Helicobacter pylori secretary Proteins-Induced oxidative stress and its role in NLRP3 inflammasome activation
This study evaluates the role of H. pylori secreted concentrated proteins (HPSCP) related oxidative stress role in NLRP3 inflammasome activation and macrophage differentiation. To perceive the role of ROS/RNS, THP-1 and AGS cells were treated with 10 μM diphenyleneiodonium (DPI), 50 μM salicyl hydroxamic acid (SHX), 5 μM Carbonyl cyanide-4-(trifluoromethoxy) phenylhydrazone (FCCP), which are specific inhibitors of NADPH oxidase (NOX), Myeloperoxidase (MPO), and mitochondrial oxidative phosphorylation respectively. Cells were also treated with 10 μM of NOS2 inhibitor l-NMMA and 10 μM of N-acetyl cysteine (NAC), a free ...
Source: Cancer Control - March 22, 2024 Category: Cancer & Oncology Authors: Sandeep Kumar Monisha Dhiman Source Type: research
Immunoglobulin G-mediated food intolerance and metabolic syndrome influence the occurrence of reflux esophagitis in < em > Helicobacter pylori < /em > -infected patients
CONCLUSION: Patients with IgG-mediated food intolerance and metabolic syndrome were at higher risk of developing reflux esophagitis, while patients with H. pylori infection were at lower risk. IgG-mediated food intolerance reduced the risk of reflux esophagitis pathogenesis in patients with H. pylori infection; however, metabolic syndrome increased the risk of patients with H. pylori infection developing reflux esophagitis.PMID:38516244 | PMC:PMC10950645 | DOI:10.3748/wjg.v30.i8.855 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 22, 2024 Category: Gastroenterology Authors: Li-Hui Wang Bin-Bin Su Sheng-Shu Wang Guan-Chao Sun Kun-Ming Lv Yi Li Hui Shi Qian-Qian Chen Source Type: research
Bibliometrics analysis based on the Web of Science: Current trends and perspective of gastric organoid during 2010-2023
CONCLUSION: Key focus areas of research using gastric organoids include unraveling disease mechanisms and enhancing drug screening techniques. Major contributions from renowned academic institutions highlight this field's dynamic growth.PMID:38516239 | PMC:PMC10950634 | DOI:10.3748/wjg.v30.i8.969 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 22, 2024 Category: Gastroenterology Authors: Kai-Lin Jiang Yue-Bo Jia Xue-Jiao Liu Qing-Ling Jia Li-Kun Guo Xiang-Xiang Wang Ke-Ming Yang Chen-Heng Wu Bei-Bei Liang Jiang-Hong Ling Source Type: research
Immunoglobulin G-mediated food intolerance and metabolic syndrome influence the occurrence of reflux esophagitis in < em > Helicobacter pylori < /em > -infected patients
CONCLUSION: Patients with IgG-mediated food intolerance and metabolic syndrome were at higher risk of developing reflux esophagitis, while patients with H. pylori infection were at lower risk. IgG-mediated food intolerance reduced the risk of reflux esophagitis pathogenesis in patients with H. pylori infection; however, metabolic syndrome increased the risk of patients with H. pylori infection developing reflux esophagitis.PMID:38516244 | PMC:PMC10950645 | DOI:10.3748/wjg.v30.i8.855 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Li-Hui Wang Bin-Bin Su Sheng-Shu Wang Guan-Chao Sun Kun-Ming Lv Yi Li Hui Shi Qian-Qian Chen Source Type: research
Bibliometrics analysis based on the Web of Science: Current trends and perspective of gastric organoid during 2010-2023
CONCLUSION: Key focus areas of research using gastric organoids include unraveling disease mechanisms and enhancing drug screening techniques. Major contributions from renowned academic institutions highlight this field's dynamic growth.PMID:38516239 | PMC:PMC10950634 | DOI:10.3748/wjg.v30.i8.969 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Kai-Lin Jiang Yue-Bo Jia Xue-Jiao Liu Qing-Ling Jia Li-Kun Guo Xiang-Xiang Wang Ke-Ming Yang Chen-Heng Wu Bei-Bei Liang Jiang-Hong Ling Source Type: research
