Associations between intravaginal practices and incidence of sexually transmitted infections and bacterial vaginosis among women enrolled in the dapivirine vaginal ring trial (The Ring Study) in southwestern Uganda: a retrospective secondary analysis
Conclusions IVP was not associated with risk of STIs/BV in the Ring Study. Trial registration number NCT01539226. (Source: BMJ Open)
Source: BMJ Open - April 8, 2024 Category: General Medicine Authors: Kusemererwa, S., Ruzagira, E., Onyango, M., Kabarambi, A., Abaasa, A. Tags: Open access, Public health Source Type: research

The burden, elimination efforts and implication for health policy of Gonorrhoea in Africa: an editorial
Ann Med Surg (Lond). 2024 Mar 4;86(4):1830-1832. doi: 10.1097/MS9.0000000000001854. eCollection 2024 Apr.NO ABSTRACTPMID:38576967 | PMC:PMC10990376 | DOI:10.1097/MS9.0000000000001854 (Source: Annals of Medicine)
Source: Annals of Medicine - April 5, 2024 Category: Internal Medicine Authors: Malik Olatunde Oduoye Amos Kipkorir Langat Hugues Cakwira Hafsah Omolola Egunsola Gaurang Narayan Chrispin Biamba Aymar Akilimali Olivier Nyakio Source Type: research

Review of mathematical models of Neisseria gonorrhoeae vaccine impact: Implications for vaccine development
Vaccine. 2024 Mar 30:S0264-410X(24)00380-3. doi: 10.1016/j.vaccine.2024.03.068. Online ahead of print.ABSTRACTAn effective prophylactic vaccine for prevention of Neisseria gonorrhoeae infection would have a major impact on sexual and reproductive health worldwide. Interest in developing gonorrhoea vaccines is growing due to the reported high rates of N. gonorrhoeae infections globally, and the threat of antimicrobial resistance. Several gonorrhoea vaccine candidates are currently under evaluation and various mathematical models have been used to assess the potential population-level impact a gonorrhoea vaccine may have onc...
Source: Vaccine - March 31, 2024 Category: Allergy & Immunology Authors: Thilini N Padeniya Ben B Hui James G Wood David G Regan Kate L Seib Source Type: research

Review of mathematical models of Neisseria gonorrhoeae vaccine impact: Implications for vaccine development
Vaccine. 2024 Mar 30:S0264-410X(24)00380-3. doi: 10.1016/j.vaccine.2024.03.068. Online ahead of print.ABSTRACTAn effective prophylactic vaccine for prevention of Neisseria gonorrhoeae infection would have a major impact on sexual and reproductive health worldwide. Interest in developing gonorrhoea vaccines is growing due to the reported high rates of N. gonorrhoeae infections globally, and the threat of antimicrobial resistance. Several gonorrhoea vaccine candidates are currently under evaluation and various mathematical models have been used to assess the potential population-level impact a gonorrhoea vaccine may have onc...
Source: Vaccine - March 31, 2024 Category: Allergy & Immunology Authors: Thilini N Padeniya Ben B Hui James G Wood David G Regan Kate L Seib Source Type: research

Review of mathematical models of Neisseria gonorrhoeae vaccine impact: Implications for vaccine development
Vaccine. 2024 Mar 30:S0264-410X(24)00380-3. doi: 10.1016/j.vaccine.2024.03.068. Online ahead of print.ABSTRACTAn effective prophylactic vaccine for prevention of Neisseria gonorrhoeae infection would have a major impact on sexual and reproductive health worldwide. Interest in developing gonorrhoea vaccines is growing due to the reported high rates of N. gonorrhoeae infections globally, and the threat of antimicrobial resistance. Several gonorrhoea vaccine candidates are currently under evaluation and various mathematical models have been used to assess the potential population-level impact a gonorrhoea vaccine may have onc...
Source: Vaccine - March 31, 2024 Category: Allergy & Immunology Authors: Thilini N Padeniya Ben B Hui James G Wood David G Regan Kate L Seib Source Type: research

