Xin-Ji-Er-Kang ameliorates kidney injury following myocardial infarction by inhibiting oxidative stress via Nrf2/HO-1 pathway in rats
ConclusionThese results demonstrated that progressive nephropathy in MI rats was associated with intrarenal activation of the renin-angiotensin-aldosterone system. Concomitantly, this process was associated with oxidative stress and impaired Nrf2 activation. The improvement in the severity of nephropathy by XJEK in this model may be associated with the reversal of these abnormalities. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - June 20, 2019 Category: Drugs & Pharmacology Source Type: research

Dynamic Systolic Compression of the Left Anterior Descending Coronary Artery as the First Clue of Post infarction Left Ventricular Pseudoaneurysm
We present a case of a patient with recent MI who presented with recurrence of chest pain and coronary angiogram showing patent vessels however with systolic compression of the distal left anterior descending coronary artery (LAD) as a first clue to post infarct LVP. (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - June 20, 2019 Category: Cardiology Source Type: research

Canadian-Australasian Randomised trial of screening kidney transplant candidates for coronary artery disease—A trial protocol for the CARSK study
Publication date: August 2019Source: American Heart Journal, Volume 214Author(s): Tracey Ying, Jagbir Gill, Angela Webster, S. Joseph Kim, Rachael Morton, Scott W. Klarenbach, Patrick Kelly, Timothy Ramsay, Gregory A. Knoll, Helen Pilmore, Gillian Hughes, Charles A. Herzog, Steven Chadban, John S. GillTransplantation is the preferred treatment for patients with kidney failure, but the need exceeds the supply of transplantable kidneys, and patients routinely wait>5 years on dialysis for a transplant. Coronary artery disease (CAD) is common in kidney failure and can exclude patients from transplantation or result in dea...
Source: American Heart Journal - June 20, 2019 Category: Cardiology Source Type: research

Differential Expression of Transforming Growth Factor-β1 Is Associated With Fetal Regeneration After Myocardial Infarction
ConclusionsTGF-β1 is increased in adult infarcts compared with regenerative, fetal infarcts after MI. Although treatment of fetal cardiac fibroblasts with TGF-β1 conveys an adult phenotype, inhibition of TGF-β1 conveys a fetal phenotype to adult cardiac fibroblasts. Decreasing TGF-β1 after MI may facilitate myocardial regeneration by “fetalizing” the otherwise fibrotic, adult response to MI. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - June 20, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

Reversal and Resumption of Antithrombotic Therapy in LVAD-Associated Intracranial Hemorrhage
ConclusionsReversal of anticoagulation appears safe after LVAD-associated intracranial hemorrhage, though inadequate reversal was common. Resumption of warfarin ± antiplatelet was associated with fewer fatal and nonfatal thrombotic events compared with antiplatelets alone, though more nonfatal hemorrhage events occurred. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - June 20, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

MiRNA-488-3p suppresses acute myocardial infarction-induced cardiomyocyte apoptosis via targeting ZNF791.
CONCLUSIONS: MiRNA-488-3p is down-regulated in AMI mice, which alleviates AMI-induced cardiomyocyte apoptosis via down-regulating ZNF791. PMID: 31210328 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - June 20, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Role and mechanism of microRNA-548c-3p/c-Myb in myocardial infarction fibrosis in rats.
CONCLUSIONS: MiR-548c-3p could improve myocardial fibrosis by targeting c-Myb. PMID: 31210326 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - June 20, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

HSP20-mediated cardiomyocyte exosomes improve cardiac function in mice with myocardial infarction by activating Akt signaling pathway.
Authors: Yu DW, Ge PP, Liu AL, Yu XY, Liu TT Abstract OBJECTIVE: To explore the role of heat shock protein 20 (HSP20)-mediated cardiomyocyte exosomes in the cardiac function in mice with myocardial infarction via the activation of the protein kinase B (Akt) signaling pathway. MATERIALS AND METHODS: A total of 30 mice were enrolled to establish the model of myocardial infarction. Next, these mice were divided into three groups, namely Blank group (healthy mice), Model group (mouse models of myocardial infarction), and HSP20 group (mouse models of myocardial infarction transfected with lentivirus to overexpress H...
Source: European Review for Medical and Pharmacological Sciences - June 20, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

