The Prevalence of Barrett ’s Esophagus Among a Saudi Arabian Population
ConclusionBE was endoscopically reported in 0.64% and histologically confirmed in 0.32% of this cohort of Saudi patients. Male gender was the only factor associated with BE. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - August 4, 2020 Category: Gastroenterology Source Type: research

Impact of gastroesophageal reflux on longitudinal lung function and quantitative computed tomography in the COPDGene cohort
Gastroesophageal reflux disease (GERD) is a common comorbidity in chronic obstructive pulmonary disease (COPD) and has been associated with increased risk of acute exacerbations, hospitalization, emergency roo... (Source: Respiratory Research)
Source: Respiratory Research - August 3, 2020 Category: Respiratory Medicine Authors: Arianne K. Baldomero, Chris H. Wendt, Ashley Petersen, Nathaniel T. Gaeckle, MeiLan K. Han and Ken M. Kunisaki Tags: Research Source Type: research

Pepsin and laryngeal and hypopharyngeal carcinomas.
Authors: Yin CY, Zhang SS, Zhong JT, Zhou SH Abstract Laryngeal and hypopharyngeal carcinomas are common malignant tumors of the head and neck, which are both exhibiting increasing incidences. Laryngopharyngeal reflux is the retrograde flow of gastric contents into the larynx, oropharynx, and/or nasopharynx. There remains controversy regarding whether laryngopharyngeal reflux is a risk factor for laryngeal and hypopharyngeal cancers. The refluxing substances mainly include hydrochloric acid, pepsin, and occasionally bile acids and bile salts, as well as bacteria that colonize the gastrointestinal tract. Loss of epi...
Source: Clinical and Experimental Otorhinolaryngology - August 1, 2020 Category: ENT & OMF Tags: Clin Exp Otorhinolaryngol Source Type: research

Impact of age on morbidity and mortality following bariatric surgery
ConclusionOverall, bariatric surgery (SG or RYGB) remains a low mortality risk procedure for all age groups. However, all age group classifications  >  45 years had higher incidence of major complications and mortality compared to patients 18–45 years (despite older individuals having lower preoperative BMI) indicating delaying surgery is detrimental. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - August 1, 2020 Category: Surgery Source Type: research

Gastrointestinal complications of cystic fibrosis
Cystic fibrosis is a multisystem disorder, and gastrointestinal disease contributes significantly to its morbidity. This review outlines the major gastrointestinal manifestations of CF, and highlights areas of common misunderstanding. Areas particularly important to practice, such as impact upon malabsorption, bowel obstruction and gastro-oesophageal reflux are considered in detail. (Source: Paediatrics and Child Health)
Source: Paediatrics and Child Health - August 1, 2020 Category: Pediatrics Authors: Christabella Ng, Andrew P. Prayle Tags: Symposium: gastroenterology Source Type: research

Risk factors for precancerous lesions of esophageal squamous cell carcinoma in high-risk areas of rural China: A population-based screening study
Although many studies in China have found that environmental or lifestyle factors are major contributors to the etiology of esophageal cancer, most of the patients in the above studies are in the middle and late stages, the early-stage patients account for a small proportion. To clarify the risk/protective factors contributing to early lesions, we conducted the present cross-sectional study. A total of 2925 healthy controls and 402 patients with esophageal precancerous lesions were included in our study by endoscopic examination. Information on risk/protective factors was collected by personal interview, and unconditional...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Association of residual gastric acid secretion with persistent symptoms in gastroesophageal reflux disease patients receiving standard-dose proton pump inhibitor therapy
AbstractBackgroundAlthough a third of gastroesophageal reflux disease (GERD) patients are refractory to proton pump inhibitor (PPI) therapy, the underlying mechanism of the refractoriness remains unclear. We compared the level of gastric acid suppression during PPI treatment between responders and non-responders by directly measuring gastric acid secretion in GERD patients taking PPIs.MethodsSeventy-five consecutive patients receiving standard-dose PPI therapy for GERD were prospectively recruited, irrespective of persistent GERD symptoms. They were asked about their GERD symptoms using a validated questionnaire, and simul...
Source: Esophagus - July 31, 2020 Category: Gastroenterology Source Type: research

