Expression of Tight Junction Proteins According to Functional Dyspepsia Subtype and Sex.
Conclusions: H. pylori can affect a variety of TJPs, particularly claudin-4 and occludin. Claudin-2 is thought to be involved in FD irrespective of H. pylori status, especially in the pathophysiology of male FD. PMID: 32235032 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 4, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

CME Exam 2: A Never-Ending Case of Helicobacter pylori
(Source: Gastroenterology)
Source: Gastroenterology - April 3, 2020 Category: Gastroenterology Tags: Continuing Medical Education (CME)/MOC Activities Source Type: research

Different Incidence of Early-Onset Gastric Carcinoma Depending on Ethnicity: Preliminary Results of a Hospital in Liangshan.
Conclusion: This study demonstrates the unequal manifestation of EOGC within the two ethnic groups of Han and Yi. However, familial clustering was infrequent. Further investigations are necessary to discover relevant risk factors apart from hereditary predisposition. PMID: 32231466 [PubMed - in process] (Source: The Scientific World Journal)
Source: The Scientific World Journal - April 2, 2020 Category: Science Tags: ScientificWorldJournal Source Type: research

TLR Agonist rHP-NAP as an Adjuvant of Dendritic Cell-Based Vaccine to Enhance Anti-Melanoma Response.
CONCLUSION: These results suggested that rHP-NAP possesses the potential for use as an adjuvant of dendritic cell-based vaccine in anti-melanoma treatment. PMID: 32224538 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - April 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Upper socioeconomic status is associated with lower Helicobacter pylori infection rate among patients undergoing gastroscopy
Introduction: Socioeconomic factors play an important role in the prevalence ofHelicobacter pylori (HP) infection. The aim of this study is to investigate HP prevalence among symptomatic patients in the upper socioeconomic segment of the population undergoing gastroscopy in an endemic urban region.Methodology: Over a 12-month period, data were collected from the first consecutive 1000 patients (500 from university hospital, 500 from community hospital) who had gastroscopy and HP evaluation.Results: Overall, 211/1000 patients (21.1 %) were found to have HP in gastric biopsies. The specificity, sensitivity, positive predicti...
Source: The Journal of Infection in Developing Countries - March 31, 2020 Category: Infectious Diseases Source Type: research

Differences in antibody levels to H. pylori virulence factors VacA and CagA among African Americans and whites in the Southeast USA
ConclusionOur findings support future studies to assess the association of differential antibody responses by race with risk of gastric cancer in the USA, which could then aid in developing targetedH. pylori eradication strategies. (Source: Cancer Causes and Control)
Source: Cancer Causes and Control - March 28, 2020 Category: Cancer & Oncology Source Type: research

Cancers, Vol. 12, Pages 816: Induction and Prevention of Gastric Cancer with Combined Helicobacter Pylori and Capsaicin Administration and DFMO Treatment, Respectively
This study provides evidence showing that a combination of H. pylori infection and capsaicin consumption leads to gastric carcinogenesis mediated through interleukin-6 (IL-6) stimulation with an incidence rate of 50%. The anti-inflammatory role of DFMO highlights the injurious effect of inflammation in gastric cancer development and the need to reduce gastric inflammation for cancer prevention by inhibiting IL-6. Accordingly, preventive measures such as reduced capsaicin consumption, H. pylori clearance, and DFMO treatment may lessen gastric cancer incidence. (Source: Cancers)
Source: Cancers - March 28, 2020 Category: Cancer & Oncology Authors: Faisal Aziz Mingxia Xin Yunfeng Gao Abhijit Chakroborty Imran Khan Josh Monts Kjersten Monson Ann M. Bode Zigang Dong Tags: Article Source Type: research

Risk Factors and Incidence of Gastric Cancer After Eradication of Helicobacter pylori
(Source: Gastroenterology)
Source: Gastroenterology - March 28, 2020 Category: Gastroenterology Authors: Yoshiharu Uno Source Type: research

