Quality appraisal of clinical guidelines for Helicobacter pylori infection and systematic analysis of the level of evidence for recommendations
ConclusionThe overall quality of CPGs for HP infection is poor, and CPG developers tend to neglect some domains, resulting in a wide variability in the quality of the CPGs. Additionally, CPGs for HP infection lack sufficient high-quality evidence, and the grading of recommendation strength should be based on the quality of evidence. The CPGs for HP infection have much room for improvement and further researches are required to minimize the evidence gap. (Source: PLoS One)
Source: PLoS One - April 10, 2024 Category: Biomedical Science Authors: Jiayin Ou Source Type: research

Estimates of global and regional prevalence of Helicobacter pylori infection among individuals with obesity: a systematic review and meta-analysis
ConclusionThe findings have the potential to influence future health policies for preventing and treatingH. pylori infection. However, there is variability among the included studies, indicating the need for more population-based research. (Source: Infection)
Source: Infection - April 10, 2024 Category: Infectious Diseases Source Type: research

Chemical constituents of the aerial parts of < em > Mitracarpus hirtus < /em > (L.) DC (Rubiaceae)
Nat Prod Res. 2024 Apr 8:1-7. doi: 10.1080/14786419.2024.2337110. Online ahead of print.ABSTRACTA phytochemical investigation of the aerial parts of Mitracarpus hirtus afforded thirteen compounds, including a new naphthoquinone di-glycoside (1), three isopentenyl isoflavones (2-4), four flavonoids (5-8), three iridoid glycosides (9 - 11) and two coumarins (12 and 13). Their structures were elucidated based on extensive spectroscopic analyses, chemical methods, and the comparison with the literature. Among them, compound 1 possesses a 2-(3-methylnaphthalen-2-yl)acetic acid core with two glucosyl groups, compounds 2-4 are th...
Source: Natural Product Research - April 8, 2024 Category: Biochemistry Authors: Xinyi Wei Yingrun Ma Mingming Xu Ding Heng Monday M Onakpa Jin-Ao Duan Chun-Tao Che Hongkai Bi Junfei Zhou Ming Zhao Source Type: research

Engineering resveratrol-loaded chitosan nanoparticles for potential use against Helicobacter pylori infection
Eur J Pharm Biopharm. 2024 Apr 6:114280. doi: 10.1016/j.ejpb.2024.114280. Online ahead of print.ABSTRACTHelicobacter pylori (H. pylori) is a microorganism directly linked to severe clinical conditions affecting the stomach. The virulence factors and its ability to form biofilms increase resistance to conventional antibiotics, growing the need for new substances and strategies for the treatment of H. pylori infection. The trans-resveratrol (RESV), a bioactive polyphenol from natural sources, has a potential activity against this gastric pathogen. Here, Chitosan nanoparticles (NP) containing RESV (RESV-NP) were developed for...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 8, 2024 Category: Drugs & Pharmacology Authors: Larissa Sp ósito Diana Fonseca Suzana Gon çalves Carvalho Rafael Miguel S ábio Gabriel Marena Ta ís Maria Bauab Andr éia Bagliotti Meneguin Paula Parreira M Cristina L Martins Marlus Chorilli Source Type: research

Chemical constituents of the aerial parts of < em > Mitracarpus hirtus < /em > (L.) DC (Rubiaceae)
Nat Prod Res. 2024 Apr 8:1-7. doi: 10.1080/14786419.2024.2337110. Online ahead of print.ABSTRACTA phytochemical investigation of the aerial parts of Mitracarpus hirtus afforded thirteen compounds, including a new naphthoquinone di-glycoside (1), three isopentenyl isoflavones (2-4), four flavonoids (5-8), three iridoid glycosides (9 - 11) and two coumarins (12 and 13). Their structures were elucidated based on extensive spectroscopic analyses, chemical methods, and the comparison with the literature. Among them, compound 1 possesses a 2-(3-methylnaphthalen-2-yl)acetic acid core with two glucosyl groups, compounds 2-4 are th...
Source: Natural Product Research - April 8, 2024 Category: Biochemistry Authors: Xinyi Wei Yingrun Ma Mingming Xu Ding Heng Monday M Onakpa Jin-Ao Duan Chun-Tao Che Hongkai Bi Junfei Zhou Ming Zhao Source Type: research

Engineering resveratrol-loaded chitosan nanoparticles for potential use against Helicobacter pylori infection
Eur J Pharm Biopharm. 2024 Apr 6:114280. doi: 10.1016/j.ejpb.2024.114280. Online ahead of print.ABSTRACTHelicobacter pylori (H. pylori) is a microorganism directly linked to severe clinical conditions affecting the stomach. The virulence factors and its ability to form biofilms increase resistance to conventional antibiotics, growing the need for new substances and strategies for the treatment of H. pylori infection. The trans-resveratrol (RESV), a bioactive polyphenol from natural sources, has a potential activity against this gastric pathogen. Here, Chitosan nanoparticles (NP) containing RESV (RESV-NP) were developed for...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 8, 2024 Category: Drugs & Pharmacology Authors: Larissa Sp ósito Diana Fonseca Suzana Gon çalves Carvalho Rafael Miguel S ábio Gabriel Marena Ta ís Maria Bauab Andr éia Bagliotti Meneguin Paula Parreira M Cristina L Martins Marlus Chorilli Source Type: research

