North American COVID-19 ST-Segment-Elevation Myocardial Infarction (NACMI) registry: Rationale, design, and implications
Publication date: September 2020Source: American Heart Journal, Volume 227Author(s): Payam Dehghani, Laura J. Davidson, Cindy L. Grines, Keshav Nayak, Jacqueline Saw, Prashant Kaul, Akshay Bagai, Ross Garberich, Christian Schmidt, Hung Q. Ly, Jay Giri, Perwaiz Meraj, Binita Shah, Santiago Garcia, Scott Sharkey, David A. Wood, Frederick G. Welt, Ehtisham Mahmud, Timothy D. Henry (Source: American Heart Journal)
Source: American Heart Journal - July 10, 2020 Category: Cardiology Source Type: research

GSE154072 Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and lncRNA-DRR-/- Heart Transcriptomes
Contributors : Wenbin Fu ; Wei E WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo understand the mechanism of lncRNA-DRR induced effect on cardiomyocyte proliferation, high-throughput transcriptome sequencing was performed on hearts of WT and lncRNA-DRR −/− mice 2w after myocardial infarction, and gene enrichment analysis revealed that cell cycle process and cellular response to DNA damage were up-regulated in hearts of lncRNA-DRR−/− mice (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - July 10, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Incidental, non-gated thoracic CT angiographic detection of proximal right coronary artery total occlusion associated with acute myocardial infarction
Publication date: 2020Source: European Journal of Radiology Open, Volume 7Author(s): Rene Epunza Kanza, Samir Ayoub, Francis Bonenfant (Source: European Journal of Radiology Open)
Source: European Journal of Radiology Open - July 10, 2020 Category: Radiology Source Type: research

Cytokine Storm in COVID-19 —Immunopathological Mechanisms, Clinical Considerations, and Therapeutic Approaches: The REPROGRAM Consortium Position Paper
Cytokine storm is an acute hyperinflammatory response that may be responsible for critical illness in many conditions including viral infections, cancer, sepsis, and multi-organ failure. The phenomenon has been implicated in critically ill patients infected with SARS-CoV-2, the novel coronavirus implicated in COVID-19. Critically ill COVID-19 patients experiencing cytokine storm are believed to have a worse prognosis and increased fatality rate. In SARS-CoV-2 infected patients, cytokine storm appears important to the pathogenesis of several severe manifestations of COVID-19: acute respiratory distress syndrome, thromboembo...
Source: Frontiers in Immunology - July 10, 2020 Category: Allergy & Immunology Source Type: research

Circadian variations in pathogenesis of ST-segment elevation myocardial infarction: an optical coherence tomography study
AbstractPrevious studies have reported a circadian variation in the onset of ST-segment elevation myocardial infarction (STEMI). However, underlying mechanisms for the circadian variation have not been fully elucidated. We investigated the relationship between onset of STEMI and the underlying pathology using optical coherence tomography (OCT). Patients with a diagnosis of STEMI were selected from a multicenter OCT registry. Patients were divided into 4 groups based on the estimated time of onset (00:00 –05:59, 06:00–11:59, 12:00–17:59, or 18:00–23:59). Underlying pathologies of MI (plaque rupture, ...
Source: Journal of Thrombosis and Thrombolysis - July 10, 2020 Category: Hematology Source Type: research

A single, shared origin for all three coronary arteries from the right coronary cusp: a case report
ConclusionSurgical management is indicated in high-risk patients, but the optimal management for a nonmalignant, shared origin for all three coronary arteries has not been explored in detail. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - July 10, 2020 Category: General Medicine Source Type: research

MiR-126 regulated myocardial autophagy on myocardial infarction.
CONCLUSIONS: The down-regulation of miR-126 will lead to the over-activation of myocardial autophagy induced by Beclin-1, which is an autophagy related protein. The plasm expression of miR-126 may be a clinical marker of autophagy after AMI. PMID: 32633391 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - July 9, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

