Case series: 7 patients with confirmed exposure to hallucinogenic stimulant 25I-NBOMe (“N-Bomb”)
25I-NBOMe
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Severe clinical toxicity associated with analytically confirmed recreational use of 25I-NBOMe: case series. Hill SL et al. Clin Toxicol 2013 Jul;51:487-492.
Abstract
25I-NBOMe is a potent stimulant and serotonin agonist that has been associated with a number of fatalities. It appears under such street names as “N-Bomb”, “smiles”, “Solaris”, and 25-I.
Since I am aware of only one previous case of 25I toxicity described in the medical literature, I found this series of 7 laboratory-confirmed cases especially welcome. Major clinical features in these cases inc...
Source: The Poison Review - July 20, 2013 Category: Toxicology Authors: Leon Tags: Medical 25I designer drug hallucinogenic n-bomb NBOMe smiles solaris stimulant sympathomimetic Source Type: news
What factors need to be considered when dosing patients on renal replacement therapies?
Source: South West Medicines Information and Training
Area: Evidence > Medicines Q & A
There are a number of factors that need to be considered when dosing patients on renal replacement therapy (RRT). Consider the drug, the patient and the type of RRT.
Alteration of drug dosage is only necessary if renal clearance exceeds 25% of total body clearance.
Drugs which are cleared by the kidneys are usually dialysed, and vice versa, although there are some anomalies.
Dose adjustment for RRT is only necessary for drugs that require dose adjustment because of the presence of renal failure. No RRT is as effective as the n...
Source: NeLM - Medicines Q and A - January 22, 2013 Category: Drugs & Pharmacology Source Type: news