Cancers, Vol. 12, Pages 803: Helicobacter pylori Avoids the Critical Activation of NLRP3 Inflammasome-Mediated Production of Oncogenic Mature IL-1 β in Human Immune Cells
Cancers, Vol. 12, Pages 803: Helicobacter pylori Avoids the Critical Activation of NLRP3 Inflammasome-Mediated Production of Oncogenic Mature IL-1β in Human Immune Cells Cancers doi: 10.3390/cancers12040803 Authors: Suneesh Kumar Pachathundikandi Nicole Blaser Heiko Bruns Steffen Backert Helicobacter pylori persistently colonizes the human stomach, and is associated with inflammation-induced gastric cancer. Bacterial crosstalk with the host immune system produces various inflammatory mediators and subsequent reactions in the host, but not bacterial clearance. Interleukin-1β (IL-1&bet...
Source: Cancers - March 27, 2020 Category: Cancer & Oncology Authors: Suneesh Kumar Pachathundikandi Nicole Blaser Heiko Bruns Steffen Backert Tags: Article Source Type: research

MicroRNA (miR) dysregulation during Helicobacter pylori-induced gastric inflammation and cancer development: critical importance of miR-155.
Authors: Prinz C, Weber D Abstract Dysregulation of noncoding microRNA molecules has been associated with immune cell activation in the context of Helicobacter pylori induced gastric inflammation as well as carcinogenesis, but also with downregulation of mismatch repair genes, and may interfere with immune checkpoint proteins that lead to the overexpression of antigens on gastric tumor cells. Numerous miR-molecules have been described as important tools and markers in gastric inflammation and cancer development -including miR-21, miR-143, miR-145, miR-201, and miR-335- all of which are downregulated in gastric tumo...
Source: Oncotarget - March 26, 2020 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Prevalence of Helicobacter pylori babA , oipA , sabA , and homB genes in isolates from Chinese patients with different gastroduodenal diseases
This study aimed to investigate the correlation between the four OMP genes (babA,oipA,sabA, andhomB) and gastroduodenal diseases. One hundred and seventy-sevenH. pylori strains were isolated from Chinese patients with different gastroduodenal diseases (49 chronic gastritis, 19 gastric ulcer, 33 gastric cancer, and 76 duodenal ulcer), 94 of which contained pathological information (41 superficial gastritis, 24 intestinal hyperplasia, and 29 gastric adenocarcinoma). The full-length amplification ofbabA,oipA,sabA,and homB genes was acquired and sequenced. Then, the genetic polymorphism was analyzed to compare with the referen...
Source: Medical Microbiology and Immunology - March 26, 2020 Category: Microbiology Source Type: research

Diagnostic Accuracy of a Noninvasive Test for Detection of Helicobacter pylori and Resistance to Clarithromycin in Stool by the Amplidiag H. pylori+ClariR Real-Time PCR Assay [Bacteriology]
The noninvasive detection of Helicobacter pylori and its resistance to clarithromycin could revolutionize the management of H. pylori-infected patients by tailoring eradication treatment without any need for endoscopy when histology is not necessary. Several real-time PCR tests performed on stools have been proposed, but their performances were either poor or they were tested on too few patients to be properly evaluated. We conducted a prospective, multicenter study including 1,200 adult patients who were addressed for gastroduodenal endoscopy with gastric biopsies and who were naive for eradication treatment in order to e...
Source: Journal of Clinical Microbiology - March 25, 2020 Category: Microbiology Authors: Pichon, M., Pichard, B., Barrioz, T., Plouzeau, C., Croquet, V., Fotsing, G., Cheron, A., Vuillemin, E., Wangermez, M., Haineaux, P.-A., Vasseur, P., Thiebault, Q., Lefevre, C., de Singly, A., Cremniter, J., Broutin, L., Michaud, A., Silvain, C., Burucoa, Tags: Bacteriology Source Type: research

Issue highlights
Lynch syndrome is the most common inherited cause of gastrointestinal cancer. Although current guidelines recommend endoscopic screening for gastric cancer and Helicobacter pylori infection in carriers of germline variants causing Lynch syndrome, there are limited data to support these recommendations. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 24, 2020 Category: Gastroenterology Authors: Vincent Wong Tags: Issue Highlights Source Type: research

Helicobacter pylori infection as a risk factor for diabetes: a meta-analysis of case-control studies
There are several studies with varied and mixed results about the possible relationship between H. pylori and diabetes. Therefore, this current meta-analysis performed to determine the association between H. pylo... (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - March 24, 2020 Category: Gastroenterology Authors: Kamyar Mansori, Yousef Moradi, Sara Naderpour, Roya Rashti, Ali Baradaran Moghaddam, Lotfolah Saed and Hedyeh Mohammadi Tags: Research article Source Type: research