Derangement of Esophageal Anatomy and Motility in Morbidly Obese Patients: a Prospective Study Based on High-resolution Impedance Manometry
Morbidly obese patients often suffer from gastroesophageal reflux disease (GERD). High-resolution impedance manometry (HRIM) allows a comprehensive evaluation of esophageal motility and esophagogastric junction (EGJ) morphology and helps to clarify GERD pathophysiology. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - July 31, 2020 Category: Surgery Authors: Hung-Hsuan Yen, Ping-Huei Tseng, Ming-Chieh Shih, Po-Jen Yang, Ming-Tsan Lin, Po-Chu Lee Tags: Original articles Source Type: research

Technique and outcome of day case laparoscopic hiatus hernia surgery for small and large hernias: a five-year retrospective review from a high-volume UK centre.
CONCLUSION: Laparoscopic anti-reflux surgery can be performed safely as a day case procedure even in larger hiatus hernias, with a dedicated care pathway and specialist nurse practitioners to support it. PMID: 32735121 [PubMed - as supplied by publisher] (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - July 31, 2020 Category: Surgery Authors: Mayo D, Darbyshire A, Mercer S, Carter N, Toh S, Somers S, Wainwright D, Fajksova V, Knight B Tags: Ann R Coll Surg Engl Source Type: research

Aerophagia During Infant Feeding Causing Gastroesophageal Reflux Disease like Symptoms
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - July 30, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Interaction Between Ethnicity and Helicobacter pylori Infection in the Occurrence of Reflux Disease
Conclusions: Gastric H. pylori infection, ethnicity, gender, and age all influence the occurrence of Barrett metaplasia, and reflux esophagitis. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - July 30, 2020 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Correction to: RECENT Advances in Endoscopic Treatments for Gastroesophageal Reflux Disease
In the article, “7RECENT Advances in Endoscopic Treatments for Gastroesophageal Reflux Disease,” published in the September issue of Current Treatment Options in Gastroenterology, the title is printed in correctly. (Source: Current Treatment Options in Gastroenterology)
Source: Current Treatment Options in Gastroenterology - July 30, 2020 Category: Gastroenterology Source Type: research

Acupuncture at the dorsal section of the governor vessel for gastroesophageal reflux disease combined with sleep disorder: a research of case series
Publication date: Available online 27 July 2020Source: World Journal of Acupuncture - MoxibustionAuthor(s): Xing-hua BAI, Juan ZHOU, Qiu-shuang TANG (Source: World Journal of Acupuncture Moxibustion)
Source: World Journal of Acupuncture Moxibustion - July 28, 2020 Category: Complementary Medicine Source Type: research

Is gastroesophageal reflux disease after peroral endoscopic myotomy a clinical problem?
Endoscopy 2020; 52: 652-653 DOI: 10.1055/a-1185-9739 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Endoscopy)
Source: Endoscopy - July 28, 2020 Category: Gastroenterology Authors: Shiwaku, Hironari Tags: Editorial Source Type: research

Stimulatory effect of gastroesophageal reflux disease (GERD) on pulmonary fibroblast differentiation
Epidemiological studies indicate that prolonged micro-aspiration of gastric fluid is associated in gastroesophageal reflux disease with the development of chronic respiratory diseases, possibly caused by inflammation-related immunomodulation. Therefore, we sought to ascertain the effect of gastric fluid exposure on pulmonary residential cells. The expression of α-smooth muscle actin as a fibrotic marker was increased in both normal human pulmonary fibroblast cells and mouse macrophages. Gastric fluid enhanced the proliferation and migration of HFL-1 cells and stimulated the expression of inflammatory cytokines in an ...
Source: Digestive and Liver Disease - July 26, 2020 Category: Gastroenterology Authors: Cheng Che Chiang, Chin-Ming Chen, Jau Ling Suen, Hsiang Han Su, Chong Chao Hsieh, Chih-Mei Cheng Tags: Alimentary Tract Source Type: research

