Relation Between Stroke and Heart Disease
Stroke is often due to sudden loss of blood supply to a region of the brain which usually results in paralysis of a part of the body. Stroke could also be due to bleeding into a part of the brain. Strokes and heart disease are linked together in various ways. In general, risk factors for stroke and some forms of heart disease are similar. Strokes due to blocks in blood vessels, can be seen along with blocks in blood vessels of the heart. Stroke can occur after a heart attack as well. Heart attack damages a part of the heart muscle. This can lead to damage of the inner lining of the heart in that region. A blood clot can fo...
Source: Cardiophile MD - April 21, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

How can Warfarin be safe “ even in ” first trimester of pregnancy ? The story behind the 5 mg cut-off !
The well known pro-coagulant state of pregnancy is an evolutionary protective process to make blood clot quicker, to save fetal loss in early pregnancy and mitigate postpartum bleeding. Still, in many women, this natural adaptive process confers an enhanced thrombotic risk. The molecular mechanisms for this pro-coagulant state are, there is increased factor VII, fibrinogen, reduced protein S. It is interesting to note, while plasminogen levels are elevated, D-dimer is also increased, indicating an ongoing fight between pro & anticoagulant forces, converting the physiological maternal- placental bed a mini harmless DIC ...
Source: Dr.S.Venkatesan MD - March 20, 2024 Category: Cardiology Authors: dr s venkatesan Tags: cardiology -pregnancy Pregnancy and heart pregnancy and heart disease Uncategorized carpreg registry zahara esc acc guidelines on pregnancy and heart disease first trmestr use of oac warfarin heparin switch over lmwh bridge in pregnancy Source Type: blogs

3D Printing In Medicine And Healthcare – The Ultimate List
3D printing has demonstrated huge potential for the future of medicine in the previous years, and its development is unstoppable. See the impressive list of 3D-printed healthcare materials and medical equipment below! How does 3D printing in medicine work? 3D printing in medicine is part of the innovative process called additive manufacturing, which means producing three-dimensional solid objects from a digital file. How the technology works, we explained in our article on bioprinting here. As technology evolves, researchers work on various solutions. For example, engineers from the University of Buffalo have ...
Source: The Medical Futurist - November 7, 2023 Category: Information Technology Authors: berci.mesko Tags: 3D Printing Biotechnology Future of Medicine Healthcare Design Medical Education Personalized Medicine 3d printed biomaterial tissue engineering Video bioprinting GC1 Innovation Source Type: blogs

Fight Aging! Newsletter, August 21st 2023
This study aimed to investigate the association between frailty index and circulating CAP2 concentration in 467 community-dwelling older adults (median age: 79; range: 65-92 years). The selected robust regression model showed that circulating CAP2 concentration was not associated with chronological age, as well as sex and education. However, circulating CAP2 concentration was significantly and inversely associated with the frailty index: a 0.1-unit increase in frailty index leads to ~0.5-point mean decrease in CAP2 concentration. Furthermore, mean CAP2 concentration was significantly lower in frail participants (i.e., fr...
Source: Fight Aging! - August 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Progress Towards Therapies for Transthyretin Amyloidosis
Transthyretin is one of the few proteins in the body that can misfold in a way that encourages other copies of the protein to also misfold, forming solid aggregates called amyloid that disrupt tissue structure and function. The resulting condition, transthyretin amyloidosis, clogs up cardiac tissue and thereby contributes to a fraction of all heart failure cases. It is thought to be a major cause of mortality in supercentenarians. Approved therapies targeting a more aggressive form of the condition resulting from a mutated transthyretin gene will not be useful against the much more common version of the condition, as they ...
Source: Fight Aging! - August 18, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Evaluation of Prosthetic Aortic Valve Obstruction
This discussion will focus beyond the basic clinical evaluation, ECG, chest X-ray and hematological workup. Hematological workup is important in aortic valve obstruction because of likelihood of associated hemolytic anemia and acquired von Willebrand Syndrome. Former is due to destruction of red blood cells across the narrowed aortic valve, and latter due to loss of the largest multimers of von Willebrand factor. High shear stress across the narrowed aortic valve exposes a region of the von Willebrand factor which is susceptible to a specific von Willebrand protease. This can lead on to gastrointestinal angiodysplasia (He...
Source: Cardiophile MD - August 9, 2023 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

I am 49 … not out, how about you TAVI ?
This post was written after coming across a case report  Oxford medical case report.   What is the life of a prosthetic Aortic valve? The standard answer needs to be, mechanical valves can last up to 25  years or more. But, we are in a techno-conflict era.  Instead of working on the longevity of the valve, ( with concerns for long-term OAC )  we fell for the biological valves. Curiously, this has made the durability of the valve, a less relevant discussion in many centers. We get excited when some company brings out a long-lasting bio-prosthetic valve that can live up to a maximum of 15 years. Now, ...
Source: Dr.S.Venkatesan MD - August 1, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized prosthetic aortic valve starr edwards valve tavi valve Source Type: blogs