Usefulness and Limitations of a Serum Screening System to Predict the Risk of Gastric Cancer.
Conclusions The ABC classification system is useful for predicting the risk of gastric cancer. However, this system was limited in group A, which included individuals with a high risk of developing gastric cancer. An endoscopic diagnosis of atrophy may be more effective than the ABC classification system for predicting the risk of gastric cancer. PMID: 32188803 [PubMed - as supplied by publisher] (Source: Internal Medicine)
Source: Internal Medicine - March 21, 2020 Category: Internal Medicine Tags: Intern Med Source Type: research

Portal Hypertensive Polyps as Gastroscopic Finding in Liver Cirrhosis.
Conclusion: Portal hypertension-associated polypoid lesions are common in advanced liver cirrhosis cases. The pathological analyses of these polyps pointed out that they were all benign and no malignant cases were detected. It was argued that these polypoid lesions, referred to as portal hypertensive polyps, were associated with elevated angiogenesis in the gastric mucosa. PMID: 32184817 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - March 20, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Analysis of by high-throughput sequencing: Helicobacter pylori infection and salivary microbiome
There have been reports of Helicobacter pylori (H. pylori) in the oral cavity and it has been suggested that the oral cavity may be a reservoir for H. pylori reflux from the stomach. High-throughput sequencing wa... (Source: BMC Oral Health)
Source: BMC Oral Health - March 20, 2020 Category: Dentistry Authors: Yingjie Ji, Xiao Liang and Hong Lu Tags: Research article Source Type: research

Obesity and helicobacter pylori infection in adults with non specific colitis
Publication date: Available online 19 March 2020Source: Journal of ColoproctologyAuthor(s): Huda Saleem H. Al-Khalidy (Source: Journal of Coloproctology)
Source: Journal of Coloproctology - March 19, 2020 Category: Gastroenterology Source Type: research

Constitutive STAT3 serine phosphorylation promotes Helicobacter-mediated gastric disease
Gastric cancer is associated with chronic inflammation (gastritis) triggered by infection with the Helicobacter pylori (H. pylori) bacterium. Elevated tyrosine phosphorylation (pY) of the latent transcription factor STAT3 is a feature of gastric cancer, including H. pylori-infected tissues, and is aligned to nuclear transcriptional activity. By contrast, the transcriptional role of STAT3 serine phosphorylation (pS), which promotes STAT3-driven mitochondrial activities, is unclear. Here, by coupling pS-STAT3-deficient Stat3SA/SA mice with chronic H. (Source: American Journal of Pathology)
Source: American Journal of Pathology - March 19, 2020 Category: Pathology Authors: Jesse J. Balic, Mohamed I. Saad, Ruby Dawson, Alice J. West, Louise McLeod, Alison C. West, Kimberley D ’Costa, Virginie Deswaerte, Anouk Dev, William Sievert, Daniel J. Gough, Prithi S. Bhathal, Richard L. Ferrero, Brendan J. Jenkins Tags: Regular Article Source Type: research

Constitutive STAT3 serine phosphorylation promotes Helicobacter-mediated gastric disease.
Abstract Gastric cancer is associated with chronic inflammation (gastritis) triggered by infection with the Helicobacter pylori (H. pylori) bacterium. Elevated tyrosine phosphorylation (pY) of the latent transcription factor STAT3 is a feature of gastric cancer, including H. pylori-infected tissues, and is aligned to nuclear transcriptional activity. By contrast, the transcriptional role of STAT3 serine phosphorylation (pS), which promotes STAT3-driven mitochondrial activities, is unclear. Here, by coupling pS-STAT3-deficient Stat3SA/SA mice with chronic H. felis infection, we reveal a key role for pS-STAT3 in pro...
Source: The American Journal of Pathology - March 19, 2020 Category: Pathology Authors: Balic JJ, Saad MI, Dawson R, West AJ, McLeod L, West AC, D'Costa K, Deswaerte V, Dev A, Sievert W, Gough DJ, Bhathal PS, Ferrero RL, Jenkins BJ Tags: Am J Pathol Source Type: research

