Case of Haemophilus influenzae urethritis in a male patient
We report a case of H. influenzae urethritis and describe a relatively novel treatment approach. A man presented to Melbourne Sexual Health Centre with a 3-day history of penile discharge and dysuria. He engaged in condomless oral and anal sex with casual male partners in preceding months. On examination, purulent urethral discharge was noted. Urethral microscopy showed Gram-positive bacilli and epithelial cells. Screening for chlamydia, gonorrhoea, Mycoplasma genitalium, Trichomonas vaginalis, HIV and syphilis was performed. He was treated for NGU with a 1-week course of doxycycline. Initial investigations were all negati...
Source: Sexually Transmitted Infections - April 18, 2024 Category: Sexual Medicine Authors: Samra, R. S., Plummer, E. L., Vodstrcil, L., Bradshaw, C. S. Tags: PostScript Source Type: research

Unusual presentation of disseminated gonococcal infection
A 30-year-old homosexual man living with HIV and receiving virologically suppressive antiretroviral treatment presented to the emergency department with a 3-day history of pain in his left wrist accompanied by fever and chills. On examination, the left wrist showed redness, swelling, tenderness and decreased range of movement. The patient had no history of trauma, insect bites or scratches. Four weeks earlier, he had engaged in unprotected oral sex with a casual partner. Nucleic acid amplification tests (NAATs) for Chlamydia trachomatis and Neisseria gonorrhoea (Ng) were performed from oropharyngeal, anal and urine samples...
Source: Sexually Transmitted Infections - April 18, 2024 Category: Sexual Medicine Authors: AlHammadi, M., Schembri, A., Calleja, L., Padovese, V. Tags: PostScript Source Type: research

Multicentre double-blind randomised placebo-controlled trial evaluating the efficacy of the meningococcal B vaccine, 4CMenB (Bexsero), against Neisseria gonorrhoeae infection in men who have sex with men: the GoGoVax study protocol
This study will evaluate the efficacy of 4CMenB against N. gonorrhoeae infection in men (cis and trans), transwomen and non-binary people who have sex with men (hereafter referred to as GBM+). Methods and analysis This is a double-blind, randomised placebo-controlled trial in GBM+, either HIV-negative on pre-exposure prophylaxis against HIV or living with HIV (CD4 count >350 cells/mm3), who have had a diagnosis of gonorrhoea or infectious syphilis in the last 18 months (a key characteristic associated with a high risk of N. gonorrhoeae infection). Participants are randomised 1:1 to receive two doses of 4CMenB or placeb...
Source: BMJ Open - April 16, 2024 Category: General Medicine Authors: Seib, K. L., Donovan, B., Thng, C., Lewis, D. A., McNulty, A., Fairley, C. K., Yeung, B., Jin, F., Fraser, D., Bavinton, B. R., Law, M., Chen, M. Y., Chow, E. P. F., Whiley, D. M., Mackie, B., Jennings, M. P., Jennison, A. V., Lahra, M. M., Grulich, A. E. Tags: Open access, Infectious diseases Source Type: research

Associations between intravaginal practices and incidence of sexually transmitted infections and bacterial vaginosis among women enrolled in the dapivirine vaginal ring trial (The Ring Study) in southwestern Uganda: a retrospective secondary analysis
Conclusions IVP was not associated with risk of STIs/BV in the Ring Study. Trial registration number NCT01539226. (Source: BMJ Open)
Source: BMJ Open - April 8, 2024 Category: General Medicine Authors: Kusemererwa, S., Ruzagira, E., Onyango, M., Kabarambi, A., Abaasa, A. Tags: Open access, Public health Source Type: research

The burden, elimination efforts and implication for health policy of Gonorrhoea in Africa: an editorial
Ann Med Surg (Lond). 2024 Mar 4;86(4):1830-1832. doi: 10.1097/MS9.0000000000001854. eCollection 2024 Apr.NO ABSTRACTPMID:38576967 | PMC:PMC10990376 | DOI:10.1097/MS9.0000000000001854 (Source: Annals of Medicine)
Source: Annals of Medicine - April 5, 2024 Category: Internal Medicine Authors: Malik Olatunde Oduoye Amos Kipkorir Langat Hugues Cakwira Hafsah Omolola Egunsola Gaurang Narayan Chrispin Biamba Aymar Akilimali Olivier Nyakio Source Type: research

