Association Between Use of Sodium-Glucose Cotransporter-2 Inhibitors or Angiotensin Receptor-Neprilysin Inhibitor and the Risk of Atherosclerotic Cardiovascular Disease With Coexisting Diabetes and Heart Failure
CONCLUSION: The study suggests that the use of SGLT2 inhibitors, alone or in combination with Entresto, may be effective in reducing the risk of ASCVD and its associated adverse outcomes in patients with diabetes and heart failure. This finding has important implications for the management of these conditions.PMID:38438119 | DOI:10.1177/10742484241233872 (Source: Atherosclerosis)
Source: Atherosclerosis - March 4, 2024 Category: Cardiology Authors: Ya-Wen Lin Chun-Hsiang Lin Cheng-Li Lin Che-Huei Lin Ming-Hung Lin Source Type: research

Tenecteplase versus alteplase for acute ischemic stroke: a systematic review and meta-analysis of randomized and non-randomized studies
ConclusionsModerate certainty evidence suggested that there was little to no difference between tenecteplase and alteplase in increasing the proportion of patients achieving excellent functional outcome at 3  months and the risk of symptomatic intracranial hemorrhage, while compared to alteplase, tenecteplase probably reduce all-cause mortality. Administration of 0.25 mg/kg tenecteplase after acute ischemic stroke is suggestive of increasing the proportion of patients that achieve excellent functional outcome at 3 months. (Source: Journal of Neurology)
Source: Journal of Neurology - March 4, 2024 Category: Neurology Source Type: research

The genetic basis of hydrocephalus: genes, pathways, mechanisms, and global impact
AbstractHydrocephalus (HC) is a heterogenous disease characterized by alterations in cerebrospinal fluid (CSF) dynamics that may cause increased intracranial pressure. HC is a component of a wide array of genetic syndromes as well as a secondary consequence of brain injury (intraventricular hemorrhage (IVH), infection, etc.) that can present across the age spectrum, highlighting the phenotypic heterogeneity of the disease. Surgical treatments include ventricular shunting and endoscopic third ventriculostomy with or without choroid plexus cauterization, both of which are prone to failure, and no effective pharmacologic trea...
Source: Fluids and Barriers of the CNS - March 4, 2024 Category: Neuroscience Source Type: research

Unraveling the complex pathophysiology of white matter hemorrhage in intracerebral stroke: A single-cell RNA sequencing approach
CONCLUSION: The study offers valuable insights into WMH's complex pathophysiology following ICH, highlighting the significance and utility of scRNA-seq in understanding the cellular dynamics and contributing to future cerebrovascular research.PMID:38433011 | DOI:10.1111/cns.14652 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 3, 2024 Category: Neuroscience Authors: Lisha Ye Xiaoyan Tang Jun Zhong Wenfeng Li Ting Xu Chao Xiang Jianjun Gu Hua Feng Qianqian Luo Guohua Wang Source Type: research

Unraveling the complex pathophysiology of white matter hemorrhage in intracerebral stroke: A single-cell RNA sequencing approach
CONCLUSION: The study offers valuable insights into WMH's complex pathophysiology following ICH, highlighting the significance and utility of scRNA-seq in understanding the cellular dynamics and contributing to future cerebrovascular research.PMID:38433011 | DOI:10.1111/cns.14652 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 3, 2024 Category: Neuroscience Authors: Lisha Ye Xiaoyan Tang Jun Zhong Wenfeng Li Ting Xu Chao Xiang Jianjun Gu Hua Feng Qianqian Luo Guohua Wang Source Type: research

MicroRNA-7 Attenuates Secondary Brain Injury Following Experimental Intracerebral Hemorrhage via Inhibition of NLRP3
Intracerebral hemorrhage (ICH), a prevalent condition in neurosurgery, constitutes approximately 10-15% of all stroke types. Its global annual incidence surpasses 200 million cases, and the associated high disability and mortality rates pose substantial burdens on families and society.1 Presently, the mechanisms driving brain damage in ICH remain incompletely deciphered, and adequate medical interventions to enhance patient prognosis are yet to be established. Mechanisms of brain tissue damage following ICH include hematoma mass effect, excitotoxicity, oxidative stress, and inflammatory reactions. (Source: Journal of Strok...
Source: Journal of Stroke and Cerebrovascular Diseases - March 2, 2024 Category: Neurology Authors: Bo Luo, Lin Li, Xu-Dong Song, Hua-Xuan Chen, De-Bo Yun, Lin Wang, Yuan Zhang Source Type: research

