Efficacy and safety of < em > Ginkgo biloba < /em > extract as an adjuvant in the treatment of Chinese patients with sudden hearing loss: a meta-analysis
CONCLUSION: The efficacy of GBE + GT for the treatment of SHL may be more promising than GT alone.PMID:36999358 | DOI:10.1080/13880209.2023.2190782 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - March 31, 2023 Category: Drugs & Pharmacology Authors: Chao Yuan Huan Zhang Cuicui Sun Kai Zhang Source Type: research
Neuroprotective potential of Ginkgo biloba on alteration of rat cerebellum following prenatal exposure to cyclophosphamide
This study investigated the cerebellar alteration in rats prenatally exposed to cyclophosphamide (SK, 20 mg/kg). We also evaluated the neuroprotective potential of Ginkgo biloba (GB, 80 mg/kg/day) against possible biological changes caused by SK in the cerebellar tissues. Twenty adult female rats (weighing 230-280 g, 12 weeks old) were divided into five groups: control, sham, SK, GB, and SK + GB. After mating, pregnant rats was treated with SK in the SK and SK + GB groups and GB in the GB and SK + GB groups from day 13 to day 21 of gestation. After parturition, eight female rats were randomly selected from each group. On d...
Source: Cancer Control - March 29, 2023 Category: Cancer & Oncology Authors: Sarmad Hayder Weli Weli Ahmad Yahyazadeh Source Type: research
Ginkgo biloba extract EGb 761 ® improves cognition and overall condition after ischemic stroke: Results from a pilot randomized trial
Conclusion: Over the 24-week period, EGb 761® treatment improved overall cognitive performance among patients with mild to moderate ischemic stroke. Our findings provide valuable recommendations for the design of future trials, including the criteria for patient selection.Clinical Trial Registration:www.isrctn.com, identifier ISRCTN11815543. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 29, 2023 Category: Drugs & Pharmacology Source Type: research
Ginkgo biloba modulates ET-I/NO signalling in Lead Acetate induced rat model of endothelial dysfunction: Involvement of oxido-inflammatory mediators
. (Source: International Journal of Environmental Health Research)
Source: International Journal of Environmental Health Research - March 24, 2023 Category: Environmental Health Authors: Jerome Ndudi Asiwe Godwin D. Yovwin Nwoke Enekabokom Ekene Simon Irikefe Ovuakporaye Anthony Chibuzor Nnamudi Eze Kingsley Nwangwa Source Type: research
Ginkgo biloba Extract EGb 761 in the Treatment of Patients with Mild Neurocognitive Impairment: A Systematic Review
(Source: Neuropsychiatric Disease and Treatment)
Source: Neuropsychiatric Disease and Treatment - March 23, 2023 Category: Psychiatry Tags: Neuropsychiatric Disease and Treatment Source Type: research
Complete Genome Sequence of Streptomyces sp. HP-A2021, a Promising Bacterium for Natural Product Discovery
Biochem Genet. 2023 Mar 16. doi: 10.1007/s10528-023-10350-8. Online ahead of print.ABSTRACTStreptomyces are one of the most prolific sources of bioactive and structurally diverse secondary metabolites for natural product drug discovery. Genome sequencing and bioinformatics analysis revealed that the genomes of Streptomyces harbor a wealth of cryptic secondary metabolite biosynthetic gene clusters that could encode novel compounds. In this work, a genome mining approach was employed to investigate the biosynthetic potential of Streptomyces sp. HP-A2021, isolated from rhizosphere soil of Ginkgo biloba L. The complete genome ...
Source: Biochemical Genetics - March 17, 2023 Category: Genetics & Stem Cells Authors: Lan-Fang Li Qing-Xuan Wu Hao Wu Yao Li Qian Peng Ren-Hao Han Da-Hu Zhang Wei-Dong Yu Rui Xu Juan Wang Zhaobin Fan Shao-Yang Hou Source Type: research
Complete Genome Sequence of Streptomyces sp. HP-A2021, a Promising Bacterium for Natural Product Discovery
Biochem Genet. 2023 Mar 16. doi: 10.1007/s10528-023-10350-8. Online ahead of print.ABSTRACTStreptomyces are one of the most prolific sources of bioactive and structurally diverse secondary metabolites for natural product drug discovery. Genome sequencing and bioinformatics analysis revealed that the genomes of Streptomyces harbor a wealth of cryptic secondary metabolite biosynthetic gene clusters that could encode novel compounds. In this work, a genome mining approach was employed to investigate the biosynthetic potential of Streptomyces sp. HP-A2021, isolated from rhizosphere soil of Ginkgo biloba L. The complete genome ...
