Neutrophil Extracellular Traps in Cardiovascular and Aortic Disease: A Narrative Review on Molecular Mechanisms and Therapeutic Targeting
Int J Mol Sci. 2024 Apr 3;25(7):3983. doi: 10.3390/ijms25073983.ABSTRACTNeutrophil extracellular traps (NETs), composed of DNA, histones, and antimicrobial proteins, are released by neutrophils in response to pathogens but are also recognized for their involvement in a range of pathological processes, including autoimmune diseases, cancer, and cardiovascular diseases. This review explores the intricate roles of NETs in different cardiovascular conditions such as thrombosis, atherosclerosis, myocardial infarction, COVID-19, and particularly in the pathogenesis of abdominal aortic aneurysms. We elucidate the mechanisms under...
Source: Atherosclerosis - April 13, 2024 Category: Cardiology Authors: Nahla Ibrahim Wolf Eilenberg Christoph Neumayer Christine Brostjan Source Type: research
Prevalence and risk evaluation of cardiovascular disease in the newly diagnosed prostate cancer population in China: A nationwide, multi-center, population-based cross-sectional study
CONCLUSIONS: Prostate cancer patients in China are diagnosed at an advanced stage. A heavy CVD burden was present at the initiation of treatment. Patients who accepted ADT-related therapy showed an original higher risk of CVD, but the awareness of cardiovascular protection was far from sufficient.PMID:38613214 | DOI:10.1097/CM9.0000000000003087 (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - April 13, 2024 Category: General Medicine Authors: Weiyu Zhang Huixin Liu Ming Liu Shi Ying Renbin Yuan Hao Zeng Zhenting Zhang Sujun Han Zhannan Si Bin Hu Simeng Wen Pengcheng Xu Weimin Yu Hui Chen Liang Wang Zhitao Lin Tao Dai Yunzhi Lin Tao Xu Source Type: research
AMPA receptor inhibition alleviates inflammatory response and myocardial apoptosis after myocardial infarction by inhibiting TLR4/NF- κB signaling pathway
This study investigated the role of AMPA receptor inhibition in myocardial infarction and elucidated the underlying mechanisms. This study established a myocardial infarction model by ligating the left anterior descending branch of the coronary artery in Sprague-Dawley rats. The findings suggested that injecting the AMPA receptor antagonist NBQX into myocardial infarction rats effectively alleviated cardiac inflammation, myocardial necrosis, and apoptosis and improved their cardiac contractile function. Conversely, injecting the AMPA receptor agonist CX546 into infarcted rats exacerbated the symptoms and tissue damage, as ...
Source: International Immunopharmacology - April 13, 2024 Category: Allergy & Immunology Authors: Zixuan Li Zhili Yu Shengyu Cui Shan Hu Bin Li Tao Chen Chuan Qu Bo Yang Source Type: research
Prevalence and risk evaluation of cardiovascular disease in the newly diagnosed prostate cancer population in China: A nationwide, multi-center, population-based cross-sectional study
CONCLUSIONS: Prostate cancer patients in China are diagnosed at an advanced stage. A heavy CVD burden was present at the initiation of treatment. Patients who accepted ADT-related therapy showed an original higher risk of CVD, but the awareness of cardiovascular protection was far from sufficient.PMID:38613214 | DOI:10.1097/CM9.0000000000003087 (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - April 13, 2024 Category: General Medicine Authors: Weiyu Zhang Huixin Liu Ming Liu Shi Ying Renbin Yuan Hao Zeng Zhenting Zhang Sujun Han Zhannan Si Bin Hu Simeng Wen Pengcheng Xu Weimin Yu Hui Chen Liang Wang Zhitao Lin Tao Dai Yunzhi Lin Tao Xu Source Type: research
Neutrophil Extracellular Traps in Cardiovascular and Aortic Disease: A Narrative Review on Molecular Mechanisms and Therapeutic Targeting
Int J Mol Sci. 2024 Apr 3;25(7):3983. doi: 10.3390/ijms25073983.ABSTRACTNeutrophil extracellular traps (NETs), composed of DNA, histones, and antimicrobial proteins, are released by neutrophils in response to pathogens but are also recognized for their involvement in a range of pathological processes, including autoimmune diseases, cancer, and cardiovascular diseases. This review explores the intricate roles of NETs in different cardiovascular conditions such as thrombosis, atherosclerosis, myocardial infarction, COVID-19, and particularly in the pathogenesis of abdominal aortic aneurysms. We elucidate the mechanisms under...
Source: Atherosclerosis - April 13, 2024 Category: Cardiology Authors: Nahla Ibrahim Wolf Eilenberg Christoph Neumayer Christine Brostjan Source Type: research
Chemokine Fractalkine and Non-Obstructive Coronary Artery Disease-Is There a Link?
Int J Mol Sci. 2024 Mar 30;25(7):3885. doi: 10.3390/ijms25073885.ABSTRACTNon-obstructive coronary artery disease (NO-CAD) constitutes a heterogeneous group of conditions collectively characterized by less than 50% narrowing in at least one major coronary artery with a fractional flow reserve (FFR) of ≤0.80 observed in coronary angiography. The pathogenesis and progression of NO-CAD are still not fully understood, however, inflammatory processes, particularly atherosclerosis and microvascular dysfunction are known to play a major role in it. Chemokine fractalkine (FKN/CX3CL1) is inherently linked to these processes. FKN/C...