MicroRNA-323-3p inhibits oxidative stress and apoptosis after myocardial infarction by targeting TGF- β2/JNK pathway.
CONCLUSIONS: MiR-323-3p was downregulated in ischemic myocardium and H2O2-treated H9c2 cells, and miR-323-3p overexpression reduced oxidative stress and apoptosis of cardiomyocytes. The protective function was achieved via regulation of TGF-β2/JNK pathway. PMID: 32633390 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - July 9, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

MiR-808 inhibits cardiomyocyte apoptosis and expressions of caspase-3 and caspase-9 in rats with myocardial infarction by regulating TGF- β1 signaling pathway.
MiR-808 inhibits cardiomyocyte apoptosis and expressions of caspase-3 and caspase-9 in rats with myocardial infarction by regulating TGF-β1 signaling pathway. Eur Rev Med Pharmacol Sci. 2020 Jun;24(12):6955-6960 Authors: Zhang JW, Long TY, Pan W, Zhong QQ, Qian ZX, Jing R Abstract OBJECTIVE: To investigate the effects of micro ribonucleic acid (miR)-808 on cardiomyocyte apoptosis and expressions of caspase-3 and caspase-9 in rats with myocardial infarction (MI) by regulating the transforming growth factor-β1 (TGF-β1) signaling pathway. MATERIALS AND METHODS: A total of 24 specific pa...
Source: European Review for Medical and Pharmacological Sciences - July 9, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Adult's perception of health care after myocardial infarction.
Acirc;TMD Abstract OBJECTIVES: to describe the Adult's perception of healthcare after Myocardium Infarction. METHODS: qualitative descriptive analysis carried out with 12 adults who had myocardial infarction and conducted from February to May 2018. The research design was based on the "Consolidated Criteria for Reporting Qualitative Research". Data collection was performed through semi-structured questionnaire, interview script and field diary. The interviews were encoded, and their content was analyzed using software support. RESULTS: three classes were obtained: "Fear, (un) certainty and...
Source: Revista Brasileira de Enfermagem - July 9, 2020 Category: Nursing Authors: Paz VP, Mantovani MF, Mercês NNAD, Mazza VA, Silva ÂTMD Tags: Rev Bras Enferm Source Type: research

[Troponin elevation in acute ischemic stroke-unspecific or acute myocardial infarction? : Diagnostics and clinical implications].
Authors: Kruska M, Fastner C, Scheitz JF, Kolb A, Rutsch M, Papavassiliu T, Borggrefe M, Alonso A, Akin I, Szabo K, Baumann S Abstract Routine determination of troponin levels is recommended for all patients with acute ischemic stroke. In 20-55% of these patients the troponin levels are elevated, which may be caused by ischemic as well as non-ischemic myocardial damage and particularly neurocardiogenic myocardial damage. In patients with acute ischemic stroke, the prevalence of previously unknown coronary heart disease is reported to be up to 27% and is prognostically relevant for these patients; however, relevant ...
Source: Herz - July 9, 2020 Category: Cardiology Tags: Herz Source Type: research

Left atrial volume index and pulmonary arterial pressure predicted MACE among patients with STEMI during 8-year follow-up: experience from a  tertiary center.
CONCLUSION: In patients that underwent P‑PCI for the treatment for STEMI, LVEF, LAVI, PAP and creatinine level independently predicted all-cause mortality and new onset HF during long-term follow-up. PMID: 32632548 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - July 9, 2020 Category: Cardiology Tags: Herz Source Type: research

Profile of use and access to statins in patients with coronary arterial disease in an outpatient clinic of a teaching hospital.
Conclusion: The level of adherence to the recommendations of U.S. and Brazilian guidelines of dyslipidemia for statin use was low. Most patients used a moderate intensity statin, despite having a high cardiovascular risk. Simvastatin was the most prescribed statin. PMID: 32634034 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 9, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Pre-hospital delay in patients with myocardial infarction: an observational study in a tertiary care hospital of northern Bangladesh
This study aimed to investigate the significant factors associated with prolonged... (Source: BMC Health Services Research)
Source: BMC Health Services Research - July 9, 2020 Category: General Medicine Authors: Abdur Rafi, Zahidus Sayeed, Papia Sultana, Saw Aik and Golam Hossain Tags: Research article Source Type: research