Review of mathematical models of Neisseria gonorrhoeae vaccine impact: Implications for vaccine development
Vaccine. 2024 Mar 30:S0264-410X(24)00380-3. doi: 10.1016/j.vaccine.2024.03.068. Online ahead of print.ABSTRACTAn effective prophylactic vaccine for prevention of Neisseria gonorrhoeae infection would have a major impact on sexual and reproductive health worldwide. Interest in developing gonorrhoea vaccines is growing due to the reported high rates of N. gonorrhoeae infections globally, and the threat of antimicrobial resistance. Several gonorrhoea vaccine candidates are currently under evaluation and various mathematical models have been used to assess the potential population-level impact a gonorrhoea vaccine may have onc...
Source: Vaccine - March 31, 2024 Category: Allergy & Immunology Authors: Thilini N Padeniya Ben B Hui James G Wood David G Regan Kate L Seib Source Type: research

Review of mathematical models of Neisseria gonorrhoeae vaccine impact: Implications for vaccine development
Vaccine. 2024 Mar 30:S0264-410X(24)00380-3. doi: 10.1016/j.vaccine.2024.03.068. Online ahead of print.ABSTRACTAn effective prophylactic vaccine for prevention of Neisseria gonorrhoeae infection would have a major impact on sexual and reproductive health worldwide. Interest in developing gonorrhoea vaccines is growing due to the reported high rates of N. gonorrhoeae infections globally, and the threat of antimicrobial resistance. Several gonorrhoea vaccine candidates are currently under evaluation and various mathematical models have been used to assess the potential population-level impact a gonorrhoea vaccine may have onc...
Source: Vaccine - March 31, 2024 Category: Allergy & Immunology Authors: Thilini N Padeniya Ben B Hui James G Wood David G Regan Kate L Seib Source Type: research

Review of mathematical models of Neisseria gonorrhoeae vaccine impact: Implications for vaccine development
Vaccine. 2024 Mar 30:S0264-410X(24)00380-3. doi: 10.1016/j.vaccine.2024.03.068. Online ahead of print.ABSTRACTAn effective prophylactic vaccine for prevention of Neisseria gonorrhoeae infection would have a major impact on sexual and reproductive health worldwide. Interest in developing gonorrhoea vaccines is growing due to the reported high rates of N. gonorrhoeae infections globally, and the threat of antimicrobial resistance. Several gonorrhoea vaccine candidates are currently under evaluation and various mathematical models have been used to assess the potential population-level impact a gonorrhoea vaccine may have onc...
Source: Vaccine - March 31, 2024 Category: Allergy & Immunology Authors: Thilini N Padeniya Ben B Hui James G Wood David G Regan Kate L Seib Source Type: research

Questioning risk compensation: pre-exposure prophylaxis (PrEP) and sexually transmitted infections among men who have sex with men, capital region of Denmark, 2019 to 2022
ConclusionWe found a 35% increase in STI incidence associated with PrEP use. It started before PrEP initiation, challenging the assumption that PrEP leads to risk compensation. Instead, the data suggest that individuals seek PrEP during periods of heightened sexual risk-taking. Consequently, PrEP programmes should include sexual health consultations, STI testing, treatment and prevention strategies to prevent HIV and improve sexual health.PMID:38551099 | DOI:10.2807/1560-7917.ES.2024.29.13.2300451 (Source: Euro Surveill)
Source: Euro Surveill - March 29, 2024 Category: Infectious Diseases Authors: Sebastian von Schreeb Susanne Kriegel Pedersen Hanne Christensen Kristina Melbardis J ørgsensen Lene Holm Harritsh øj Frederik Boetius Hertz Magnus Glindvad Ahlstr öm Anne-Mette Lebech Suzanne Lunding Lars N ørregaard Nielsen Jan Gerstoft Gitte Kronbo Source Type: research