Evaluation of the Direct Economic Cost per Eradication Treatment Regimen against Helicobacter pylori Infection in Greece: Do National Health Policy-Makers Need to Care?
Abstract Helicobacter pylori (Hp) management has undoubtedly resulted in a notable economic burden on healthcare systems globally, including Greece. Its cost has never been estimated so far, especially during the recent 10-year unprecedented financial crisis. Direct medical and procedural costs for one attempt "outpatient" Hp eradication treatment were estimated as the following: (I) first-line regimens: 10 and 14 days standard triple, 10 and 14 days sequential, 10 and 14 days concomitant non-bismuth quadruple, 14 days hybrid, (II) second-line salvage regimens: 10 and 14 days levofloxacin-containing trip...
Source: Medicina (Kaunas) - March 18, 2020 Category: Universities & Medical Training Authors: Liatsos C, Papaefthymiou A, Kyriakos N, Giakoumis M, Kountouras J, Galanopoulos M, Apostolopoulos P, Georgopoulos SD, Mavrogiannis C, Exadaktylos AK, Srivastava DS, Rokkas T, Doulberis M Tags: Medicina (Kaunas) Source Type: research

Amelioration of Alcohol Induced Gastric Ulcers Through the Administration of Lactobacillus plantarum APSulloc 331261 Isolated From Green Tea
In this study the potential of Lactobacillus plantarum APSulloc 331261 (GTB1TM), isolated from green tea, was investigated for alleviating gastric inflammation in an alcohol induced gastric ulcer murine model (positive control). Treatment with the test strain significantly influenced the expression of pro-inflammatory and anti-inflammatory biomarkers, interleukin 6 (IL6) and interleukin 10 (IL10), of which the former was down- and the latter up-regulated when the alcohol induced mice were treated with the test strain. This positive effect was also indicated by less severe gastric morphological changes and the histological ...
Source: Frontiers in Microbiology - March 17, 2020 Category: Microbiology Source Type: research

Helicobacter pylori-induced adrenomedullin modulates IFN-γ-producing T-cell responses and contributes to gastritis
Cell Death & Disease, Published online: 17 March 2020; doi:10.1038/s41419-020-2391-6Helicobacter pylori-induced adrenomedullin modulates IFN-γ-producing T-cell responses and contributes to gastritis (Source: Cell death and disease)
Source: Cell death and disease - March 17, 2020 Category: Internal Medicine Authors: Hui Kong Nan You Han Chen Yong-sheng Teng Yu-gang Liu Yi-pin Lv Fang-yuan Mao Ping Cheng Weisan Chen Zhuo Zhao Quan-ming Zou Gang Guo Jin-yu Zhang Yuan Zhuang Source Type: research

Molecules, Vol. 25, Pages 1352: Synthesis and Structure –Activity Relationship of Palmatine Derivatives as a Novel Class of Antibacterial Agents against Helicobacter pylori
Molecules, Vol. 25, Pages 1352: Synthesis and Structure–Activity Relationship of Palmatine Derivatives as a Novel Class of Antibacterial Agents against Helicobacter pylori Molecules doi: 10.3390/molecules25061352 Authors: Fan Guo Zeng Wei You Wang Pang Song Taking palmatine (PMT) as the lead, 20 new PMT derivatives were synthesized and examined for their antibacterial activities against six tested metronidazole (MTZ)-resistant Helicobacter pylori (H. pylori) strains. The structure–activity relationship (SAR) indicated that the introduction of a suitable secondary amine subs...
Source: Molecules - March 16, 2020 Category: Chemistry Authors: Fan Guo Zeng Wei You Wang Pang Song Tags: Article Source Type: research

