Normobaric hyperoxia alleviates complement C3-mediated synaptic pruning and brain injury after intracerebral hemorrhage
CONCLUSIONS: Our results revealed that NBO exerts its neuroprotective effects by reducing C3-mediated synaptic pruning, which suggested that NBO therapy could be used for the clinical treatment of ICH.PMID:38532579 | DOI:10.1111/cns.14694 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 27, 2024 Category: Neuroscience Authors: Moxin Wu Kai Chen Yasong Zhao Min Jiang Bing Bao Wenmin Yu Zhiying Chen Xiaoping Yin Source Type: research
Proteomics on human cerebral cavernous malformations reveals novel biomarkers in neurovascular dysfunction for the disease pathology
Biochim Biophys Acta Mol Basis Dis. 2024 Mar 25:167139. doi: 10.1016/j.bbadis.2024.167139. Online ahead of print.ABSTRACTBACKGROUND: Cerebral cavernous malformation (CCM) is a disease associated with elevated risk of focal neurological deficits, seizures, and hemorrhagic stroke. The disease has an inflammation profile and improved knowledge of CCM pathology mechanisms and exploration of candidate biomarkers will enable new non-invasive treatments.METHODS: We analyzed protein expression signature in human CCM tissue samples by using a highly specific and sensitive multiplexing technique, proximity extension assay.FINDINGS: ...
Source: Biochimica et Biophysica Acta - March 27, 2024 Category: Biochemistry Authors: Suvi Jauhiainen Favour C Onyeogaziri Francesca Lazzaroni Lei Liu Conze Johanna P Laakkonen Nihay Laham Karam Aki Laakso Mika Niemel ä Behnam Rezai Jahromi Peetra U Magnusson Source Type: research
Normobaric hyperoxia alleviates complement C3-mediated synaptic pruning and brain injury after intracerebral hemorrhage
CONCLUSIONS: Our results revealed that NBO exerts its neuroprotective effects by reducing C3-mediated synaptic pruning, which suggested that NBO therapy could be used for the clinical treatment of ICH.PMID:38532579 | PMC:PMC10966135 | DOI:10.1111/cns.14694 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 27, 2024 Category: Neuroscience Authors: Moxin Wu Kai Chen Yasong Zhao Min Jiang Bing Bao Wenmin Yu Zhiying Chen Xiaoping Yin Source Type: research
Proteomics on human cerebral cavernous malformations reveals novel biomarkers in neurovascular dysfunction for the disease pathology
Biochim Biophys Acta Mol Basis Dis. 2024 Mar 25:167139. doi: 10.1016/j.bbadis.2024.167139. Online ahead of print.ABSTRACTBACKGROUND: Cerebral cavernous malformation (CCM) is a disease associated with elevated risk of focal neurological deficits, seizures, and hemorrhagic stroke. The disease has an inflammation profile and improved knowledge of CCM pathology mechanisms and exploration of candidate biomarkers will enable new non-invasive treatments.METHODS: We analyzed protein expression signature in human CCM tissue samples by using a highly specific and sensitive multiplexing technique, proximity extension assay.FINDINGS: ...
Source: Biochimica et Biophysica Acta - March 27, 2024 Category: Biochemistry Authors: Suvi Jauhiainen Favour C Onyeogaziri Francesca Lazzaroni Lei Liu Conze Johanna P Laakkonen Nihay Laham Karam Aki Laakso Mika Niemel ä Behnam Rezai Jahromi Peetra U Magnusson Source Type: research
Pathologic Features of Brain Hemorrhage After Radiation Treatment: Case Series with Somatic Mutation Analysis
Benefits of radiation treatment are severely limited by adverse radiation effects (ARE), also referred to as radionecrosis, with a reported incidence of 5-68% after brain irradiation1. Clinical and imaging definitions have not been consistent2, and the specific prevalence of brain bleeding within the context of ARE is not known. Pathologic substrates and molecular features of hemorrhagic ARE have not been systematically studied3. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - March 27, 2024 Category: Neurology Authors: Roberto J Alcazar-Felix, Abhinav Srinath, Stephanie Hage, Akash Bindal, Andrew Ressler, Peter Pytel, Sammy Allaw, Romuald Girard, Douglas A Marchuk, Issam A Awad, Sean P Polster Source Type: research
Primary and secondary prevention of stroke and cardiovascular events using evolocumab and alirocumab: Meta-analysis of randomized controlled trials
CONCLUSION: Our findings indicate that evolocumab and alirocumab are significantly effective without increasing the risk of hemorrhagic stroke. Based on this, the PCSK9 inhibitors can be highly recommended for cholesterol management.PMID:38529927 | DOI:10.5414/CP204506 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - March 26, 2024 Category: Drugs & Pharmacology Authors: Kwang-Hee Shin Hye Duck Choi Source Type: research
Inhibition of soluble epoxide hydrolase as a therapeutic approach for blood-brain barrier dysfunction
Biochimie. 2024 Mar 24:S0300-9084(24)00073-7. doi: 10.1016/j.biochi.2024.03.015. Online ahead of print.ABSTRACTThe blood-brain barrier (BBB) is a protective semi-permeable structure that regulates the exchange of biomolecules between the peripheral blood and the central nervous system (CNS). Due to its specialized tight junctions and low vesicle trafficking, the BBB strictly limits the paracellular passage and transcellular transport of molecules to maintain the physiological condition of brain tissues. BBB breakdown is associated with many CNS disorders. Soluble epoxide hydrolase (sEH) is a hydrolase enzyme that converts ...