RSPO3 induced by Helicobacter pylori extracts promotes gastric cancer stem cell properties through the GNG7/ β‐catenin signaling pathway
ConclusionRSPO3 enhanced the stemness ofH. pylori extracts-infected GC cells through the GNG7/ β-catenin signaling pathway. (Source: Cancer Medicine)
Source: Cancer Medicine - April 6, 2024 Category: Cancer & Oncology Authors: Xiwu Rao, Zhipeng Zhang, Yunzhou Pu, Gang Han, Hangjun Gong, Hao Hu, Qing Ji, Ningning Liu Tags: RESEARCH ARTICLE Source Type: research

Effects of Helicobacter pylori and Moluodan on the Wnt/beta-catenin signaling pathway in mice with precancerous gastric cancer lesions
CONCLUSION: H. pylori can activate the Wnt/β-catenin signaling pathway, thereby facilitating the development and progression of PLGC. Moluodan suppressed the activation of the Wnt/β-catenin signaling pathway, thereby decreasing the progression of PLGC.PMID:38577474 | PMC:PMC10989371 | DOI:10.4251/wjgo.v16.i3.979 (Source: Cancer Control)
Source: Cancer Control - April 5, 2024 Category: Cancer & Oncology Authors: Yi-Mei Wang Zheng-Wei Luo Yu-Lin Shu Xiu Zhou Lin-Qing Wang Chun-Hong Liang Chao-Qun Wu Chang-Ping Li Source Type: research

Treatment of < em > Helicobacter pylori < /em > with potassium competitive acid blockers: A systematic review and meta-analysis
CONCLUSION: VPZ-based triple therapy outperformed conventional PPI-based triple therapy in eradicating H. pylori, positioning it as a highly effective first-line regimen. Additionally, TPZ-based triple therapy was non-inferior to classical PPI triple therapy.PMID:38577188 | PMC:PMC10989498 | DOI:10.3748/wjg.v30.i9.1213 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Joseph Edwin Kanu Jonathan Soldera Source Type: research

Treatment of < em > Helicobacter pylori < /em > with potassium competitive acid blockers: A systematic review and meta-analysis
CONCLUSION: VPZ-based triple therapy outperformed conventional PPI-based triple therapy in eradicating H. pylori, positioning it as a highly effective first-line regimen. Additionally, TPZ-based triple therapy was non-inferior to classical PPI triple therapy.PMID:38577188 | PMC:PMC10989498 | DOI:10.3748/wjg.v30.i9.1213 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 5, 2024 Category: Gastroenterology Authors: Joseph Edwin Kanu Jonathan Soldera Source Type: research

Treatment of < em > Helicobacter pylori < /em > with potassium competitive acid blockers: A systematic review and meta-analysis
CONCLUSION: VPZ-based triple therapy outperformed conventional PPI-based triple therapy in eradicating H. pylori, positioning it as a highly effective first-line regimen. Additionally, TPZ-based triple therapy was non-inferior to classical PPI triple therapy.PMID:38577188 | PMC:PMC10989498 | DOI:10.3748/wjg.v30.i9.1213 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Joseph Edwin Kanu Jonathan Soldera Source Type: research

Treatment of < em > Helicobacter pylori < /em > with potassium competitive acid blockers: A systematic review and meta-analysis
CONCLUSION: VPZ-based triple therapy outperformed conventional PPI-based triple therapy in eradicating H. pylori, positioning it as a highly effective first-line regimen. Additionally, TPZ-based triple therapy was non-inferior to classical PPI triple therapy.PMID:38577188 | PMC:PMC10989498 | DOI:10.3748/wjg.v30.i9.1213 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 5, 2024 Category: Gastroenterology Authors: Joseph Edwin Kanu Jonathan Soldera Source Type: research

Treatment of < em > Helicobacter pylori < /em > with potassium competitive acid blockers: A systematic review and meta-analysis
CONCLUSION: VPZ-based triple therapy outperformed conventional PPI-based triple therapy in eradicating H. pylori, positioning it as a highly effective first-line regimen. Additionally, TPZ-based triple therapy was non-inferior to classical PPI triple therapy.PMID:38577188 | PMC:PMC10989498 | DOI:10.3748/wjg.v30.i9.1213 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Joseph Edwin Kanu Jonathan Soldera Source Type: research

Treatment of < em > Helicobacter pylori < /em > with potassium competitive acid blockers: A systematic review and meta-analysis
CONCLUSION: VPZ-based triple therapy outperformed conventional PPI-based triple therapy in eradicating H. pylori, positioning it as a highly effective first-line regimen. Additionally, TPZ-based triple therapy was non-inferior to classical PPI triple therapy.PMID:38577188 | PMC:PMC10989498 | DOI:10.3748/wjg.v30.i9.1213 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 5, 2024 Category: Gastroenterology Authors: Joseph Edwin Kanu Jonathan Soldera Source Type: research

Treatment of < em > Helicobacter pylori < /em > with potassium competitive acid blockers: A systematic review and meta-analysis
CONCLUSION: VPZ-based triple therapy outperformed conventional PPI-based triple therapy in eradicating H. pylori, positioning it as a highly effective first-line regimen. Additionally, TPZ-based triple therapy was non-inferior to classical PPI triple therapy.PMID:38577188 | PMC:PMC10989498 | DOI:10.3748/wjg.v30.i9.1213 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 5, 2024 Category: Gastroenterology Authors: Joseph Edwin Kanu Jonathan Soldera Source Type: research