IJERPH, Vol. 17, Pages 4939: Healthcare Service Use for Mood and Anxiety Disorders Following Acute Myocardial Infarction: A Cohort Study of the Role of Neighbourhood Socioenvironmental Characteristics in a Largely Rural Population
This study aimed to describe associations between socioeconomic and built environment characteristics of neighbourhood environments and mental health service contacts following an acute myocardial infarction (AMI or heart attack) among adults in the province of New Brunswick, Canada. This province is characterized largely by residents in small towns and rural areas. A cohort of all adults aged 45 and over surviving AMI and without a recent record of mental disorders was identified by linking provincial medical-administrative datasets. Residential histories were tracked over time to assign neighbourhood measures of marginal...
Source: International Journal of Environmental Research and Public Health - July 9, 2020 Category: Environmental Health Authors: Ismael Foroughi Neeru Gupta Dan Lawson Crouse Tags: Article Source Type: research

BNP as a New Biomarker of Cardiac Thyroid Hormone Function
The objective of this study was to investigate BNP as a potential serum biomarker for TH function in the heart.MethodsTwo animal models of thyroid hormone deficiency: (1) 8-weeks of propyl thiouracil-induced hypothyroidism (Hypo) in adult female rats were subsequently treated with oral T3 (10 μg/kg/d) for 3, 6, or 14 days; (2) HF induced by coronary artery ligation (myocardial infarction, MI) in adult female rats was treated daily with low dose oral T3 (5 μg/kg/d) for 8 or 16 wks.ResultsSix days of T3 treatment of Hypo rats normalized most cardiac functional parameters. Serum levels of BNP increased 5-fold in Hypo ra...
Source: Frontiers in Physiology - July 9, 2020 Category: Physiology Source Type: research

Suppressed Vascular Leakage and Myocardial Edema Improve Outcome From Myocardial Infarction
ConclusionSuppression of VEGFA/VEGFR2-regulated vascular permeability leads to diminished edema without affecting vascular density correlating with improved myocardial parameters and survival after MI. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - July 9, 2020 Category: Physiology Source Type: research

Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Disease
AbstractPurpose of ReviewThe purpose of this review article is to summarize the preclinical and clinical evidence supporting the notion of clonal hematopoiesis of indeterminate potential (CHIP), highlight current knowledge gap, and provide future directions.Recent FindingsEpidemiological studies show that advanced age is a major risk factor for the development of cardiovascular disease (CVD) and cancer, the two leading causes of morbidity and mortality worldwide. While the negative effect of aging on CVD is a reflection of cumulative exposure to various established traditional CVD risk factors, genetic sequencing of whole ...
Source: Current Oncology Reports - July 9, 2020 Category: Cancer & Oncology Source Type: research

Targeting the forkhead box protein P1 pathway as a novel therapeutic approach for cardiovascular diseases
AbstractCardiovascular disease (CVD) is the leading cause of death worldwide and encompasses diverse diseases of the vasculature, myocardium, cardiac electrical circuit, and cardiac development. Forkhead box protein P1 (Foxp1) is a large multi-domain transcriptional regulator belonging to the Fox family with winged helix DNA-binding protein, which plays critical roles in cardiovascular homeostasis and disorders. The broad distribution of Foxp1 and alternative splicing isoforms implicate its distinct functions in diverse cardiac and vascular cells and tissue types. Foxp1 is essential for diverse biological processes and has...
Source: Heart Failure Reviews - July 9, 2020 Category: Cardiology Source Type: research

Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo
ConclusionsThe rapidly hydrolysed malonate prodrug MAM can protect against cardiac I/R injury in a clinically relevant mouse model. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - July 9, 2020 Category: Cardiology Source Type: research

