Germ cell-specific gene 2 accelerates cell cycle in epithelial ovarian cancer by inhibiting GSK3 α-p27 cascade
In this study, GSG2-knockdown cells and GSG2-overexpress cells were established through lentivirus-mediated transfection with Human ovarian cancer cells HO8910 and SKOV3. Knockdown of GSG2 inhibited cell proliferation and induced G2/M phase arrest in EOC. Interestingly, the expression of p27, a well-known regulator of the cell cycle showed a most significant increase after GSG2 knockdown. Further phosphorylation-protein array demonstrated the phosphorylation of GSK3 αSer21 decreased in GSG2-knockdown cells to the most extent. Notably, inhibiting GSK3α activity effectively rescued GSG2 knockdown’s suppression on cell cy...
Source: Journal of Molecular Histology - April 13, 2024 Category: Laboratory Medicine Source Type: research
Paratesticular cellular angiofibroma: a case report
ConclusionThe pathological findings were compatible for cellular angiofibroma. The tumor was successfully resected, and no apparent recurrence was observed at 5 years after surgery. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - April 11, 2024 Category: General Medicine Source Type: research
Occupational exposure to organic solvents and the risk of developing testicular germ cell tumors (TESTIS study): Effect of combined exposure assessment on risk estimation
CONCLUSION: The results suggest that some organic solvents might be involved in the pathogenesis of TGCT among occupationally exposed men. The combined use of JEM+SQ+EA seemed to limit misclassification by considering individual exposure variability and is, therefore, an appealing approach to assess occupational exposures in epidemiological studies.PMID:38597023 | DOI:10.5271/sjweh.4161 (Source: Cancer Control)
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Margot Guth Corinne Pilorget Marie Lefevre Astrid Coste Aur élie Danjou Brigitte Dananch é Delphine Praud Olivia P érol Myriam Daudin Marie-Ange Clarotti St éphanie Lattes C éline Bouillon Ad èle Paul Joachim Sch üz Louis Bujan Ann Olsson B éatric Source Type: research
Occupational exposure to organic solvents and the risk of developing testicular germ cell tumors (TESTIS study): Effect of combined exposure assessment on risk estimation
CONCLUSION: The results suggest that some organic solvents might be involved in the pathogenesis of TGCT among occupationally exposed men. The combined use of JEM+SQ+EA seemed to limit misclassification by considering individual exposure variability and is, therefore, an appealing approach to assess occupational exposures in epidemiological studies.PMID:38597023 | DOI:10.5271/sjweh.4161 (Source: Scandinavian Journal of Work, Environment and Health)
Source: Scandinavian Journal of Work, Environment and Health - April 10, 2024 Category: Occupational Health Authors: Margot Guth Corinne Pilorget Marie Lefevre Astrid Coste Aur élie Danjou Brigitte Dananch é Delphine Praud Olivia P érol Myriam Daudin Marie-Ange Clarotti St éphanie Lattes C éline Bouillon Ad èle Paul Joachim Sch üz Louis Bujan Ann Olsson B éatric Source Type: research
Occupational exposure to organic solvents and the risk of developing testicular germ cell tumors (TESTIS study): Effect of combined exposure assessment on risk estimation
CONCLUSION: The results suggest that some organic solvents might be involved in the pathogenesis of TGCT among occupationally exposed men. The combined use of JEM+SQ+EA seemed to limit misclassification by considering individual exposure variability and is, therefore, an appealing approach to assess occupational exposures in epidemiological studies.PMID:38597023 | DOI:10.5271/sjweh.4161 (Source: Scandinavian Journal of Work, Environment and Health)
Source: Scandinavian Journal of Work, Environment and Health - April 10, 2024 Category: Occupational Health Authors: Margot Guth Corinne Pilorget Marie Lefevre Astrid Coste Aur élie Danjou Brigitte Dananch é Delphine Praud Olivia P érol Myriam Daudin Marie-Ange Clarotti St éphanie Lattes C éline Bouillon Ad èle Paul Joachim Sch üz Louis Bujan Ann Olsson B éatric Source Type: research
Occupational exposure to organic solvents and the risk of developing testicular germ cell tumors (TESTIS study): Effect of combined exposure assessment on risk estimation
Conclusion The results suggest that some organic solvents might be involved in the pathogenesis of TGCT among occupationally exposed men. The combined use of JEM+SQ+EA seemed to limit misclassification by considering individual exposure variability and is, therefore, an appealing approach to assess occupational exposures in epidemiological studies.
by Guth M, Pilorget C, Lefevre M, Coste A, Danjou A, Dananché B, Praud D, Pérol O, Daudin M, Clarotti M-A, Lattes S, Bouillon C, Paul A, Schüz J, Bujan L, Olsson A, Fervers B, Charbotel B, The TESTIS study group. doi:10.5271/sjweh.4153 (Source: Scandinavian Journal of Wo...
Source: Scandinavian Journal of Work, Environment and Health - April 10, 2024 Category: Occupational Health Tags: Original article Source Type: research
Pediatric-Like Brain Tumors in Adults
Adv Tech Stand Neurosurg. 2024;50:147-183. doi: 10.1007/978-3-031-53578-9_5.ABSTRACTPediatric brain tumors are different to those found in adults in pathological type, anatomical site, molecular signature, and probable tumor drivers. Although these tumors usually occur in childhood, they also rarely present in adult patients, either as a de novo diagnosis or as a delayed recurrence of a pediatric tumor in the setting of a patient that has transitioned into adult services.Due to the rarity of pediatric-like tumors in adults, the literature on these tumor types in adults is often limited to small case series, and treatment d...
