10.1080/15569527.2024.2340440. Online ahead of print.ABSTRACTThe overexposure of human skin to ultraviolet radiation (UVR) can trigger photodamage, UV burn, pigmentation, erythema, and enhance the chance of dermal carcinoma. UVR causes DNA damage, leading to dermal cancer. Daily sunscreen application protects the skin from the adverse effects of sun rays, particularly UVB (290-320 nm) and UVA (320-400 nm). The ozone layer filters UVC (200-290 nm) radiation upon entry into the Earth's atmosphere. UVB causes sunburn, photo damage, and induces mutagenic changes in nucleic acids. UVA ...
Source: Cutaneous and Ocular Toxicology - April 12, 2024 Category: Toxicology Authors: Pasupathi M Natarajan B Kumar T Source Type: research
A Review on Protease Inhibitors of Herbal Origin to Combat Malignancy
J Environ Pathol Toxicol Oncol. 2024;43(3):1-11. doi: 10.1615/JEnvironPatholToxicolOncol.2024052872.ABSTRACTProtease is the enzyme accountable for the breakdown of proteins i.e., proteolysis. Proteases are reportedly involved in the events of growth, development, progression and metastasis of cancers. If any agent could inhibit/retard the protease enzyme, i.e., protease inhibitor, it would arrest the cancer; thus indicating the significance of exploring protease inhibitors for latest anti-malignant drug discovery. Higher plants are the rich sources of different protease inhibitors that are effective against several types o...
Source: Journal of Environmental Pathology, Toxicology and Oncology - April 12, 2024 Category: Environmental Health Authors: Sanjib Bhattacharya Source Type: research
Investigations of Limeum indicum Plant for Diabetes Mellitus and Alzheimer's disease Dual Therapy: Phytochemical, GC-MS Chemical Profiling, Enzyme Inhibition, Molecular Docking and In-vivo Studies
Chem Biodivers. 2024 Apr 12:e202301858. doi: 10.1002/cbdv.202301858. Online ahead of print.ABSTRACTLimeum indicum has been widely utilized in traditional medicine but no experimental work has been done on this herb. The primary objective of this study was to conduct a phytochemical analysis and assess the multifunctional capabilities of aforementioned plant in dual therapy for Alzheimer's disease (AD) and Type 2 diabetes (T2D). The phytochemical screening of ethanol, methanol extract, and their derived fractions of Limeum indicum was conducted using GC-MS, HPLC, UV-analysis and FTIR. The antioxidant capacity was evaluated ...
Source: Chemistry and Biodiversity - April 12, 2024 Category: Biochemistry Authors: Tahira Shamim Hafiz Muhammad Asif Syeda Abida Ejaz Zahid Hussain Tanveer A Wani Laila Sumreen Muhammad Abdullah Zubair Ahmed Jamshed Iqbal Song Ja Kim Muhammad Kamal Shah Source Type: research
Merging total synthesis and NMR technology for deciphering the realistic structure of natural 2,6-dideoxyglycosides
Sci Adv. 2024 Apr 12;10(15):eadn1305. doi: 10.1126/sciadv.adn1305. Epub 2024 Apr 12.ABSTRACTThe structural identification and efficient synthesis of bioactive 2,6-dideoxyglycosides are daunting challenges. Here, we report the total synthesis and structural revision of a series of 2,6-dideoxyglycosides from folk medicinal plants Ecdysanthera rosea and Chonemorpha megacalyx, which feature pregnane steroidal aglycones bearing an 18,20-lactone and glycans consisting of 2,6-dideoxy-3-O-methyl-β-pyranose residues, including ecdysosides A, B, and F and ecdysantheroside A. All the eight possible 2,6-dideoxy-3-O-methyl-β-pyranosi...
Source: Adv Data - April 12, 2024 Category: Epidemiology Authors: Zhaolun Zhang Renjie Wu Shen Cao Jiaji Li Guangen Huang Haoyu Wang Tao Yang Wei Tang Peng Xu Biao Yu Source Type: research
Research status and challenges of plant-derived exosome-like nanoparticles
Biomed Pharmacother. 2024 Apr 11;174:116543. doi: 10.1016/j.biopha.2024.116543. Online ahead of print.ABSTRACTIn recent years, there has been an increasing number of related studies on exosomes. Most studies have focused on exosomes derived from mammals, confirming the important role that exosomes play in cell communication. Plants, as a natural ingredient, plant-derived exosomes have been confirmed to have similar structures and functions to mammalian-derived exosomes. Plant-derived exosome-like nanoparticles (PELNs) are lipid bilayer membrane nanovesicles containing bioactive constituents such as miRNA, mRNA, protein, an...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 12, 2024 Category: Drugs & Pharmacology Authors: Chunmei Bai Jianrong Liu Xumin Zhang Yang Li Qin Qin Haixia Song Caixia Yuan Ziwei Huang Source Type: research