Ethnic and Racial Disparities in Acute Myocardial Infarction
AbstractPurpose of ReviewSignificant racial and ethnic healthcare disparities exist in the management and outcomes of patients with acute myocardial infarction (AMI). This review will highlight the recent studies focusing on disparities in AMI care and how practice patterns have changed over time, and discuss solutions and future directions to overcome disparities in AMI care.Recent FindingsAMI continues to be a leading cause of morbidity and mortality in the USA. Racial and ethnic disparities continue to be present in the care and outcomes associated with AMI. Non-white individuals continue to receive less guideline-conco...
Source: Current Cardiology Reports - July 9, 2020 Category: Cardiology Source Type: research

Immunomodulation of the NLRP3 Inflammasome in Atherosclerosis, Coronary Artery Disease, and Acute Myocardial Infarction
AbstractCardiovascular disease (CVD) remains the leading cause of mortality and morbidity worldwide. Atherosclerosis is responsible for the majority of cardiovascular disorders with inflammation as one of its driving processes. The nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, responsible for the release of the pro-inflammatory cytokines, interleukin-1 β (IL-1β), and interleukin-18 (IL-18), has been studied extensively and showed to play a pivotal role in the progression of atherosclerosis, coronary artery disease (CAD), and myocardial ischemia repe...
Source: Journal of Cardiovascular Translational Research - July 9, 2020 Category: Cardiology Source Type: research

Artificial intelligence for STEMI detection: The “Shanghai Algorithm” provides a step forward
In this IJC issue, Zhao and colleagues [1] publish a novel and important paper that demonstrates the feasibility of applying Artificial Intelligence (AI) to the diagnosis of acute ST-elevation myocardial infarction (STEMI) from standard 12-lead electrocardiograms (ECGs). The results demonstrate that the performance of the AI-algorithm exceeded the diagnostic ability of most physicians and a rule-based commercial algorithm. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - July 9, 2020 Category: Cardiology Authors: Ivan C. Rokos Tags: Editorial Source Type: research

Cacao Bean Polyphenols Inhibit Cardiac Hypertrophy and Systolic Dysfunction in Pressure Overload-induced Heart Failure Model Mice
In conclusion, these findings suggest that cacao bean polyphenols prevent pressure overload-induced cardiac hypertrophy and systolic dysfunction by inhibiting the extracellular signal-regulated kinase 1/2-GATA binding protein 4 pathway in cardiomyocytes. Thus, cacao bean polyphenols may be useful for heart failure therapy in humans. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Planta Medica)
Source: Planta Medica - July 9, 2020 Category: Drugs & Pharmacology Authors: Sari, Nurmila Katanasaka, Yasufumi Honda, Hiroki Miyazaki, Yusuke Sunagawa, Yoichi Funamoto, Masafumi Shimizu, Kana Shimizu, Satoshi Wada, Hiromichi Hasegawa, Koji Morimoto, Tatsuya Tags: Original Papers Source Type: research

Dilemnas raised by implementation of an unqualified STEMI algorithm
The authors of the study of the impact of patient delay in a modern real world STEMI network have rightly focussed on the adverse impact of delay in implementation of percutaneous coronary intervention [1]. The dilemna which faces clinicians who are aware of the existence of the entity of the mimicry of ST segment elevation myocardial infarction(STEMI) by dissecting aortic aneurysm(DAA), and the mimicry of STEMI by pulmonary embolism(PE) is that strategies such as point-of-care transthoracic echocardiography(TTE), which might mitigate the risk of misdiagnosis, also incur the risk of compounding the delay in achieving timel...
Source: The American Journal of Emergency Medicine - July 9, 2020 Category: Emergency Medicine Authors: Oscar M.P. Jolobe Source Type: research

Efficacy and safety of short-term 1-3 months versus standard 12 months dual antiplatelet therapy in patients undergoing percutaneous coronary intervention: a meta-analysis of randomized clinical trials.
In conclusion, the short-term DAPT can reduce the risk of bleeding compared with standard DAPT, without increasing the risk of death or ischemia (Registered by PROSPERO, CRD42020153881). PMID: 32627616 [PubMed - as supplied by publisher] (Source: Platelets)
Source: Platelets - July 8, 2020 Category: Hematology Tags: Platelets Source Type: research

