Factors associated with hepatitis A susceptibility among men who have sex with men using HIV pre-exposure prophylaxis in Northeastern Brazil: A cross-sectional study
by Hareton Teixeira Vechi, M ônica Baumgardt Bay, Cláudio Henrique Silva de Freitas, Júlia Gomes Fernandes Costa de Sant’anna, Carlos Brites, Kenio Costa de Lima Hepatitis A virus (HAV) infection has disproportionately affected more men who have sex with men (MSM), occurring in outbreaks, despite being vaccine-preventable. We determined the prevalence and factors associated with HAV susceptibility among cisgender MSM on HIV pre-exposure prophylaxis (PrEP) in Northeastern Brazil. From September 30, 2021 to June 19, 2023, 282 cisgender MSM receiving HIV PrEP were enrolled into this cross-sectional study. Sociodemograph...
Source: PLoS One - March 28, 2024 Category: Biomedical Science Authors: Hareton Teixeira Vechi Source Type: research

Potential use of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition and prevention method in viral infection
Microb Cell Fact. 2024 Mar 25;23(1):90. doi: 10.1186/s12934-024-02355-8.ABSTRACTCellular lipid membranes serve as the primary barrier preventing viral infection of the host cell and provide viruses with a critical initial point of contact. Occasionally, viruses can utilize lipids as viral receptors. Viruses depend significantly on lipid rafts for infection at virtually every stage of their life cycle. The pivotal role that proprotein convertase subtilisin/kexin Type 9 (PCSK9) plays in cholesterol homeostasis and atherosclerosis, primarily by post-transcriptionally regulating hepatic low-density lipoprotein receptor (LDLR) ...
Source: Atherosclerosis - March 26, 2024 Category: Cardiology Authors: Khursheed Muzammil Mohammad Hosseini Hooshiar Shirin Varmazyar Thabit Moath Omar Manal Morad Karim Sadeq Aadi Shaylan Kalavi Saman Yasamineh Source Type: research

Potential use of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition and prevention method in viral infection
Microb Cell Fact. 2024 Mar 25;23(1):90. doi: 10.1186/s12934-024-02355-8.ABSTRACTCellular lipid membranes serve as the primary barrier preventing viral infection of the host cell and provide viruses with a critical initial point of contact. Occasionally, viruses can utilize lipids as viral receptors. Viruses depend significantly on lipid rafts for infection at virtually every stage of their life cycle. The pivotal role that proprotein convertase subtilisin/kexin Type 9 (PCSK9) plays in cholesterol homeostasis and atherosclerosis, primarily by post-transcriptionally regulating hepatic low-density lipoprotein receptor (LDLR) ...
Source: Atherosclerosis - March 26, 2024 Category: Cardiology Authors: Khursheed Muzammil Mohammad Hosseini Hooshiar Shirin Varmazyar Thabit Moath Omar Manal Morad Karim Sadeq Aadi Shaylan Kalavi Saman Yasamineh Source Type: research

Global burden and trends of acute viral hepatitis among children and adolescents from 1990 to 2019: a systematic analysis of the Global Burden of Disease Study 2019
ConclusionEffective vaccines and treatments for hepatitis B and C offer eradication opportunities. Broadening diagnostic and therapeutic coverage is vital to address disparities in service provision for children and adolescents. (Source: Hepatology International)
Source: Hepatology International - March 26, 2024 Category: Infectious Diseases Source Type: research

The role of new hepatitis B vaccines in South Africa
S Afr Med J. 2024 Feb 13;114(2):e1473. doi: 10.7196/SAMJ.2024.v114i2.1473.ABSTRACTVaccination is key to eliminating hepatitis B virus infection in South Africa (SA). Despite introducing immunisation in 1995, as part of the expanded programme of immunisation (EPI), hepatitis B virus infection remains endemic, and EPI vaccine coverage is incomplete. In addition to infants, non-immune adults at risk of infection through their occupation or with behavioural risk factors should receive vaccination. SA has many individuals with diabetes mellitus (a prevalence of almost 13%), obesity, HIV (8.45 million) or older age (5 million &g...
Source: South African Medical Journal - March 25, 2024 Category: African Health Authors: G U Van Zyl T Maponga H Rabie J Taljaard Source Type: research

