Psidium guajava induces cytotoxicity in human malignant glioblastoma cell line: Role of reactive oxygen species (ROS)
Toxicol In Vitro. 2023 Feb 7:105567. doi: 10.1016/j.tiv.2023.105567. Online ahead of print.ABSTRACTOne of the deadliest types of CNS primary brain cancers is glioblastoma multiforme (GBM), and the survival rate of patients is about 7.2%. The standard treatment for GBM is surgical interventions followed by temozolomide. We investigated for the first time, the cytotoxic impacts of Psidium guajava (P. guajava) on the U87 GBM cell line. We measured cell toxicity through the MTT test following 24 h, 48 h, and 72 h treatment with different concentrations of fruit and seed hydroalcoholic extracts of P. guajava (25-400 μg/ml). Li...
Source: Toxicology in Vitro - February 9, 2023 Category: Toxicology Authors: Azar Hosseini Mohaddeseh Sadat Alavi Amir Reza Shahraki Arezoo Rajabian Amir Reza Afshari Prashant Kesharwani Amirhossein Sahebkar Source Type: research
Psidium guajava induces cytotoxicity in human malignant glioblastoma cell line: Role of reactive oxygen species
Toxicol In Vitro. 2023 Feb 8;89:105567. doi: 10.1016/j.tiv.2023.105567. Online ahead of print.ABSTRACTOne of the deadliest types of CNS primary brain cancers is glioblastoma multiforme (GBM), and the survival rate of patients is about 7.2%. The standard treatment for GBM is surgical interventions followed by temozolomide. We investigated for the first time, the cytotoxic impacts of Psidium guajava (P. guajava) on the U87 GBM cell line. We measured cell toxicity through the MTT test following 24 h, 48 h, and 72 h treatment with different concentrations of fruit and seed hydroalcoholic extracts of P. guajava (25-400 μg/ml)....
Source: Toxicology in Vitro - February 9, 2023 Category: Toxicology Authors: Azar Hosseini Mohaddeseh Sadat Alavi Amir Reza Shahraki Arezoo Rajabian Amir Reza Afshari Prashant Kesharwani Amirhossein Sahebkar Source Type: research
Psidium guajava induces cytotoxicity in human malignant glioblastoma cell line: Role of reactive oxygen species
Toxicol In Vitro. 2023 Feb 8;89:105567. doi: 10.1016/j.tiv.2023.105567. Online ahead of print.ABSTRACTOne of the deadliest types of CNS primary brain cancers is glioblastoma multiforme (GBM), and the survival rate of patients is about 7.2%. The standard treatment for GBM is surgical interventions followed by temozolomide. We investigated for the first time, the cytotoxic impacts of Psidium guajava (P. guajava) on the U87 GBM cell line. We measured cell toxicity through the MTT test following 24 h, 48 h, and 72 h treatment with different concentrations of fruit and seed hydroalcoholic extracts of P. guajava (25-400 μg/ml)....
Source: Toxicology in Vitro - February 9, 2023 Category: Toxicology Authors: Azar Hosseini Mohaddeseh Sadat Alavi Amir Reza Shahraki Arezoo Rajabian Amir Reza Afshari Prashant Kesharwani Amirhossein Sahebkar Source Type: research
Psidium guajava induces cytotoxicity in human malignant glioblastoma cell line: Role of reactive oxygen species
Toxicol In Vitro. 2023 Feb 8;89:105567. doi: 10.1016/j.tiv.2023.105567. Online ahead of print.ABSTRACTOne of the deadliest types of CNS primary brain cancers is glioblastoma multiforme (GBM), and the survival rate of patients is about 7.2%. The standard treatment for GBM is surgical interventions followed by temozolomide. We investigated for the first time, the cytotoxic impacts of Psidium guajava (P. guajava) on the U87 GBM cell line. We measured cell toxicity through the MTT test following 24 h, 48 h, and 72 h treatment with different concentrations of fruit and seed hydroalcoholic extracts of P. guajava (25-400 μg/ml)....
Source: Toxicology in Vitro - February 9, 2023 Category: Toxicology Authors: Azar Hosseini Mohaddeseh Sadat Alavi Amir Reza Shahraki Arezoo Rajabian Amir Reza Afshari Prashant Kesharwani Amirhossein Sahebkar Source Type: research
Psidium guajava induces cytotoxicity in human malignant glioblastoma cell line: Role of reactive oxygen species
Toxicol In Vitro. 2023 Feb 8;89:105567. doi: 10.1016/j.tiv.2023.105567. Online ahead of print.ABSTRACTOne of the deadliest types of CNS primary brain cancers is glioblastoma multiforme (GBM), and the survival rate of patients is about 7.2%. The standard treatment for GBM is surgical interventions followed by temozolomide. We investigated for the first time, the cytotoxic impacts of Psidium guajava (P. guajava) on the U87 GBM cell line. We measured cell toxicity through the MTT test following 24 h, 48 h, and 72 h treatment with different concentrations of fruit and seed hydroalcoholic extracts of P. guajava (25-400 μg/ml)....