ST-elevation acute myocardial infarction during COVID-19 pandemic: Are we missing the boat?
Publication date: August 2020Source: IJC Heart & Vasculature, Volume 29Author(s): Andrea Buono, Enrico Ammirati (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - July 8, 2020 Category: Cardiology Source Type: research

Qiliqiangxin Improves Cardiac Function through Regulating Energy Metabolism via HIF-1 α-Dependent and Independent Mechanisms in Heart Failure Rats after Acute Myocardial Infarction.
Qiliqiangxin Improves Cardiac Function through Regulating Energy Metabolism via HIF-1α-Dependent and Independent Mechanisms in Heart Failure Rats after Acute Myocardial Infarction. Biomed Res Int. 2020;2020:1276195 Authors: Wang Y, Fu M, Wang J, Zhang J, Han X, Song Y, Fan Y, Hu K, Zhou J, Ge J Abstract The present study is aimed at investigating whether Qiliqiangxin (QL) could regulate myocardial energy metabolism in heart failure rats after acute myocardial infarction (AMI) and further exploring the underlying mechanisms. AMI was established by ligating the left anterior descending coronary ar...
Source: Biomed Res - July 8, 2020 Category: Research Authors: Wang Y, Fu M, Wang J, Zhang J, Han X, Song Y, Fan Y, Hu K, Zhou J, Ge J Tags: Biomed Res Int Source Type: research

The association between glucose-related variables and plaque morphology in patients with ST-segment elevated myocardial infarction
Plaque rupture (PR) and plaque erosion (PE) are main causes of acute myocardial infarction with different demographic and histology characteristics and need different treatment strategy. PR and PE can be ident... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 8, 2020 Category: Cardiology Authors: Jinxin Liu, Shanjie Wang, Can Cui, Hengxuan Cai, Rong Sun, Weili Pan, Shaohong Fang and Bo Yu Tags: Original investigation Source Type: research

Use, Persistence, Efficacy, and Safety of Apixaban in Patients with Non-Valvular Atrial Fibrillation in Unselected Patients in Germany. Results of the Prospective Apixaban in Atrial Fibrillation (APAF) Registry
ConclusionsIn this prospective experience in unselected patients with atrial fibrillation, persistence to apixaban was high, and efficacy and safety were comparable to the results in clinical trials, supporting its use in clinical practice. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - July 8, 2020 Category: Cardiology Source Type: research

The Role of Biomarkers in Cardio-Oncology
AbstractIn the field of cardio-oncology, it is well recognised that despite the benefits of chemotherapy in treating and possibly curing cancer, it can cause catastrophic damage to bystander tissues resulting in a range of potentially of life-threatening cardiovascular toxicities, and leading to a number of damaging side effects including heart failure and myocardial infarction. Cardiotoxicity is responsible for significant morbidity and mortality in the long-term in oncology patients, specifically due to left ventricular dysfunction. There is increasing emphasis on the early use of biomarkers in order to detect the cardio...
Source: Journal of Cardiovascular Translational Research - July 8, 2020 Category: Cardiology Source Type: research

Acquired haemophilia A, concomitant acute myocardial infarction and urgent major surgery: How to successfully treat a critical patient with rpFVIII (Obizur ®)
Association of acute myocardial infarction (AMI) and acquired haemophilia A (AHA) is extremely rare, and very difficult to treat, if the patient then presents several serious comorbidities and must undergo an urgent major surgery, the correct choice of haemostatic therapy is essential to avoid potentially life-threatening adverse events for the patient. The recombinant porcine FVIII (rpFVIII) is considered, together with the bypassing agents, as first-line therapy for the AHA, but compared to these it presents a reduced thromboembolic risk which makes it safer in patients who already present at the onset of haemorrhagic ev...
Source: Thrombosis Research - July 8, 2020 Category: Hematology Authors: Zanon Ezio, Pasca Samantha, Spiezia Luca, Poletto Francesco, Gherardi Simone, Simioni Paolo Tags: Letter to the Editors-in-Chief Source Type: research