Chinese National Clinical Practice Guidelines on the Prevention, Diagnosis, and Treatment of Early Gastric Cancer
CONCLUSIONS: This CPG can lead to optimum care for patients and populations by providing up-to-date medical information. We intend this CPG for widespread adoption to increase the standard of prevention, screening, diagnosis, treatment, and follow-up of early gastric cancer; thereby, contributing to improving national health care and patient quality of life.PMID:38515297 | DOI:10.1097/CM9.0000000000003101 (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 22, 2024 Category: General Medicine Authors: Society of Digestive Endoscopy of the Chinese Medical Association, Colorectal Surgery Group of the Chinese Medical Association, Chinese Association of Gastroenterologists & Hepatologists, National Clinical Research Center for Digestive Diseases, Workshop Source Type: research
Clinicopathological and endoscopic features of Helicobacter pylori infection-negative gastric cancer in Japan: a retrospective study
CONCLUSIONS: This study revealed that tumors from each gastric region exhibited distinct macroscopic and histological types in HPNGC.PMID:38514987 | DOI:10.5946/ce.2023.258 (Source: Clinical Endoscopy)
Source: Clinical Endoscopy - March 22, 2024 Category: Gastroenterology Authors: Kentaro Imamura Kenshi Yao Satoshi Nimura Takao Kanemitsu Masaki Miyaoka Yoichiro Ono Toshiharu Ueki Hiroshi Tanabe Source Type: research
Novel carbonic anhydrase inhibitors for the treatment of < em > Helicobacter pylori < /em > infection
Expert Opin Investig Drugs. 2024 Mar 22. doi: 10.1080/13543784.2024.2334714. Online ahead of print.ABSTRACTINTRODUCTION: Helicobacter pylori, the causative agent of peptic ulcer, gastritis and gastric cancer encodes two carbonic anhydrases (CA, EC 4.2.1.1) belonging to the α- and β-class (HpCAα/β), which have been validated as antibacterial drug targets. Acetazolamide and ethoxzolamide were also clinically used for the management of peptic ulcer.AREAS COVERED: Sulfonamides were the most investigated HpCAα/β compounds, with several low nanomolar inhibitors indentified, some of which also crystallized as adducts with H...
Source: Expert Opinion on Investigational Drugs - March 22, 2024 Category: Drugs & Pharmacology Authors: Claudiu T Supuran Source Type: research
Helicobacter pylori secretary Proteins-Induced oxidative stress and its role in NLRP3 inflammasome activation
This study evaluates the role of H. pylori secreted concentrated proteins (HPSCP) related oxidative stress role in NLRP3 inflammasome activation and macrophage differentiation. To perceive the role of ROS/RNS, THP-1 and AGS cells were treated with 10 μM diphenyleneiodonium (DPI), 50 μM salicyl hydroxamic acid (SHX), 5 μM Carbonyl cyanide-4-(trifluoromethoxy) phenylhydrazone (FCCP), which are specific inhibitors of NADPH oxidase (NOX), Myeloperoxidase (MPO), and mitochondrial oxidative phosphorylation respectively. Cells were also treated with 10 μM of NOS2 inhibitor l-NMMA and 10 μM of N-acetyl cysteine (NAC), a free ...
Source: Cellular Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Sandeep Kumar Monisha Dhiman Source Type: research
Helicobacter pylori secretary Proteins-Induced oxidative stress and its role in NLRP3 inflammasome activation
This study evaluates the role of H. pylori secreted concentrated proteins (HPSCP) related oxidative stress role in NLRP3 inflammasome activation and macrophage differentiation. To perceive the role of ROS/RNS, THP-1 and AGS cells were treated with 10 μM diphenyleneiodonium (DPI), 50 μM salicyl hydroxamic acid (SHX), 5 μM Carbonyl cyanide-4-(trifluoromethoxy) phenylhydrazone (FCCP), which are specific inhibitors of NADPH oxidase (NOX), Myeloperoxidase (MPO), and mitochondrial oxidative phosphorylation respectively. Cells were also treated with 10 μM of NOS2 inhibitor l-NMMA and 10 μM of N-acetyl cysteine (NAC), a free ...
