Overlapping Symptoms of Gastroesophageal Reflux and Aspiration Highlight the Limitations of Validated Questionnaires
Objectives: Infants frequently present with feeding difficulties and respiratory symptoms, which are often attributed to gastroesophageal reflux but may be because of oropharyngeal dysphagia with aspiration. The Infant Gastroesophageal Reflux Questionnaire Revised (I-GERQ-R) is a clinical measure of gastroesophageal reflux disease but now there is greater understanding of dysphagia as a reflux mimic. We aimed to determine the degree of overlap between I-GERQ-R and evidence of dysphagia, measured by Pediatric Eating Assessment Tool-10 (Pedi-EAT-10) and videofluoroscopic swallow study (VFSS). Methods: We performed...
Source: Journal of Pediatric Gastroenterology and Nutrition - February 25, 2021 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Gastroesophageal Reflux Disease and Idiopathic Lung Fibrosis. From Heartburn to Lung Transplant, and Beyond
Am Surg. 2021 Feb 25:3134821998686. doi: 10.1177/0003134821998686. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) and gastroesophageal reflux disease (GERD) are undoubtedly related. Even though it is not clear yet which one is the primary disease, they certainly interact increasing each other's severity. Symptoms are unreliable to diagnose GERD in patients with IPF, and objective evaluation with pH monitoring and/or bronchoalveolar lavage analysis is mandatory. Pharmacological treatment with proton pump inhibitors (PPIs) may bring control of IPF in few patients, but PPIs do not control reflux but just ch...
Source: The American Surgeon - February 25, 2021 Category: Surgery Authors: Fernando A M Herbella Marco G Patti Source Type: research

Advanced Endoscopic Evaluation of Gastroesophageal Reflux Disease in Morbidly Obese Patients in a Rural Setting
CONCLUSION: Performing diagnostic studies for GERD for morbidly obese patients in critical access hospitals is safe. Patient selection, proper training and adequate preparation are critical prerequisites for good outcomes.PMID:33629869 | DOI:10.1177/0003134821998677 (Source: The American Surgeon)
Source: The American Surgeon - February 25, 2021 Category: Surgery Authors: Medhat Fanous Wei Wei David Lorenson Jamison Gould Source Type: research

Eradication of Helicobacter Pylori Infections and GERD: A systematic review and meta-analysis
CONCLUSION: Eradication of H. pylori infection is found to be associated with GERD, although regional differences may exist in the prevalence. Well-designed studies especially those with stratification of patients' basic conditions are needed to seek refined evidence of the association between H. pylori eradication and the GERD.PMID:33625997 | DOI:10.5152/tjg.2020.19699 (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - February 24, 2021 Category: Gastroenterology Authors: Wen-Ling Mou Meng-Yao Feng Li-Hua Hu Source Type: research

Sleeve gastrectomy with tailored 360 ° fundoplication according to Rossetti in patients affected by obesity and gastroesophageal reflux: a prospective observational study
CONCLUSION: LSG + Rossetti fundoplication was shown to be a safe and effective intervention. It could be considered an option in obese patients affected by GERD. A longer follow-up is needed to establish the long-term outcomes.PMID:33622604 | DOI:10.1016/j.soard.2021.01.007 (Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery)
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - February 24, 2021 Category: Surgery Authors: Stefano Olmi Giovanni Cesana Lucia D'Angiolella Marta Bonaldi Matteo Uccelli Lorenzo Mantovani Source Type: research

Trends in Fundoplication Volume for Pediatric Gastroesophageal Reflux Disease
Fundoplication for gastro-esophageal reflux disease (GERD) has been commonly performed by pediatric surgeons, however there are no recent data documenting fundoplication trends. Changes in fundoplication volume impact pediatric surgical training and may reflect changes in care for children with severe GERD. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - February 24, 2021 Category: Surgery Authors: Nathan L. Maassel, Matthew P. Shaughnessy, Daniel G. Solomon, Robert A. Cowles Source Type: research