Pathophysiology, Classification, and MRI Parallels in Microvascular Disease of the Heart and Brain
AbstractDiagnostic imaging technology in vascular disease has long focused on large vessels and the pathologic processes that impact them. With improved diagnostic techniques, investigators are now able to uncover many underlying mechanisms and prognostic factors for microvascular disease. In the heart and brain, these pathologic entities include coronary microvascular disease and cerebral small vessel disease, both of which have significant impact on patients, causing angina, myocardial infarction, heart failure, stroke and dementia. In the current paper we will discuss parallels in pathophysiology, classification, and di...
Source: Microcirculation - July 8, 2020 Category: Research Authors: Michael A. Thomas, Saman Hazany, Benjamin M. Ellingson, Peng Hu, Kim ‐Lien Nguyen Tags: REVIEWS Source Type: research

Tenascin ‐C aggravates ventricular dilatation and angiotensin‐converting enzyme activity after myocardial infarction in mice
AbstractAimsTenascin ‐C (TN‐C) is suggested to be detrimental in cardiac remodelling after myocardial infarction (MI). The aim of this study is to reveal the effects of TN‐C on extracellular matrix organization and its haemodynamic influence in an experimental mouse model of MI and in myocardial cell culture durin g hypoxic conditions.Methods and resultsMyocardial infarction was induced in TN ‐C knockout (TN‐C KO) and wild‐type mice. Six weeks later, cardiac function was studied by magnetic resonance imaging and under isolated working heart conditions. Myocardial mRNA levels and immunoreactivity of TN‐C, TIMP...
Source: ESC Heart Failure - July 8, 2020 Category: Cardiology Authors: David Santer, Felix Nagel, In ês Fonseca Gonçalves, Christoph Kaun, Johann Wojta, Miklós Fagyas, Martin Krššák, Ágnes Balogh, Zoltán Papp, Attila Tóth, Viktor Bánhegyi, Karola Trescher, Attila Kiss, Bruno K. Podesser Tags: Original Research Article Source Type: research

Effect of icosapent ethyl on susceptibility to ventricular arrhythmias in postinfarcted rat hearts: Role of GPR120-mediated connexin43 phosphorylation.
Abstract The ω-3 fatty acids exert as an antioxidant via the G protein-coupled receptor 120 (GPR120). Icosapent ethyl, a purified eicosapentaenoic acid, showed a marked reduction in sudden cardiac death. Connexin43 is sensitive to redox status. We assessed whether icosapent ethyl attenuates fatal arrhythmias after myocardial infarction, a status of high oxidative stress, through increased connexin43 expression and whether the GPR120 signalling is involved in the protection. Male Wistar rats after ligating coronary artery were assigned to either vehicle or icosapent ethyl for 4 weeks. The postinfarction ...
Source: J Cell Mol Med - July 8, 2020 Category: Molecular Biology Authors: Chen WT, Chen SY, Wu DW, Lee CC, Lee TM Tags: J Cell Mol Med Source Type: research

Thromboembolic or atherosclerotic? Optical coherence tomography in determining the cause of myocardial infarction with ST-segment elevation.
PMID: 32640773 [PubMed - as supplied by publisher] (Source: Polish Heart Journal)
Source: Polish Heart Journal - July 8, 2020 Category: Cardiology Authors: Iwańczyk S, Skorupski WJ, Kępski S, Grygier M, Lesiak M Tags: Kardiol Pol Source Type: research

Speckle tracking echocardiography in a patient with viral myocarditis and acute myocardial infarction
Publication date: Available online 7 July 2020Source: Journal of Cardiology CasesAuthor(s): Adrienn Tünnemann-Tarr, Stephan Stöbe, Ulrich Laufs, Andreas Hagendorff, Bhupendar Tayal (Source: Journal of Cardiology Cases)
Source: Journal of Cardiology Cases - July 7, 2020 Category: Cardiology Source Type: research