Helicobacter pylori infection impairs chaperone-assisted maturation of Na,K-ATPase in gastric epithelium.
Abstract Helicobacter pylori infection always induces gastritis, which may progress to ulcer disease or cancer. The mechanisms underlying mucosal injury by the bacteria are incompletely understood. Here we identify a novel pathway for H. pylori-induced gastric injury, the impairment of maturation of the essential transport enzyme and cell adhesion molecule, Na,K-ATPase. The Na,K-ATPase is comprised of α and β subunits that assemble in the ER prior to trafficking to the plasma membrane. Attachment of H. pylori to gastric epithelial cells increased Na,K-ATPase ubiquitylation, decreased its surface and tot...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - March 16, 2020 Category: Physiology Authors: Marcus EA, Tokhtaeva E, Jimenez JL, Wen Y, Naini BV, Heard AN, Kim S, Capri J, Cohn W, Whitelegge JP, Vagin O Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Structural characterization of pectin-bismuth complexes and their aggregation in acidic conditions.
In this study, pectin-bismuth (PB) was prepared and the changes of PB structure in acidic environment were reported for the first time. The structure of PB was characterized by FT-IR, XRD, and TGA, which suggested that combined with bismuth could alter the crystal structure of pectin. XPS confirmed the ionic binding of Bi3+ with carboxyl groups of pectin. The aggregating of PB with different pH level were also investigated, and the influence of pH on PB structure were observed by SEM. Results showed that PB has much larger volume of flocculation in acidic environment compared with bismuth nitrate. Additionally, apparent sh...
Source: International Journal of Biological Macromolecules - March 16, 2020 Category: Biochemistry Authors: Jiang WX, Qi JR, Liao JS, Wan ZL, Liang WL, Huang JY, Cao Y, Xiao J, Yang XQ Tags: Int J Biol Macromol Source Type: research

Quality Indicators for the Detection of Helicobacter Pylori-Negative Early Gastric Cancer: A Retrospective Observational Study.
Authors: Ishibashi F, Kobayashi K, Fukushima K, Tanaka R, Kawakami T, Kato J, Sugihara K Abstract Background/Aims: While Helicobacter pylori (HP)-negative gastric cancer is frequently reported, little is known about the predictors for detecting HP-negative early gastric cancer (EGC). We aimed to evaluate the predictors for the detection of HP-negative EGC. Methods: We retrospectively reviewed 13,477 consecutive asymptomatic cases where upper endoscopy was performed by nine physicians from April 2017 to March 2019 and analyzed the detection rate of high-risk lesions (HRLs), including EGC, tubular adenoma, and ly...
Source: Clinical Endoscopy - March 14, 2020 Category: Gastroenterology Tags: Clin Endosc Source Type: research

Association of duodenal eosinophilia with Helicobacter pylori-negative functional dyspepsia
Publication date: Available online 13 March 2020Source: Arab Journal of GastroenterologyAuthor(s): Md Abdul Mumit Sarkar, Shabnam Akhter, Masudur Rahman Khan, Madhusudan Saha, Projesh Kumar Roy (Source: Arab Journal of Gastroenterology)
Source: Arab Journal of Gastroenterology - March 14, 2020 Category: Gastroenterology Source Type: research

Cyanidin-3-O-glucoside protects human gastric epithelial cells against Helicobacter pylori lipopolysaccharide-induced disorders by modulating TLR-mediated NF-κB pathway
Publication date: May 2020Source: Journal of Functional Foods, Volume 68Author(s): Jinlong Tian, Xu Si, Yuehua Wang, Ersheng Gong, Xu Xie, Ye Zhang, Chi Shu, Bin Li (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - March 14, 2020 Category: Nutrition Source Type: research

Prevalence of Gastric Intestinal Metaplasia in a Multi-Ethnic United States Veterans Population
We examined the prevalence of gastric intestinal metaplasia, detected by upper endoscopy biopsy analysis, in different race and ethnic sub-groups. We also investigated the extent to which Helicobacter pylori infection, with or without acute and chronic gastritis, accounts for observed associations between race or ethnicity and risk of gastric intestinal metaplasia. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 14, 2020 Category: Gastroenterology Authors: Theresa H. Nguyen, Mimi C. Tan, Yan Liu, Massimo Rugge, Aaron P. Thrift, Hashem B. El-Serag Source Type: research

Global whole family based-Helicobacter pylori eradication strategy to prevent its related diseases and gastric cancer.
Abstract Helicobacter pylori (H. pylori) infects approximately 50% of the world population. The multiple gastrointestinal and extra-gastrointestinal diseases caused by H. pylori infection pose a major healthcare threat to families and societies; it is also a heavy economic and healthcare burden for countries that having high infection rates. Eradication of H. pylori is recommended for all infected individuals. Traditionally, "test and treat" and "screen and treat" strategies are available for various infected populations. However, clinical practice has noticed that these strategies have some sh...
Source: World Journal of Gastroenterology : WJG - March 14, 2020 Category: Gastroenterology Authors: Ding SZ Tags: World J Gastroenterol Source Type: research