Source: Cancer Control - March 22, 2024 Category: Cancer & Oncology Authors: Sandeep Kumar Monisha Dhiman Source Type: research
Immunoglobulin G-mediated food intolerance and metabolic syndrome influence the occurrence of reflux esophagitis in < em > Helicobacter pylori < /em > -infected patients
CONCLUSION: Patients with IgG-mediated food intolerance and metabolic syndrome were at higher risk of developing reflux esophagitis, while patients with H. pylori infection were at lower risk. IgG-mediated food intolerance reduced the risk of reflux esophagitis pathogenesis in patients with H. pylori infection; however, metabolic syndrome increased the risk of patients with H. pylori infection developing reflux esophagitis.PMID:38516244 | PMC:PMC10950645 | DOI:10.3748/wjg.v30.i8.855 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Li-Hui Wang Bin-Bin Su Sheng-Shu Wang Guan-Chao Sun Kun-Ming Lv Yi Li Hui Shi Qian-Qian Chen Source Type: research
Bibliometrics analysis based on the Web of Science: Current trends and perspective of gastric organoid during 2010-2023
CONCLUSION: Key focus areas of research using gastric organoids include unraveling disease mechanisms and enhancing drug screening techniques. Major contributions from renowned academic institutions highlight this field's dynamic growth.PMID:38516239 | PMC:PMC10950634 | DOI:10.3748/wjg.v30.i8.969 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Kai-Lin Jiang Yue-Bo Jia Xue-Jiao Liu Qing-Ling Jia Li-Kun Guo Xiang-Xiang Wang Ke-Ming Yang Chen-Heng Wu Bei-Bei Liang Jiang-Hong Ling Source Type: research
Chinese National Clinical Practice Guidelines on the Prevention, Diagnosis, and Treatment of Early Gastric Cancer
CONCLUSIONS: This CPG can lead to optimum care for patients and populations by providing up-to-date medical information. We intend this CPG for widespread adoption to increase the standard of prevention, screening, diagnosis, treatment, and follow-up of early gastric cancer; thereby, contributing to improving national health care and patient quality of life.PMID:38515297 | DOI:10.1097/CM9.0000000000003101 (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 22, 2024 Category: General Medicine Authors: Society of Digestive Endoscopy of the Chinese Medical Association, Colorectal Surgery Group of the Chinese Medical Association, Chinese Association of Gastroenterologists & Hepatologists, National Clinical Research Center for Digestive Diseases, Workshop Source Type: research
Clinicopathological and endoscopic features of Helicobacter pylori infection-negative gastric cancer in Japan: a retrospective study
CONCLUSIONS: This study revealed that tumors from each gastric region exhibited distinct macroscopic and histological types in HPNGC.PMID:38514987 | DOI:10.5946/ce.2023.258 (Source: Clinical Endoscopy)
Source: Clinical Endoscopy - March 22, 2024 Category: Gastroenterology Authors: Kentaro Imamura Kenshi Yao Satoshi Nimura Takao Kanemitsu Masaki Miyaoka Yoichiro Ono Toshiharu Ueki Hiroshi Tanabe Source Type: research
Novel carbonic anhydrase inhibitors for the treatment of < em > Helicobacter pylori < /em > infection
Expert Opin Investig Drugs. 2024 Mar 22. doi: 10.1080/13543784.2024.2334714. Online ahead of print.ABSTRACTINTRODUCTION: Helicobacter pylori, the causative agent of peptic ulcer, gastritis and gastric cancer encodes two carbonic anhydrases (CA, EC 4.2.1.1) belonging to the α- and β-class (HpCAα/β), which have been validated as antibacterial drug targets. Acetazolamide and ethoxzolamide were also clinically used for the management of peptic ulcer.AREAS COVERED: Sulfonamides were the most investigated HpCAα/β compounds, with several low nanomolar inhibitors indentified, some of which also crystallized as adducts with H...
Source: Expert Opinion on Investigational Drugs - March 22, 2024 Category: Drugs & Pharmacology Authors: Claudiu T Supuran Source Type: research