Adverse Cardiac Remodelling after Acute Myocardial Infarction: Old and New Biomarkers.
Authors: Berezin AE, Berezin AA Abstract The prevalence of heart failure (HF) due to cardiac remodelling after acute myocardial infarction (AMI) does not decrease regardless of implementation of new technologies supporting opening culprit coronary artery and solving of ischemia-relating stenosis with primary percutaneous coronary intervention (PCI). Numerous studies have examined the diagnostic and prognostic potencies of circulating cardiac biomarkers in acute coronary syndrome/AMI and heart failure after AMI, and even fewer have depicted the utility of biomarkers in AMI patients undergoing primary PCI. Although c...
Source: Disease Markers - July 7, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Diosmetin alleviates hypoxia ‑induced myocardial apoptosis by inducing autophagy through AMPK activation.
Diosmetin alleviates hypoxia‑induced myocardial apoptosis by inducing autophagy through AMPK activation. Mol Med Rep. 2020 Jun 16;: Authors: Si Q, Shi Y, Huang D, Zhang N Abstract Diosmetin has shown great potential in the control of several diseases. The aim of the present study was to evaluate the role of diosmetin as a candidate agent for the treatment of myocardial infarction which was mainly caused by hypoxia. The model of hypoxia‑injured myocardial cells was established using the H9c2 cell line. Cell viability was determined using Cell Counting Kit‑8, cell apoptosis was determined by Annexi...
Source: Molecular Medicine Reports - July 7, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

RP105 plays a cardioprotective role in myocardial ischemia reperfusion injury by regulating the Toll ‑like receptor 2/4 signaling pathways.
RP105 plays a cardioprotective role in myocardial ischemia reperfusion injury by regulating the Toll‑like receptor 2/4 signaling pathways. Mol Med Rep. 2020 Jun 16;: Authors: Huang W, Yang J, He C, Yang J Abstract The revascularization of blood vessels after myocardial infarction can lead to serious myocardial damage. Previous studies showed that radioprotective 105 kDa protein (RP105) is a specific negative regulator of myocardial ischemia reperfusion injury (MIRI). RP105 can modulate the Toll‑like receptor (TLR)2/TLR4 signaling pathways. However, the synergistic effect of TLR2/4 regulated by...
Source: Molecular Medicine Reports - July 7, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Cardiovascular disease management during the coronavirus disease 2019 pandemic.
Authors: Lee WH, Chen YC, Chen SC, Chen CJ, Hsu PC, Tsai WC, Chu CY, Lee CS, Lin TH, Voon WC, Kuo CH, Su HM Abstract Based on clinical presentation, pathophysiology, high infectivity, high cardiovascular involvement, and therapeutic agents with cardiovascular toxicity of coronavirus disease 2019 (COVID-19), regular cardiovascular treatment is being changing greatly. Despite angiotensin-converting enzyme 2 serving as the portal for infection, the continuation of clinically indicated renin-angiotensin-aldosterone blockers is recommended according to the present evidence. Fibrinolytic therapy can be considered a reaso...
Source: International Journal of Medical Sciences - July 7, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Outcome in Patients Resuscitated following Myocardial Infarction with Acute Kidney Injury.
Authors: Kanic V, Ekart R, Kanic Z Abstract Background: Data on acute kidney injury (AKI) in patients with myocardial infarction (MI) who underwent percutaneous coronary intervention (PCI) after cardiac arrest are scarce. The prevalence of AKI, as classified by the Kidney Disease: Improving Global Outcomes (KDIGO) criteria; and its possible association with 30-day mortality were assessed. Methods: Data on 6387 patients with MI, 342 (5.3%) with out-of-hospital cardiac arrest or arrest immediately after admission before PCI, were retrospectively analyzed. The AKI and no-AKI groups were compared. The 30-day mortality ...
Source: International Journal of Medical Sciences - July 7, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Usefulness of four-limb blood pressure measurement in prediction of overall and cardiovascular mortality in acute myocardial infarction.
Authors: Hsu PC, Lee WH, Tsai WC, Chu CY, Lee CS, Yen HW, Lin TH, Voon WC, Lai WT, Sheu SH, Su HM Abstract Four-limb blood pressure measurement could improve mortality prediction in the elderly. However, there was no study to evaluate whether such measurement was still useful in predicting overall and cardiovascular (CV) mortality in acute myocardial infarction (AMI). Two hundred AMI patients admitted to cardiac care unit were enrolled. The 4-limb blood pressures, inter-limb blood pressure differences, and ankle brachial index (ABI) were measured using an ABI-form device. The median follow-up to mortality was 64 mo...
Source: International Journal of Medical Sciences - July 7, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