Acid Exposure Time > 6% Might Not Improve the Therapeutic Outcome in Chinese Gastroesophageal Reflux Disease Patients.
Conclusions: The efficacy of PPI therapy was similar in patients with AET> 6% and 4-6%. The increase of the AET threshold did not influence the clinical outcome of Chinese GERD patients. PMID: 32699186 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 25, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

A further step forward in our knowledge of the pathogenetic role of gastroesophageal reflux in pulmonary fibrosis
Pulmonary fibrosis is a repair response in lung tissue injury that involves loss of epithelial cells and accumulation of fibroblasts/myofibroblasts [1]. The main triggers of this fibrotic progression might be viral infections, organic and inorganic dusts, smoking and Gastroesophageal Reflux Disease (GERD). Furthermore, the majority of published studies have suggested that there is a strong comorbidity between GERD and Idiopathic pulmonary fibrosis (IPF) [2,3]. Based on this knowledge, we have read with interest the paper entitled “Stimulatory Effect of Gastroesophageal Reflux Disease (GERD) on Pulmonary Fibroblast Di...
Source: Digestive and Liver Disease - July 25, 2020 Category: Gastroenterology Authors: Pelin Erg ün, Vincenzo Savarino Tags: Commentary Source Type: research

Platelet-rich plasma PRP vs. absorbable mesh as cruroplasty reinforcement: a study on an animal model.
CONCLUSIONS: No residual materials or evidence of anatomical distortion were found. Animal model was safe and reliable. This is the first report of complete absorption of Bio-A® positioned on crural area. HP results suggest the clinical application of PRP in HHR as a promising co-adjuvant to local remodeling and healing. Abbreviations: ASA: American Society of Anesthesiologists; AB: Alcian Blue; PAS: Periodic Acid-Schiff; CP: platelet concentrate; fPC: filtered plasma concentrate; GERD: gastro-esophageal reflux disease; HSA: hiatal surface area; HHR: hiatal hernia repair; HP: histopathological; HH: hiatal hernia; HE: h...
Source: Minimally Invasive Therapy and Allied Technologies - July 24, 2020 Category: Surgery Tags: Minim Invasive Ther Allied Technol Source Type: research

A comparison of the efficacy and safety of complementary and alternative therapies for gastroesophageal reflux disease: A protocol for network meta-analysis
Conclusions: The findings will be an available reference to evaluate the efficacy and safety of complementary and alternative therapies on GERD and may provide decision-making reference on which method to choose for clinicians. PROSPERO registration number: PROSPERO CRD42020169332. (Source: Medicine)
Source: Medicine - July 24, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Safety and effectiveness of peroral endoscopic myotomy in patients on antiplatelet or anticoagulant therapy: an international multicenter case-control study
In patients undergoing peroral endoscopic myotomy (POEM) who are receiving antithrombotic therapy, the risk of bleeding and thromboembolic events is unknown. Our primary aim was to assess the safety of POEM in this patient subset. Secondary outcomes assessed were rates of clinical success, gastroesophageal reflux disease (GERD) and procedure-related outcomes. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - July 24, 2020 Category: Gastroenterology Authors: Enrique Rodr íguez de Santiago, Yuto Shimamura, Mathieu Pioche, Nikos Eleftheriadis, Eduardo Albéniz, Robert Bechara, Philip Way Yan Chiu, Charlie Guarner-Argente, Alberto Herreros de Tejada, Hugo Uchima, Yusuke Fujiyoshi, Thierry Ponchon, Gonzalo Gonz Source Type: research

The Effects of Fasting Status on the Relative Risk of Pulmonary Aspiration in Acute Care Surgery Patients.
Abstract BACKGROUND: Acute care surgery patients are often unfasted at the time of surgery, presenting a unique opportunity to study the effects of fasting on the risk of pulmonary aspiration. We aimed to determine the relative risk of aspiration in patients who were fasted at the time of surgery according to guidelines versus those in an unfasted state. METHODS: A retrospective chart review of 100 patients who underwent appendectomy (n = 76) or exploratory laparotomy (n = 24) was conducted at a single institution in 2016-2017. Using the American Society of Anesthesiologists (ASA) Practice Guidelines for Preo...
Source: The American Surgeon - July 24, 2020 Category: Surgery Authors: Reed LaSala V, Morgan ME, Bradburn EH, Vernon TM, Maish GO Tags: Am Surg Source Type: research