Comments on " Sleeve Gastrectomy with tailored 360 ° fundoplication according to Rossetti in patients affected by obesity and gastro-oesophageal reflux: a prospective observational study"
I read with interest the manuscript entitled " Sleeve Gastrectomy with tailored 360 ° fundoplication according to Rossetti in patients affected by obesity and gastro-oesophageal reflux: a prospective observational study" in which 58 patients underwent a laparoscopic sleeve gastrectomy with a Rossetti anti-reflux fundoplication in patients affected by morbid obesity and GERD.1 One year after surgery, patients had an expected decrease in Body Mass Index (BMI), of nearly 14 kg/m2 and GERD improvement in 97 % of patients. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - February 24, 2021 Category: Surgery Authors: Michel Gagner Source Type: research

Shuddering attacks in children: A retrospective analysis of 19 cases from a single-center in Turkey
CONCLUSION: We speculate that there might be an indirect link between SA and teething and teething may be a triggering or an aggravating factor for SA.PMID:33621812 | DOI:10.1016/j.yebeh.2021.107827 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - February 23, 2021 Category: Neurology Authors: Selcan Ozturk Yakup Peduk Hakan Gumus Huseyin Per Source Type: research

Twenty years' experience of laparoscopic 1-anastomosis gastric bypass: surgical risk and long-term results
Surg Obes Relat Dis. 2021 Jan 21:S1550-7289(21)00036-8. doi: 10.1016/j.soard.2021.01.010. Online ahead of print.ABSTRACTBACKGROUND: Laparoscopic 1- (single-) anastomosis gastric bypass (OAGB) was developed as a simplified technique of Roux-en-Y gastric bypass (RYGB), but super long-term data are lacking.OBJECTIVES: To evaluate the risks and long-term results of OAGB over a period of 20 years.SETTING: Tertiary teaching hospital.METHODS: A total of 2223 patients underwent OAGB from 2001 to 2020; the mean age was 35.3 ± 11.4 years (range, 14-71 yr), 70.2% were female, and the mean body mass index was 40.2 ± 11.9...
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - February 23, 2021 Category: Surgery Authors: Meshari Almuhanna Tien-Chou Soong Wei-Jei Lee Jung-Chien Chen Chun-Chi Wu Yi-Chih Lee Source Type: research

Shuddering attacks in children: A retrospective analysis of 19 cases from a single-center in Turkey
CONCLUSION: We speculate that there might be an indirect link between SA and teething and teething may be a triggering or an aggravating factor for SA.PMID:33621812 | DOI:10.1016/j.yebeh.2021.107827 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - February 23, 2021 Category: Neurology Authors: Selcan Ozturk Yakup Peduk Hakan Gumus Huseyin Per Source Type: research

Twenty years' experience of laparoscopic 1-anastomosis gastric bypass: surgical risk and long-term results
Surg Obes Relat Dis. 2021 Jan 21:S1550-7289(21)00036-8. doi: 10.1016/j.soard.2021.01.010. Online ahead of print.ABSTRACTBACKGROUND: Laparoscopic 1- (single-) anastomosis gastric bypass (OAGB) was developed as a simplified technique of Roux-en-Y gastric bypass (RYGB), but super long-term data are lacking.OBJECTIVES: To evaluate the risks and long-term results of OAGB over a period of 20 years.SETTING: Tertiary teaching hospital.METHODS: A total of 2223 patients underwent OAGB from 2001 to 2020; the mean age was 35.3 ± 11.4 years (range, 14-71 yr), 70.2% were female, and the mean body mass index was 40.2 ± 11.9...
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - February 23, 2021 Category: Surgery Authors: Meshari Almuhanna Tien-Chou Soong Wei-Jei Lee Jung-Chien Chen Chun-Chi Wu Yi-Chih Lee Source Type: research

Commentary on Trends in Fundoplication Volume for Pediatric Gastroesophageal Reflux Disease
This is a commentary on the manuscript by Maassel N, Shaughnessy M, Solomon D, Cowles R titled “Trends in Fundoplication Volume for Pediatric Gastroesophageal Reflux Disease”. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - February 23, 2021 Category: Surgery Authors: Thomas T. Sato Source Type: research