Fight Aging! Newsletter, July 24th 2023
In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells. Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Ligature placement caused progressive periodontal disease and bone resorption that was already significant on day 1 post-ligation and continued to increase until day 30. The severity of periodontal disease increased the frequency of activated microglia in the brains on day 30 by 36...
Source: Fight Aging! - July 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Presence of Streptococcus Species in the Gut Microbiome Correlates with Atherosclerotic Plaque Burden
It is presently possible to cheaply and reliably determine the bacterial populations making up the gut microbiome via 16S rRNA sequencing. This capability is giving rise to great deal of new knowledge regarding the ways in which changes in the gut microbiome affect health. Populations can provoke inflammation, known to drive the onset and progression of many age-related conditions, or generate harmful or helpful metabolites, about which less is known of the interaction with specific aspects of aging. Adjusting the balance of populations in the gut microbiome, particularly to restore a more youthful gut microbiome in older ...
Source: Fight Aging! - July 19, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Heart Valves Made in Minutes
Researchers at Harvard University have developed a technique that lets them create biomaterial heart valves in a matter of minutes. The approach, called ‘Focused Rotary Jet Spinning’, has been described by the researchers as ‘a cotton-candy machine with a hair dryer behind it.’ Essentially, the technique involves using jets of air to direct polymer strands onto a heart valve shaped frame. This results in a porous scaffold that allows cardiac cells to enter and grow. The formed constructs also have the mechanical properties to function as a one-way valve within the heart. The scaffolds contain nanoscale ...
Source: Medgadget - July 6, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Cardiac Surgery Cardiology Materials Source Type: blogs

5 Causes Of Low Blood Pressure You Might Not Know About
Conclusion Low blood pressure, although often associated with a healthy cardiovascular system, can also indicate underlying health issues. It is crucial to recognize that low blood pressure should not be disregarded, particularly when accompanied by symptoms or fluctuations. This article explored the causes of low blood pressure, including cardiovascular conditions, hormonal imbalances, and neurological disorders. Smart heart care, including the use of blood pressure monitors and natural supplements, was emphasized as a proactive approach to maintaining a healthy life. Understanding the causes and implementi...
Source: The EMT Spot - June 8, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs

Asking Bard And ChatGPT To Find The Best Medical Care, I Got Truth And Truthiness
BY MICHAEL MILLENSON If you ask ChatGPT how many procedures a certain surgeon does or a specific hospital’s infection rate, the OpenAI and Microsoft chatbot inevitably replies with some version of, “I don’t do that.” But depending upon how you ask, Google’s Bard provides a very different response, even recommending a “consultation” with particular clinicians. Bard told me how many knee replacement surgeries were performed by major Chicago hospitals in 2021, their infection rates and the national average. It even told me which Chicago surgeon does the most knee surgeries and his infection rate. When I...
Source: The Health Care Blog - May 22, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Tech Uncategorized Bard ChatGPT Michael Millenson OpenAPI Source Type: blogs

Chest Wearable Provides Key Heart Measurements
Researchers at the University of Texas at Austin have developed a new chest wearable that can obtain both electrocardiogram and seismocardiogram data from the underlying heart. While basic ECG can be monitored via smart watches, no other wearable combines it with seismocardiography, which would conventionally be obtained by listening to the heart using a stethoscope. Pairing both measurements into one device allows clinicians to get a more complete picture of cardiac health, while freeing patients to go about their daily activities wearing an unobtrusive wearable.    Wearables are changing how we monitor patients and ...
Source: Medgadget - May 10, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Cardiology ECG electrocardiography seismocardiography UTAustin Source Type: blogs

This Antidepressant Can Contribute To Heart Valve Disease
This antidepressant may adversely affect the heart's mitral valve, contributing to a heart disease. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - January 19, 2023 Category: Psychiatry & Psychology Authors: P R Tags: PR Source Type: blogs

Thrombus, tumor or vegetation?
This question is often faced by the echocardiographer while evaluating a mass detected on the heart valves or cardiac chambers. Usual method is to take it in the clinical context. There could also be non-infective vegetations of marantic endocarditis which are almost impossible to differentiate from infective vegetations. Marantic vegetations can be suspected in the presence of small and multiple vegetations changing from one examination to another, without associated abscess or valve destruction [1]. It may be noted that echocardiography is neither 100% specific nor 100% sensitive for the diagnosis of infective endocardi...
Source: Cardiophile MD - December 15, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs