Molecules, Vol. 28, Pages 1377: Study on Synergistic Anti-Inflammatory Effect of Typical Functional Components of Extracts of Ginkgo Biloba Leaves
Linguo Zhao
There are some differences in the anti-inflammatory activities of four typical components in EGB (extracts of ginkgo biloba leaves), and there is also a synergistic relationship. The order of inhibiting the NO-release ability of single functional components is OA > GF > OPC > G. Ginkgolide (G), proanthocyanidins (OPC), and organic acids (OA) all have synergistic effects on ginkgo flavonoids (GF). GF:OA (1:9) is the lowest interaction index among all complexes, showing the strongest synergy. The anti-inflammatory mechanism of the compound affects the expression of p-JNK, p-P3...
Source: Molecules - February 1, 2023 Category: Chemistry Authors: Lihu Zhang Xianying Fang Jihu Sun Erzheng Su Fuliang Cao Linguo Zhao Tags: Article Source Type: research
Molecules, Vol. 28, Pages 1375: Identifying the Anti-MERS-CoV and Anti-HcoV-229E Potential Drugs from the Ginkgo biloba Leaves Extract and Its Eco-Friendly Synthesis of Silver Nanoparticles
Yuanda Song
The present study aimed to estimate the antiviral activities of Ginkgo biloba (GB) leaves extract and eco-friendly free silver nanoparticles (Ag NPs) against the MERS-CoV (Middle East respiratory syndrome-coronavirus) and HCoV-229E (human coronavirus 229E), as well as isolation and identification of phytochemicals from GB. Different solvents and high-performance liquid chromatography (HPLC) were used to extract and identify flavonoids and phenolic compounds from GB leaves. The green, silver nanoparticle synthesis was synthesized from GB leaves aqueous extract and investigated for their possible effects as a...
Source: Molecules - February 1, 2023 Category: Chemistry Authors: Ezzat H. Elshazly Alyaa Nasr Mohamed E. Elnosary Gamal A. Gouda Hassan Mohamed Yuanda Song Tags: Article Source Type: research
Ginkgolide B caused the activation of the Akt/eNOS pathway through the antioxidant effect of SOD1 in the diabetic aorta
This study was designed to figure out the molecular basis on which GBE protects from endothelial dysfunction in diabetes because the underlying mechanisms are unclear. Studies were performed in a normal control group and streptozotocin/nicotinamide-induced DM group. In aortas, notably diabetic aortas, GBE, and ginkgolide B (GB), a constituent of GBE, produced a dose-dependent relaxation. The relaxation by GB was abolished by prior incubation with L-NNA (an endothelial nitric oxide synthase (NOS) inhibitor), LY294002 (a phosphoinositide 3-kinase (PI3K) inhibitor), and Akt inhibitor, confirming the essential role of PI3K/Akt...
Source: Pflugers Archiv : European Journal of Physiology - January 30, 2023 Category: Physiology Authors: Kumiko Taguchi Kanami Okudaira Takayuki Matsumoto Tsuneo Kobayashi Source Type: research
Ginkgolide B caused the activation of the Akt/eNOS pathway through the antioxidant effect of SOD1 in the diabetic aorta
This study was designed to figure out the molecular basis on which GBE protects from endothelial dysfunction in diabetes because the underlying mechanisms are unclear. Studies were performed in a normal control group and streptozotocin/nicotinamide-induced DM group. In aortas, notably diabetic aortas, GBE, and ginkgolide B (GB), a constituent of GBE, produced a dose-dependent relaxation. The relaxation by GB was abolished by prior incubation with L-NNA (an endothelial nitric oxide synthase (NOS) inhibitor), LY294002 (a phosphoinositide 3-kinase (PI3K) inhibitor), and Akt inhibitor, confirming the essential role of PI3K/Akt...
Source: Pflugers Archiv : European Journal of Physiology - January 30, 2023 Category: Physiology Authors: Kumiko Taguchi Kanami Okudaira Takayuki Matsumoto Tsuneo Kobayashi Source Type: research
Ginkgolide B caused the activation of the Akt/eNOS pathway through the antioxidant effect of SOD1 in the diabetic aorta
This study was designed to figure out the molecular basis on which GBE protects from endothelial dysfunction in diabetes because the underlying mechanisms are unclear. Studies were performed in a normal control group and streptozotocin/nicotinamide-induced DM group. In aortas, notably diabetic aortas, GBE, and ginkgolide B (GB), a constituent of GBE, produced a dose-dependent relaxation. The relaxation by GB was abolished by prior incubation with L-NNA (an endothelial nitric oxide synthase (NOS) inhibitor), LY294002 (a phosphoinositide 3-kinase (PI3K) inhibitor), and Akt inhibitor, confirming the essential role of PI3K/Akt...
Source: Pflugers Archiv : European Journal of Physiology - January 30, 2023 Category: Physiology Authors: Kumiko Taguchi Kanami Okudaira Takayuki Matsumoto Tsuneo Kobayashi Source Type: research
Ginkgolide B caused the activation of the Akt/eNOS pathway through the antioxidant effect of SOD1 in the diabetic aorta
This study was designed to figure out the molecular basis on which GBE protects from endothelial dysfunction in diabetes because the underlying mechanisms are unclear. Studies were performed in a normal control group and streptozotocin/nicotinamide-induced DM group. In aortas, notably diabetic aortas, GBE, and ginkgolide B (GB), a constituent of GBE, produced a dose-dependent relaxation. The relaxation by GB was abolished by prior incubation with L-NNA (an endothelial nitric oxide synthase (NOS) inhibitor), LY294002 (a phosphoinositide 3-kinase (PI3K) inhibitor), and Akt inhibitor, confirming the essential role of PI3K/Akt...
Source: Pflugers Archiv : European Journal of Physiology - January 30, 2023 Category: Physiology Authors: Kumiko Taguchi Kanami Okudaira Takayuki Matsumoto Tsuneo Kobayashi Source Type: research
Ginkgolide B caused the activation of the Akt/eNOS pathway through the antioxidant effect of SOD1 in the diabetic aorta
This study was designed to figure out the molecular basis on which GBE protects from endothelial dysfunction in diabetes because the underlying mechanisms are unclear. Studies were performed in a normal control group and streptozotocin/nicotinamide-induced DM group. In aortas, notably diabetic aortas, GBE, and ginkgolide B (GB), a constituent of GBE, produced a dose-dependent relaxation. The relaxation by GB was abolished by prior incubation with L-NNA (an endothelial nitric oxide synthase (NOS) inhibitor), LY294002 (a phosphoinositide 3-kinase (PI3K) inhibitor), and Akt inhibitor, confirming the essential role of PI3K/Akt...
Source: Pflugers Archiv : European Journal of Physiology - January 30, 2023 Category: Physiology Authors: Kumiko Taguchi Kanami Okudaira Takayuki Matsumoto Tsuneo Kobayashi Source Type: research
Ginkgolide B caused the activation of the Akt/eNOS pathway through the antioxidant effect of SOD1 in the diabetic aorta
This study was designed to figure out the molecular basis on which GBE protects from endothelial dysfunction in diabetes because the underlying mechanisms are unclear. Studies were performed in a normal control group and streptozotocin/nicotinamide-induced DM group. In aortas, notably diabetic aortas, GBE, and ginkgolide B (GB), a constituent of GBE, produced a dose-dependent relaxation. The relaxation by GB was abolished by prior incubation with L-NNA (an endothelial nitric oxide synthase (NOS) inhibitor), LY294002 (a phosphoinositide 3-kinase (PI3K) inhibitor), and Akt inhibitor, confirming the essential role of PI3K/Akt...
Source: Pflugers Archiv : European Journal of Physiology - January 30, 2023 Category: Physiology Authors: Kumiko Taguchi Kanami Okudaira Takayuki Matsumoto Tsuneo Kobayashi Source Type: research
Genes, Vol. 14, Pages 343: Genome-Wide Identification, Evolutionary and Functional Analyses of WRKY Family Members in Ginkgo biloba
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Yadi Chen
WRKY transcription factors (TFs) are one of the largest families in plants which play essential roles in plant growth and stress response. Ginkgo biloba is a living fossil that has remained essentially unchanged for more than 200 million years, and now has become widespread worldwide due to the medicinal active ingredients in its leaves. Here, 37 WRKY genes were identified, which were distributed randomly in nine chromosomes of G. biloba. Results of the phylogenetic analysis indicated that the GbWRKY could be divided into three groups. Furthermore, the expression patterns of GbWRKY genes were analyzed. Ge...
Source: Genes - January 28, 2023 Category: Genetics & Stem Cells Authors: Weixing Li Nan Xiao Yawen Wang Ximeng Liu Zhaoyu Chen Xiaoyin Gu Yadi Chen Tags: Article Source Type: research
[ASAP] Ginkgo Biflavones Cause p53 Wild-Type Dependent Cell Death in a Transcription-Independent Manner of p53
Journal of Natural ProductsDOI: 10.1021/acs.jnatprod.2c00959 (Source: Journal of Natural Products)
Source: Journal of Natural Products - January 26, 2023 Category: Biochemistry Authors: Siyu Zhang, Yujie Sun, Fengli Yao, Hongju Li, Yacong Yang, Xionghao Li, Zhongyue Bai, Yu Hu, Peng Wang, and Ximing Xu Source Type: research
Study on Computer Screening and Drug Properties of Herbs Intervening in Copper Death
CONCLUSION: This study preliminarily discussed the material basis and medicinal properties of herbs that can intervene in copper death, which can provide reference for the theoretical discussion, drug development, and clinical research of Chinese medicine regulating copper death.PMID:36684691 | PMC:PMC9848818 | DOI:10.1155/2023/3311834 (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - January 23, 2023 Category: Statistics Authors: Zhong Dayuan Li Lan Cheng Hui Li Huanjie Liu Yumei Luo Yumiao Liu Deliang Li Dingxiang Deng Yihui Source Type: research
Effect of < em > in vitro < /em > gastrointestinal digestion on the chemical composition and antioxidant properties of < em > Ginkgo biloba < /em > leaves decoction and commercial capsules
In this study Ginkgo biloba leaves (GBL) decoction and commercial capsules were digested using an in vitro model. Thirty-six active compounds were identified and quantified by HPLC-ESI-MS analysis based on the MS/MS patterns (precursor ions and product ions) and retention times, in comparison with reference standards. Most compounds in GBL showed a significant decrease during intestinal digestion, with an exception of vanillic acid and biflavonoids. Bioaccessibility values of chemical compositions varied between decoction and capsules samples. Also, significant reductions of total flavonoids and total phenolic content was ...
Source: Acta Pharmaceutica - January 18, 2023 Category: Drugs & Pharmacology Authors: Yubo Zhou Yingxin Yang Minyan Ma Lingyun Xie Aijuan Yan Wen Cao Source Type: research