Five-Year Outcome of Laparoscopic Fundoplication in Pediatric GERD Patients: a Multicenter, Prospective Cohort Study
AbstractBackgroundGastroesophageal reflux disease (GERD) is a common disease in children. When drug treatment fails, laparoscopic anti-reflux surgery (LARS) is considered. Short-term follow-up studies report high success rates; however, few studies report long-term results. The aim of this study was to describe the long-term effects of LARS in pediatric patients.MethodsA prospective, multicenter study of 25 laparoscopic fundoplication patients was performed. At 3  months and 1, 2, and 5 years postoperatively, patients and caregivers were asked to complete the gastroesophageal reflux symptom questionnaire to asses...
Source: Journal of Gastrointestinal Surgery - July 22, 2020 Category: Surgery Source Type: research

The presence of gastroesophageal reflux disease increases the risk of developing post-operative shoulder stiffness after arthroscopic rotator cuff repair.
Postoperative shoulder stiffness (SS) after arthroscopic rotator cuff (RC) repair has been reported with variable incidence and numerous preoperative risk factors have been described. This prospective study aims to document the incidence of postoperative SS and to evaluate the role of preoperative risk factors in the development of this complication, with special focus on the role of gastroesophageal reflux disease (GERD). (Source: Journal of Shoulder and Elbow Surgery)
Source: Journal of Shoulder and Elbow Surgery - July 21, 2020 Category: Orthopaedics Authors: Davide Cucchi, Alessandra Menon, Francesca Maria Feroldi, Linda Boerci, Pietro S. Randelli Tags: Original Article Source Type: research

Gastroesophageal reflux-like symptoms are associated with hyposalivation and oropharyngeal problems in patients with asthma
Publication date: Available online 19 July 2020Source: Respiratory InvestigationAuthor(s): Setsuko Koshiyama, Kazuya Tanimura, Kayoko Ito, Saori Funayama, Daiki Hira, Yuko Komase, Susumu Sato (Source: Respiratory Investigation)
Source: Respiratory Investigation - July 20, 2020 Category: Respiratory Medicine Source Type: research

Non-active implantable device treating acid reflux with a new dynamic treatment approach: 1-year results
RefluxStop ™ is an implantable, non-active, single use device used in the laparoscopic treatment of GERD. RefluxStop™ aims to block the movement of the LES up into the thorax and keep the angle of His in its or... (Source: BMC Surgery)
Source: BMC Surgery - July 20, 2020 Category: Surgery Authors: Milo š Bjelović, László Harsányi, Áron Altorjay, Zsolt Kincses and Peter Forsell Tags: Research article Source Type: research

Efficacy evaluation of pepsin in laparoscopic antireflux surgery for gastroesophageal reflux disease.
CONCLUSIONS: Laparoscopic fundoplication and hiatus hernia repair may effectively control the symptoms of GERD. Furthermore, the detection of pepsin is non-invasive and easy to operate. PMID: 32741794 [PubMed - as supplied by publisher] (Source: Technology and Health Care)
Source: Technology and Health Care - July 20, 2020 Category: Medical Devices Authors: Gao X, Liu DG, Wang F, Zhang C, Du X, Wu JM, Wang ZG, Li F Tags: Technol Health Care Source Type: research

Molecular Dynamics in Esophageal Adenocarcinoma: Who's in Control?
Abstract Esophageal adenocarcinoma (EAC) is one of the fastest-growing cancers in the world. It occurs primarily due to the chronic gastroesophageal reflux disease (GERD), during which the esophageal epithelium is frequently exposed to the acidic fluid coming up from the stomach. This triggers gene mutations in the esophageal cells, which may lead to EAC development. While p53 is activated to get rid of the mutated cells, NFB orchestrates the remaining cells to heal the wound. However, if the mutations happen to TP53 (a common occasion), the mutant product turns to support tumorigenesis. In this case, NFκ...
Source: Current Cancer Drug Targets - July 19, 2020 Category: Cancer & Oncology Authors: Dang T, Chai J Tags: Curr Cancer Drug Targets Source Type: research