Alzheimer ’s disease and gastrointestinal microbiota; impact of Helicobacter pylori infection involvement
. (Source: International Journal of Neuroscience)
Source: International Journal of Neuroscience - March 13, 2020 Category: Neuroscience Authors: Michael Doulberis Georgios Kotronis Dimitra Gialamprinou Stergios A. Polyzos Apostolis Papaefthymiou Panagiotis Katsinelos Jannis Kountouras Source Type: research

Association between polymorphisms in HLA-A, HLA-B, HLA-DR, and DQ genes from gastric cancer and duodenal ulcer patients and cagL among cagA-positive Helicobacter pylori strains: The first study in a Turkish population.
eybek B Abstract Colonization of the human gastric mucosa by H. pylori may cause peptic and duodenal ulcers (DUs), gastric lymphomas, and gastric cancers. The cagL gene is a component of cag T4SS and is involved in cagA translocation into host. An association between the risk of gastric cancer and the type of HLA class II (DR and/or DQ) was suggested in different populations. The aim of this study was to investigate, the clinical association of the cagL gene with host HLA alleles in H. pylori strains that were isolated from patients with gastric cancer, DU, and non-ulcer dyspepsia (NUD) and to determine the HLA al...
Source: Infection, Genetics and Evolution - March 13, 2020 Category: Genetics & Stem Cells Authors: Kocak BT, Saribas S, Demiryas S, Yilmaz E, Uysal O, Kepil N, Demirci M, Dınc HO, Akkus S, Gülergün R, Gareayaghi N, Dağdeviren HE, Ozbey D, Dağ HH, Tokman HB, Tasci I, Kocazeybek B Tags: Infect Genet Evol Source Type: research

Relationship between helicobacter pylori infection and pityriasis versicolor: Can helicobacter pylori infection be a new etiologic factor for pityriasis versicolor?
In this study, we aimed to evaluate the association between H. pylori and pityriasis versicolor. MATERIALS AND METHODS: This was a prospective study performed in the Gastroenterology and Dermatology and Venereology departments of the Health Sciences University, Ankara Training and Research Center. A total of 57 consecutive patients (27 pityriasis versicolor, 30 telogen effluvium) were enrolled from the department of Dermatology and Venereology. All patients were screened for H. pylori IgG and CagA. In addition, urea breath test was carried out to detect the existence of H. pylori infection. RESULTS: There were sign...
Source: Turkish Journal of Medical Sciences - March 12, 2020 Category: General Medicine Tags: Turk J Med Sci Source Type: research

Precancerous Gastric Lesions with Helicobacter pylori vacA +/babA2+/oipA + Genotype Increase the Risk of Gastric Cancer.
Conclusion: In this present study, we reported on the virulence genes of H. pylori infection to reveal their association with increased risk of chronic gastritis, precancerous gastric lesions, and gastric cancer. Precancerous gastric lesions with H. pylori vacA+/babA2+/oipA+ genotype increased the risk of gastric cancer.H. pylori), host genetic susceptibility, and host immune responses. This study investigated the presence of H. pylori vacA +/babA2, and oipA genes and their association with clinical outcomes. PMID: 32149129 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - March 11, 2020 Category: Research Authors: Bartpho TS, Wattanawongdon W, Tongtawee T, Paoin C, Kangwantas K, Dechsukhum C Tags: Biomed Res Int Source Type: research

Gastric Xanthoma Associated with Gastric Cancer Development: An Updated Review.
Authors: Moumin FA, Mohamed AA, Osman AA, Cai J Abstract Gastric xanthelasma (GX) is a rare tumor-like lesion customarily found as an incidental finding due to its asymptomatic appearance. Grossly, it is a well-marked yellow-white plaque created in the lamina propria by microscopic clusters of foamy macrophages. Xanthelasma is rarely correlated with gastric hyperplastic polyps; gastric xanthomas are rare benign lesions that appear to be associated with inflammation of the gastric mucosa. Etiopathogenesis is also unclear, but it has been suggested to be involved in chronic gastritis, infection with Helicobacter pylo...
Source: Canadian Journal of Gastroenterology - March 11, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Effect of Previous Nitroimidazole Treatment on Helicobacter pylori Eradication Success
Goals: The goal of this study was to examine the impact of prior treatment with a nitroimidazole antibiotic on the success of Helicobacter pylori treatment. Background: Prior nitroimidazole exposure may increase the likelihood of nitroimidazole-resistant H. pylori. Current H. pylori treatment guidelines recommend that, in the absence of susceptibility testing, patients with prior nitroimidazole exposure should not be treated with a nitroimidazole antibiotic. Data to support this recommendation are lacking. Study: We searched the Clalit Health Services database to identify subjects 25 to 60 years old who underwent a...
Source: Journal of Clinical Gastroenterology - March 11, 2020 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

