Combining anatomical and biochemical markers in the detection and risk stratification of coronary artery disease
CONCLUSION: The combination of the Ca-score with hs-cTnT increases the prognostic accuracy for future events defining fCAD, but does not provide incremental value versus the Ca-Score alone for the diagnosis of fCAD.PMID:38591997 | DOI:10.1093/ehjci/jeae093 (Source: Atherosclerosis)
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Miriam Albus Tobias Zimmermann Daniela Median Klara Rumora Ganna Isayeva Melissa Amrein Ibrahim Schaefer Joan Walter Evita Michel Gabrielle Hur é Ivo Strebel Federico Caobelli Philip Haaf Simon M Frey Christian Mueller Michael J Zellweger Source Type: research
Profiling of differentially expressed MicroRNAs in familial hypercholesterolemia via direct hybridization
CONCLUSIONS: The case-control nature of this study precluded the possibility of assessing the predictive role of the identified differentially expressed miRNAs for cardiovascular events. Therefore, the signature of miRNAs reflecting the pathogenesis of both HeFH and HoFH.PMID:38590435 | PMC:PMC10999490 | DOI:10.1016/j.ncrna.2024.02.017 (Source: Cell Research)
Source: Cell Research - April 9, 2024 Category: Cytology Authors: Erika Cione Maryam Mahjoubin-Tehran Tiziana Bacchetti Maciej Banach Gianna Ferretti Amirhossein Sahebkar Source Type: research
Red Blood Cell Distribution Width as a Risk Factor for 30/90-Day Mortality in Patients with Gastrointestinal Bleeding: Analysis of the MIMIC-IV Database
ConclusionThe current research showed that RDW could be utilized as an independent indicator of short-term mortality in critically ill GIB patients at 30 and 90 days of hospital admission. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 9, 2024 Category: Gastroenterology Source Type: research
Association of minor electrocardiographic (ECG) abnormalities with epilepsy duration in children: a manifestation of the epileptic heart?
A myriad of ictal and interictal cardiac alterations has been described in individuals with epilepsy, such as rhythm disturbances, increased arrhythmogenic potential, and impaired cardiac function [1 –16]. Increasing evidence indicates that adults with epilepsy may be at a higher risk for major cardiovascular events such as myocardial infarction, arrhythmias, and sudden cardiac death [17–21]. Together, these observations in adults support the concept of “the epileptic heart”: cardiac str uctural and functional abnormalities as result of chronic epilepsy, which may lead to potentially deleterious sequelae [22]. (Sou...
Source: Seizure: European Journal of Epilepsy - April 9, 2024 Category: Neurology Authors: Brittnie Bartlett-Lee, Leslie Dervan, Christina Miyake, R. Scott Watson, See Wai Chan, Anne E. Anderson, Yi-Chen Lai Source Type: research
Viruses, Vol. 16, Pages 578: Achievement of Primary Prevention Cardiometabolic Targets in Women with HIV: An Urgent Call to Action to Pursue Cardiovascular Health
Conclusions: H/Dy/DT target achievement is suboptimal, especially in migrants. A more aggressive pharmacological treatment, also assessing adherence to medical prescriptions, and promotion of healthy lifestyle should be urgently implemented, possibly redrawing the current model of care. (Source: Viruses)