Comparison of Short Versus Long Esophageal Myotomy in Cases With Idiopathic Achalasia: A Randomized Controlled Trial.
In this study, we aim to compare the outcomes of short (3 cm) versus long (6 cm and above) esophageal myotomy in patients undergoing POEM for achalasia cardia. Methods: Consecutive patients with idiopathic achalasia (type I and II) were randomized to receive short (3 cm) or long esophageal myotomy (≥ 6 cm). Both groups were compared for clinical success, operative time, adverse events, and gastroesophageal reflux disease (GERD). Results: Seventy-one consecutive patients with type I and II achalasia underwent POEM with short (n = 34) or long (n = 37) esophageal myotomy techniques. Mean length of esophageal myotom...
Source: Journal of Neurogastroenterology and Motility - July 18, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

The Association between Frailty and Abdominal Symptoms: A Hospital-based Cross-sectional Study.
Authors: Asaoka D, Takeda T, Inami Y, Abe D, Shimada Y, Matsumoto K, Ueyama H, Matsumoto K, Komori H, Akazawa Y, Osada T, Hojo M, Nagahara A Abstract Objective The association between frailty and abdominal symptoms has not been evaluated. Methods We conducted a hospital-based, retrospective cross-sectional study of consecutive outpatients ≥65 years old at the Department of Gastroenterology, Juntendo Tokyo Koto Geriatric Medical Center from 2017 to 2019. Patients were included in the study if all of the following information was available from their medical records: patient's profile, the evaluation of osteoporos...
Source: Internal Medicine - July 18, 2020 Category: Internal Medicine Tags: Intern Med Source Type: research

Sleeve gastrectomy and gastroesophageal reflux: a comprehensive endoscopic and pH-manometric prospective study
The impact of sleeve gastrectomy (SG) on gastroesophageal reflux disease (GERD) is still greatly debated. Most of the current evidence available is solely based on symptom evaluation or medication usage, while a minority have implemented objective functional measurements. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - July 18, 2020 Category: Surgery Authors: Lidia Castagneto-Gissey, Alfredo Genco, Giulia Del Corpo, Danilo Badiali, Anna Maria Pronio, Giovanni Casella Tags: Original articles Source Type: research

Different Traditional Herbal Medicines for the Treatment of Gastroesophageal Reflux Disease in Adults
ConclusionThis research indicates that Ligan Hewei therapy and Jianpi therapy, or these therapies separately combined with PPIs, should be recommended as appropriate complementary and alternative treatments based on the specific characteristics of GERD. However, additional well-designed RCTs with high methodological quality are still needed for future research. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - July 16, 2020 Category: Drugs & Pharmacology Source Type: research

Understanding the relationship between esophageal motor disorders and reflux disease.
Authors: Ribolsi M, de Carlo G, Balestrieri P, Guarino MPL, Cicala M Abstract INTRODUCTION: The management of gastro-esophageal reflux disease (GERD) patients is often complex as the clinical presentation is heterogeneous and the mechanisms underlying symptoms are multifactorial. In the past decades, investigations conducted with conventional manometry and, above all, the more accurate high resolution manometry (HRM), helped us in exploring the field of esophageal motility and in understanding the link between motor features and GERD pathogenesis. AREAS COVERED: Several studies carried out with conventional man...
Source: Expert Review of Gastroenterology and Hepatology - July 15, 2020 Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research

GSE137109 Cross validated serum exosomal microRNAs for the detection of oropharyngeal squamous cell carcinoma
This study therefore used stabilised nested cross validation to investigate whether circulating miRNAs could be used to differentiate OPSCCs from healthy controls and patients with gastro-oesophageal reflux disease. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - July 15, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by RT-PCR Homo sapiens Source Type: research

