Molecules, Vol. 29, Pages 556: Goldenseal (Hydrastis canadensis L.) Extracts Inhibit the Growth of Fungal Isolates Associated with American Ginseng (Panax quinquefolius L.)
This study suggests that goldenseal extracts have the potential to be used as a botanical fungicide to control plant fungal diseases caused by A. panax, F. sporotrichioides, or P. nanjingensis. (Source: Molecules)
Source: Molecules - January 23, 2024 Category: Chemistry Authors: Ying Gao Ethan Swiggart Kaela Wolkiewicz Prabha Liyanapathiranage Fulya Baysal-Gurel Farhat A. Avin Eleanor F. P. Lopez Rebecca T. Jordan Joshua Kellogg Eric P. Burkhart Tags: Article Source Type: research
Neuroactivity screening of botanical extracts using microelectrode array (MEA) recordings
Food Chem Toxicol. 2024 Jan 6:114438. doi: 10.1016/j.fct.2024.114438. Online ahead of print.ABSTRACTToxicity testing of botanicals is challenging because of their chemical complexity and variability. Since botanicals may affect many different modes of action involved in neuronal function, we used microelectrode array (MEA) recordings of primary rat cortical cultures to screen 16 different botanical extracts for their effects on cell viability and neuronal network function in vitro. Our results demonstrate that extract materials (50 μg/mL) derived from goldenseal, milk thistle, tripterygium, and yohimbe decrease mitochondr...
Source: Food and Chemical Toxicology - January 8, 2024 Category: Food Science Authors: Regina G D M van Kleef Michelle R Embry Constance A Mitchell Remco H S Westerink Source Type: research
Non-targeted chemical analysis of consumer botanical products labeled as blue cohosh (Caulophyllum thalictroides), goldenseal (Hydrastis canadensis), or yohimbe bark (Pausinystalia yohimbe) by NMR and MS
Anal Bioanal Chem. 2023 Nov 1. doi: 10.1007/s00216-023-05004-y. Online ahead of print.ABSTRACTConsumers have unprecedented access to botanical dietary supplements through online retailers, making it difficult to ensure product quality and authenticity. Therefore, methods to survey and compare chemical compositions across botanical products are needed. Nuclear magnetic resonance (NMR) spectroscopy and non-targeted mass spectrometry (MS) were used to chemically analyze commercial products labeled as containing one of three botanicals: blue cohosh, goldenseal, and yohimbe bark. Aqueous and organic phase extracts were prepared...
Source: Analytical and Bioanalytical Chemistry - November 1, 2023 Category: Chemistry Authors: Giovanni O Quiroz-Delfi Cynthia V Rider Stephen S Ferguson Alan K Jarmusch Geoffrey A Mueller Source Type: research
Evaluation of Therapeutic Potential of Selected Plant-Derived Homeopathic Medicines for their Action against Cervical Cancer
CONCLUSION: The study has shown a comparative evaluation of the potential of several plant-derived MTs and HMs to affect CaCx cell line survival in vitro (through cytotoxicity and free radical scavenging) and their theoretical molecular targets in silico for the first time. Data demonstrated that MTs of BA and BV are likely to be the most potent HMs that strongly inhibited CaCx growth and have a strong anti-HPV phytochemical constitution.PMID:36858077 | DOI:10.1055/s-0042-1756436 (Source: Homeopathy)
Source: Homeopathy - March 1, 2023 Category: Complementary Medicine Authors: Tejveer Singh Nikita Aggarwal Kulbhushan Thakur Arun Chhokar Joni Yadav Tanya Tripathi Mohit Jadli Anjali Bhat Arun Kumar Ritika Hasija Narula Pankaj Gupta Anil Khurana Alok Chandra Bharti Source Type: research
Evaluation of Therapeutic Potential of Selected Plant-Derived Homeopathic Medicines for their Action against Cervical Cancer
CONCLUSION: The study has shown a comparative evaluation of the potential of several plant-derived MTs and HMs to affect CaCx cell line survival in vitro (through cytotoxicity and free radical scavenging) and their theoretical molecular targets in silico for the first time. Data demonstrated that MTs of BA and BV are likely to be the most potent HMs that strongly inhibited CaCx growth and have a strong anti-HPV phytochemical constitution.PMID:36858077 | DOI:10.1055/s-0042-1756436 (Source: Homeopathy)
Source: Homeopathy - March 1, 2023 Category: Complementary Medicine Authors: Tejveer Singh Nikita Aggarwal Kulbhushan Thakur Arun Chhokar Joni Yadav Tanya Tripathi Mohit Jadli Anjali Bhat Arun Kumar Ritika Hasija Narula Pankaj Gupta Anil Khurana Alok Chandra Bharti Source Type: research
Protective effects of berberine against β-amyloid-induced neurotoxicity in HT22 cells via the Nrf2/HO-1 pathway
In this study, a neuronal apoptotic model was established in vitro using HT22 cells induced by Aβ25-35 to explore whether BBR contributes to protecting neurons against Aβ25-35-induced neurotoxicity, as well as its potential mechanisms. BBR was applied to HT22 cells for 1 h prior to exposing the cells to Aβ25-35 for 24 h. A CCK-8 assay was utilized to assess cell viability, and Annexin V - fluorescein isothiocyanate (FITC)/propidium iodide and Hoechst 33342 fluorescence staining were used to measure the rate of cell apoptosis. Existing scientific literature was also reviewed to further determine the effects of BBR on ROS...