Concurrent Outbreaks of Hepatitis A, Invasive Meningococcal Disease, and Mpox, Florida, USA, 2021-2022
Emerg Infect Dis. 2024 Apr;30(4). doi: 10.3201/eid3004.231392.ABSTRACTIn 2022, concurrent outbreaks of hepatitis A, invasive meningococcal disease (IMD), and mpox were identified in Florida, USA, primarily among men who have sex with men. The hepatitis A outbreak (153 cases) was associated with hepatitis A virus genotype IA. The IMD outbreak (44 cases) was associated with Neisseria meningitidis serogroup C, sequence type 11, clonal complex 11. The mpox outbreak in Florida (2,845 cases) was part of a global epidemic. The hepatitis A and IMD outbreaks were concentrated in Central Florida and peaked during March--June, wherea...
Source: Emerging Infectious Diseases - March 25, 2024 Category: Infectious Diseases Authors: Timothy J Doyle Megan Gumke Danielle Stanek Joshua Moore Brian Buck Timothy Locksmith Kelly Tomson Sarah Schmedes George Churchwell Shan Justin Hubsmith Baskar Krishnamoorthy Karalee Poschman Brandi Danforth Daniel Chacreton outbreak investigation team1 Source Type: research

The role of new hepatitis B vaccines in South Africa
S Afr Med J. 2024 Feb 13;114(2):e1473. doi: 10.7196/SAMJ.2024.v114i2.1473.ABSTRACTVaccination is key to eliminating hepatitis B virus infection in South Africa (SA). Despite introducing immunisation in 1995, as part of the expanded programme of immunisation (EPI), hepatitis B virus infection remains endemic, and EPI vaccine coverage is incomplete. In addition to infants, non-immune adults at risk of infection through their occupation or with behavioural risk factors should receive vaccination. SA has many individuals with diabetes mellitus (a prevalence of almost 13%), obesity, HIV (8.45 million) or older age (5 million &g...
Source: South African Medical Journal - March 25, 2024 Category: African Health Authors: G U Van Zyl T Maponga H Rabie J Taljaard Source Type: research

Concurrent Outbreaks of Hepatitis A, Invasive Meningococcal Disease, and Mpox, Florida, USA, 2021-2022
Emerg Infect Dis. 2024 Apr;30(4). doi: 10.3201/eid3004.231392.ABSTRACTIn 2022, concurrent outbreaks of hepatitis A, invasive meningococcal disease (IMD), and mpox were identified in Florida, USA, primarily among men who have sex with men. The hepatitis A outbreak (153 cases) was associated with hepatitis A virus genotype IA. The IMD outbreak (44 cases) was associated with Neisseria meningitidis serogroup C, sequence type 11, clonal complex 11. The mpox outbreak in Florida (2,845 cases) was part of a global epidemic. The hepatitis A and IMD outbreaks were concentrated in Central Florida and peaked during March--June, wherea...
Source: Emerging Infectious Diseases - March 25, 2024 Category: Infectious Diseases Authors: Timothy J Doyle Megan Gumke Danielle Stanek Joshua Moore Brian Buck Timothy Locksmith Kelly Tomson Sarah Schmedes George Churchwell Shan Justin Hubsmith Baskar Krishnamoorthy Karalee Poschman Brandi Danforth Daniel Chacreton outbreak investigation team1 Source Type: research

Knowledge, Attitude, and Practice of Hepatitis B Vaccination among Dentists in Lebanon
CONCLUSION: This study sheds light on the KAP of hepatitis B immunization among Lebanese dentists. The findings emphasize the significance of focused educational efforts in view of improving awareness and encouraging a more thorough understanding of the benefits of vaccination. The study provides useful data that can be used to influence public health policies as well as activities aimed at increasing hepatitis B vaccination rates among dental professionals in Lebanon. How to cite this article: Yared G, Sokhn ES, Al-Khatib A, et al. Knowledge, Attitude, and Practice of Hepatitis B Vaccination among Dentists in Lebanon. J C...
Source: J Contemp Dent Pract - March 21, 2024 Category: Dentistry Authors: Ghassan Yared Elie S Sokhn Aynaa Al-Khatib Cynthia Kassis Ronald Younes Source Type: research

