Hepatomegaly in a patient with a history of acute myeloid leukemia
In February 2018, a 30-year-old man was referred to the outpatient clinic for recent hepatomegaly. He had a history of acute myeloid leukemia in 2009, treated with cytarabine and doxorubicin, followed a few months later by allogeneic hematopoietic stem cell transplantation. The conditioning regimen included cyclophosphamide and busulfan. The post-transplant course was uneventful. In 2010, the patient developed graft-versus-host disease of the skin and liver, which was rapidly responsive to corticosteroids and cyclosporine. (Source: Journal of Hepatology)
Source: Journal of Hepatology - March 16, 2024 Category: Gastroenterology Authors: Lucile Moga, Val érie Paradis, Onorina Bruno, Dominique Valla, Pierre-Emmanuel Rautou Tags: What Is Your Diagnosis? Source Type: research
Natural history of mucopolysaccharidosis type III in a series of Colombian patients
CONCLUSIONS: MPS III is a challenge for diagnosis, particularly in its early stages and in patients in which the course of the disease is attenuated. This is due to its variable course, non-specific early neuropsychiatric symptoms, and the absence of obvious somatic features compared to other types of MPS. After a definitive diagnosis has been made, interdisciplinary care must be provided for the patient and their family, and support given for the treatment of physical symptoms, ensuring the best possible care and quality of life for the patient and their family, as the condition is neurodegenerative.PMID:38482704 | DOI:10...
Source: Revista de Neurologia - March 14, 2024 Category: Neurology Authors: L Cabarcas J L Ram ón E Espinosa G P Guerrero N Mart ínez N Santamar ía I Lince S Reyes Source Type: research
Natural history of mucopolysaccharidosis type III in a series of Colombian patients
CONCLUSIONS: MPS III is a challenge for diagnosis, particularly in its early stages and in patients in which the course of the disease is attenuated. This is due to its variable course, non-specific early neuropsychiatric symptoms, and the absence of obvious somatic features compared to other types of MPS. After a definitive diagnosis has been made, interdisciplinary care must be provided for the patient and their family, and support given for the treatment of physical symptoms, ensuring the best possible care and quality of life for the patient and their family, as the condition is neurodegenerative.PMID:38482704 | DOI:10...
Source: Revista de Neurologia - March 14, 2024 Category: Neurology Authors: L Cabarcas J L Ram ón E Espinosa G P Guerrero N Mart ínez N Santamar ía I Lince S Reyes Source Type: research
Natural history of mucopolysaccharidosis type III in a series of Colombian patients
CONCLUSIONS: MPS III is a challenge for diagnosis, particularly in its early stages and in patients in which the course of the disease is attenuated. This is due to its variable course, non-specific early neuropsychiatric symptoms, and the absence of obvious somatic features compared to other types of MPS. After a definitive diagnosis has been made, interdisciplinary care must be provided for the patient and their family, and support given for the treatment of physical symptoms, ensuring the best possible care and quality of life for the patient and their family, as the condition is neurodegenerative.PMID:38482704 | DOI:10...
Source: Revista de Neurologia - March 14, 2024 Category: Neurology Authors: L Cabarcas J L Ram ón E Espinosa G P Guerrero N Mart ínez N Santamar ía I Lince S Reyes Source Type: research
Natural history of mucopolysaccharidosis type III in a series of Colombian patients
CONCLUSIONS: MPS III is a challenge for diagnosis, particularly in its early stages and in patients in which the course of the disease is attenuated. This is due to its variable course, non-specific early neuropsychiatric symptoms, and the absence of obvious somatic features compared to other types of MPS. After a definitive diagnosis has been made, interdisciplinary care must be provided for the patient and their family, and support given for the treatment of physical symptoms, ensuring the best possible care and quality of life for the patient and their family, as the condition is neurodegenerative.PMID:38482704 | DOI:10...