Assessment of the Multiple Rapid Swallows Test for Gauging Esophageal Reflux Burden in Patients with Refractory Gastroesophageal Reflux Disease.
CONCLUSIONS Esophageal contraction reserve is heterogeneous within the reflux burden and symptomatic phenotypes of patients with rGERD. PMID: 33602889 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 21, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Lymphocytic Esophagitis With Predominance of CD4 T Cells and Expansion of Th1 Cells Is Associated With Achalasia
CONCLUSIONS: Achalasia should be considered in the differential diagnosis of clinical entities associated with CD4-predominant LyE. Additional studies to explore the significance of Th1 cells in achalasia-associated LyE are warranted.PMID:33609026 | DOI:10.1093/ajcp/aqaa239 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 20, 2021 Category: Pathology Authors: Kristen Muller Jenny Xiao Juan Putra Richard Rothstein Collin McCourt Liza Konnikova Mikhail Lisovsky Source Type: research

Lymphocytic Esophagitis With Predominance of CD4 T Cells and Expansion of Th1 Cells Is Associated With Achalasia
CONCLUSIONS: Achalasia should be considered in the differential diagnosis of clinical entities associated with CD4-predominant LyE. Additional studies to explore the significance of Th1 cells in achalasia-associated LyE are warranted.PMID:33609026 | DOI:10.1093/ajcp/aqaa239 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 20, 2021 Category: Pathology Authors: Kristen Muller Jenny Xiao Juan Putra Richard Rothstein Collin McCourt Liza Konnikova Mikhail Lisovsky Source Type: research

Lymphocytic Esophagitis With Predominance of CD4 T Cells and Expansion of Th1 Cells Is Associated With Achalasia.
CONCLUSIONS: Achalasia should be considered in the differential diagnosis of clinical entities associated with CD4-predominant LyE. Additional studies to explore the significance of Th1 cells in achalasia-associated LyE are warranted. PMID: 33609026 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 20, 2021 Category: Pathology Authors: Muller K, Xiao J, Putra J, Rothstein R, McCourt C, Konnikova L, Lisovsky M Tags: Am J Clin Pathol Source Type: research

Five-year Outcomes of Sleeve Gastrectomy: A Prospective Multicenter study
CONCLUSIONS: Five years after SG, weight loss was satisfactory; the reduction of comorbidities was significant for dyslipidemia, OSAS, and HTN, but not diabetes and GERD. Age>50 years old, BMI>50 kg/m2, and previous LAGB were independent predictors of weight loss failure.PMID:33605784 | DOI:10.1177/0003134821991984 (Source: The American Surgeon)
Source: The American Surgeon - February 19, 2021 Category: Surgery Authors: Imad El Moussaoui Etienne Van Vyve Hubert Johanet Andr é Dabrowski Arnaud Piquard Thierry Delaunay Beno ît Navez Philippe Hauters Frank Sirisier Patrizia Loi Jean Closset Source Type: research

Long-term clinical results of per-oral endoscopic myotomy (POEM) for achalasia: First report of more than 10-year patient experience as assessed with a questionnaire-based survey
Conclusions Clinical results of POEM over 10 years were favorable regardless of various factors. Symptoms improved even in patients who required additional treatments, suggesting that POEM plays a significant role in treatment of achalasia. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: Endoscopy International Open)
Source: Endoscopy International Open - February 19, 2021 Category: Gastroenterology Authors: Onimaru, Manabu Inoue, Haruhiro Fujiyoshi, Yusuke Abad, Mary Raina Angeli Nishikawa, Yohei Toshimori, Akiko Shimamura, Yuto Tanabe, Mayo Sumi, Kazuya Ikeda, Haruo Tags: Original article Source Type: research

Five-year Outcomes of Sleeve Gastrectomy: A Prospective Multicenter study.
CONCLUSIONS: Five years after SG, weight loss was satisfactory; the reduction of comorbidities was significant for dyslipidemia, OSAS, and HTN, but not diabetes and GERD. Age>50 years old, BMI>50 kg/m2, and previous LAGB were independent predictors of weight loss failure. PMID: 33605784 [PubMed - as supplied by publisher] (Source: The American Surgeon)
Source: The American Surgeon - February 19, 2021 Category: Surgery Authors: El Moussaoui I, Van Vyve E, Johanet H, Dabrowski A, Piquard A, Delaunay T, Navez B, Hauters P, Sirisier F, Loi P, Closset J Tags: Am Surg Source Type: research