Esophageal Functional Lumen Imaging Probe (FLIP): How Can FLIP Enhance Your Clinical Practice?
AbstractRecent innovations in esophageal diagnostic testing have enhanced gastroenterology clinical practice by facilitating more nuanced and advanced evaluation of esophageal symptoms. Among these pivotal advances is the FDA-approved functional lumen imaging probe (FLIP), which utilizes impedance planimetry via volumetric distension of a catheter-mounted balloon at the time of sedated upper endoscopy, to acquire esophageal dimensions and pressures. In real time, FLIP can display cross-sectional areas (CSA) and distensibility indices (ratios of CSA to intra-balloon pressures) throughout the esophagus, most notably at the e...
Source: Digestive Diseases and Sciences - July 15, 2020 Category: Gastroenterology Source Type: research

Robotic Excision of Choledochal Cyst with Hepaticoduodenostomy (HD): Report of HD Technique, Initial Experience, and Early Outcome
Conclusion Robot-assisted CC excision with HD is feasible as proven by the outcome of 19 patients presented in this series. HD is to be done away from pylorus in distal part of down curving D2. This particular step prevents DGR and is the most important point of technique in doing HD. The presented series is the first report of robotic excision of CC with HD. The robot is a facilitator for complex and difficult operations as CC excision and HD. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Sourc...
Source: European Journal of Pediatric Surgery - July 15, 2020 Category: Surgery Authors: Nazki, Saalim Kanojia, Ravi Prakash Bawa, Monika Binu, Vineet Lal, Sadhna Sood, Ashwani Samujh, Ram Tags: Original Article Source Type: research

High grade dysplasia or esophageal adenocarcinoma in patients with a history of Roux-en-Y gastric bypass surgery: a case series
Conclusions RYGB patients are still at risk of developing esophageal cancer. Patients at risk should be screened prior to RYGB and those with Barret’s esophagus need to undergo rigorous endoscopic surveillance following surgery. If detected early, EMR and ESD are invaluable in managing those who progress. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Endoscopy)
Source: Endoscopy - July 14, 2020 Category: Gastroenterology Authors: Alaber, Omer Mansoor, Emad Perez, Lady Katherine Mejia Dumot, John Bhatt, Amit Chak, Amitabh Tags: Innovations and brief communications Source Type: research

Brunner’s gland cyst: rare differential diagnosis of dyspeptic symptoms
abstract A 60-year-old woman was under investigation of dyspeptic symptoms. The upper gastrointestinal endoscopy showed a cystic subepithelial lesion in the second portion of the duodenum, measuring 8 mm in its longest diameter. The biopsy showed dilated Brunner ’ s gland lobular ducts with scattered stromal elements, what characterized a Brunner ’ s gland cyst. Brunner ’ s gland cyst should be included in the differential diagnosis of gastrointestinal bleeding, dyspepsia, gastroesophageal reflux disease (GERD), malabsorption syndrome, anemia, among others. The correct nomenclature is important to facilit...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - July 13, 2020 Category: Pathology Source Type: research

Late-term hiatal hernia after gastric bypass: an emerging problem “What came first, the chicken or the egg?”
This study is welcomed because we strongly agree on giving importance to the complex interplay between gastroesophageal reflux disease (GERD) symptoms and HH, even in patients who underwent LRYGB. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - July 13, 2020 Category: Surgery Authors: Rossella Palma, Luigi Angrisani, Antonella Santonicola, Francesca Fierro, Paola Iovino Tags: Letter to the Editor Source Type: research

Green synthesis of pyrano [3,2-b]pyran derivatives using nano Si –Mg–fluorapatite catalyst and the evaluation of their antibacterial and antioxidant properties
In this study, we synthesize 2-amino-4-alkyl/aryl-6-(hydroxymethyl)-8-oxopyrano[3,2-b] pyran-3-carbonitriles derivatives using a multicomponent reaction featuring aromatic or aliphatic aldehydes, kojic acid, and malononitrile catalyzed by nano fluoroapatite doped with Si and Mg (Si –Mg–FA). All reactions were carried out in EtOH as the solvent under reflux and green condition. The process demonstrates various advantages, including high yields, short reaction times, and simple workup. In addition, toxic organic solvent is not used, nor is chromatographic purification of pro ducts required. We characterized the s...
Source: Medicinal Chemistry Research - July 13, 2020 Category: Chemistry Source Type: research