Source: Revista de Neurologia - March 14, 2024 Category: Neurology Authors: L Cabarcas J L Ram ón E Espinosa G P Guerrero N Mart ínez N Santamar ía I Lince S Reyes Source Type: research
Natural history of mucopolysaccharidosis type III in a series of Colombian patients
CONCLUSIONS: MPS III is a challenge for diagnosis, particularly in its early stages and in patients in which the course of the disease is attenuated. This is due to its variable course, non-specific early neuropsychiatric symptoms, and the absence of obvious somatic features compared to other types of MPS. After a definitive diagnosis has been made, interdisciplinary care must be provided for the patient and their family, and support given for the treatment of physical symptoms, ensuring the best possible care and quality of life for the patient and their family, as the condition is neurodegenerative.PMID:38482704 | DOI:10...
Source: Revista de Neurologia - March 14, 2024 Category: Neurology Authors: L Cabarcas J L Ram ón E Espinosa G P Guerrero N Mart ínez N Santamar ía I Lince S Reyes Source Type: research
Single-cell RNA sequencing reveals the heterogeneity of hepatic non-parenchymal cell responses to chronic PFO5DoDA exposure in male mice
Environ Pollut. 2024 Mar 8:123721. doi: 10.1016/j.envpol.2024.123721. Online ahead of print.ABSTRACTPerfluoroalkyl ether carboxylic acids (PFECA) have emerged as novel alternatives to legacy per- and polyfluoroalkyl substances (PFAS). Existing research has revealed hepatoxicity induced by various PFAS, including PFECA. However, these studies have primarily focused on overall changes in whole liver tissue, particularly in hepatocytes, with the impact of PFAS on diverse liver non-parenchymal cells (NPCs) still inadequately understood. In the present study, we examined the heterogeneous responses of hepatic NPCs following exp...
Source: Environmental Pollution - March 10, 2024 Category: Environmental Health Authors: Chunyu Yang Wei Xie Huayu Fu Mengxue Zhi Hongxia Zhang Yong Guo Jianshe Wang Source Type: research
Single-cell RNA sequencing reveals the heterogeneity of hepatic non-parenchymal cell responses to chronic PFO5DoDA exposure in male mice
Environ Pollut. 2024 Mar 8:123721. doi: 10.1016/j.envpol.2024.123721. Online ahead of print.ABSTRACTPerfluoroalkyl ether carboxylic acids (PFECA) have emerged as novel alternatives to legacy per- and polyfluoroalkyl substances (PFAS). Existing research has revealed hepatoxicity induced by various PFAS, including PFECA. However, these studies have primarily focused on overall changes in whole liver tissue, particularly in hepatocytes, with the impact of PFAS on diverse liver non-parenchymal cells (NPCs) still inadequately understood. In the present study, we examined the heterogeneous responses of hepatic NPCs following exp...
Source: Environmental Pollution - March 10, 2024 Category: Environmental Health Authors: Chunyu Yang Wei Xie Huayu Fu Mengxue Zhi Hongxia Zhang Yong Guo Jianshe Wang Source Type: research
Primary Hepatic Neuroblastoma in a 5.5-Month-Old Boy: A Case Report
This study presents a 5.5-month-old boy with primary hepatic NB. This case study describes a male 5.5-month-old preterm infant who presented with overt hepatomegaly. Laboratory tests showed an abnormally high level of alpha-fetoprotein. A sonography-guided liver needle biopsy was performed, so histopathological examination suggested the diagnosis of a small round-cell tumor. Immunohistochemical staining demonstrated evidence of neuronal differentiation in the tumor. The sum of these findings was in favor of the diagnosis of NB. Bone marrow aspiration and biopsy were normal. The full-body computed tomography scan revealed a...