New Five-Factor Modified Frailty Index Predicts Morbidity and Mortality in Geriatric Hip Fractures
Conclusions: The mFI-5 is an independent predictor of postoperative morbidity and mortality in elderly patients undergoing surgery for hip fractures. This clinical tool can be used by hospitals and surgeons to identify high-risk patients, accurately council patients and families with transparency, and guide perioperative care to optimize patient outcomes. Level of Evidence: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence. (Source: Journal of Orthopaedic Trauma)
Source: Journal of Orthopaedic Trauma - June 20, 2019 Category: Orthopaedics Tags: Original Article Source Type: research

Long-term follow-up and safety assessment of angiogenic gene therapy trial VIF-CAD: Transcatheter intramyocardial administration of a bicistronic plasmid expressing VEGF-A165/bFGF cDNA for the treatment of refractory coronary artery disease
This study presents the results of over 10-year (median 133 months, range 95–149) safety follow-up of VIF-CAD patients. Overall, 12 (36.4%) patients died in VIF and 8 (42.1%) in Placebo group (P = .68). Cardiovascular mortality was 12/33 (36.4%) in the VIF group and 6/19 (31.6%) in Placebo group (P = .73). Two Placebo patients died due to malignancies, but no VIF patients (P = .17). The Kaplan–Meier curves of combined endpoint: cardiovascular mortality, myocardial infarction and stroke were similar for both patient groups (P = .71). Odds ratio of Placebo group increa...
Source: American Heart Journal - June 20, 2019 Category: Cardiology Source Type: research

Everolimus- vs. novolimus-eluting bioresorbable scaffolds in patients with acute coronary syndrome.
CONCLUSION: In this study, similar 12-month event rates were observed for both BRS types after implantation for the treatment of ACS. PMID: 31209520 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - June 20, 2019 Category: Cardiology Tags: Herz Source Type: research

Antipsychotic drug use and risk of stroke and myocardial infarction: a systematic review and meta-analysis
The effect of antipsychotic (AP) drugs on risk of stroke and myocardial infarction (MI) remains unclear due to methodological limitations of, and inconsistencies across, existing studies. We aimed to systemati... (Source: BMC Psychiatry)
Source: BMC Psychiatry - June 20, 2019 Category: Psychiatry Authors: Sanja Zivkovic, Chan Hee Koh, Nandita Kaza and Caroline A. Jackson Tags: Research article Source Type: research

Acute Myocardial Infarction Associated with Initial Alemtuzumab Infusion Cycle in Relapsing-Remitting Multiple Sclerosis
We report a 30-year-old woman with relapsing-remitting multiple sclerosis who developed a type 2 non-ST elevated myocardial infarction (NSTEMI) during her first alemtuzumab infusion cycle. While acute coronary syndrome has been described with alemtuzumab in the treatment of lymphoma, alemtuzumab-associated cardiac ischemia in multiple sclerosis is uncommon and can occur in patients without cardiovascular risk factors. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 19, 2019 Category: Neurology Source Type: research

Real-world use of ticagrelor versus clopidogrel in percutaneous coronary intervention-treated ST-elevation myocardial infarction patients: A single-center registry study
Publication date: Available online 31 May 2019Source: Journal of the Saudi Heart AssociationAuthor(s): Leia Hee, Oliver J. Gibbs, Joseph G. Assad, Lokesh D. Sharma, Andrew Hopkins, Craig P. Juergens, Sidney Lo, Christian J. MussapAbstractObjectivesThe primary aim was to investigate the efficacy and safety of dual antiplatelet therapy (DAPT) using ticagrelor (T-DAPT) versus clopidogrel (C-DAPT) in a real-world ST-elevation myocardial infarction (STEMI) population.MethodsWe retrospectively analyzed 655 consecutive patients having primary percutaneous coronary intervention (PCI) for STEMI at Liverpool Hospital, Sydney, Austra...
Source: Journal of the Saudi Heart Association - June 19, 2019 Category: Cardiology Source Type: research