Source: Advances and Technical Standards in Neurosurgery - April 9, 2024 Category: Neurosurgery Authors: Sandra Fernandes Dias Oliver Richards Martin Elliot Paul Chumas Source Type: research
Regionalization of Testis Cancer Care —Is It Necessary?
Testicular germ cell tumors are rare genitourinary malignancies, but they represent the most common malignancies in men aged 15 to 30 years. Whereas the initial steps of management such as staging imaging studies, inguinal orchiectomy, and tumor marker can be performed elsewhere, the surgical and cytotoxic therapy needs to be done at reference centers. Regionalization of testis care has been shown to result in superior oncologic al outcome. (Source: Urologic Clinics of North America)
Source: Urologic Clinics of North America - April 9, 2024 Category: Urology & Nephrology Authors: Axel Heidenreich, Pia Paffenholz, David Pfister Source Type: research
Restricted access and advanced disease in post-pandemic testicular cancer
CONCLUSIONS: There was a 16.8% rise in clinical stage III disease from the pre-pandemic to post-pandemic period. Our study failed to identify a statistically significant increase in metastatic testis cancer incidence upon lifting of pandemic restrictions. Further study is necessary to confirm suspicions that pandemic restrictions contributed to increased incidence of metastatic testis cancer.PMID:38587978 | DOI:10.5489/cuaj.8648 (Source: Canadian Urological Association Journal)
Source: Canadian Urological Association Journal - April 8, 2024 Category: Urology & Nephrology Authors: Mitchell Fagan W C Ian Janes Matthew Andrews David R Harvey Geoff M Warden Michael K Organ Paul Johnston Source Type: research
Restricted access and advanced disease in post-pandemic testicular cancer
CONCLUSIONS: There was a 16.8% rise in clinical stage III disease from the pre-pandemic to post-pandemic period. Our study failed to identify a statistically significant increase in metastatic testis cancer incidence upon lifting of pandemic restrictions. Further study is necessary to confirm suspicions that pandemic restrictions contributed to increased incidence of metastatic testis cancer.PMID:38587978 | DOI:10.5489/cuaj.8648 (Source: Canadian Urological Association Journal)
Source: Canadian Urological Association Journal - April 8, 2024 Category: Urology & Nephrology Authors: Mitchell Fagan W C Ian Janes Matthew Andrews David R Harvey Geoff M Warden Michael K Organ Paul Johnston Source Type: research
Restricted access and advanced disease in post-pandemic testicular cancer
CONCLUSIONS: There was a 16.8% rise in clinical stage III disease from the pre-pandemic to post-pandemic period. Our study failed to identify a statistically significant increase in metastatic testis cancer incidence upon lifting of pandemic restrictions. Further study is necessary to confirm suspicions that pandemic restrictions contributed to increased incidence of metastatic testis cancer.PMID:38587978 | DOI:10.5489/cuaj.8648 (Source: Canadian Urological Association Journal)
Source: Canadian Urological Association Journal - April 8, 2024 Category: Urology & Nephrology Authors: Mitchell Fagan W C Ian Janes Matthew Andrews David R Harvey Geoff M Warden Michael K Organ Paul Johnston Source Type: research
Restricted access and advanced disease in post-pandemic testicular cancer
CONCLUSIONS: There was a 16.8% rise in clinical stage III disease from the pre-pandemic to post-pandemic period. Our study failed to identify a statistically significant increase in metastatic testis cancer incidence upon lifting of pandemic restrictions. Further study is necessary to confirm suspicions that pandemic restrictions contributed to increased incidence of metastatic testis cancer.PMID:38587978 | DOI:10.5489/cuaj.8648 (Source: Canadian Urological Association Journal)
Source: Canadian Urological Association Journal - April 8, 2024 Category: Urology & Nephrology Authors: Mitchell Fagan W C Ian Janes Matthew Andrews David R Harvey Geoff M Warden Michael K Organ Paul Johnston Source Type: research
Fertility preservation in hematological cancer patients
AbstractAmong adolescents and young adults, hematological malignancies are the most common malignancies. Although the survival rate of hematological malignancies in young patients has been dramatically improved, due to the continuous improvement and development of tumor diagnosis and treatment options, cytotoxic therapies can significantly reduce a patient ’s reproductive capacity and cause irreversible infertility. The most two established solutions are embryo cryopreservation and oocyte cryopreservation which can be considered in single female. Sperm or testicular tissue cryopreservation in adult male are feasible appr...
Source: Clinical and Translational Oncology - April 4, 2024 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 16, Pages 1379: Advancing GCT Management: A Review of miR-371a-3p and Other miRNAs in Comparison to Traditional Serum Tumor Markers
Aditya Bagrodia
MicroRNAs, short non-protein coding RNAs, are overexpressed in GCTs. Circulating levels of germ cell tumor (GCT)-associated miRNAs, such as miR-371a-3p, can be utilized as efficient and cost-effective alternatives in diagnosing and managing patients presenting with GCTs. This quality of miRNAs has demonstrated favorable performance characteristics as a reliable blood-based biomarker with high diagnostic accuracy compared to current serum tumor markers (STMs), including α-fetoprotein (AFP), beta human chorionic gonadotropin (β-hCG), and lactate dehydrogenase (LDH). The conven...
Source: Cancers - March 31, 2024 Category: Cancer & Oncology Authors: Crystal L. Seales Dhruv Puri Nuphat Yodkhunnatham Kshitij Pandit Kit Yuen Sarah Murray Jane Smitham John T. Lafin Aditya Bagrodia Tags: Review Source Type: research