Source: Atherosclerosis - April 13, 2024 Category: Cardiology Authors: Aleksandra Stangret Karol Artur Sadowski Konrad Jab łoński Janusz Kochman Grzegorz Opolski Marcin Grabowski Mariusz Tomaniak Source Type: research
The Net Clinical Outcome of Dual-Pathway Inhibition in Clinical Practice: The "Xarelto plus Acetylsalicylic Acid: Treatment Patterns and Outcomes in Patients with Atherosclerosis" Registry
Conclusions: In the real-world XATOA registry, the annual rate of NCO events was low and numerically similar to those seen in the treatment group in the randomized COMPASS trial.PMID:38610724 | DOI:10.3390/jcm13071956 (Source: Atherosclerosis)
Source: Atherosclerosis - April 13, 2024 Category: Cardiology Authors: Alexander Breitenstein Alain Gay Kai Vogtl änder Keith A A Fox Jan Steffel XATOA Publication Committee Source Type: research
Intravenous antiplatelet therapy in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention
AbstractThe use of intravenous antiplatelet therapy during primary percutaneous coronary intervention (PPCI) is not fully standardized. The aim is to evaluate the effectiveness and safety of periprocedural intravenous administration of cangrelor or tirofiban in a contemporary ST-segment elevation myocardial infarction (STEMI) population undergoing PPCI. This was a multicenter prospective cohort study including consecutive STEMI patients who received cangrelor or tirofiban during PPCI at seven Italian centers. The primary effectiveness measure was the angiographic evidence of thrombolysis in myocardial infarction (TIMI) flo...
Source: Journal of Thrombosis and Thrombolysis - April 13, 2024 Category: Hematology Source Type: research
FBXL8 inhibits post-myocardial infarction cardiac fibrosis by targeting Snail1 for ubiquitin-proteasome degradation
Cell Death & Disease, Published online: 13 April 2024; doi:10.1038/s41419-024-06646-1FBXL8 inhibits post-myocardial infarction cardiac fibrosis by targeting Snail1 for ubiquitin-proteasome degradation (Source: Cell death and disease)
Source: Cell death and disease - April 13, 2024 Category: Internal Medicine Authors: Ya Li Caojian Zuo Xiaoyu Wu Yu Ding Yong Wei Songwen Chen Xiaofeng Lu Juan Xu Shaowen Liu Genqing Zhou Lidong Cai Source Type: research
Heterogeneous effects of hospital competition on inpatient quality: an analysis of five common diseases in China
ConclusionsThere is the heterogeneous impact of hospital competition on quality across various diseases in China. Policymakers who intend to leverage hospital competition as a tool to enhance healthcare quality must be cognizant of the possible influences of it. (Source: Health Economics Review)
Source: Health Economics Review - April 13, 2024 Category: International Medicine & Public Health Source Type: research
Effect of Cardiac Rehabilitation Nursing on Patients with Myocardial Infarction
CONCLUSION: For patients with myocardial infarction, the implementation of cardiac rehabilitation nursing can effectively alleviate the anxiety and depression of patients, decrease the incidence of complications as well as inflammatory factors levels, and further shorten the hospital stay of patients, with high safety. Our study provides a clinical reference for patients with myocardial infarction w who need nursing care.PMID:38607218 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Yi Zhou Xiaolan Wu Chengting Qin Youni Tong Shuang Tian Xiaoli Huang Source Type: research
Effect of Cardiac Rehabilitation Nursing on Patients with Myocardial Infarction
CONCLUSION: For patients with myocardial infarction, the implementation of cardiac rehabilitation nursing can effectively alleviate the anxiety and depression of patients, decrease the incidence of complications as well as inflammatory factors levels, and further shorten the hospital stay of patients, with high safety. Our study provides a clinical reference for patients with myocardial infarction w who need nursing care.PMID:38607218 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Yi Zhou Xiaolan Wu Chengting Qin Youni Tong Shuang Tian Xiaoli Huang Source Type: research
One case of acute myocardial infarction combined with cardiac rupture
Asian J Surg. 2024 Apr 11:S1015-9584(24)00609-2. doi: 10.1016/j.asjsur.2024.03.182. Online ahead of print.NO ABSTRACTPMID:38609823 | DOI:10.1016/j.asjsur.2024.03.182 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 12, 2024 Category: Surgery Authors: Jian Yang Xudong Liu Yanyan Song Source Type: research
Associations of Serum 25-hydroxyvitamin D and Vitamin D Receptor Polymorphisms with Risks of Cardiovascular Disease and Mortality among Patients with Chronic Kidney Disease: A Prospective Study
CONCLUSIONS: Higher serum 25(OH)D concentrations were significantly associated with lower risks of total and subtypes of CVD incidence and mortality among individuals with CKD. These findings highlight the importance of maintaining adequate vitamin D status in the prevention of CVD and mortality in patients with CKD.PMID:38608754 | DOI:10.1016/j.ajcnut.2024.04.001 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - April 12, 2024 Category: Nutrition Authors: Shiyu Zhao Xue Chen Zhenzhen Wan Tingting Geng Qi Lu Hancheng Yu Xiaoyu Lin An Pan Gang Liu Source Type: research
Associations of Serum 25-hydroxyvitamin D and Vitamin D Receptor Polymorphisms with Risks of Cardiovascular Disease and Mortality among Patients with Chronic Kidney Disease: A Prospective Study
CONCLUSIONS: Higher serum 25(OH)D concentrations were significantly associated with lower risks of total and subtypes of CVD incidence and mortality among individuals with CKD. These findings highlight the importance of maintaining adequate vitamin D status in the prevention of CVD and mortality in patients with CKD.PMID:38608754 | DOI:10.1016/j.ajcnut.2024.04.001 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - April 12, 2024 Category: Nutrition Authors: Shiyu Zhao Xue Chen Zhenzhen Wan Tingting Geng Qi Lu Hancheng Yu Xiaoyu Lin An Pan Gang Liu Source Type: research