Conservative Therapy of Reflux Disease and its Limits
Zentralbl Chir. 2021 Feb 17. doi: 10.1055/a-1309-2368. Online ahead of print.ABSTRACTGastrooesophageal reflux disease (GORD) is common. Proton pump inhibitors (PPI) are regarded as first line therapy for all clinical manifestations. However, their efficacy is inadequate for at least 30% of patients and they are occasionally poorly tolerated. Moreover, some patients would prefer an alternative therapy. Alginate cause mechanical reflux inhibition by forming a gelatinous layer in the so-called acid pocket, an acid reservoir that forms on the surface of the chyme in the gastric corpus immediately after food intake. They may be...
Source: Zentralblatt fur Chirurgie - February 18, 2021 Category: Surgery Authors: Joachim Labenz Source Type: research

Conservative Therapy of Reflux Disease and its Limits
Zentralbl Chir. 2021 Feb 17. doi: 10.1055/a-1309-2368. Online ahead of print.ABSTRACTGastrooesophageal reflux disease (GORD) is common. Proton pump inhibitors (PPI) are regarded as first line therapy for all clinical manifestations. However, their efficacy is inadequate for at least 30% of patients and they are occasionally poorly tolerated. Moreover, some patients would prefer an alternative therapy. Alginate cause mechanical reflux inhibition by forming a gelatinous layer in the so-called acid pocket, an acid reservoir that forms on the surface of the chyme in the gastric corpus immediately after food intake. They may be...
Source: Zentralblatt fur Chirurgie - February 18, 2021 Category: Surgery Authors: Joachim Labenz Source Type: research

Disappearance of Gastric Hyperplastic Polyps after the Discontinuation of Proton Pump Inhibitor in a Patient with Liver Cirrhosis
Here, we report on a rare case of gastric hyperplastic polyps which disappeared after the discontinuation of proton pump inhibitor (PPI). The patient was an 83-year-old woman with liver cirrhosis and portal hypertension, along with gastroesophageal reflux disease treated by PPI. An initial upper gastrointestinal endoscopy showed unique polypoid lesions in the greater curvature of the stomach. Biopsy specimens of the lesions were diagnosed as hyperplastic polyps and she was followed. One year later, a second endoscopy showed that the lesions had increased in number and size, and an endoscopic mucosal resection (EMR) was per...
Source: Case Reports in Gastroenterology - February 18, 2021 Category: Gastroenterology Source Type: research

The Relationship Between Otitis Media With Effusion and Gastroesophageal Reflux Disease: A Meta-analysis
Objective: Recent studies have investigated the mechanism by which refluxed gastric materials reach the middle ear, to establish otitis media with effusion (OME) causal relation between them in both children and adults. Therefore, the relationship between OME and gastro-esophageal reflux disease (GERD) should be further studied extensively. Methods: To identify eligible original articles, we searched a range of computerized databases, including Medline via PubMed, EMBASE, CNKI, and Web of Science with a systematic searching strategy. Subgroup analysis was performed to analyze heterogeneity and Egger and Begg fun...
Source: Otology and Neurotology - February 18, 2021 Category: ENT & OMF Tags: REVIEW ARTICLES Source Type: research

Cancers, Vol. 13, Pages 852: Weakly Acidic Bile Is a Risk Factor for Hypopharyngeal Carcinogenesis Evidenced by DNA Damage, Antiapoptotic Function, and Premalignant Dysplastic Lesions In Vivo
Conclusion: Weakly acidic pH increases the risk of bile-related hypopharyngeal neoplasia. The oncogenic properties of biliary esophageal reflux on the epithelium of the upper aerodigestive tract may not be fully modified when antacid therapy is applied. We believe that due to bile content, alternative therapeutic strategies using specific inhibitors of relevant molecular pathways or receptors may be considered in patients with refractory GERD. (Source: Cancers)
Source: Cancers - February 18, 2021 Category: Cancer & Oncology Authors: Clarence T. Sasaki Sotirios G. Doukas Panagiotis G. Doukas Dimitra P. Vageli Tags: Article Source Type: research