Questioning risk compensation: pre-exposure prophylaxis (PrEP) and sexually transmitted infections among men who have sex with men, capital region of Denmark, 2019 to 2022
ConclusionWe found a 35% increase in STI incidence associated with PrEP use. It started before PrEP initiation, challenging the assumption that PrEP leads to risk compensation. Instead, the data suggest that individuals seek PrEP during periods of heightened sexual risk-taking. Consequently, PrEP programmes should include sexual health consultations, STI testing, treatment and prevention strategies to prevent HIV and improve sexual health.PMID:38551099 | DOI:10.2807/1560-7917.ES.2024.29.13.2300451 (Source: Euro Surveill)
Source: Euro Surveill - March 29, 2024 Category: Infectious Diseases Authors: Sebastian von Schreeb Susanne Kriegel Pedersen Hanne Christensen Kristina Melbardis J ørgsensen Lene Holm Harritsh øj Frederik Boetius Hertz Magnus Glindvad Ahlstr öm Anne-Mette Lebech Suzanne Lunding Lars N ørregaard Nielsen Jan Gerstoft Gitte Kronbo Source Type: research

Questioning risk compensation: pre-exposure prophylaxis (PrEP) and sexually transmitted infections among men who have sex with men, capital region of Denmark, 2019 to 2022
ConclusionWe found a 35% increase in STI incidence associated with PrEP use. It started before PrEP initiation, challenging the assumption that PrEP leads to risk compensation. Instead, the data suggest that individuals seek PrEP during periods of heightened sexual risk-taking. Consequently, PrEP programmes should include sexual health consultations, STI testing, treatment and prevention strategies to prevent HIV and improve sexual health.PMID:38551099 | PMC:PMC10979528 | DOI:10.2807/1560-7917.ES.2024.29.13.2300451 (Source: Euro Surveill)
Source: Euro Surveill - March 29, 2024 Category: Infectious Diseases Authors: Sebastian von Schreeb Susanne Kriegel Pedersen Hanne Christensen Kristina Melbardis J ørgsensen Lene Holm Harritsh øj Frederik Boetius Hertz Magnus Glindvad Ahlstr öm Anne-Mette Lebech Suzanne Lunding Lars N ørregaard Nielsen Jan Gerstoft Gitte Kronbo Source Type: research

Questioning risk compensation: pre-exposure prophylaxis (PrEP) and sexually transmitted infections among men who have sex with men, capital region of Denmark, 2019 to 2022
ConclusionWe found a 35% increase in STI incidence associated with PrEP use. It started before PrEP initiation, challenging the assumption that PrEP leads to risk compensation. Instead, the data suggest that individuals seek PrEP during periods of heightened sexual risk-taking. Consequently, PrEP programmes should include sexual health consultations, STI testing, treatment and prevention strategies to prevent HIV and improve sexual health.PMID:38551099 | PMC:PMC10979528 | DOI:10.2807/1560-7917.ES.2024.29.13.2300451 (Source: Euro Surveill)
Source: Euro Surveill - March 29, 2024 Category: Infectious Diseases Authors: Sebastian von Schreeb Susanne Kriegel Pedersen Hanne Christensen Kristina Melbardis J ørgsensen Lene Holm Harritsh øj Frederik Boetius Hertz Magnus Glindvad Ahlstr öm Anne-Mette Lebech Suzanne Lunding Lars N ørregaard Nielsen Jan Gerstoft Gitte Kronbo Source Type: research

Questioning risk compensation: pre-exposure prophylaxis (PrEP) and sexually transmitted infections among men who have sex with men, capital region of Denmark, 2019 to 2022
ConclusionWe found a 35% increase in STI incidence associated with PrEP use. It started before PrEP initiation, challenging the assumption that PrEP leads to risk compensation. Instead, the data suggest that individuals seek PrEP during periods of heightened sexual risk-taking. Consequently, PrEP programmes should include sexual health consultations, STI testing, treatment and prevention strategies to prevent HIV and improve sexual health.PMID:38551099 | PMC:PMC10979528 | DOI:10.2807/1560-7917.ES.2024.29.13.2300451 (Source: Euro Surveill)
Source: Euro Surveill - March 29, 2024 Category: Infectious Diseases Authors: Sebastian von Schreeb Susanne Kriegel Pedersen Hanne Christensen Kristina Melbardis J ørgsensen Lene Holm Harritsh øj Frederik Boetius Hertz Magnus Glindvad Ahlstr öm Anne-Mette Lebech Suzanne Lunding Lars N ørregaard Nielsen Jan Gerstoft Gitte Kronbo Source Type: research

