Novel oral selective estrogen receptor degraders (SERDs) to target hormone receptor positive breast cancer: Elacestrant as the poster-child
Expert Rev Anticancer Ther. 2024 Apr 20. doi: 10.1080/14737140.2024.2346188. Online ahead of print.ABSTRACTINTRODUCTION: Estrogen receptor positive (ER+) breast cancer is the most common breast cancer subtype, and therapeutic management relies primarily on inhibiting ER signaling. In the metastatic setting, ER signaling is typically targeted by selective estrogen receptor degraders (SERDs) or aromatase inhibitors (AIs), the latter of which prevent estrogen production. Activating ESR1 mutations are among the most common emergent breast cancer mutations and confer resistance to AIs.AREAS COVERED: Until 2023, fulvestrant was ...
Source: Expert Review of Anticancer Therapy - April 20, 2024 Category: Cancer & Oncology Authors: Jennifer C Keenan Arielle J Medford Charles S Dai Seth A Wander Laura M Spring Aditya Bardia Source Type: research
Survival outcomes in HER2-low versus HER2-zero breast cancer after neoadjuvant chemotherapy: a meta-analysis
The survival outcomes in HER2-low versus HER2-zero breast cancer (BC) after neoadjuvant chemotherapy (NACT) remain unclear. The meta-analysis was conducted to summarize current evidence about the survival outc... (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - April 20, 2024 Category: Cancer & Oncology Authors: Lin-Yu Xia, Xu-Chen Cao and Yue Yu Tags: Research Source Type: research
Survival outcomes for women with a solitary extracranial metastasis from breast cancer
CONCLUSION: Among patients with a solitary extracranial metastasis from breast cancer, TNBC was associated with the poorest OS and DPFS rates. Identification of other significant prognostic factors for oligometastatic breast cancer patients may inform guidelines for metastasis directed treatments.PMID:38640551 | DOI:10.1016/j.breast.2024.103730 (Source: Breast)
Source: Breast - April 19, 2024 Category: Cancer & Oncology Authors: Patrick Dyer Jing Xie Phillip K Tran Keelan Byrne Source Type: research
Survival outcomes for women with a solitary extracranial metastasis from breast cancer
CONCLUSION: Among patients with a solitary extracranial metastasis from breast cancer, TNBC was associated with the poorest OS and DPFS rates. Identification of other significant prognostic factors for oligometastatic breast cancer patients may inform guidelines for metastasis directed treatments.PMID:38640551 | PMC:PMC11035361 | DOI:10.1016/j.breast.2024.103730 (Source: Breast)
Source: Breast - April 19, 2024 Category: Cancer & Oncology Authors: Patrick Dyer Jing Xie Phillip K Tran Keelan Byrne Source Type: research
Distribution of PD-L1, TROP2 and HER2- “lowness” in early triple-negative breast cancer: an opportunity for treatment de-escalation
ConclusionsEarly HER2-low, PD-L1-positive TNBC patients have a very good prognosis, particularly if treated with anthracycline/taxane- or carboplatin-containing regimes. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 19, 2024 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 16, Pages 1572: The Genomic, Transcriptomic, and Immunologic Landscape of HRAS Mutations in Solid Tumors
In conclusion, this study provides new insights into the unique molecular profiles of HRASmt tumors that may help to identify new targets and guide future clinical trial design. (Source: Cancers)
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Samuel A. Kareff Asaad Trabolsi Harris B. Krause Timothy Samec Andrew Elliott Estelamari Rodriguez Coral Olazagasti Dionysios C. Watson Matias A. Bustos Dave S. B. Hoon Stephanie L. Graff Emmanuel S. Antonarakis Sanjay Goel George Sledge Gilberto Lopes Tags: Article Source Type: research
SLC35A2 expression is associated with HER2 expression in breast cancer
This study aimed to investigate the expression of SLC35A2 and clinicopathological variables in breast cancer patients. Immunohistochemical analysis of SLC35A2 protein was conductedon 40 adjacent non-neoplastic tissues and 320 breast cancer tissues. The study also assesed the association between SLC35A2 expression and breast cancer clinicopathological features of breast cancer, as well as its impact on overall survival. In comparison to adjacent non-neoplastic tissues, a significantly higher expression of SLC35A2 was observed in breast cancer tissues (P = 0.020), and this expression was found to be independently correla...
Source: Hormones and Cancer - April 19, 2024 Category: Cancer & Oncology Source Type: research
Inflammatory breast cancer: Epidemiologic data and therapeutic results
In this study, we reviewed the literature using the Surveillance, Epidemiology, and End Results (SEER) database compared to other published series. We observed that in the high incidence areas (North of Africa) when compared to "classical" breast cancer, IBC was associated to younger age (less than 50 years) with rapid evolution of signs and symptoms (in less than 3 up to 6 months), and more aggressive clinical and histopathological-molecular parameters, due to the predominance of triple-negative and HER2+ subtypes in around 60% of cases. An epidemiologic trend was observed in both high and low incidence areas since the ei...
Source: Mol Biol Cell - April 18, 2024 Category: Molecular Biology Authors: Hamouda Boussen Yosra Berrazaga None Sherif Kullab Maroua Manai Narjess Berrada Nesrine Mejri Ismail Siala Paul H Levine Massimo Cristofanilli Source Type: research
Inflammatory breast cancer: An overview about the histo-pathological aspect and diagnosis
Int Rev Cell Mol Biol. 2024;384:47-61. doi: 10.1016/bs.ircmb.2024.02.001. Epub 2024 Mar 29.ABSTRACTInflammatory Breast Cancer (IBC) is a rare and aggressive form of locally advanced breast cancer, classified as stage T4d according to the tumor-node-metastasis staging criteria. This subtype of breast cancer is known for its rapid progression and significantly lower survival rates compared to other forms of breast cancer. Despite its distinctive clinical features outlined by the World Health Organization, the histopathological characteristics of IBC remain not fully elucidated, presenting challenges in its diagnosis and trea...