Revision of a Previous Capella Bypass due to dysphagia, GERD and Candy Cane Syndrome
ConclusionsIn conclusion, bariatric revisional surgery can lead to serious complications, but it is justified in patients with  poor quality of life. A ringed retrocolic retrogastric bypass poses more difficulties in revisional procedures. It is mandatory to know which technique was performed before. The duration of the procedure can result in more complications like liver damage. (Source: Obesity Surgery)
Source: Obesity Surgery - February 18, 2021 Category: Surgery Source Type: research

[Conservative Therapy of Reflux Disease and its Limits].
Abstract Gastrooesophageal reflux disease (GORD) is common. Proton pump inhibitors (PPI) are regarded as first line therapy for all clinical manifestations. However, their efficacy is inadequate for at least 30% of patients and they are occasionally poorly tolerated. Moreover, some patients would prefer an alternative therapy. Alginate cause mechanical reflux inhibition by forming a gelatinous layer in the so-called acid pocket, an acid reservoir that forms on the surface of the chyme in the gastric corpus immediately after food intake. They may be used an alternative to treat the symptoms of uncomplicated GORD an...
Source: Zentralblatt fur Chirurgie - February 17, 2021 Category: Surgery Authors: Labenz J Tags: Zentralbl Chir Source Type: research

Severe Upper Gastrointestinal Hemorrhage Caused by Reflux Esophagitis
ConclusionsFor patients with severe UGIB caused by RE, (1) the prevalence has increased significantly over the past three decades, (2) the reasons for this increase and preventive strategies warrant further study, (3) most patients lacked GERD symptoms and did not take acid suppressants, and (4) those with focal ulcers and SRH had more severe esophagitis and were treated endoscopically. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - February 16, 2021 Category: Gastroenterology Source Type: research

Gastric dysrhythmia in gastroesophageal reflux disease: a systematic review and meta-analysis
This study aimed to systematically review and meta-analyse the existing literature in which EGG was used in patients with GERD.MethodsDatabases were systematically searched for studies using EGG in adults with GERD. The primary outcome was the percentage of recording time in the normogastric frequency range. Secondary outcomes were dominant frequency, dominant power, power ratio and prevalence of any EGG abnormality.ResultsIn total, 591 participants (427 patients with GERD; 164 healthy controls) from 13 studies were included. GERD patients spent 17.3% (SMD  − 1.18, 95%CI: − 1.84,&thi...
Source: Esophagus - February 16, 2021 Category: Gastroenterology Source Type: research

Long-Term Implications of GERD After Sleeve Gastrectomy
AbstractPurpose of reviewTo review the relationship between obesity and Gastroesophageal reflux disease (GERD), and study rates and implications of GERD diagnosis before and after Laparoscopic Sleeve gastrectomy (LSG) and Laparoscopic Gastric Bypass (LRYGB).Recent findingsObesity is one of the major risk factors for GERD, and GERD is common in patients seeking bariatric surgery. GERD outcomes are superior with LRYGB compared to LSG, and de novo GERD and Barrett ’s esophagus have been reported after LSG. Prevention and treatment strategies for GERD and Barrett’s esophagus after LSG are under scrutiny.SummaryDete...
Source: Current Surgery Reports - February 15, 2021 Category: Surgery Source Type: research

Stimulated saliva secretion is reduced in proton pump inhibitor-resistant severe reflux esophagitis patients
ConclusionStimulated saliva secretion was reduced in PPI-resistant severe reflux esophagitis patients. (Source: Esophagus)
Source: Esophagus - February 15, 2021 Category: Gastroenterology Source Type: research

Effect of omeprazole on symptoms of gastroesophageal reflux disease in children with cystic fibrosis. A randomized, double-blind, placebo-controlled trial.
CONCLUSIONS: Treatment of GERD in children with CF seems not to have a stronger effect than a placebo on the severity of cough and abdominal pain. Considering this, as well as the previously raised concerns about the impact of chronic proton pump inhibitor treatment on the course of CF, perhaps one should be more careful in intensively treating suspected atypical GERD symptoms in patients with CF. PMID: 33577055 [PubMed - as supplied by publisher] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 14, 2021 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Updates in association of gastroesophageal reflux disease and dental erosion: systematic review.
The objective of this systematic review was to evaluate the association and prevalence of erosive wear in patients with GERD. The bibliographic search was performed in the Pubmed and Web of Science databases, using the descriptors "gastroesophageal reflux disease" AND "dental erosion", considering clinical studies recently published from 2012 to 2020. EXPERT OPINION: : GERD can be considered a risk factor for the development of erosive dental lesions, whose prevalence was significantly higher in this group. However, several other factors can be commonly associated with the prevalence and severity of...
Source: Expert Review of Gastroenterology and Hepatology - February 13, 2021 Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research