Source: Biochemical Genetics - March 17, 2023 Category: Genetics & Stem Cells Authors: Lan-Fang Li Qing-Xuan Wu Hao Wu Yao Li Qian Peng Ren-Hao Han Da-Hu Zhang Wei-Dong Yu Rui Xu Juan Wang Zhaobin Fan Shao-Yang Hou Source Type: research
Complete Genome Sequence of Streptomyces sp. HP-A2021, a Promising Bacterium for Natural Product Discovery
Biochem Genet. 2023 Mar 16. doi: 10.1007/s10528-023-10350-8. Online ahead of print.ABSTRACTStreptomyces are one of the most prolific sources of bioactive and structurally diverse secondary metabolites for natural product drug discovery. Genome sequencing and bioinformatics analysis revealed that the genomes of Streptomyces harbor a wealth of cryptic secondary metabolite biosynthetic gene clusters that could encode novel compounds. In this work, a genome mining approach was employed to investigate the biosynthetic potential of Streptomyces sp. HP-A2021, isolated from rhizosphere soil of Ginkgo biloba L. The complete genome ...
Source: Biochemical Genetics - March 17, 2023 Category: Genetics & Stem Cells Authors: Lan-Fang Li Qing-Xuan Wu Hao Wu Yao Li Qian Peng Ren-Hao Han Da-Hu Zhang Wei-Dong Yu Rui Xu Juan Wang Zhaobin Fan Shao-Yang Hou Source Type: research
Ginaton reduces M1-polarized macrophages in hypertensive cardiac remodeling via NF- κB signaling
Conclusion: Our study showed that Ginaton treatment inhibits Ang II-induced M1 phenotype macrophage activation, macrophage adhesion, and mitigation, as well as the inflammatory response leading to impaired and dysfunctional hypertension and cardiac remodeling. Gianton may be a powerful treatment for heart disease. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 13, 2023 Category: Drugs & Pharmacology Source Type: research
Pharmacological activities and effective substances of the component-based Chinese medicine of Ginkgo biloba leaves based on serum pharmacochemistry, metabonomics and network pharmacology
As a potential drug candidate for the treatment of hypertension and complications, it is speculated that the component-based Chinese medicine of Ginkgo biloba leaves (GBCCM) which mainly composed of flavonoid aglycones (FAs) and terpene lactones (TLs) may have different pharmacological effects at different doses or ratios. Taking the normal mice as the study object, metabonomics was conducted by giving different doses of GBCCM. Based on the components of GBCCM absorbed into the blood, the network pharmacological prediction was carried out. By integrating the results of metabonomics and network pharmacology, predict the pos...
Source: Frontiers in Pharmacology - March 10, 2023 Category: Drugs & Pharmacology Source Type: research
Purification of total flavonoids from Ginkgo biloba flowers with resin column chromatography and evaluation of antioxidant activities in vi
(Source: Preparative Biochemistry)
Source: Preparative Biochemistry - March 9, 2023 Category: Biochemistry Authors: Li, Ruihong Xia, Ziming Tian, Ying Guan, Mengjia Zheng, Yaping Bin, Li Dong, Junxing Jiang, Qingcheng Du, Lina Li, Min Source Type: research
A systematic review of cognitive interventions for adult patients with brain tumours
ConclusionThe 35 studies identified in this systematic review have indicated potential cognitive benefits for a number of pharmacological and nonpharmacological interventions in patients with brain tumours. Study limitations were identified and further studies should focus on improved study reporting, methods to reduce bias and minimise participant drop-out and withdrawal where possible, and consider standardisation of methods and interventions across studies. Greater collaboration between centres could result in larger studies with standardised methods and outcome measures, and should be a focus of future research in the ...
Source: Cancer Medicine - March 7, 2023 Category: Cancer & Oncology Authors: Matthew A. Kirkman,
Justyna O. Ekert,
Benjamin H. M. Hunn,
Michael S. C. Thomas,
Andrew K. Tolmie Tags: REVIEW Source Type: research