Source: Toxicology in Vitro - February 9, 2023 Category: Toxicology Authors: Azar Hosseini Mohaddeseh Sadat Alavi Amir Reza Shahraki Arezoo Rajabian Amir Reza Afshari Prashant Kesharwani Amirhossein Sahebkar Source Type: research
Psidium guajava induces cytotoxicity in human malignant glioblastoma cell line: Role of reactive oxygen species
Toxicol In Vitro. 2023 Feb 8;89:105567. doi: 10.1016/j.tiv.2023.105567. Online ahead of print.ABSTRACTOne of the deadliest types of CNS primary brain cancers is glioblastoma multiforme (GBM), and the survival rate of patients is about 7.2%. The standard treatment for GBM is surgical interventions followed by temozolomide. We investigated for the first time, the cytotoxic impacts of Psidium guajava (P. guajava) on the U87 GBM cell line. We measured cell toxicity through the MTT test following 24 h, 48 h, and 72 h treatment with different concentrations of fruit and seed hydroalcoholic extracts of P. guajava (25-400 μg/ml)....
Source: Toxicology in Vitro - February 9, 2023 Category: Toxicology Authors: Azar Hosseini Mohaddeseh Sadat Alavi Amir Reza Shahraki Arezoo Rajabian Amir Reza Afshari Prashant Kesharwani Amirhossein Sahebkar Source Type: research
Psidium guajava induces cytotoxicity in human malignant glioblastoma cell line: Role of reactive oxygen species
Toxicol In Vitro. 2023 Feb 8;89:105567. doi: 10.1016/j.tiv.2023.105567. Online ahead of print.ABSTRACTOne of the deadliest types of CNS primary brain cancers is glioblastoma multiforme (GBM), and the survival rate of patients is about 7.2%. The standard treatment for GBM is surgical interventions followed by temozolomide. We investigated for the first time, the cytotoxic impacts of Psidium guajava (P. guajava) on the U87 GBM cell line. We measured cell toxicity through the MTT test following 24 h, 48 h, and 72 h treatment with different concentrations of fruit and seed hydroalcoholic extracts of P. guajava (25-400 μg/ml)....
Source: Toxicology in Vitro - February 9, 2023 Category: Toxicology Authors: Azar Hosseini Mohaddeseh Sadat Alavi Amir Reza Shahraki Arezoo Rajabian Amir Reza Afshari Prashant Kesharwani Amirhossein Sahebkar Source Type: research
Psidium guajava induces cytotoxicity in human malignant glioblastoma cell line: Role of reactive oxygen species
Toxicol In Vitro. 2023 Feb 8;89:105567. doi: 10.1016/j.tiv.2023.105567. Online ahead of print.ABSTRACTOne of the deadliest types of CNS primary brain cancers is glioblastoma multiforme (GBM), and the survival rate of patients is about 7.2%. The standard treatment for GBM is surgical interventions followed by temozolomide. We investigated for the first time, the cytotoxic impacts of Psidium guajava (P. guajava) on the U87 GBM cell line. We measured cell toxicity through the MTT test following 24 h, 48 h, and 72 h treatment with different concentrations of fruit and seed hydroalcoholic extracts of P. guajava (25-400 μg/ml)....
Source: Toxicology in Vitro - February 9, 2023 Category: Toxicology Authors: Azar Hosseini Mohaddeseh Sadat Alavi Amir Reza Shahraki Arezoo Rajabian Amir Reza Afshari Prashant Kesharwani Amirhossein Sahebkar Source Type: research
Psidium guajava induces cytotoxicity in human malignant glioblastoma cell line: Role of reactive oxygen species
Toxicol In Vitro. 2023 Feb 8;89:105567. doi: 10.1016/j.tiv.2023.105567. Online ahead of print.ABSTRACTOne of the deadliest types of CNS primary brain cancers is glioblastoma multiforme (GBM), and the survival rate of patients is about 7.2%. The standard treatment for GBM is surgical interventions followed by temozolomide. We investigated for the first time, the cytotoxic impacts of Psidium guajava (P. guajava) on the U87 GBM cell line. We measured cell toxicity through the MTT test following 24 h, 48 h, and 72 h treatment with different concentrations of fruit and seed hydroalcoholic extracts of P. guajava (25-400 μg/ml)....