The ATM rs189037 G > A polymorphism is associated with the risk and prognosis of gastric cancer in Chinese individuals: a case-control study.
In conclusion, the ATM rs189037 G> A polymorphism was related to increased susceptibility to and poorer prognosis in GC in this Chinese population. PMID: 32171823 [PubMed - as supplied by publisher] (Source: Gene)
Source: Gene - March 11, 2020 Category: Genetics & Stem Cells Authors: Tao Y, Mei Y, Ying R, Chen S, Wei Z Tags: Gene Source Type: research

The Yield of Upper Gastrointestinal Endoscopy at a Pediatric Tertiary Care Center.
CONCLUSIONS: Our findings suggest a general high diagnostic yield for EGD in pediatric patients, stemming mainly from patients in whom a specific condition was suspected a priori. However, the role of the procedure in the diagnosis and management of non-specific gastrointestinal complaints was minor suggesting that EGD may be superfluous for some of these patients. PMID: 32147981 [PubMed - in process] (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - March 10, 2020 Category: General Medicine Tags: Isr Med Assoc J Source Type: research

Mutational diversity in mutY deficient Helicobacter pylori and its effect on adaptation to the gastric environment.
Abstract Helicobacter pylori, a pathogenic bacterium that colonizes in the human stomach, harbors DNA repair genes to counter the gastric environment during chronic infection. In addition, H. pylori adapts to the host environment by undergoing antigenic phase variation caused by genomic mutations. The emergence of mutations in nucleotide sequences is one of the major factors underlying drug resistance and genetic diversity in bacteria. However, it is not clear how DNA repair genes contribute to driving the genetic change of H. pylori during chronic infection. To elucidate the physiological roles of DNA r...
Source: Biochemical and Biophysical Research communications - March 9, 2020 Category: Biochemistry Authors: Kinoshita-Daitoku R, Kiga K, Sanada T, Ogura Y, Bo Z, Iida T, Yokomori R, Kuroda E, Tanaka M, Sood A, Suzuki T, Nakai K, Hayashi T, Mimuro H Tags: Biochem Biophys Res Commun Source Type: research

Is the Utilization of Helicobacter pylori Stool Antigen Tests Appropriate in an Urban Canadian Population?
Abstract OBJECTIVES: Helicobacter pylori stool antigen test (HpSAT) appropriateness was investigated by assessing its testing and positivity rates in Calgary, Canada. METHODS: The laboratory information system was accessed for all patients who received an HpSAT in 2018. Testing volume, test results, age, and sex of patients were collected. Sociodemographic risk factors and geospatial analysis were performed by matching laboratory data to the 2016 census data. Testing appropriateness was defined as a concordance between testing and positivity rates for each sociodemographic variable. RESULTS: In 2018, 25,...
Source: American Journal of Clinical Pathology - March 7, 2020 Category: Pathology Authors: Ma I, Guo M, Pillai DR, Church DL, Naugler C Tags: Am J Clin Pathol Source Type: research

Relationship between DLEC1 and PBX3 promoter methylation and the risk and prognosis of gastric cancer in peripheral blood leukocytes
In this study, the associations betweenDLEC1 andPBX3 promoter methylation in peripheral blood leukocytes (PBLs) and the risk and prognosis of GC were investigated.MethodsThe methylation status ofDLEC1 andPBX3 promoter in PBLs of 368 GC cases and 382 controls was detected by the methylation-sensitive high-resolution melting (MS-HRM) method. Logistic and Cox regression were adopted to analyze the associations ofDLEC1 andPBX3 methylation with GC risk and prognosis, respectively. Confounding biases were controlled by propensity score (PS).ResultsCompared with negative methylation (Nm),DLEC1-positive methylation (Pm) was associ...
Source: Journal of Cancer Research and Clinical Oncology - March 6, 2020 Category: Cancer & Oncology Source Type: research