Letter to the Editor by the American Foregut Society Bariatric Committee on Combined Magnetic Sphincter Augmentation and Bariatric Surgery
A recent review of the MBSAQIP (Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program) by authors Clapp, et al. 1 observed that magnetic sphincter augmentation (MSA) is being performed prophylactically for gastroesophageal reflux disease (GERD) at the time of primary bariatric surgery (18 in laparoscopic sleeve gastrectomy [LSG] and 6 in Roux-en-Y gastric bypass [RYGB] patients). The authors made several observations: (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - February 13, 2021 Category: Surgery Authors: Leena Khaitan, Barham K. Abu Dayyeh, John Lipham, Reginald Bell, Peter Kahrilas, American Foregut Society Bariatric Committee Tags: Letter to the Editor Source Type: research

A new diagnostic paradigm for laryngopharyngeal reflux disease: correlation of impedance-pH monitoring and digital reflux scintigraphy results
ConclusionReflux scintigraphy has a high yield in LPR patients. Scintigraphic time-activity curves correlated with validated MII-pH results. A high rate of pulmonary microaspiration was found in LPR patients. This study demonstrated a high level of pharyngeal contamination by scintigraphy and MII-pH, which supports the use of digital reflux scintigraphy in diagnosing LPR. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - February 13, 2021 Category: ENT & OMF Source Type: research

Acupuncture and Related Therapies for the Treatment of Gastrointestinal Diseases
Gastrointestinal diseases are very common worldwide. Patients with gastroesophageal reflux disease, functional dyspepsia, irritable bowel syndrome, and inflammatory bowel diseases frequently recur to complementary medicine, including acupuncture, likely because of the recurrence of symptoms and the sometimes lack of efficacy of conventional treatments. Acupuncture is a medical practice used in Asian country with benefits for thousands years. In the last decades, growing attention has been given to acupuncture also in Western countries and many studies have investigated the role of acupuncture in gastroenterology. This revi...
Source: Journal of Clinical Gastroenterology - February 12, 2021 Category: Gastroenterology Tags: CLINICAL REVIEWS Source Type: research

The frequency of gastroesophageal reflux when radiofrequency catheter ablation procedures for atrial fibrillation under general anesthesia with a supraglottic device: Observational pilot study
Gastroesophageal reflux (GER) in radiofrequency catheter ablation (RFCA) occurs due to vagal plexus damage during pulmonary vein isolation. We hypothesized that the frequency of GER in the oropharynx will be less compared to other areas (low-esophagus, mid-esophagus). We confirmed the frequency of GER before and after RFCA in 3 areas. We studied 30 patients who were scheduled for RFCA under general anesthesia. Anesthesia was performed using supraglottic devices (SGD) with a suction port. Two esophageal temperature probes capable of suction and measuring temperature were inserted through the suction port. The pH of the 3...
Source: Medicine - February 12, 2021 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Dietary Intakes and Food Habits of Wheelchair Basketball Athletes compared to Gym Attendees and Individuals who do not Practice Sport Activity.
CONCLUSIONS: In WBA, commitment to wellness (ON and Med-D adherence) could be a response to gastrointestinal and starvation symptoms. WBA should be involved in setting their own individualized dietary strategies. PMID: 33563163 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 12, 2021 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

INCIDENCE AND RISK FACTORS FOR CALCIFICATION AFTER DEXTRANOMER/HYALURONIC ACID (Dx/HA) COPOLYMER INJECTION FOR VESICOURETERAL REFLUX
Since the first case of dextranomer/hyaluronic acid (Dx/HA) implant calcification in 2008, concern about the long-term sequelae of Dx/HA injection has been growing. According to previous reports, the incidence of Dx/HA calcification 4 years after injection would be around 2%. (Source: Journal of Pediatric Urology)
Source: Journal of Pediatric Urology - February 12, 2021 Category: Urology & Nephrology Authors: Andrea Soria-Gondek, Oriol Mart ín-Solé, Sonia Pérez-Bertólez, Alba Martín-Lluis, Xavier Tarrado, Luis García-Aparicio Source Type: research