Knowledge, Attitude, and Practice of Hepatitis B Vaccination among Dentists in Lebanon
CONCLUSION: This study sheds light on the KAP of hepatitis B immunization among Lebanese dentists. The findings emphasize the significance of focused educational efforts in view of improving awareness and encouraging a more thorough understanding of the benefits of vaccination. The study provides useful data that can be used to influence public health policies as well as activities aimed at increasing hepatitis B vaccination rates among dental professionals in Lebanon. How to cite this article: Yared G, Sokhn ES, Al-Khatib A, et al. Knowledge, Attitude, and Practice of Hepatitis B Vaccination among Dentists in Lebanon. J C...
Source: J Contemp Dent Pract - March 21, 2024 Category: Dentistry Authors: Ghassan Yared Elie S Sokhn Aynaa Al-Khatib Cynthia Kassis Ronald Younes Source Type: research

Knowledge, Attitude, and Practice of Hepatitis B Vaccination among Dentists in Lebanon
CONCLUSION: This study sheds light on the KAP of hepatitis B immunization among Lebanese dentists. The findings emphasize the significance of focused educational efforts in view of improving awareness and encouraging a more thorough understanding of the benefits of vaccination. The study provides useful data that can be used to influence public health policies as well as activities aimed at increasing hepatitis B vaccination rates among dental professionals in Lebanon. How to cite this article: Yared G, Sokhn ES, Al-Khatib A, et al. Knowledge, Attitude, and Practice of Hepatitis B Vaccination among Dentists in Lebanon. J C...
Source: J Contemp Dent Pract - March 21, 2024 Category: Dentistry Authors: Ghassan Yared Elie S Sokhn Aynaa Al-Khatib Cynthia Kassis Ronald Younes Source Type: research

Knowledge, Attitude, and Practice of Hepatitis B Vaccination among Dentists in Lebanon
CONCLUSION: This study sheds light on the KAP of hepatitis B immunization among Lebanese dentists. The findings emphasize the significance of focused educational efforts in view of improving awareness and encouraging a more thorough understanding of the benefits of vaccination. The study provides useful data that can be used to influence public health policies as well as activities aimed at increasing hepatitis B vaccination rates among dental professionals in Lebanon. How to cite this article: Yared G, Sokhn ES, Al-Khatib A, et al. Knowledge, Attitude, and Practice of Hepatitis B Vaccination among Dentists in Lebanon. J C...
Source: J Contemp Dent Pract - March 21, 2024 Category: Dentistry Authors: Ghassan Yared Elie S Sokhn Aynaa Al-Khatib Cynthia Kassis Ronald Younes Source Type: research

Knowledge, Attitude, and Practice of Hepatitis B Vaccination among Dentists in Lebanon
CONCLUSION: This study sheds light on the KAP of hepatitis B immunization among Lebanese dentists. The findings emphasize the significance of focused educational efforts in view of improving awareness and encouraging a more thorough understanding of the benefits of vaccination. The study provides useful data that can be used to influence public health policies as well as activities aimed at increasing hepatitis B vaccination rates among dental professionals in Lebanon. How to cite this article: Yared G, Sokhn ES, Al-Khatib A, et al. Knowledge, Attitude, and Practice of Hepatitis B Vaccination among Dentists in Lebanon. J C...
Source: J Contemp Dent Pract - March 21, 2024 Category: Dentistry Authors: Ghassan Yared Elie S Sokhn Aynaa Al-Khatib Cynthia Kassis Ronald Younes Source Type: research

Multi-epitope vaccine design for hepatitis E virus based on protein ORF2 and ORF3
DiscussionThese findings provide a foundation for future HEV vaccine studies. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - March 21, 2024 Category: Microbiology Source Type: research

When an Immunization Stress-Related Response Interrupts a School-Based Vaccination Program: The Case of France
France has been struggling with negative perceptions surrounding vaccine safety for years due to various controversies and incidents. These events have eroded public trust in vaccines and led to a decrease in vaccination rates. One such example is the hepatitis B vaccination campaign in schools in 1998. It was disrupted following a controversy about a supposed link between the vaccine and multiple sclerosis, four years after its launch [1]. This failure left a lasting impression on public opinion and decision-makers [2], to the extent that no vaccination program was introduced in schools for the next 25  years. (Source: J...
Source: Journal of Adolescent Health - March 20, 2024 Category: Child Development Authors: Fadia Dib, Pierre Chauvin, Odile Launay Tags: Letter to the editor Source Type: research