Source: Archives of Iranian Medicine - March 3, 2024 Category: Middle East Health Authors: Farzad Kompani Alieh Safari Sharari Elmira Haji Esmaeil Memar Mahya Ghahremanloo Source Type: research
Mixed Hepatocellular-Neuroendocrine Carcinoma: A Case Report and Literature Review
We report a case of a 44-yearold Tunisian man who was admitted for diffuse abdominal pain. Body computed tomography showed multinodular hepatomegaly. Pathologic findings concluded to HCC-NEC. Clinicians should be aware about this entity. Further collection of case reports is needed to standardize the optimal treatment.PMID:38431952 | DOI:10.34172/aim.2023.104 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - March 3, 2024 Category: Middle East Health Authors: Wala Ben Kridis Ahmed Jribi Rim Kallel Tahia Boudawara Afef Khanfir Source Type: research
Primary Hepatic Neuroblastoma in a 5.5-Month-Old Boy: A Case Report
This study presents a 5.5-month-old boy with primary hepatic NB. This case study describes a male 5.5-month-old preterm infant who presented with overt hepatomegaly. Laboratory tests showed an abnormally high level of alpha-fetoprotein. A sonography-guided liver needle biopsy was performed, so histopathological examination suggested the diagnosis of a small round-cell tumor. Immunohistochemical staining demonstrated evidence of neuronal differentiation in the tumor. The sum of these findings was in favor of the diagnosis of NB. Bone marrow aspiration and biopsy were normal. The full-body computed tomography scan revealed a...
Source: Archives of Iranian Medicine - March 3, 2024 Category: Middle East Health Authors: Farzad Kompani Alieh Safari Sharari Elmira Haji Esmaeil Memar Mahya Ghahremanloo Source Type: research
Mixed Hepatocellular-Neuroendocrine Carcinoma: A Case Report and Literature Review
We report a case of a 44-yearold Tunisian man who was admitted for diffuse abdominal pain. Body computed tomography showed multinodular hepatomegaly. Pathologic findings concluded to HCC-NEC. Clinicians should be aware about this entity. Further collection of case reports is needed to standardize the optimal treatment.PMID:38431952 | DOI:10.34172/aim.2023.104 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - March 3, 2024 Category: Middle East Health Authors: Wala Ben Kridis Ahmed Jribi Rim Kallel Tahia Boudawara Afef Khanfir Source Type: research
Primary Hepatic Neuroblastoma in a 5.5-Month-Old Boy: A Case Report
This study presents a 5.5-month-old boy with primary hepatic NB. This case study describes a male 5.5-month-old preterm infant who presented with overt hepatomegaly. Laboratory tests showed an abnormally high level of alpha-fetoprotein. A sonography-guided liver needle biopsy was performed, so histopathological examination suggested the diagnosis of a small round-cell tumor. Immunohistochemical staining demonstrated evidence of neuronal differentiation in the tumor. The sum of these findings was in favor of the diagnosis of NB. Bone marrow aspiration and biopsy were normal. The full-body computed tomography scan revealed a...
Source: Archives of Iranian Medicine - March 3, 2024 Category: Middle East Health Authors: Farzad Kompani Alieh Safari Sharari Elmira Haji Esmaeil Memar Mahya Ghahremanloo Source Type: research
Mixed Hepatocellular-Neuroendocrine Carcinoma: A Case Report and Literature Review
We report a case of a 44-yearold Tunisian man who was admitted for diffuse abdominal pain. Body computed tomography showed multinodular hepatomegaly. Pathologic findings concluded to HCC-NEC. Clinicians should be aware about this entity. Further collection of case reports is needed to standardize the optimal treatment.PMID:38431952 | PMC:PMC10915923 | DOI:10.34172/aim.2023.104 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - March 3, 2024 Category: Middle East Health Authors: Wala Ben Kridis Ahmed Jribi Rim Kallel Tahia Boudawara Afef Khanfir Source Type: research
Primary Hepatic Neuroblastoma in a 5.5-Month-Old Boy: A Case Report
This study presents a 5.5-month-old boy with primary hepatic NB. This case study describes a male 5.5-month-old preterm infant who presented with overt hepatomegaly. Laboratory tests showed an abnormally high level of alpha-fetoprotein. A sonography-guided liver needle biopsy was performed, so histopathological examination suggested the diagnosis of a small round-cell tumor. Immunohistochemical staining demonstrated evidence of neuronal differentiation in the tumor. The sum of these findings was in favor of the diagnosis of NB. Bone marrow aspiration and biopsy were normal. The full-body computed tomography scan revealed a...
Source: Archives of Iranian Medicine - March 3, 2024 Category: Middle East Health Authors: Farzad Kompani Alieh Safari Sharari Elmira Haji Esmaeil Memar Mahya Ghahremanloo Source Type: research