Design and rationale of the COMPLETE trial: A randomized, comparative effectiveness study of complete versus culprit-only percutaneous coronary intervention to treat multivessel coronary artery disease in patients presenting with ST-segment elevation myocardial infarction
ConclusionsThe COMPLETE trial is an international multicenter randomized trial that will help determine whether complete revascularization involving staged PCI of non-culprit lesions improves outcomes in patients with STEMI and multivessel CAD. (clinicaltrials.gov NCT01740479). (Source: American Heart Journal)
Source: American Heart Journal - June 19, 2019 Category: Cardiology Source Type: research

How Monocytes Contribute to Increased Risk of Atherosclerosis in Virologically-Suppressed HIV-Positive Individuals Receiving Combination Antiretroviral Therapy
Combination antiretroviral therapy (ART) is effective at suppressing HIV viremia to undetectable levels in peripheral blood in the majority of individuals with access and ability to maintain adherence to treatment. However, ART is less effective at eliminating HIV-associated inflammation and innate immune activation. To the extent that inflammation and immune activation persist, virologically-suppressed people living with HIV (PLWH) have increased risk of inflammatory co-morbidities, and adjunctive therapies may be needed to reduce HIV-related inflammation and fully restore the health of virologically suppressed HIV+ indiv...
Source: Frontiers in Immunology - June 19, 2019 Category: Allergy & Immunology Source Type: research

Regulation mechanism of aquaporin 9 gene on inflammatory response and cardiac function in rats with myocardial infarction through extracellular signal-regulated kinase1/2 pathway
AbstractThe aim of this study was to investigate the regulation mechanism of aquaporin 9 (AQP9) gene on inflammatory response and cardiac function in rats with myocardial infarction (MI) through extracellular signal-regulated kinase1/2 (ERK1/2) pathway. The constructed rats models of MI were randomly divided into 6 groups: control group (sham operation group, MI modeling sham operation), model group (MI modeling), NC group (MI modeling, tail vein injection of AQP9 negative control sequence vector), AQP9 shRNA group (MI modeling, tail vein injection of AQP9 shRNA plasmid vector), U0126 group (MI modeling, tail vein injectio...
Source: Heart and Vessels - June 19, 2019 Category: Cardiology Source Type: research

Recombinant Elabela-Fc fusion protein has extended plasma half-life and mitigates post-infarct heart dysfunction in rats
Myocardial infarction (MI), via change of either the structure and/or the functioning, is a common cause of the heart failure [1]. The main characteristic of MI-induced heart failure is reduced ejection fraction (HFrEF). The current first line treatment strategy (long-duration pharmacologic therapy) carries adverse remodeling risks [2,3]. Newer strategies reducing recurrent adverse remodeling as well as reinforce cardiac resynchronization are needed. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - June 19, 2019 Category: Cardiology Authors: Yajing Wang Tags: Editorial Source Type: research

Silence of lncRNA MIAT protects ATDC5 cells against lipopolysaccharides challenge via up-regulating miR-132.
This study attempted to see the role of MIAT in a cell model of osteoarthritis (OA). ATDC5 cells were subjected to lipopolysaccharides (LPS) to mimic a cell model of OA. The effects of MIAT on the model were tested by performing CCK-8 assay, flow cytometry, qRT-PCR, western blot and ELISA. The downstream miRNA and signalling pathways were studied by utilizing qRT-PCR and western blot. Transfection of ATDC5 cells with the shRNA specific against MIAT significantly attenuated LPS-evoked apoptosis and cytokines release. At the meantime, the viability loss and the cleavage of caspases were ameliorated as well. MIAT overexpresse...
Source: Artificial Cells, Nanomedicine and Biotechnology - June 18, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Plasma levels of receptor interacting protein kinase-3 correlated with coronary artery disease.
Abstract BACKGROUND: Necroptosis plays an important role in human atherosclerosis and atheroma development. Since receptor interacting protein kinase-3 (RIP3) acts as a key mediator of necroptosis, this study aimed to explore its relationship between plasma RIP3 levels and coronary artery disease (CAD) and discover a potential new biomarker for screening CAD subtypes and severity. METHODS: A total of 318 patients with CAD who had coronary angiography and 166 controls in Peking Union Medical College Hospital from September 2017 to January 2018 were enrolled in this study. Patients with CAD were divided into th...
Source: Chinese Medical Journal - June 18, 2019 Category: General Medicine Authors: Hu XM, Chen X, Pang HY, Liu HH, Chen PP, Shi JL, Tang S, Wu ZH, Zhang SY Tags: Chin Med J (Engl) Source Type: research