Gastric per-oral endoscopic pyloromyotomy (g-poem) for severe post lung transplant gastroparesis: a single center experience
Gastroparesis is frequently identified following lung transplantation with incidence rates as high as 44%.1 Gastroparesis post lung transplant is of significant concern, as complications directly related to gastroparesis, specifically gastroesophageal reflux and aspiration, have been linked to the development of bronchiolitis obliterans syndrome (BOS), the primary cause of graft failure and the main cause of late morbidity and mortality following lung transplantation.1 The therapy for medically refractory post lung transplant gastroparesis represents a significant therapeutic challenge, as current therapies (such as botuli...
Source: The Journal of Heart and Lung Transplantation - July 10, 2020 Category: Transplant Surgery Authors: Alexander J Podboy, John O Clarke, Linda A Nguyen, Joshua J Mooney, Gundeep S Dhillon, Joo Ha Hwang Tags: Research Correspondence Source Type: research

Reflux Hypersensitivity: How to Approach Diagnosis and Management
AbstractPurpose of ReviewThis paper aims to review the definition and diagnostic criteria for reflux hypersensitivity and comment on the present and future management of this condition.Recent FindingsIn 2016, the Rome IV criteria redefined reflux hypersensitivity as characterized by typical reflux symptoms, absence of endoscopic mucosal disease, absence of pathologic gastroesophageal reflux, and positive symptom correlation between reflux and heartburn episodes. Though uncertain, TPRV1 receptors have been implicated in the pathophysiology of reflux hypersensitivity. Recent studies have shown neuromodulators like SSRIs, SNR...
Source: Current Gastroenterology Reports - July 10, 2020 Category: Gastroenterology Source Type: research

Non-acid Reflux: When It Matters and Approach to Management
AbstractPurpose of ReviewThis narrative review focuses on the presentation, contributing factors, diagnosis, and treatment of non-acid reflux. We also propose algorithms for diagnosis and treatment.Recent FindingsThere is a paucity of recent data regarding non-acid reflux. The recent Porto and Lyon consensus statements do not fully address non-acid reflux or give guidance on classification. However, recent developments in the lung transplantation field, as well as older data in the general population, argue for the importance of non-acid reflux.SummaryExtrapolating from the Porto and Lyon consensus, we generally classify p...
Source: Current Gastroenterology Reports - July 10, 2020 Category: Gastroenterology Source Type: research

Gastric per-oral endoscopic myotomy for severe post-lung transplant gastroparesis: A single-center experience
Gastroparesis is frequently identified after lung transplantation with incidence rates as high as 44%.1 Gastroparesis after lung transplantation is of significant concern because complications directly related to gastroparesis, specifically gastroesophageal reflux and aspiration, have been linked to the development of bronchiolitis obliterans syndrome, the primary cause of graft failure and the main cause of late morbidity and mortality following lung transplantation.1 The therapy for medically refractory post-lung transplant gastroparesis represents a significant therapeutic challenge because current therapies (such as bo...
Source: The Journal of Heart and Lung Transplantation - July 10, 2020 Category: Transplant Surgery Authors: Alexander J. Podboy, John O. Clarke, Linda A. Nguyen, Joshua J. Mooney, Gundeep S. Dhillon, Joo Ha Hwang Tags: RESEARCH CORRESPONDENCE Source Type: research

7RECENT Advances in Endoscopic Treatments for Gastroesophageal Reflux Disease
AbstractPurpose of reviewThere is a growing interest in minimally invasive approaches to the management of gastroesophageal reflux disease (GERD), including endoscopic GERD therapy. This review evaluates available endoscopic therapeutic options utilized in GERD management.Recent findingsApplication of radiofrequency energy at the esophagogastric junction (EGJ) reduces reflux symptoms, but esophageal acid exposure does not necessarily normalize, and esophageal sensation is compromised. Two approaches to the creation of a valve at the EGJ, the Medigus ultrasonic surgical stapler (ultrasound guided stapling of the gastric fun...
Source: Current Treatment Options in Gastroenterology - July 9, 2020 Category: Gastroenterology Source Type: research

