Galectin-8-like isoform X1 mediates antibacterial, antiviral, and antioxidant responses in red-lip mullet (Planiliza haematocheilus) through positive modulation of pro-inflammatory cytokine, chemokine, and enzymatic antioxidant activity
This study identified Galectin-8-like isoform X1 (PhGal8X1) from red-lip mullet (Planiliza haematocheilus) and investigated its role in regulating fish immunity. The open reading frame of PhGal8X1 was 918bp, encoding a soluble protein of 305 amino acids. The protein had a theoretical isoelectric (pI) point of 7.7 and an estimated molecular weight of 34.078 kDa. PhGal8X1 was expressed in various tissues of the fish, with prominent levels in the brain, stomach, and intestine. PhGal8X1 expression was significantly (p<0.05) induced in the blood and spleen upon challenge with different immune stimuli, including polyinosinic:...
Source: Developmental and Comparative Immunology - April 18, 2024 Category: Allergy & Immunology Authors: W A D L R Warnakula H M V Udayantha D S Liyanage E M T Tharanga W K M Omeka M A H Dilshan H A C R Hanchapola J D H E Jayasinghe Taehyug Jeong Qiang Wan Jehee Lee Source Type: research
Galectin-8-like isoform X1 mediates antibacterial, antiviral, and antioxidant responses in red-lip mullet (Planiliza haematocheilus) through positive modulation of pro-inflammatory cytokine, chemokine, and enzymatic antioxidant activity
This study identified Galectin-8-like isoform X1 (PhGal8X1) from red-lip mullet (Planiliza haematocheilus) and investigated its role in regulating fish immunity. The open reading frame of PhGal8X1 was 918bp, encoding a soluble protein of 305 amino acids. The protein had a theoretical isoelectric (pI) point of 7.7 and an estimated molecular weight of 34.078 kDa. PhGal8X1 was expressed in various tissues of the fish, with prominent levels in the brain, stomach, and intestine. PhGal8X1 expression was significantly (p<0.05) induced in the blood and spleen upon challenge with different immune stimuli, including polyinosinic:...
Source: Developmental and Comparative Immunology - April 18, 2024 Category: Allergy & Immunology Authors: W A D L R Warnakula H M V Udayantha D S Liyanage E M T Tharanga W K M Omeka M A H Dilshan H A C R Hanchapola J D H E Jayasinghe Taehyug Jeong Qiang Wan Jehee Lee Source Type: research
CSF1R blockade slows progression of cerebral hemorrhage by reducing microglial proliferation and increasing infiltration of CD8 + CD122+ T cells into the brain
Int Immunopharmacol. 2024 Apr 16;133:112071. doi: 10.1016/j.intimp.2024.112071. Online ahead of print.ABSTRACTMicroglia play a pivotal role in the neuroinflammatory response after brain injury, and their proliferation is dependent on colony-stimulating factors. In the present study, we investigated the effect of inhibiting microglia proliferation on neurological damage post intracerebral hemorrhage (ICH) in a mouse model, an aspect that has never been studied before. Using a colony-stimulating factor-1 receptor antagonist (GW2580), we observed that inhibition of microglia proliferation significantly ameliorated neurobehavi...
Source: International Immunopharmacology - April 18, 2024 Category: Allergy & Immunology Authors: Fangyuan Cheng Conglin Wang Bo Yan Zhenyu Yin Yaru Liu Lan Zhang Meimei Li Pan Liao Han Gao Zexi Jia Dai Li Qiang Liu Ping Lei Source Type: research
Correction to "GSK3 β inhibitor TDZD8 ameliorates brain damage through both ROS scavenging and inhibition of apoptosis in hyperglycemic subarachnoid haemorrhage rats"
Clin Exp Pharmacol Physiol. 2024 Jun;51(6):e13853. doi: 10.1111/1440-1681.13853.NO ABSTRACTPMID:38636943 | DOI:10.1111/1440-1681.13853 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - April 18, 2024 Category: Drugs & Pharmacology Source Type: research
Loganin exerts neuroprotective effect by inhibiting neuronal pyroptosis in rat with cerebral haemorrhage
This study aimed to assess the neuroprotective effects of loganin in a rat ICH model. Sprague-Dawley rats were used, subjected to a collagenase-induced ICH model, followed by loganin treatment at doses of 2.5, 5 and 10 mg/kg. Neurological functions were evaluated using the modified neurological severity score (mNSS) and a rotarod test. Results indicated a significant improvement in neurological functions in loganin-treated groups, evident from the mNSS and rotarod tests, suggesting dose-dependent neuroprotection. Loganin also effectively reduced the blood-brain barrier (BBB) permeability and cerebral oedema. Additionally, ...