Gastropericardial fistula in a patient with upside-down stomach and stomach perforation: A case report.
Conclusions: Gastropericardial fistula is a rare acute complication of the diseases of the upper GIT. It is invariably a serious, life-threatening condition. Diagnosis is confirmed by thoracic CT and a contrast swallow study. The necessity of acute surgical treatment is widely accepted. The type of procedure must be selected based on the patient's individual criteria. PMID: 31204899 [PubMed - as supplied by publisher] (Source: Acta Chirurgica Belgica)
Source: Acta Chirurgica Belgica - June 18, 2019 Category: Surgery Tags: Acta Chir Belg Source Type: research

Cardiac Rupture Due to Reinfarction in the Early Phase of Apical Myocardial Infarction.
Authors: Matsumura K, Kin H, Matsuki R, Adachi K, Goda T, Yamamoto Y, Sugiura T, Shiojima I Abstract A 72-year-old woman with hypertension, dyslipidemia, and diabetes mellitus presented to our hospital because of the sudden onset of chest pain. Emergency coronary angiography showed acute occlusion of the distal left anterior descending artery and coronary intervention with a drug-eluting stent was performed. Sudden cardiopulmonary arrest occurred on the sixth day of hospitalization, but coronary angiography showed no remarkable progression of the coronary artery diseases, including the site of stent implantation. A...
Source: International Heart Journal - June 18, 2019 Category: Cardiology Tags: Int Heart J Source Type: research

Clinical Profile and Outcome in Patients with Coronary Slow Flow Phenomenon.
Abstract The coronary slow flow phenomenon (CSFP) is a poorly recognized clinical entity characterized by delayed distal vessel opacification in the absence of epicardial coronary stenosis and presently lack of specific data on the clinical profile and outcome. We investigated a cohort of 429 patients who fulfilled the criteria for CSFP to explore the clinical feature, outcome, and risk factor of prognosis. Two teams (clinical center and core lab) were blind to patient data for the assessment of coronary angiograph using corrected thrombolysis in myocardial infarction (TIMI) frame count (CTFC). The study cohort co...
Source: Cardiology Research and Practice - June 18, 2019 Category: Cardiology Authors: Zhu X, Shen H, Gao F, Wu S, Ma Q, Jia S, Zhao Z, Tong S, Zhang Z, Zhou Y Tags: Cardiol Res Pract Source Type: research

GSE132880 Single cell RNA-seq of adult mouse heart endothelial transcriptomes following myocardial infarction
Contributors : Ziwen Li ; Marco Meloni ; Richard S Tylor ; Ross Dobie ; Beth E Henderson ; Mairi BrittanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusA better understanding of the pathways that regulate regeneration of the coronary vasculature is of fundamental importance for the advancement of strategies to treat patients with heart disease. By analyzing single cell transcriptome of resident cardiac endothelial cells (ECs) in adult mouse hearts under both healthy and myocardial infarction (MI) settings, we provide molecular definitions of murine cardiac endothelial heterogeneity an...
Source: GEO: Gene Expression Omnibus - June 18, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Shear stress–induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure
Hypertension is a primary risk factor for cardiovascular diseases including myocardial infarction and stroke. Major determinants of blood pressure are vasodilatory factors such as nitric oxide (NO) released from the endothelium under the influence of fluid shear stress exerted by the flowing blood. Several endothelial signaling processes mediating fluid shear stress–induced formation and release of vasodilatory factors have been described. It is, however, still poorly understood how fluid shear stress induces these endothelial responses. Here we show that the endothelial mechanosensitive cation channel PIEZO1 mediate...
Source: Journal of Clinical Investigation - June 18, 2019 Category: Biomedical Science Authors: Andras Iring, Young-June Jin, Julián Albarrán-Juárez, Mauro Siragusa, ShengPeng Wang, Péter T. Dancs, Akiko Nakayama, Sarah Tonack, Min Chen, Carsten Künne, Anna M. Sokol, Stefan Günther, Alfredo Martínez, Ingrid Fleming, Nina Wettschureck, Johanne Source Type: research