Efficacy of vonoprazan for refractory reflux esophagitis after esophagectomy
Background: Refractory reflux esophagitis (RRE), unresponsive to conventional proton-pump inhibitors (PPIs) is a complication in esophagectomy with gastric pull-up. Vonoprazan, a novel potassium-competitive acid blocker, has been available in Japan since 2015. Here, we investigated the efficacy of vonoprazan on PPI-resistant RRE after esophagectomy with gastric pull-up. Methods: This was a single-center retrospective study. We used the revised Los Angeles (r-LA) classification based on the Los Angeles (LA) classification and the modified Los Angeles (m-LA) classification to evaluate abnormal forms of mucosal breaks such ...
Source: Digestive Diseases - February 9, 2021 Category: Gastroenterology Source Type: research

Clinical judgement in chest pain: a case report  
ConclusionAs a result of the availability of multiple noninvasive diagnostic tests with almost similar sensitivities for CAD, physicians often face this dilemma of choosing the right test for optimal evaluation of chest pain in patients with intermediate pretest probability of CAD. Optimal test selection requires an individualized patient approach. Our experience with this case emphasizes the role of history taking, clinical judgement, and the risk/benefit ratio in deciding further workup when faced with inconclusive stress test results. Physicians should have a lower threshold for further workup of patients with inconclus...
Source: Journal of Medical Case Reports - February 9, 2021 Category: General Medicine Source Type: research

Proton Pump Inhibitors, Associated Complications, and Alternative Therapies: A Shifting Risk Benefit Ratio.
CONCLUSIONS: Anti-reflux control can be safely achieved with either PPI or surgical options; however, the long-term side effects noted in the review such as increased risk of cardiovascular events, renal disease, and gut dysbiosis may suggest surgical anti-reflux control as a better long-term option. PMID: 33560890 [PubMed - as supplied by publisher] (Source: The American Surgeon)
Source: The American Surgeon - February 9, 2021 Category: Surgery Authors: Friedman AJ, Elseth AJ, Brockmeyer JR Tags: Am Surg Source Type: research

Reflux symptoms – functional and structural diseases The approach from the GI specialist
The GI specialist has an important role to play in the long-term management of gastroesophageal reflux disease (GERD) patients; to secure a proper diagnosis and the selection of best possible therapeutic strategy. Through intensified information and education the implementation of national and international guidelines can be more effectively processed, whereupon a significant improvements in also cost-effectiveness of the current management will be fostered. Regarding the more specific group of GERD patients, as represented by the so called PPI refractory patients, data have now emerged to guide us into the future. Notewor...
Source: Digestive Diseases - February 8, 2021 Category: Gastroenterology Source Type: research

Reflux symptoms – functional and structural diseases The approach from the general practitioner (GP)
A primary care management strategy of gastroesophageal reflux disease (GERD) should pay attention to the epidemiology, prevalence and distribution of reflux-like symptoms in the community, to the special characteristics of patients presenting for the first time with reflux symptoms in primary care. General practitioners (GPs) encounter daily challenges to make cost-effective differential diagnostic and therapeutic decisions, avoiding needless and costly investigation or referral. They should provide long-term effective control of symptoms and esophageal healing in a personalized, symptom based, patient-centered and evidenc...
Source: Digestive Diseases - February 8, 2021 Category: Gastroenterology Source Type: research

Gastritis and gastroesophageal reflux disease are strongly associated with non-allergic nasal disorders
Gastroesophageal reflux disease (GERD) has been reported to be significantly associated with chronic rhinosinusitis, but the strength of the association is still debated. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - February 8, 2021 Category: Respiratory Medicine Authors: Eliana Finocchio, Francesca Locatelli, Francesca Sanna, Roberta Vesentini, Pierpaolo Marchetti, Gianluca Spiteri, Leonardo Antonicelli, Salvatore Battaglia, Roberto Bono, Angelo Guido Corsico, Marcello Ferrari, Nicola Murgia, Pietro Pirina, Mario Olivieri Tags: Research article Source Type: research