Source: Viruses - April 9, 2024 Category: Virology Authors: Maria Mazzitelli Vincenzo Scaglione Claudia Cozzolino Marco Zuin Cristina Putaggio Beatrice Bragato Eleonora Vania Lolita Sasset Davide Leoni Vincenzo Baldo Annamaria Cattelan Tags: Article Source Type: research
The role of coronary artery disease in lung transplantation: a propensity-matched analysis
CONCLUSION: In this cohort, relevant CAD was not associated with worse outcomes and should therefore not be considered a contraindication for LuTx. Nonetheless, cardiovascular events in CAD patients highlight the necessity of control of cardiovascular risk factors and a structured cardiac follow-up.PMID:38587564 | DOI:10.1007/s00392-024-02445-y (Source: Clin Med Res)
Source: Clin Med Res - April 8, 2024 Category: Research Authors: Enzo L üsebrink Nils Gade Paula Seifert Felix Ceelen Tobias Veit Fabian Fohrer Sabine Hoffmann Julia H öpler Leonhard Binzenh öfer Daniel Roden Inas Saleh Hugo Lanz Sebastian Michel Christian Schneider Michael Irlbeck Roland Tomasi Rudolf Hatz J örg H Source Type: research
The role of coronary artery disease in lung transplantation: a propensity-matched analysis
CONCLUSION: In this cohort, relevant CAD was not associated with worse outcomes and should therefore not be considered a contraindication for LuTx. Nonetheless, cardiovascular events in CAD patients highlight the necessity of control of cardiovascular risk factors and a structured cardiac follow-up.PMID:38587564 | DOI:10.1007/s00392-024-02445-y (Source: Clin Med Res)
Source: Clin Med Res - April 8, 2024 Category: Research Authors: Enzo L üsebrink Nils Gade Paula Seifert Felix Ceelen Tobias Veit Fabian Fohrer Sabine Hoffmann Julia H öpler Leonhard Binzenh öfer Daniel Roden Inas Saleh Hugo Lanz Sebastian Michel Christian Schneider Michael Irlbeck Roland Tomasi Rudolf Hatz J örg H Source Type: research
Asparagine Synthetase Marks a Distinct Dependency Threshold for Cardiomyocyte Dedifferentiation
CONCLUSIONS: We discovered a novel gene Asns as both a molecular marker and an essential mediator, marking a distinct threshold that appears in common for at least 4 models of CMDD, and revealing an Asns/mammalian target of rapamycin complex 1 axis dependency for dedifferentiating cardiomyocytes. Further study will be needed to extrapolate and assess its relevance to other cell state transitions as well as in heart regeneration.PMID:38586957 | DOI:10.1161/CIRCULATIONAHA.123.063965 (Source: Circulation)
Source: Circulation - April 8, 2024 Category: Cardiology Authors: Yike Zhu Matthew Ackers-Johnson Muthu K Shanmugam Leroy Sivappiragasam Pakkiri Chester Lee Drum Yanpu Chen Johnny Kim Wyatt G Paltzer Ahmed I Mahmoud Wilson Lek Wen Tan Mick Chang Jie Lee Jianming Jiang Danh Anh Tuan Luu Shi Ling Ng Peter Yi Qing Li Anhui Source Type: research
Home versus in-centre haemodialysis for people with kidney failure
CONCLUSIONS: Based on low to very low certainty evidence, HHD, compared with ICHD, has uncertain associations or may be associated with decreased cardiovascular and all-cause death, hospitalisation rate, slower post-dialysis recovery time, and decreased SBP and LVMI. HHD has uncertain cost-effectiveness compared with ICHD in the first and second years of treatment. The majority of studies included in this review were observational and subject to potential selection bias and confounding, especially as patients treated with HHD tended to be younger with fewer comorbidities. Variation from study to study in the choice of outc...