[Corrigendum] Bax inhibitor ‑1 suppresses early brain injury following experimental subarachnoid hemorrhage in rats
Int J Mol Med. 2024 Apr;53(4):38. doi: 10.3892/ijmm.2024.5362. Epub 2024 Mar 1.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, in Fig. 6 on p. 2898, the 'SAH' and 'SAH+NC' data panels contained an apparently overlapping section of data, such that these data appeared to have been derived from the same original source, even though they were intended to show the results from differently performed experiments. The authors have examined their original data, and realize that the 'SAH+NC' data panel had inadvertently been selected incorrectly for this figure. In ad...
Source: Molecular Medicine - March 1, 2024 Category: Molecular Biology Authors: Jiaxin Liu Shuai Zhou Yueting Zhang Xiuying Li Xiying Qian Weihua Tao Lide Jin Jianhua Zhao Source Type: research

Differences in outcome between left-sided and right-sided mechanical thrombectomy for acute ischemic stroke: A systematic review and meta-analysis
CONCLUSIONS: There does not appear to be a difference in outcomes for patients undergoing left-sided or right-sided thrombectomy.PMID:38425287 | DOI:10.1177/15910199241236329 (Source: Interventional Neuroradiology)
Source: Interventional Neuroradiology - March 1, 2024 Category: Radiology Authors: Abdullah Ramzan Sherief Ghozy Cem Bilgin Alejandro A Rabinstein Ramanathan Kadirvel David F Kallmes Source Type: research

[Corrigendum] Bax inhibitor ‑1 suppresses early brain injury following experimental subarachnoid hemorrhage in rats
Int J Mol Med. 2024 Apr;53(4):38. doi: 10.3892/ijmm.2024.5362. Epub 2024 Mar 1.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, in Fig. 6 on p. 2898, the 'SAH' and 'SAH+NC' data panels contained an apparently overlapping section of data, such that these data appeared to have been derived from the same original source, even though they were intended to show the results from differently performed experiments. The authors have examined their original data, and realize that the 'SAH+NC' data panel had inadvertently been selected incorrectly for this figure. In ad...
Source: International Journal of Molecular Medicine - March 1, 2024 Category: Molecular Biology Authors: Jiaxin Liu Shuai Zhou Yueting Zhang Xiuying Li Xiying Qian Weihua Tao Lide Jin Jianhua Zhao Source Type: research

Long-term outcome of endovascular treatment for indirect carotid-cavernous fistulas
CONCLUSIONS: In this study, complete obliteration of an indirect CCF was achieved in more than 90% of patients. Despite the occurrence of some new postprocedural ocular CN palsy, ocular symptoms improved in most patients in long-term follow-up. The transvenous approach was the most effective method for treating the indirect CCF. Coiling was safer than LEAs for the embolization of the indirect CCF.PMID:38427986 | DOI:10.3171/2023.12.FOCUS23795 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - March 1, 2024 Category: Neurosurgery Authors: Humain Baharvahdat Farid Qoorchi Moheb Seraj Amira Al-Raaisi Raphael Blanc Sajjad Najafi Mohammad Hossein Mirbolouk Hocine Redjem Feizollah Ebrahimnia Simon Escalard Samira Zabihyan Jean-Philipe Desilles Ashkan Mowla Willian Boisseau Mikael Mazighi Stanis Source Type: research