Oral rinses in growth inhibition and treatment of Helicobacter pylori infection
Helicobacter pylori (H. pylori) is well-known for its role in chronic gastritis and gastric cancer. Eradication of these carcinogenic bacteria from the gut is one of the challenges for clinicians. The complexity ... (Source: BMC Microbiology)
Source: BMC Microbiology - March 4, 2020 Category: Microbiology Authors: Dharmendra Kashyap, Budhadev Baral, Tarun Prakash Verma, Charu Sonkar, Debi Chatterji, Ajay Kumar Jain and Hem C. Jha Tags: Research article Source Type: research

Evaluation of Mutations in 23S rRNA , rdxA and frxA Genes of Helicobacter pylori in Paraffin-Embedded Gastric Biopsy Specimens from Iranian Gastric Cancer and Gastritis Patients
ConclusionA2143G mutation is the most frequent mutation among clarithromycin resistant genes in Iran. Also, missense and frameshift mutations are frequent inrdxA andfrxA genes. Screening for these mutations could help researchers to investigate the most effective anti-H. pylori antibiotics and to prevent antibiotic resistance. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - March 4, 2020 Category: Cancer & Oncology Source Type: research

Transcriptome hallmarks in Helicobacter pylori infection influence gastric cancer and MALT lymphoma
Epigenomics, Ahead of Print. (Source: Future Medicine: Epigenomics)
Source: Future Medicine: Epigenomics - March 4, 2020 Category: Genetics & Stem Cells Authors: Jian Zhang Jiamin Wei Zhixiong Wang Yun Feng Zhewei Wei Xun Hou Jianbo Xu Yulong He Dongjie Yang Source Type: research

Helicobacter pylori Is Associated With Precancerous and Cancerous Lesions of the Gastric Cardia Mucosa: Results of a Large Population-Based Study in China
Background:Helicobacter pylori (H. pylori) is widely accepted to be the most important cause of gastric non-cardia adenocarcinoma (GNCA), while its role in the development of gastric cardia adenocarcinoma (GCA) is not well-defined. We aimed to investigate current H. pylori infection in relation to the severity of both precancerous and cancerous lesions of the gastric cardia in an Asian population at high risk of GCA.Methods: A population-based cross-sectional study was conducted in Linzhou County, Henan Province, China. Two thousand three (2,003) randomly selected participants with data on current H. pylori infection, assa...
Source: Frontiers in Oncology - March 3, 2020 Category: Cancer & Oncology Source Type: research

Effect of Saccharomyces boulardii CNCM I-745 as complementary treatment of Helicobacter pylori infection on gut microbiome
AbstractConventional therapy forH. pylori infection includes the combination of antibiotics and a proton-pump inhibitor. Addition of probiotics as adjuvants forH. pylori antibiotic treatment can increase eradication rate and decrease treatment side effects. Although many studies show the benefits ofS. boulardii CNCM I-745 in the treatment ofH. pylori infection, the mechanism by which those benefits are achieved is unknown. Here, we report clinical characteristics and fecal microbiota changes comparing conventional anti-H. pylori therapy versus conventional therapy supplemented withS. boulardii CNCM I-745. A total of 74 pat...
Source: European Journal of Clinical Microbiology and Infectious Diseases - March 3, 2020 Category: Microbiology Source Type: research

Relationship Between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease (NAFLD) in a Developing Country: A Cross-Sectional Study
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - March 2, 2020 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research

MUC1 is associated with TFF2 methylation in gastric cancer
Emerging evidence has shown that MUC1 and TFF2 play crucial roles in the H. pylori-infected pathogenesis of gastric cancer (GC). A recent study revealed that H. pylori infection induced obviously increased Tff2 m... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 2, 2020 Category: Research Authors: Yuqiu Ge, Gaoxiang Ma, Hanting Liu, Yadi Lin, Gang Zhang, Mulong Du, Meilin Wang, Haiyan Chu, Haiyan Zhang and Zhengdong Zhang Tags: Research Source Type: research