Source: Cochrane Database of Systematic Reviews - April 8, 2024 Category: General Medicine Authors: Melissa S Cheetham Isabelle Ethier Rathika Krishnasamy Yeoungjee Cho Suetonia C Palmer David W Johnson Jonathan C Craig Paul Stroumza Luc Frantzen Jorgen Hegbrant Giovanni Fm Strippoli Source Type: research
Factors Influencing Time to First Medical Contact in Patients with Acute ST-Segment Elevation Myocardial Infarction: A Retrospective Analysis
CONCLUSIONS Patients with persistent chest tightness/pain, EMS admission, and vascular characteristics (RCADL or LCADL) experienced shorter S2FMC and higher compliance rate (S2FMC ≤180 min). At the same time, age and other vascular features played an inverse role. This study proposes enhancing follow-up and monitoring measures, and shows the consequences of intermittent chest pain should not be disregarded.PMID:38584384 | DOI:10.12659/MSM.942080 (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 8, 2024 Category: Research Authors: Yong Sun Qinnan Yang Hongjin Liu Binshi Li Puqing Lin Yanrong Chen Xuehua Wan Qingxuan Yu Chunxia Qi Changjiang Hong Source Type: research
The role of coronary artery disease in lung transplantation: a propensity-matched analysis
CONCLUSION: In this cohort, relevant CAD was not associated with worse outcomes and should therefore not be considered a contraindication for LuTx. Nonetheless, cardiovascular events in CAD patients highlight the necessity of control of cardiovascular risk factors and a structured cardiac follow-up.PMID:38587564 | DOI:10.1007/s00392-024-02445-y (Source: Clin Med Res)
Source: Clin Med Res - April 8, 2024 Category: Research Authors: Enzo L üsebrink Nils Gade Paula Seifert Felix Ceelen Tobias Veit Fabian Fohrer Sabine Hoffmann Julia H öpler Leonhard Binzenh öfer Daniel Roden Inas Saleh Hugo Lanz Sebastian Michel Christian Schneider Michael Irlbeck Roland Tomasi Rudolf Hatz J örg H Source Type: research
New approaches to triglyceride reduction: Is there any hope left?
Am J Prev Cardiol. 2024 Mar 22;18:100648. doi: 10.1016/j.ajpc.2024.100648. eCollection 2024 Jun.ABSTRACTTriglycerides play a crucial role in the efficient storage of energy in the body. Mild and moderate hypertriglyceridemia (HTG) is a heterogeneous disorder with significant association with atherosclerotic cardiovascular disease (ASCVD), including myocardial infarction, ischemic stroke, and peripheral artery disease and represents an important component of the residual ASCVD risk in statin treated patients despite optimal low-density lipoprotein cholesterol reduction. Individuals with severe HTG (>1,000 mg/dL) rarely d...
Source: Atherosclerosis - April 8, 2024 Category: Cardiology Authors: Annalisa Filtz Siddhant Parihar Garred S Greenberg Christine M Park Andrea Scotti Daniel Lorenzatti Juan J Badimon Daniel E Soffer Peter P Toth Carl J Lavie Vera Bittner Salim S Virani Leandro Slipczuk Source Type: research
Asparagine Synthetase Marks a Distinct Dependency Threshold for Cardiomyocyte Dedifferentiation
CONCLUSIONS: We discovered a novel gene Asns as both a molecular marker and an essential mediator, marking a distinct threshold that appears in common for at least 4 models of CMDD, and revealing an Asns/mammalian target of rapamycin complex 1 axis dependency for dedifferentiating cardiomyocytes. Further study will be needed to extrapolate and assess its relevance to other cell state transitions as well as in heart regeneration.PMID:38586957 | DOI:10.1161/CIRCULATIONAHA.123.063965 (Source: Circulation)
Source: Circulation - April 8, 2024 Category: Cardiology Authors: Yike Zhu Matthew Ackers-Johnson Muthu K Shanmugam Leroy Sivappiragasam Pakkiri Chester Lee Drum Yanpu Chen Johnny Kim Wyatt G Paltzer Ahmed I Mahmoud Wilson Lek Wen Tan Mick Chang Jie Lee Jianming Jiang Danh Anh Tuan Luu Shi Ling Ng Peter Yi Qing Li Anhui Source Type: research
Hybrid optimized temporal convolutional networks with long short-term memory for heart disease prediction with deep features
Comput Methods Biomech Biomed Engin. 2024 Apr 8:1-25. doi: 10.1080/10255842.2024.2310075. Online ahead of print.ABSTRACTA heart attack is intended as top prevalent among all ruinous ailments. Day by day, the number of affected people count is increasing globally. The medical field is struggling to detect heart disease in the initial step. Early prediction can help patients to save their life. Thus, this paper implements a novel heart disease prediction model with the help of a hybrid deep learning strategy. The developed framework consists of various steps like (i) Data collection, (ii) Deep feature extraction, and (iii) D...
Source: Computer Methods in Biomechanics and Biomedical Engineering - April 8, 2024 Category: Biomedical Engineering Authors: M Balamurugan Dr S Meera Source Type: research