The Correlation of Comorbidities on the Mortality in Patients with COVID-19: an Observational Study Based on the Korean National Health Insurance Big Data.
CONCLUSION: We hope that this study could provide information on high risk groups for preemptive interventions. In the future, if a vaccine for COVID-19 is developed, it is expected that this study will be the basic data for recommending immunization by selecting those with chronic disease that had high risk of death, as recommended target diseases for vaccination. PMID: 32627443 [PubMed - in process] (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - July 7, 2020 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Cardiovascular mortality and morbidity in patients undergoing percutaneous coronary intervention after out-of-hospital cardiac arrest: a systematic review and meta-analysis.
CONCLUSIONS: Almost one third of OHCA patients undergoing PCI die and more than one third of the fatalities are attributable to cardiovascular causes. The burden of ischemic and bleeding complications was consistently higher and the success rates of PCI lower among OHCA as compared to non-OHCA patients. PMID: 32624462 [PubMed - as supplied by publisher] (Source: EuroIntervention)
Source: EuroIntervention - July 7, 2020 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Angiographic predictors of outcome in myocardial infarction patients presenting with cardiogenic shock: A CULPRIT-SHOCK angiographic substudy.
CONCLUSIONS: Post-PCI TIMI and TMPG are associated with mortality after PCI. TMPG is a better discriminator, supporting microcirculation rather than epicardial reperfusion for prognosis estimation. PMID: 32624460 [PubMed - as supplied by publisher] (Source: EuroIntervention)
Source: EuroIntervention - July 7, 2020 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Association of Statin Use With All-Cause and Cardiovascular Mortality in US Veterans 75 and Older
This retrospective cohort study uses Veterans Health Administration data on adults free of atherosclerotic cardiovascular disease (ASCVD) to evaluate the association between new statin use and all-cause and cardiovascular mortality, and a composite of ASCVD events (myocardial infarction, ischemic stroke, and revascularization with CABG surgery or PCI), in veterans 75 years and older. (Source: JAMA)
Source: JAMA - July 7, 2020 Category: General Medicine Source Type: research

Preference of individuals in the treatment strategies of acute myocardial infarction in China: a discrete choice experiment
Acute myocardial infarction (AMI) is a significant cause of mortality and morbidity worldwide. Today, with increasing life quality and social economy, people pay much attention to the cost-effectiveness of a t... (Source: Health and Quality of Life Outcomes)
Source: Health and Quality of Life Outcomes - July 7, 2020 Category: International Medicine & Public Health Authors: Weiqian Dai, Chang Liu, Jiahe Liu, Yaduan Lin, Yu Cheng and Wai-kit Ming Tags: Research Source Type: research

Small Things Matter: Relevance of MicroRNAs in Cardiovascular Disease
MicroRNAs (miRNAs) are short sequences of non-coding RNA that play an important role in the regulation of gene expression and thereby in many physiological and pathological processes. Furthermore, miRNAs are released in the extracellular space, for example in vesicles, and are detectable in various biological fluids, such as serum, plasma, and urine. Over the last years, it has been shown that miRNAs are crucial in the development of several cardiovascular diseases (CVDs). This review discusses the (patho)physiological implications of miRNAs in CVD, ranging from cardiovascular risk factors (i.e., hypertension, diabetes, dy...
Source: Frontiers in Physiology - July 7, 2020 Category: Physiology Source Type: research

Correction to: Impact of Morphine Treatment With and Without Metoclopramide Coadministration on Ticagrelor-Induced Platelet Inhibition in Acute Myocardial Infarction: The Randomized MonAMI Trial.
Authors: PMID: 32628547 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - July 7, 2020 Category: Cardiology Tags: Circulation Source Type: research