Source: Clinical and Experimental Pharmacology and Physiology - April 18, 2024 Category: Drugs & Pharmacology Authors: Yu Wang Min Zhao Jing Li Yue Liu Source Type: research
Galectin-3 modulates microglial activation and neuroinflammation in early brain injury after subarachnoid hemorrhage
CONCLUSION: These findings suggest that regulating microglia polarization by galectin-3 after SAH to improve neuroinflammation may be a potential therapeutic target.PMID:38636772 | DOI:10.1016/j.expneurol.2024.114777 (Source: Experimental Neurology)
Source: Experimental Neurology - April 18, 2024 Category: Neurology Authors: Yuqi Shen Weiwei Zhang Hanxiao Chang Zheng Li Chao Lin Guangjian Zhang Lei Mao Chencheng Ma Ning Liu Hua Lu Source Type: research
DMT1 ubiquitination by Nedd4 protects against ferroptosis after intracerebral hemorrhage
CONCLUSION: The results demonstrated that ferroptosis occurs via the Nedd4/DMT1 pathway during ICH, suggesting it potential as a valuable target to inhibit ferroptosis for the treatment of ICH.PMID:38634270 | PMC:PMC11024684 | DOI:10.1111/cns.14685 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 18, 2024 Category: Neuroscience Authors: Bingchen Lv Ping Fu Miao Wang Likun Cui Lei Bao Xingzhi Wang Lu Yu Chao Zhou Mengxin Zhu Fei Wang Ye Pang Suhua Qi Zuohui Zhang Guiyun Cui Source Type: research
Informed non-dissent for brain death testing in children: ethical and legal perspectives
A 14-year-old girl, Hana, is admitted to the paediatric intensive care unit following a sudden collapse at home. She is found to have sustained a severe haemorrhagic stroke. Despite emergency neurosurgical intervention, she deteriorates over several days. Her family have been struggling to accept the possibility that she would not recover. Hana remains unresponsive, has fixed dilated pupils and has developed diabetes insipidus. The clinical team suspect that she is brain dead. Should the family’s consent be sought for brain death testing? (This case is fictitious.) In mid-2022, the high profile case of Archie Batters...
Source: Archives of Disease in Childhood - April 18, 2024 Category: Pediatrics Authors: Wilkinson, D., Miller, C., Turner, S. W. Tags: Ethics and law for clinical practice Source Type: research
Correction to: PDK4 Decrease Neuronal Apoptosis via Inhibiting ROS-ASK1/P38 Pathway in Early Brain Injury After Subarachnoid Hemorrhage, by Gao et al. Antioxid Redox Signal 2022;36(7 –9):505–524; doi: 10.1089/ars.2021.0083
Antioxidants&Redox Signaling, Ahead of Print. (Source: Antioxidants and Redox Signaling)
Source: Antioxidants and Redox Signaling - April 18, 2024 Category: Research Source Type: research
Protein kinase C-inhibition reduces critical weight loss and improves functional outcome after experimental subarachnoid haemorrhage
This study was undertaken to analyse functional outcomes up to 14 days after experimental SAH. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 18, 2024 Category: Neurology Authors: Jesper P B ömers, Anja Holm, Spyridoula Kazantzi, Professor Lars Edvinsson, Professor Tiit I Mathiesen, Kristian A Haanes Source Type: research
Targeting brain-peripheral immune responses for secondary brain injury after ischemic and hemorrhagic stroke
The notion that the central nervous system is an immunologically immune-exempt organ has changed over the past two decades, with increasing evidence of strong links and interactions between the central nervous... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 18, 2024 Category: Neurology Authors: Mingxu Duan, Ya Xu, Yuanshu Li, Hua Feng and Yujie Chen Tags: Review Source Type: research
Predictors of acute post-thrombectomy intracranial hemorrhage expansion in anterior circulation infarcts
CONCLUSION: Expansion of post-MT ICH on 24-h interval MRI relative to immediate post-thrombectomy DEHCT is significantly associated with baseline anticoagulant usage and petechial hemorrhage inside the infarct margins or presence of intraparenchymal hematoma (ECASS-II HI2/PH1/PH2).PMID:38629465 | DOI:10.1177/15910199241247884 (Source: Interventional Neuroradiology)
Source: Interventional Neuroradiology - April 17, 2024 Category: Radiology Authors: Akshay Bhamidipati Nishit Mummareddy Seoiyoung Ahn Gabriel Bendfeldt Alexander T Lyons Surya Gangavarapu Jeffrey Chen Jacob Jo Naveed Kamal Steven G Roth Michael T Froehler Rohan V Chitale Matthew R Fusco Source Type: research
Transmastoid pediatric penetrating brain injury, interdisciplinary, and tailored patient's treatment
CONCLUSION: Radiological tools, notably skull X-rays and head CT scans, are pivotal for the precise diagnosis of pediatric PBI. The combined mastoidectomy and retro sigmoid craniotomy approach offers a safe and efficient means of foreign body removal. Tailoring treatments to individual patient needs enhances outcomes.PMID:38628538 | PMC:PMC11021077 | DOI:10.25259/SNI_18_2024 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Tommy Alfandy Nazwar Farhad Bal'afif Donny Wisnu Wardhana Akmal Niam Firdaus Masyhudi Christin Panjaitan Source Type: research
Remote supratentorial intraparenchymal bleed after posterior fossa surgery: A rare occurrence
CONCLUSION: We report this case due to the unique case observation of an intracranial bleed at a remote site rather than at the operated site.PMID:38628529 | PMC:PMC11021087 | DOI:10.25259/SNI_748_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Abbas Hibtullah Moaiyadi Mayank Tripathi Pavan Tulshiram Lanjewar Simran Kaur Syal Binoy Kumar Singh Shailendra Anjankar Charandeep Singh Gandhoke Source Type: research
Rare vermian pilocytic astrocytoma with recurrent spontaneous hemorrhage in the elderly: A case report and review of literature
CONCLUSION: PA in the elderly is a rare disease with distinct histologic and genetic peculiarities. This case review showed one of the oldest cases of cerebellar vermian PA presenting with recurrent spontaneous intratumoral hemorrhage, an extremely rare occurrence in benign glioma. Although complete surgical excision is recommended, partial resection is advocated for morbidly adherent tumors. Overall prognosis is worse in elderly PA.PMID:38628526 | PMC:PMC11021065 | DOI:10.25259/SNI_978_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Campbell Chukwuebuka Francis Kohei Kanaya Kohei Nagamine Tetsuya Goto Tetsuyoshi Horiuchi Samuel Chukwunonyerem Ohaegbulam Source Type: research