Characterization of esophageal motor activity, gastroesophageal reflux, and evaluation of prokinetic effectiveness in mechanically ventilated critically ill patients: a high-resolution impedance manometry study
Motility disorders of upper gastrointestinal tract are common in critical illness and associated with significant clinical consequences. However, detailed quantitative and qualitative analyses of esophageal mo... (Source: Critical Care)
Source: Critical Care - February 8, 2021 Category: Intensive Care Authors: Karel Balihar, Jan Kotyza, Lucie Zdrhova, Jana Kozeluhova, Michal Krcma and Martin Matejovic Tags: Research Source Type: research

[Use of Mesh in Hiatal Hernia Repair and Gastroesophageal Reflux Disease - Pro].
BP Abstract Net augmentation in surgical care of hiatus hernias has many advantages, but is still controversial. Optimal surgical treatment of symptomatic hiatus hernia is to provide long-term correction of the malposition of the stomach and other organs that have been displaced in the thorax, as well as reducing the necessity of risky reoperations. In order to assess the role of net augmentation in repair of the hiatus here, the benefit in the form of the avoidance of symptomatic recurrence and reoperations must be balanced against the risk of net-associated complications. In the present review article, we prese...
Source: Zentralblatt fur Chirurgie - February 8, 2021 Category: Surgery Authors: Nickel F, Cizmic A, Müller-Stich BP Tags: Zentralbl Chir Source Type: research

[Reflux Symptoms - No Difference in Severity and Intensity in Patients with and without Functional Verified Gastroesophageal Reflux Disease].
CONCLUSION: Patients with functional complaints suffer just as much from their symptoms as patients with objectively diagnosed GERD. Differentiation between gastroesophageal reflux disease and functional reflux symptoms is only possible by means of functional diagnostic testing. PMID: 33556980 [PubMed - as supplied by publisher] (Source: Zentralblatt fur Chirurgie)
Source: Zentralblatt fur Chirurgie - February 8, 2021 Category: Surgery Authors: Grechenig M, Gruber R, Weitzendorfer M, von Rahden BHA, Widmann B, Emmanuel K, Koch O Tags: Zentralbl Chir Source Type: research

Decline incidence in upper gastrointestinal bleeding in several recent years: data of the Japan claims database of 13 million accumulated patients.
This study was to examine the recent trends in upper gastrointestinal bleeding in Japan using a large-scale real-world database. The incidence of upper gastrointestinal bleeding was evaluated in the Japan Medical Data Center claims database of 13,019,713 patients aged 20 to 74 years with traceability for 3 months from 2009 to 2014. The incidence was compared with peptic ulcers and gastroesophageal reflux disease. The prescription of medications was also evaluated. The incidence of bleeding was 0.137%, 0.121%, 0.113%, 0.106%, 0.099%, and 0.105% during 2009 to 2014 with a time-dependent decline (p10 times higher than the inc...
Source: Journal of Clinical Biochemistry and Nutrition - February 6, 2021 Category: Nutrition Tags: J Clin Biochem Nutr Source Type: research

Esophageal cancer after sleeve gastrectomy: a population-based comparative cohort study
CONCLUSIONS: Long-term incidence of esophageal cancer after reflux-prone bariatric surgery is not greater than RYGB. While crude incidence of esophageal cancer after reflux-prone surgery is higher than in nonsurgical patients with obesity, such difference disappears after accounting for confounders. Given the low incidence of esophageal cancer and slow progression of dysplastic Barrett esophagus, studies with longer follow-up are needed.PMID:33547014 | DOI:10.1016/j.soard.2020.12.011 (Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery)
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - February 6, 2021 Category: Surgery Authors: Amin Andalib Philippe Bouchard Sebastian Demyttenaere Lorenzo E Ferri Olivier Court Source Type: research

Gastroesophageal Reflux Disease – Health-Related Quality of Life Questionnaire: prospective development and validation in Italian
Conclusion The MI-GERD-HRQL questionnaire proved good consistency, reliability, sensitivity and specificity in the evaluation of typical GERD symptoms. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - February 4, 2021 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research