Questioning risk compensation: pre-exposure prophylaxis (PrEP) and sexually transmitted infections among men who have sex with men, capital region of Denmark, 2019 to 2022
ConclusionWe found a 35% increase in STI incidence associated with PrEP use. It started before PrEP initiation, challenging the assumption that PrEP leads to risk compensation. Instead, the data suggest that individuals seek PrEP during periods of heightened sexual risk-taking. Consequently, PrEP programmes should include sexual health consultations, STI testing, treatment and prevention strategies to prevent HIV and improve sexual health.PMID:38551099 | PMC:PMC10979528 | DOI:10.2807/1560-7917.ES.2024.29.13.2300451 (Source: Euro Surveill)
Source: Euro Surveill - March 29, 2024 Category: Infectious Diseases Authors: Sebastian von Schreeb Susanne Kriegel Pedersen Hanne Christensen Kristina Melbardis J ørgsensen Lene Holm Harritsh øj Frederik Boetius Hertz Magnus Glindvad Ahlstr öm Anne-Mette Lebech Suzanne Lunding Lars N ørregaard Nielsen Jan Gerstoft Gitte Kronbo Source Type: research

Questioning risk compensation: pre-exposure prophylaxis (PrEP) and sexually transmitted infections among men who have sex with men, capital region of Denmark, 2019 to 2022
ConclusionWe found a 35% increase in STI incidence associated with PrEP use. It started before PrEP initiation, challenging the assumption that PrEP leads to risk compensation. Instead, the data suggest that individuals seek PrEP during periods of heightened sexual risk-taking. Consequently, PrEP programmes should include sexual health consultations, STI testing, treatment and prevention strategies to prevent HIV and improve sexual health.PMID:38551099 | PMC:PMC10979528 | DOI:10.2807/1560-7917.ES.2024.29.13.2300451 (Source: Euro Surveill)
Source: Euro Surveill - March 29, 2024 Category: Infectious Diseases Authors: Sebastian von Schreeb Susanne Kriegel Pedersen Hanne Christensen Kristina Melbardis J ørgsensen Lene Holm Harritsh øj Frederik Boetius Hertz Magnus Glindvad Ahlstr öm Anne-Mette Lebech Suzanne Lunding Lars N ørregaard Nielsen Jan Gerstoft Gitte Kronbo Source Type: research

Questioning risk compensation: pre-exposure prophylaxis (PrEP) and sexually transmitted infections among men who have sex with men, capital region of Denmark, 2019 to 2022
ConclusionWe found a 35% increase in STI incidence associated with PrEP use. It started before PrEP initiation, challenging the assumption that PrEP leads to risk compensation. Instead, the data suggest that individuals seek PrEP during periods of heightened sexual risk-taking. Consequently, PrEP programmes should include sexual health consultations, STI testing, treatment and prevention strategies to prevent HIV and improve sexual health. (Source: Eurosurveillance)
Source: Eurosurveillance - March 28, 2024 Category: Infectious Diseases Authors: Sebastian von Schreeb, Susanne Kriegel Pedersen, Hanne Christensen, Kristina Melbardis J ørgsensen, Lene Holm Harritshøj, Frederik Boetius Hertz, Magnus Glindvad Ahlström, Anne-Mette Lebech, Suzanne Lunding, Lars Nørregaard Nielsen, Jan Gerstoft, Gitt Source Type: research

Australian consensus statement on doxycycline post-exposure prophylaxis (doxy-PEP) for the prevention of syphilis, chlamydia and gonorrhoea among gay, bisexual and other men who have sex with men
Med J Aust. 2024 Mar 13. doi: 10.5694/mja2.52258. Online ahead of print.ABSTRACTINTRODUCTION: Doxycycline post-exposure prophylaxis (doxy-PEP) involves consuming 200 mg of doxycycline up to 72 hours after a condomless sex act to reduce the risk of bacterial sexually transmitted infections (STIs). Recent clinical trials of doxy-PEP have demonstrated significant reductions in syphilis, chlamydia and, to a lesser degree, gonorrhoea among gay, bisexual and other men who have sex with men (GBMSM). There is a high level of interest in doxy-PEP in the GBMSM community and, in response, the Australasian Society for HIV, Viral Hepat...
Source: Medical Journal of Australia - March 13, 2024 Category: General Medicine Authors: Vincent J Cornelisse Benjamin Riley Nicholas A Medland Source Type: research