Source: Mol Biol Cell - April 18, 2024 Category: Molecular Biology Authors: Ghada Sahraoui Nabil Rahoui Maha Driss Karima Mrad Source Type: research
Association Between < sup > 18 < /sup > F-FDG PET Activity and HER2 Status in Breast Cancer Brain Metastases
CONCLUSION: The SUVmax ratio may help to identify the HER2 status of breast cancer brain metastases, if validated prospectively.PMID:38633284 | PMC:PMC11018722 | DOI:10.1007/s13139-024-00843-8 (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Jonathan R Young Julie A Ressler Joanne E Mortimer Daniel Schmolze Mariko Fitzgibbons Bihong T Chen Source Type: research
Inflammatory breast cancer: An overview about the histo-pathological aspect and diagnosis
Int Rev Cell Mol Biol. 2024;384:47-61. doi: 10.1016/bs.ircmb.2024.02.001. Epub 2024 Mar 29.ABSTRACTInflammatory Breast Cancer (IBC) is a rare and aggressive form of locally advanced breast cancer, classified as stage T4d according to the tumor-node-metastasis staging criteria. This subtype of breast cancer is known for its rapid progression and significantly lower survival rates compared to other forms of breast cancer. Despite its distinctive clinical features outlined by the World Health Organization, the histopathological characteristics of IBC remain not fully elucidated, presenting challenges in its diagnosis and trea...
Source: International Review of Cell and Molecular Biology - April 18, 2024 Category: Cytology Authors: Ghada Sahraoui Nabil Rahoui Maha Driss Karima Mrad Source Type: research
Inflammatory breast cancer: Epidemiologic data and therapeutic results
In this study, we reviewed the literature using the Surveillance, Epidemiology, and End Results (SEER) database compared to other published series. We observed that in the high incidence areas (North of Africa) when compared to "classical" breast cancer, IBC was associated to younger age (less than 50 years) with rapid evolution of signs and symptoms (in less than 3 up to 6 months), and more aggressive clinical and histopathological-molecular parameters, due to the predominance of triple-negative and HER2+ subtypes in around 60% of cases. An epidemiologic trend was observed in both high and low incidence areas since the ei...
Source: International Review of Cell and Molecular Biology - April 18, 2024 Category: Cytology Authors: Hamouda Boussen Yosra Berrazaga None Sherif Kullab Maroua Manai Narjess Berrada Nesrine Mejri Ismail Siala Paul H Levine Massimo Cristofanilli Source Type: research
Methodology for Using Real-World Data From Electronic Health Records to Assess Chemotherapy Administration in Women With Breast Cancer
CONCLUSION: We describe the challenges and approaches to operationalize complex, real-world data to identify intended chemotherapy regimens in large, observational studies. This methodology can improve efficiency of use of large-scale clinical data in real-world populations, helping answer critical questions to improve care delivery and patient outcomes.PMID:38635936 | DOI:10.1200/CCI.23.00209 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 18, 2024 Category: Cancer & Oncology Authors: Jenna Bhimani Kelli O'Connell Isaac J Ergas Marilyn Foley Grace B Gallagher Jennifer J Griggs Narre Heon Tatjana Kolevska Yuriy Kotsurovskyy Candyce H Kroenke Cecile A Laurent Raymond Liu Kanichi G Nakata Sonia Persaud Donna R Rivera Janise M Roh Sara Tab Source Type: research
Bifunctional HDAC and DNMT inhibitor induces viral mimicry activates the innate immune response in triple-negative breast cancer
In this study, the bifunctional HDAC and DNMT inhibitor J208 exhibited antitumour activity in TNBC cell lines. J208 effectively induced apoptosis and cell cycle arrest at the G0/G1 phase, inhibiting cell migration and invasion in TNBC. Moreover, this bifunctional inhibitor induced the expression of endogenous retroviruses (ERVs) and elicited a viral mimicry response, which increased the intracellular levels of double-stranded RNA (dsRNA) to activate the innate immune signalling pathway in TNBC. In summary, we demonstrated that the bifunctional inhibitor J208, which is designed to inhibit HDAC and DNMT, has potent anticance...
Source: European Journal of Pharmaceutical Sciences - April 18, 2024 Category: Drugs & Pharmacology Authors: Weiwen Fan Wenkai Li Lulu Li Meirong Qin Chengzhou Mao Zigao Yuan Ping Wang Bizhu Chu Yuyang Jiang Source Type: research
Methodology for Using Real-World Data From Electronic Health Records to Assess Chemotherapy Administration in Women With Breast Cancer
CONCLUSION: We describe the challenges and approaches to operationalize complex, real-world data to identify intended chemotherapy regimens in large, observational studies. This methodology can improve efficiency of use of large-scale clinical data in real-world populations, helping answer critical questions to improve care delivery and patient outcomes.PMID:38635936 | DOI:10.1200/CCI.23.00209 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 18, 2024 Category: Cancer & Oncology Authors: Jenna Bhimani Kelli O'Connell Isaac J Ergas Marilyn Foley Grace B Gallagher Jennifer J Griggs Narre Heon Tatjana Kolevska Yuriy Kotsurovskyy Candyce H Kroenke Cecile A Laurent Raymond Liu Kanichi G Nakata Sonia Persaud Donna R Rivera Janise M Roh Sara Tab Source Type: research