Source: Bioorganic Chemistry - February 1, 2023 Category: Chemistry Authors: Ru-Lan Zhang Bing-Xi Lei Guo-Yong Wu Yuan-Yuan Wang Qi-Hui Huang Source Type: research
Protective effects of berberine against β-amyloid-induced neurotoxicity in HT22 cells via the Nrf2/HO-1 pathway
In this study, a neuronal apoptotic model was established in vitro using HT22 cells induced by Aβ25-35 to explore whether BBR contributes to protecting neurons against Aβ25-35-induced neurotoxicity, as well as its potential mechanisms. BBR was applied to HT22 cells for 1 h prior to exposing the cells to Aβ25-35 for 24 h. A CCK-8 assay was utilized to assess cell viability, and Annexin V - fluorescein isothiocyanate (FITC)/propidium iodide and Hoechst 33342 fluorescence staining were used to measure the rate of cell apoptosis. Existing scientific literature was also reviewed to further determine the effects of BBR on ROS...
Source: Bioorganic Chemistry - February 1, 2023 Category: Chemistry Authors: Ru-Lan Zhang Bing-Xi Lei Guo-Yong Wu Yuan-Yuan Wang Qi-Hui Huang Source Type: research
Physiologically based pharmacokinetic model predictions of natural product-drug interactions between goldenseal, berberine, imatinib and bosutinib
ConclusionPBPK model-based predictions highlighted potential clinically significant interactions between goldenseal extract and bosutinib, but not imatinib. Dose adjustment may need to be considered if co-administration is desirable. These findings should be confirmed with optimally designed controlled drug interaction studies. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - March 16, 2022 Category: Drugs & Pharmacology Source Type: research
Benzylisoquinoline alkaloid content in goldenseal (Hydrastis canadensis L.) is influenced by phenological stage, reproductive status, and time-of-day
Publication date: April 2021Source: Phytochemistry Letters, Volume 42Author(s): Grady H. Zuiderveen, Eric P. Burkhart, Joshua D. Lambert (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - February 22, 2021 Category: Chemistry Source Type: research
Assessing Transporter-Mediated Natural Product-Drug Interactions via In vitro-In vivo Extrapolation: Clinical Evaluation with a Probe Cocktail.
Abstract
The botanical natural product goldenseal can precipitate clinical drug interactions by inhibiting cytochrome P450 (CYP) 3A and CYP2D6. Besides P-glycoprotein, effects of goldenseal on other clinically relevant transporters remain unknown. Established transporter-expressing cell systems were used to determine the inhibitory effects of a goldenseal extract, standardized to the major alkaloid berberine, on transporter activity. Using recommended basic models, the extract was predicted to inhibit the efflux transporter breast cancer resistance protein (BCRP) and uptake transporters organic anion trans...
Source: Clinical Pharmacology and Therapeutics - November 11, 2020 Category: Drugs & Pharmacology Authors: Nguyen JT, Tian DD, Tanna RS, Hadi DL, Bansal S, Calamia JC, Arian CM, Shireman LM, Molnár B, Horváth M, Kellogg JJ, Layton ME, White JR, Cech NB, Boyce RD, Unadkat JD, Thummel KE, Paine MF Tags: Clin Pharmacol Ther Source Type: research
Goldenseal (Hydrastis canadensis L.) and its active constituents: A critical review of their efficacy and toxicological issues
Publication date: October 2020Source: Pharmacological Research, Volume 160Author(s): Sudip Kumar Mandal, Amal Kumar Maji, Siddhartha Kumar Mishra, Pir Mohammad Ishfaq, Hari Prashed Devkota, Ana Sanches Silva, Niranjan Das (Source: Pharmacological Research)
Source: Pharmacological Research - July 30, 2020 Category: Drugs & Pharmacology Source Type: research
Chemical Evaluation of the Effects of Storage Conditions on the Botanical Goldenseal using Marker-based and Metabolomics Approaches.
Authors: Khin M, Cech NB, Kellogg JJ, Caesar LK
Abstract
Hydrastis canadensis, commonly known as goldenseal, is a botanical native to the southeastern United States that has been used for the treatment of infection. The activity of goldenseal is often attributed to the presence of alkaloids (cyclic, nitrogen-containing compounds) present within its roots. Chemical components of botanical supplements like goldenseal may face degradation if not stored properly. The purpose of the research was to analyze the stability of known and unknown metabolites of H. canadensis during exposure to different storage condi...
Source: The Yale Journal of Biology and Medicine - July 2, 2020 Category: Universities & Medical Training Tags: Yale J Biol Med Source Type: research
Effects of Hydrastis Canadensis, Commiphora Habessinica, Phytolacca Americana, and Echinacea Purpurea on Bacterial Growth.
Conclusions: The results demonstrated that H. canadensis had antibacterial activity against S. epidermidis, but the HMPE formula was not active against S. epidermidis, when a zone of inhibition threshold of 12 millimeters (mm) was used to determine antibiotic activity. Because the HMPE formula was shown to be less effective than H. canadensis alone, the formula might benefit from an increased percentage of H. canadensis.
PMID: 32619202 [PubMed - as supplied by publisher] (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - June 30, 2020 Category: Complementary Medicine Authors: Corn J, Tibbitts D, Ito H, Schafer M, Vasilevsky N Tags: Altern Ther Health Med Source Type: research
In Vitro Assessment of Homeopathic Potencies of Hydrastis canadensis on Hormone-Dependent and Independent Breast Cancer.
CONCLUSION: Hydrastis may have a selective cytotoxic effect against hormone-dependent breast cancer MCF 7 cells, leading to cell cycle arrest in the G0/G1 phase, which could be the plausible reason for the induction of apoptosis. The results need to be validated in vivo.
PMID: 32610349 [PubMed - as supplied by publisher] (Source: Homeopathy)
Source: Homeopathy - June 30, 2020 Category: Complementary Medicine Authors: Khan S, Nayak D, Khurana A, Manchanda RK, Tandon C, Tandon S Tags: Homeopathy Source Type: research