Source: Toxicology in Vitro - February 9, 2023 Category: Toxicology Authors: Azar Hosseini Mohaddeseh Sadat Alavi Amir Reza Shahraki Arezoo Rajabian Amir Reza Afshari Prashant Kesharwani Amirhossein Sahebkar Source Type: research
Molecules, Vol. 28, Pages 1297: Self-Emulsifying Micellization of Crude Extracts from Apple (Malus domestica cv. Anna), Plum (Prunus domestica cv. Satsuma), and Guava (Psidium guajava L.) Fruits
In this study, we evaluated the effects of micellar emulsification of tropical apple (Malus domestica cv. Anna), plum (Prunus domestica cv. Satsuma), and guava (Psidium guajava L.) extracts regarding particle size and stability, polyphenol-loading efficiency, antioxidant capacity, and cytotoxic activity in human and murine cells. Simple food-grade extraction protocols were implemented to obtain apple, plum, and guava extracts. Total polyphenols, flavonoids, and antioxidant activity (DPPH) were determined in the fruit extracts, and their polyphenol profile was further characterized by liquid chromatography (HPLC-DAD). The d...
Source: Molecules - January 29, 2023 Category: Chemistry Authors: Laura A. Calvo-Castro Andrea Ir ías-Mata Daronne Cano-Contreras Elizabeth Arn áez-Serrano Randall Chac ón-Cerdas Ricardo Starbird-P érez Johan Morales-S ánchez Carolina Centeno-Cerdas Tags: Article Source Type: research
Molecules, Vol. 28, Pages 1219: Potential Biological Properties of Lycopene in a Self-Emulsifying Drug Delivery System
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Manuela Pintado
In recent years, lycopene has been highlighted due to its antioxidant and anti-inflammatory properties, associated with a beneficial effect on human health. The aim of this study was to advance the studies of antioxidant and anti-inflammatory mechanisms on human keratinocytes cells (HaCaT) of a self-emulsifying drug delivery system (SEDDS) loaded with lycopene purified from red guava (nanoLPG). The characteristics of nanoLPG were a hydrodynamic diameter of 205 nm, a polydispersity index of 0.21 and a zeta potential of −20.57, providing physical stability for the nanosystem. NanoLPG dem...
Source: Molecules - January 26, 2023 Category: Chemistry Authors: S ônia Nair Báo Manuela Machado Ana Luisa Da Silva Adma Melo Sara Cunha S érgio S. Sousa Ana Rita Malheiro Rui Fernandes Jos é Roberto S. A. Leite Andreanne G. Vasconcelos Jo ão Relvas Manuela Pintado Tags: Article Source Type: research
Silk nanoparticles for the protection and delivery of guava leaf ( < em > Psidium guajava < /em > L.) extract for cosmetic industry, a new approach for an old herb
Drug Deliv. 2023 Dec;30(1):2168793. doi: 10.1080/10717544.2023.2168793.ABSTRACTGuava (Psidium guajava L.) is a well-known plant containing high levels of natural antioxidants, the phenolic compounds, which have been employed in numerous cosmetic products. However, these molecules are unstable to oxidants, light, temperature, pH, water, and enzymatic activities. Therefore, to enhance their stability and preserve their antioxidant activity, this study investigated the silk fibroin nanoparticles (SFNs) ability to encapsulate, deliver, and heat-protect the phenolic compounds of the guava leaves ethanolic extract. Firstly, the ...
Source: Drug Delivery - January 25, 2023 Category: Drugs & Pharmacology Authors: Duy Toan Pham Doan Xuan Tien Nguyen Ruby Lieu Quoc Cuong Huynh Ngoc Yen Nguyen Tran Thi Bich Quyen Van De Tran Source Type: research
Silk nanoparticles for the protection and delivery of guava leaf ( < em > Psidium guajava < /em > L.) extract for cosmetic industry, a new approach for an old herb
Drug Deliv. 2023 Dec;30(1):2168793. doi: 10.1080/10717544.2023.2168793.ABSTRACTGuava (Psidium guajava L.) is a well-known plant containing high levels of natural antioxidants, the phenolic compounds, which have been employed in numerous cosmetic products. However, these molecules are unstable to oxidants, light, temperature, pH, water, and enzymatic activities. Therefore, to enhance their stability and preserve their antioxidant activity, this study investigated the silk fibroin nanoparticles (SFNs) ability to encapsulate, deliver, and heat-protect the phenolic compounds of the guava leaves ethanolic extract. Firstly, the ...
Source: Drug Delivery - January 25, 2023 Category: Drugs & Pharmacology Authors: Duy Toan Pham Doan Xuan Tien Nguyen Ruby Lieu Quoc Cuong Huynh Ngoc Yen Nguyen Tran Thi Bich Quyen Van De Tran Source Type: research