Letter by Khalid et al Regarding Article, "Unloading the Left Ventricle Before Reperfusion in Patients With Anterior ST-Segment-Elevation Myocardial Infarction: A Pilot Study Using the Impella CP".
Letter by Khalid et al Regarding Article, "Unloading the Left Ventricle Before Reperfusion in Patients With Anterior ST-Segment-Elevation Myocardial Infarction: A Pilot Study Using the Impella CP". Circulation. 2019 Jun 18;139(25):e1040-e1041 Authors: Khalid N, Shlofmitz E, Waksman R PMID: 31206333 [PubMed - in process] (Source: Circulation)
Source: Circulation - June 18, 2019 Category: Cardiology Authors: Khalid N, Shlofmitz E, Waksman R Tags: Circulation Source Type: research

Cardiac Proteome Profiling in Ischemic and Dilated Cardiomyopathy Mouse Models
Heart failure is a worldwide pandemic with an unacceptable high level of morbidity and mortality. Understanding the different pathophysiological mechanisms will contribute to prevention and individualized therapy of heart failure. We established mouse models for ischemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM) by inducing myocardial infarction and Coxsackievirus B3 infection respectively. Isobaric tags for relative and absolute quantitation and liquid chromatography coupled with tandem mass spectrometry technology was used to identify the protein expression profiles in control and failing hearts. A total of 1...
Source: Frontiers in Physiology - June 18, 2019 Category: Physiology Source Type: research

Annals Consult Guys - Length of Stay After Myocardial Infarction: How Low Can We Go?
PMID: 31207644 [PubMed - in process] (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - June 18, 2019 Category: Internal Medicine Authors: Merli GJ, Weitz HH Tags: Ann Intern Med Source Type: research

Robotic totally endoscopic off ‐pump unroofing of left anterior descending coronary artery myocardial bridge: A report of two cases
We report two cases of symptomatic MBs, which were treated with surgical unroofing, using a totally endoscopic robotic ‐assisted off‐pump approach. (Source: Journal of Cardiac Surgery)
Source: Journal of Cardiac Surgery - June 18, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Saeid Mirzai, Brooke Patel, Husam H. Balkhy Tags: CASE REPORT Source Type: research

Acute myocardial infarction in a patient with active actinic rectitis bleeding: Between the sword and the wall
AbstractA The coronary artery bypass graft (CABG) is common. Sometimes can be challenging. Here we present a 79 ‐year‐old man presented with unstable angina and simultaneous activelower gastrointestinal bleeding (hemoglobin level, 5.1 g/L) due to actinic rectitis after radiation therapy for prostate carcinoma performed 1 year previously. Coronary angiography showed marked stenosis of the left anterior d escending artery. Antiplatelet aggregation therapy, such as percutaneous coronary intervention or systemic heparin therapy for coronary artery bypass, was not feasible owing to the active rectal bleeding. Therefo...
Source: Journal of Cardiac Surgery - June 18, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Valdano Manuel, Samuel P. Steffen, F ábio A. Gaiotto, Luiz B. Puig Tags: CASE REPORT Source Type: research

Mesenchymal stem cells rejuvenate cardiac muscle through regulating macrophage polarization.
Abstract We have shown that the effects of transplantation of CD146+ mesenchymal stem cells (MSCs) on myocardial regeneration after myocardial infarction (MI) exceeds the effects of transplantation of MSCs, likely resulting from reduction of aging-associated cellular reactive oxygen species in injured cardiac muscle cells (CMCs). Since the role of macrophages in the MSC-mediated recovery of heart function after MI remains unclear, this question was thus addressed in the current study. We found that transplantation of MSCs did not alter the total number of the macrophages in the injured heart, but induced their pol...
Source: Aging - June 18, 2019 Category: Biomedical Science Authors: Zhang B, Zhao N, Zhang J, Liu Y, Zhu D, Kong Y Tags: Aging (Albany NY) Source Type: research