Questioning risk compensation: pre-exposure prophylaxis (PrEP) and sexually transmitted infections among men who have sex with men, capital region of Denmark, 2019 to 2022
ConclusionWe found a 35% increase in STI incidence associated with PrEP use. It started before PrEP initiation, challenging the assumption that PrEP leads to risk compensation. Instead, the data suggest that individuals seek PrEP during periods of heightened sexual risk-taking. Consequently, PrEP programmes should include sexual health consultations, STI testing, treatment and prevention strategies to prevent HIV and improve sexual health.PMID:38551099 | PMC:PMC10979528 | DOI:10.2807/1560-7917.ES.2024.29.13.2300451 (Source: Euro Surveill)
Source: Euro Surveill - March 29, 2024 Category: Infectious Diseases Authors: Sebastian von Schreeb Susanne Kriegel Pedersen Hanne Christensen Kristina Melbardis J ørgsensen Lene Holm Harritsh øj Frederik Boetius Hertz Magnus Glindvad Ahlstr öm Anne-Mette Lebech Suzanne Lunding Lars N ørregaard Nielsen Jan Gerstoft Gitte Kronbo Source Type: research

Questioning risk compensation: pre-exposure prophylaxis (PrEP) and sexually transmitted infections among men who have sex with men, capital region of Denmark, 2019 to 2022
ConclusionWe found a 35% increase in STI incidence associated with PrEP use. It started before PrEP initiation, challenging the assumption that PrEP leads to risk compensation. Instead, the data suggest that individuals seek PrEP during periods of heightened sexual risk-taking. Consequently, PrEP programmes should include sexual health consultations, STI testing, treatment and prevention strategies to prevent HIV and improve sexual health.PMID:38551099 | PMC:PMC10979528 | DOI:10.2807/1560-7917.ES.2024.29.13.2300451 (Source: Euro Surveill)
Source: Euro Surveill - March 29, 2024 Category: Infectious Diseases Authors: Sebastian von Schreeb Susanne Kriegel Pedersen Hanne Christensen Kristina Melbardis J ørgsensen Lene Holm Harritsh øj Frederik Boetius Hertz Magnus Glindvad Ahlstr öm Anne-Mette Lebech Suzanne Lunding Lars N ørregaard Nielsen Jan Gerstoft Gitte Kronbo Source Type: research

Questioning risk compensation: pre-exposure prophylaxis (PrEP) and sexually transmitted infections among men who have sex with men, capital region of Denmark, 2019 to 2022
ConclusionWe found a 35% increase in STI incidence associated with PrEP use. It started before PrEP initiation, challenging the assumption that PrEP leads to risk compensation. Instead, the data suggest that individuals seek PrEP during periods of heightened sexual risk-taking. Consequently, PrEP programmes should include sexual health consultations, STI testing, treatment and prevention strategies to prevent HIV and improve sexual health.PMID:38551099 | PMC:PMC10979528 | DOI:10.2807/1560-7917.ES.2024.29.13.2300451 (Source: Euro Surveill)
Source: Euro Surveill - March 29, 2024 Category: Infectious Diseases Authors: Sebastian von Schreeb Susanne Kriegel Pedersen Hanne Christensen Kristina Melbardis J ørgsensen Lene Holm Harritsh øj Frederik Boetius Hertz Magnus Glindvad Ahlstr öm Anne-Mette Lebech Suzanne Lunding Lars N ørregaard Nielsen Jan Gerstoft Gitte Kronbo Source Type: research

Questioning risk compensation: pre-exposure prophylaxis (PrEP) and sexually transmitted infections among men who have sex with men, capital region of Denmark, 2019 to 2022
ConclusionWe found a 35% increase in STI incidence associated with PrEP use. It started before PrEP initiation, challenging the assumption that PrEP leads to risk compensation. Instead, the data suggest that individuals seek PrEP during periods of heightened sexual risk-taking. Consequently, PrEP programmes should include sexual health consultations, STI testing, treatment and prevention strategies to prevent HIV and improve sexual health.PMID:38551099 | PMC:PMC10979528 | DOI:10.2807/1560-7917.ES.2024.29.13.2300451 (Source: Euro Surveill)
Source: Euro Surveill - March 29, 2024 Category: Infectious Diseases Authors: Sebastian von Schreeb Susanne Kriegel Pedersen Hanne Christensen Kristina Melbardis J ørgsensen Lene Holm Harritsh øj Frederik Boetius Hertz Magnus Glindvad Ahlstr öm Anne-Mette Lebech Suzanne Lunding Lars N ørregaard Nielsen Jan Gerstoft Gitte Kronbo Source Type: research