Source: Biochimie - March 26, 2024 Category: Biochemistry Authors: Shuo Li Huijia Song Yanping Sun Yongjun Sun Huimin Zhang Zibin Gao Source Type: research
Huperzine A ameliorates neurological deficits after spontaneous subarachnoid hemorrhage through endothelial cell pyroptosis inhibition
In this study, Evans blue assay, TUNEL staining, immunofluorescence, western blot analysis, and ELISA are conducted. We find that Huperzine A can improve neurological deficits and inhibit the apoptosis of nerve cells in SAH rats. Huperzine A treatment can improve the upregulation of brain water content, damage of blood-brain barrier, fibrinogen and matrix metalloprotein 9 expressions and the downregulation of ZO-1 and occludin expressions induced by SAH. Huperzine A inhibit the expressions of proteins involved in pyroptosis in endothelial cells in SAH rats. The increase in MDA content and decrease in SOD activity in SAH ra...
Source: Acta Biochimica et Biophysica Sinica - March 26, 2024 Category: Biochemistry Authors: Qiang Hu Rong Zhang Xiaoqiao Dong Dingbo Yang Wenhua Yu Quan Du Source Type: research
ERBB1 alleviates secondary brain injury induced by experimental intracerebral hemorrhage in rats by modulating neuronal death via PLC- γ/PKC pathway
CONCLUSIONS: ERBB1 can improve SBI and has a neuroprotective effect in experimental ICH rats via PLC-γ/PKC pathway.PMID:38528842 | PMC:PMC10964039 | DOI:10.1111/cns.14679 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 26, 2024 Category: Neuroscience Authors: Bing Li Jiang Wu Demao Cao Cheng Cao Juyi Zhang Xiang Li Haiying Li Haitao Shen Zhengquan Yu Source Type: research
Primary and secondary prevention of stroke and cardiovascular events using evolocumab and alirocumab: Meta-analysis of randomized controlled trials
CONCLUSION: Our findings indicate that evolocumab and alirocumab are significantly effective without increasing the risk of hemorrhagic stroke. Based on this, the PCSK9 inhibitors can be highly recommended for cholesterol management.PMID:38529927 | DOI:10.5414/CP204506 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - March 26, 2024 Category: Drugs & Pharmacology Authors: Kwang-Hee Shin Hye Duck Choi Source Type: research
Primary and secondary prevention of stroke and cardiovascular events using evolocumab and alirocumab: Meta-analysis of randomized controlled trials
CONCLUSION: Our findings indicate that evolocumab and alirocumab are significantly effective without increasing the risk of hemorrhagic stroke. Based on this, the PCSK9 inhibitors can be highly recommended for cholesterol management.PMID:38529927 | DOI:10.5414/CP204506 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - March 26, 2024 Category: Drugs & Pharmacology Authors: Kwang-Hee Shin Hye Duck Choi Source Type: research
Inhibition of soluble epoxide hydrolase as a therapeutic approach for blood-brain barrier dysfunction
Biochimie. 2024 Mar 24:S0300-9084(24)00073-7. doi: 10.1016/j.biochi.2024.03.015. Online ahead of print.ABSTRACTThe blood-brain barrier (BBB) is a protective semi-permeable structure that regulates the exchange of biomolecules between the peripheral blood and the central nervous system (CNS). Due to its specialized tight junctions and low vesicle trafficking, the BBB strictly limits the paracellular passage and transcellular transport of molecules to maintain the physiological condition of brain tissues. BBB breakdown is associated with many CNS disorders. Soluble epoxide hydrolase (sEH) is a hydrolase enzyme that converts ...
Source: Biochimie - March 26, 2024 Category: Biochemistry Authors: Shuo Li Huijia Song Yanping Sun Yongjun Sun Huimin Zhang Zibin Gao Source Type: research
Huperzine A ameliorates neurological deficits after spontaneous subarachnoid hemorrhage through endothelial cell pyroptosis inhibition
In this study, Evans blue assay, TUNEL staining, immunofluorescence, western blot analysis, and ELISA are conducted. We find that Huperzine A can improve neurological deficits and inhibit the apoptosis of nerve cells in SAH rats. Huperzine A treatment can improve the upregulation of brain water content, damage of blood-brain barrier, fibrinogen and matrix metalloprotein 9 expressions and the downregulation of ZO-1 and occludin expressions induced by SAH. Huperzine A inhibit the expressions of proteins involved in pyroptosis in endothelial cells in SAH rats. The increase in MDA content and decrease in SOD activity in SAH ra...
Source: Acta Biochimica et Biophysica Sinica - March 26, 2024 Category: Biochemistry Authors: Qiang Hu Rong Zhang Xiaoqiao Dong Dingbo Yang Wenhua Yu Quan Du Source Type: research
Primary and secondary prevention of stroke and cardiovascular events using evolocumab and alirocumab: Meta-analysis of randomized controlled trials
CONCLUSION: Our findings indicate that evolocumab and alirocumab are significantly effective without increasing the risk of hemorrhagic stroke. Based on this, the PCSK9 inhibitors can be highly recommended for cholesterol management.PMID:38529927 | DOI:10.5414/CP204506 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - March 26, 2024 Category: Drugs & Pharmacology Authors: Kwang-Hee Shin Hye Duck Choi Source Type: research