[Corrigendum] Bax inhibitor ‑1 suppresses early brain injury following experimental subarachnoid hemorrhage in rats
Int J Mol Med. 2024 Apr;53(4):38. doi: 10.3892/ijmm.2024.5362. Epub 2024 Mar 1.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, in Fig. 6 on p. 2898, the 'SAH' and 'SAH+NC' data panels contained an apparently overlapping section of data, such that these data appeared to have been derived from the same original source, even though they were intended to show the results from differently performed experiments. The authors have examined their original data, and realize that the 'SAH+NC' data panel had inadvertently been selected incorrectly for this figure. In ad...
Source: International Journal of Molecular Medicine - March 1, 2024 Category: Molecular Biology Authors: Jiaxin Liu Shuai Zhou Yueting Zhang Xiuying Li Xiying Qian Weihua Tao Lide Jin Jianhua Zhao Source Type: research

Differences in outcome between left-sided and right-sided mechanical thrombectomy for acute ischemic stroke: A systematic review and meta-analysis
CONCLUSIONS: There does not appear to be a difference in outcomes for patients undergoing left-sided or right-sided thrombectomy.PMID:38425287 | DOI:10.1177/15910199241236329 (Source: Interventional Neuroradiology)
Source: Interventional Neuroradiology - March 1, 2024 Category: Radiology Authors: Abdullah Ramzan Sherief Ghozy Cem Bilgin Alejandro A Rabinstein Ramanathan Kadirvel David F Kallmes Source Type: research

[Corrigendum] Bax inhibitor ‑1 suppresses early brain injury following experimental subarachnoid hemorrhage in rats
Int J Mol Med. 2024 Apr;53(4):38. doi: 10.3892/ijmm.2024.5362. Epub 2024 Mar 1.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, in Fig. 6 on p. 2898, the 'SAH' and 'SAH+NC' data panels contained an apparently overlapping section of data, such that these data appeared to have been derived from the same original source, even though they were intended to show the results from differently performed experiments. The authors have examined their original data, and realize that the 'SAH+NC' data panel had inadvertently been selected incorrectly for this figure. In ad...
Source: Molecular Medicine - March 1, 2024 Category: Molecular Biology Authors: Jiaxin Liu Shuai Zhou Yueting Zhang Xiuying Li Xiying Qian Weihua Tao Lide Jin Jianhua Zhao Source Type: research

Long-term outcome of endovascular treatment for indirect carotid-cavernous fistulas
CONCLUSIONS: In this study, complete obliteration of an indirect CCF was achieved in more than 90% of patients. Despite the occurrence of some new postprocedural ocular CN palsy, ocular symptoms improved in most patients in long-term follow-up. The transvenous approach was the most effective method for treating the indirect CCF. Coiling was safer than LEAs for the embolization of the indirect CCF.PMID:38427986 | DOI:10.3171/2023.12.FOCUS23795 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - March 1, 2024 Category: Neurosurgery Authors: Humain Baharvahdat Farid Qoorchi Moheb Seraj Amira Al-Raaisi Raphael Blanc Sajjad Najafi Mohammad Hossein Mirbolouk Hocine Redjem Feizollah Ebrahimnia Simon Escalard Samira Zabihyan Jean-Philipe Desilles Ashkan Mowla Willian Boisseau Mikael Mazighi Stanis Source Type: research

Nrf2 activation by neferine mitigates microglial neuroinflammation after subarachnoid hemorrhage through inhibiting TAK1-NF- κB signaling
Int Immunopharmacol. 2024 Feb 29;130:111693. doi: 10.1016/j.intimp.2024.111693. Online ahead of print.ABSTRACTOxidative stress and neuroinflammation are two major causes leading to early brain injury after subarachnoid hemorrhage (SAH). Nuclear factor E2-related factor 2 (Nrf2) is a critical transcription factor that contributes to antioxidant responses. Additionally, Nrf2 could inhibit transforming growth factor beta-activated kinase 1 (TAK1), which plays a vital role in microglial activation-mediated neuroinflammation. Neferine (NE) exhibits considerable protective effects in diverse disease models. However, the detailed...
Source: International Immunopharmacology - March 1, 2024 Category: Allergy & Immunology Authors: Xiaotian Zhang Jun Li Changchun Cao Zhichao Liu Qiushi Chen Zhijiang Gu Weijie Wang Dazhao Fang QianQian Ge Lianshu Ding Cong Pang Xiaodong Wang Source Type: research