Inhibition of FPR2 impaired leukocytes recruitment and elicited non-resolving inflammation in acute heart failure
Publication date: Available online 16 June 2019Source: Pharmacological ResearchAuthor(s): Vasundhara Kain, Jeevan Kumar Jadapalli, Bochra Tourki, Ganesh V. HaladeAbstractLifestyle or age-related risk factors over-activate the inflammation that triggers acute heart failure (HF)-related mortality following myocardial infarction (MI). Post-MI activated leukocytes express formyl peptide receptor 2 (FPR2) that is essential for inflammation-resolution and in cardiac healing. However, the role of FPR2 in acute HF is incomplete and remain of interest. Here, we aimed to determine whether pharmacological inhibition of FPR2 perturb l...
Source: Pharmacological Research - June 17, 2019 Category: Drugs & Pharmacology Source Type: research

Effect of typhaneoside on ventricular remodeling and regulation of PI3K/Akt/mTOR pathway.
CONCLUSION: Typhaneoside regulates IL-6 and TNF-α as well as MMP-2 and MMP-9 in rats with heart failure after myocardial infarction. Typhaneoside can improve cardiac morphological structure and myocardial remodeling and enhance heart function. It may mediate autophagy inhibition in the cardiomyocyte anoxia/reoxygenation (A/R) pathway through the PI3K/Akt/mTOR autophagy transduction pathway. PMID: 31201434 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - June 17, 2019 Category: Cardiology Tags: Herz Source Type: research

Inpatient Echocardiography Use and Outcomes in Adult Patients With Acute Myocardial Infarction
This cohort study uses a large multihospital database to evaluate the association between hospital rates of echocardiogram use and outcomes in adult patients with acute myocardial infarction. (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - June 17, 2019 Category: Internal Medicine Source Type: research

TLR9 is essential for HMGB1-mediated post-myocardial infarction tissue repair through affecting apoptosis, cardiac healing, and angiogenesis
Cell Death & Disease, Published online: 17 June 2019; doi:10.1038/s41419-019-1718-7TLR9 is essential for HMGB1-mediated post-myocardial infarction tissue repair through affecting apoptosis, cardiac healing, and angiogenesis (Source: Cell death and disease)
Source: Cell death and disease - June 17, 2019 Category: Internal Medicine Authors: Fang-Yuan Liu Di Fan Zheng Yang Nan Tang Zhen Guo Shu-Qing Ma Zhen-Guo Ma Hai-Ming Wu Wei Deng Qi-Zhu Tang Source Type: research

LncRNA PCFL promotes cardiac fibrosis via miR-378/GRB2 pathway following myocardial infarction
Long noncoding RNAs (lncRNAs) are a class of novel molecular regulators in cardiac development and diseases. However, the role of specific lncRNAs in cardiac fibrosis remains to be fully explored. The aim of the present study was to investigate the effects and underlying mechanisms of lncRNA PCFL (pro-cardiac fibrotic lncRNA) on cardiac fibrosis after myocardial infarction (MI).Cardiac fibroblasts (CFs) with gain and loss of function of PCFL and mice with global knockout or overexpression of PCFL were used to explore the effects of PCFL on cardiac fibrosis. (Source: Journal of Molecular and Cellular Cardiology)
Source: Journal of Molecular and Cellular Cardiology - June 17, 2019 Category: Cytology Authors: Fei Sun, Yuting Zhuang, Haixia Zhu, Hao Wu, Danyang Li, Linfeng Zhan, Wanqi Yang, Yin Yuan, Yilin Xie, Shuang Yang, Shenjian Luo, Wenmei Jiang, Jifan Zhang, Zhenwei Pan, Yanjie Lu Source Type: research

Association of Hyperglycemia and Final TIMI Flow with One-Year Mortality of Patients with Acute ST-Segment Elevation Myocardial Infarction Undergoing Primary PCI
Int J Angiol DOI: 10.1055/s-0039-1691811The association of hyperglycemia at admission and final thrombolysis in myocardial infarction (TIMI) flow with 1-year mortality of patient with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) has not much been explored. We evaluated the association of hyperglycemia and final TIMI flow with 1-year mortality in patients with acute STEMI who underwent primary PCI.We retrospectively analyzed 856 patients with STEMI who underwent primary PCI in a tertiary care academic center between January 2014 and July 2016. Based on ...
Source: International Journal of Angiology - June 17, 2019 Category: Cardiology Authors: Dharma, Surya Mahavira, Andi Haryono, Nur Sukmawan, Renan Dakota, Iwan Siswanto, Bambang B. Rao, Sunil V. Tags: Original Article Source Type: research