Risk factors for digestive morbidities after esophageal atresia repair
Conclusion: The incidence of postoperative GERD and esophageal stricture was 67.2% and 37.9%, respectively. The risk factors for postoperative esophageal stricture were long-gap EA/TEF and postoperative GERD.What is Known:•EA/TEF is a congenital digestive tract anomaly with a high postoperative survival rate but can be complicated by many long-term morbidities.What is New:•Long-gap EA/TEF and postoperative GERD are risk factors of anastomotic stricture after repair.•Surgeons and pediatricians should be highly experienced in managing anastomotic tension and the GERD. (Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - July 9, 2020 Category: Pediatrics Source Type: research

Long-term use of proton pump inhibitors as a risk factor for various adverse manifestations.
Abstract The long-term use of proton pump inhibitors (PPIs) can lead to increased gastric pH, hypochlorhydria and in some cases to achlorhydria when compared to other acid-suppressing agents like histamine-2 (H2) receptor blockers and antacids. These consequences by the use of long-term PPIs may lead to significant vitamin (B12 and C) and mineral (iron, calcium and magnesium) deficiencies which needs gastric acid for their absorption and bioavailability. Long-term use of PPIs by the pregnant patients may impose a potential risk of congenital malformations. Various studies have recommended the life style modificati...
Source: Therapie - July 9, 2020 Category: Psychiatry & Psychology Authors: Koyyada A Tags: Therapie Source Type: research

Guideline on screening for esophageal adenocarcinoma in patients with chronic gastroesophageal reflux disease.
Authors: Groulx S, Limburg H, Doull M, Klarenbach S, Singh H, Wilson BJ, Thombs B, Canadian Task Force on Preventive Health Care PMID: 32631908 [PubMed - in process] (Source: Canadian Medical Association Journal)
Source: Canadian Medical Association Journal - July 8, 2020 Category: General Medicine Tags: CMAJ Source Type: research

Laparoscopic Modified Nissen Fundoplication over Roux-En-Y Gastric Bypass and Hiatal hernia repair for Intractable Gastroesophageal Reflux
Roux-en-Y gastric bypass (RYGB) is an effective treatment for morbid obesity and gastroesophageal reflux disease (GERD) 1. Despite majority of patients with resolution of GERD after RYGB, some patients will continue to complain of significant, persistent reflux symptomatology or develop de novo symptoms despite aggressive medical management. It ’s true incidence is unknown and one study showed an improvement in GERD but not resolution in 22% of patients after RYGB with GERD2. Possible mechanisms may include primary lower esophageal sphincter incompetence, disruption of the angle of His or development of hiatal hernia...
Source: Surgery for Obesity and Related Diseases - July 7, 2020 Category: Surgery Authors: Pearl Ma, Kelvin Higa Tags: VIDEO CASE REPORT Source Type: research

Nutrition Interventions Associated With Favorable Growth in Infants With Congenital Diaphragmatic Hernia.
Abstract Nutrition complications are common in survivors of congenital diaphragmatic hernia (CDH). Infants diagnosed with CDH may demonstrate poor growth despite receiving enteral tube feedings and gastroesophageal reflux treatment. This literature review was conducted to determine nutrition interventions resulting in favorable growth, which may improve outcomes in these infants. Results indicate that early nutrition support, including supplemental parenteral nutrition with provisions of ≥125 kcal/kg/d and ≥2.3 g/kg/d protein (which are higher than dietary reference intakes for infants), may have a positive ...
Source: Nutrition in Clinical Practice - July 4, 2020 Category: Nutrition Authors: Bathgate JR, Rigassio Radler D, Zelig R, Lagoski M, Murthy K Tags: Nutr Clin Pract Source Type: research

Can We Apply the Salivary Pepsin Test for Patients With Gastroesophageal Reflux Disease in Primary Practice?
Authors: Lee TH PMID: 32606262 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 2, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research