Cardiovascular outcomes of vildagliptin in patients with type  2 diabetes mellitus after acute coronary syndrome or acute ischemic stroke
ConclusionsAmong patients with type  2 diabetes mellitus after a recent acute coronary syndrome or acute ischemic stroke, treatment with vildagliptin was not associated with increased risks of CV death, non‐fatal myocardial infarction, non‐fatal stroke and hospitalization for HF. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - June 17, 2019 Category: Endocrinology Authors: Dong ‐Yi Chen, Yan‐Rong Li, Chun‐Tai Mao, Chi‐Nan Tseng, I‐Chang Hsieh, Ming‐Jui Hung, Pao‐Hsien Chu, Chao‐Hung Wang, Ming‐Shien Wen, Wen‐Jin Cherng, Tien‐Hsing Chen Tags: Original Article Source Type: research

Mirt2 functions in synergy with miR-377 to participate in inflammatory pathophysiology of Sj ögren's syndrome.
Conclusion: Mirt2 was elevated in IFN-γ-treated SGECs and then up-regulated miR-377 in response to inflammatory lesions. Mechanically, in synergy with miR-377 Mirt2 blocked IFN-γ-evoked activation of NF-κB and JAK/STAT signalling pathway. PMID: 31198060 [PubMed - in process] (Source: Artificial Cells, Nanomedicine and Biotechnology)
Source: Artificial Cells, Nanomedicine and Biotechnology - June 16, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Aloe-Emodin Attenuates Myocardial Infarction and Apoptosis Via Up-Regulating MiR-133 Expression
Publication date: Available online 14 June 2019Source: Pharmacological ResearchAuthor(s): Yang Yu, Huibin Liu, Di Yang, Fang He, Ye Yuan, Jing Guo, Juan Hu, Jie Yu, Xiuqing Yan, Shuo Wang, Zhimin DuAbstractAloe-emodin (AE) is an anthraquinone derived from rhubarb and has a variety of pharmacological actions. However, the role of AE in regulating ischemic heart diseases is still unclear. The present study investigated the effect of AE on cardiac injuries induced by myocardial infarction (MI) in vivo and oxidative insults in vitro and explored the mechanisms involved. TUNEL and Flow cytometry were performed to measure cell a...
Source: Pharmacological Research - June 16, 2019 Category: Drugs & Pharmacology Source Type: research

Atrioventricular mechanical coupling and major adverse cardiac events in female patients following acute ST elevation myocardial infarction
Sex-specific outcome data following myocardial infarction (MI) are inconclusive with some evidence suggesting association of female sex and increased major adverse cardiac events (MACE). Since mechanistic principles remain elusive, we aimed to quantify the underlying phenotype using cardiovascular magnetic resonance (CMR) quantitative deformation imaging and tissue characterisation. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - June 16, 2019 Category: Cardiology Authors: S ören J. Backhaus, Johannes T. Kowallick, Thomas Stiermaier, Torben Lange, Alexander Koschalka, Jenny-Lou Navarra, Johannes Uhlig, Joachim Lotz, Shelby Kutty, Boris Bigalke, Matthias Gutberlet, Gerd Hasenfuß, Holger Thiele, Ingo Eitel, Andreas Schuster Source Type: research

Myocardial Infarction as a Transient Risk Factor for Incident Venous Thromboembolism: Results from a Population-Based Case-Crossover Study.
In conclusion, our findings suggest that the increased VTE risk after MI may to a large extent be explained by concomitant conditions related to MI, particularly infections and immobilization. PMID: 31203579 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - June 16, 2019 Category: Hematology Authors: Sejrup JK, Børvik T, Grimnes G, Isaksen T, Hindberg K, Hansen JB, Morelli VM, Brækkan SK Tags: Thromb Haemost Source Type: research

Effects of Cardiac Hypertrophy, Diabetes, Aging, and Pregnancy on the Cardioprotective Effects of Postconditioning in Male and Female Rats.
The objective of this study was to investigate the vulnerability of hearts with aging, LVH, diabetes, and pregnancy to ischemic insult and their response to pacing postconditioning- (PPC-) induced heart protection. Methods: Hearts isolated from aged, spontaneously hypertensive and diabetic male and female rats and hearts from pregnant female rats (n=8 per group) were subjected to coronary occlusion followed by reperfusion using a modified Langendorff system. Hemodynamics data were computed digitally, and cardiac damage was accessed by measurements of infarct size and cardiac enzyme release. Results: There were no...
Source: Cardiology Research and Practice - June 15, 2019 Category: Cardiology Authors: Babiker F, Al-Jarallah A, Al-Awadi M Tags: Cardiol Res Pract Source Type: research

Primary Mechanism Study of Panax notoginseng Flower (Herb) on Myocardial Infarction in Rats.
Conclusions: PN-F demonstrated a potential herb to treat rats with myocardial infarction through promoting angiogenesis and inhibition of apoptosis in the infarct area. PMID: 31192006 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - June 15, 2019 Category: Cardiology Authors: Zhou X, Li ZC, Chen PP, Xie RF Tags: Cardiol Res Pract Source Type: research

Circulating MicroRNA-499 as a Diagnostic Biomarker for Acute Myocardial Infarction: A Meta-analysis.
Conclusion: The results showed that circulating microRNA-499 is a reliable biomarker for diagnosing AMI patients. PMID: 31191754 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - June 15, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Acute thrombotic vascular events complicating influenza-associated pneumonia
Publication date: Available online 14 June 2019Source: Respiratory Medicine Case ReportsAuthor(s): Takashi Ishiguro, Keisuke Matsuo, Shinya Fujii, Noboru TakayanagiAbstractA 58-year-old man with previous myocardial infarction presented to our hospital with fever, cough, and dyspnea. PCR testing with nasopharyngeal swabs confirmed influenza virus infection, and enhanced computed tomography and transthoracic echocardiography revealed bilateral ground-glass opacities and consolidation, deep venous thrombosis, acute pulmonary artery embolism, and acute arterial embolism that appeared to originate from thrombus in the left vent...
Source: Respiratory Medicine Case Reports - June 15, 2019 Category: Respiratory Medicine Source Type: research

Drug-coated balloon for treatment of de-novo coronary artery lesions in patients with high bleeding risk (DEBUT): a single-blind, randomised, non-inferiority trial
Publication date: Available online 13 June 2019Source: The LancetAuthor(s): Tuomas T Rissanen, Sanna Uskela, Jaakko Eränen, Pirjo Mäntylä, Annika Olli, Hannu Romppanen, Antti Siljander, Mikko Pietilä, Mikko J Minkkinen, Jerry Tervo, Jussi M Kärkkäinen, Aija Vatanen, Anssi Perälä, Miriam Müller, Pekka Porela, Eeva PalojokiSummaryBackgroundThe optimal technique of percutaneous coronary intervention in patients at high bleeding risk is not known. The hypothesis of the DEBUT trial was that percutaneous coronary intervention with drug-coated balloons is non-inferior to percutaneous c...
Source: The Lancet - June 14, 2019 Category: General Medicine Source Type: research

Development of a Yoga-Based Cardiac Rehabilitation (Yoga-CaRe) Programme for Secondary Prevention of Myocardial Infarction.
In conclusion, a novel yoga-based CR programme has been developed, which promises to provide a scalable CR solution for India and an alternative choice for CR globally. It is currently being evaluated in a large multicentre randomised controlled trial across India. PMID: 31186666 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 14, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The low dose colchicine after myocardial infarction (LoDoCo-MI) study: A pilot randomized placebo controlled trial of colchicine following acute myocardial infarction
ConclusionTreatment with low dose colchicine was safe and well tolerated, but was not associated with a significantly increased likelihood of achieving a CRP level
Source: American Heart Journal - June 14, 2019 Category: Cardiology Source Type: research

[Effect of humor training on stress, cheerfulness and depression in patients with coronary artery disease and refractory angina pectoris].
CONCLUSION: Patients with refractory angina pectoris and stable CAD benefit from a professional humor coaching. This effect was shown in a) a significant decrease in cortisol concentrations in the hair segment analysis, b) an improvement in cheerfulness in the STCI and c) a significant difference in the BDI between pre-post values. PMID: 31187195 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - June 14, 2019 Category: Cardiology Tags: Herz Source Type: research