In vitro Investigation of the Pediculicidal Activities of the Volatile Oil Components of Some Medical Plants Raised in Turkey.
CONCLUSION: The results showed that the volatile oil of Rosmarinus officinalis (two different chemotypes) was more effective than the other oils. PMID: 29318991 [PubMed - in process] (Source: Turkish Society for Parasitology)
Source: Turkish Society for Parasitology - December 1, 2017 Category: Parasitology Authors: Limoncu ME, Balcıoğlu C, Oyur T, Zeybek G, Zeybek U Tags: Turkiye Parazitol Derg Source Type: research

Contact dermatitis caused by Geranium robertianum with erythema multiforme ‐like reaction
(Source: Contact Dermatitis)
Source: Contact Dermatitis - November 21, 2017 Category: Dermatology Authors: Antoine Badaoui, Catherine Pecquet, C éline Fargeas, Emmanuel Mahé Tags: Contact Point Source Type: research

Frankincense, pine needle and geranium essential oils suppress tumor progression through the regulation of the AMPK/mTOR pathway in breast cancer.
In conclusion, the present study indicated that frankincense, pine needle and geranium essential oils were involved in the progression of BC cells possibly through the AMPK/mTOR pathway. PMID: 29115548 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - November 9, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Effects of geranium aroma on anxiety among patients with acute myocardial infarction: A triple-blind randomized clinical trial.
CONCLUSION: Inhalation aromatherapy with geranium essential oil is recommended as an easy-to-use, intervention to reduce anxiety among patients with AMI. PMID: 29122262 [PubMed - in process] (Source: Complementary Therapies in Clinical Practice)
Source: Complementary Therapies in Clinical Practice - November 1, 2017 Category: Complementary Medicine Authors: Shirzadegan R, Gholami M, Hasanvand S, Birjandi M, Beiranvand A Tags: Complement Ther Clin Pract Source Type: research

Geraniin is a diuretic by inhibiting the Na+:K+:2Cl- cotransporter, NKCC2.
This study was designed to determinate whether geraniin possesses diuretic activity and to elucidate the mechanism of action. Geraniin was extracted and purified from Geranium seemannii Peyr. Male Wistar rats were divided into four groups: 1) Control, 2) 75 mg/kg of geraniin, 3) 20 mg/Kg of furosemide, and 4) 10 mg/Kg of hydrochlorothiazide. Each treatment was administered by gavage every 24 h for 7 days. The urinary excretion of electrolytes and the fractional excretion of sodium (FENa) were determined. To uncover the molecular target of geraniin, Xenopus laevis oocytes were microinjected with cRNAs encoding the Na-Cl cot...
Source: American Journal of Physiology. Renal Physiology - October 18, 2017 Category: Physiology Authors: Moreno E, Gayosso JA, Montejano JR, Almaguer G, Vázquez N, Cruz C, Mercado A, Bobadilla NA, Gamba G, Sierra A, Ramírez V Tags: Am J Physiol Renal Physiol Source Type: research

Geraniin inhibits migration and invasion of human osteosarcoma cancer cells through regulation of PI3K/Akt and ERK1/2 signaling pathways
Geraniin, an active compound isolated from Geranium sibiricum, was found to inhibit proliferation and induce apoptosis of tumor cells. However, the antimetastatic effects of geraniin remain elusive. Our study found the potential antitumor mechanisms of geraniin through inhibiting the migration and invasion of human osteosarcoma U2OS cells. The western blot, gelatin zymography, and reversed transcription-PCR analysis showed that geraniin suppressed matrix metalloproteinase-9 (MMP-9) expression in a concentration-dependent manner. Geraniin potently suppressed the phosphorylation of extracellular signal regulating kinase (ERK...
Source: Anti-Cancer Drugs - September 16, 2017 Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research

Paternal arbuscular mycorrhizal fungal status affects DNA methylation in seeds.
In this study, we compared the amount of global DNA methylation in seeds of the gynodioecious plant Geranium sylvaticum in relation to the gender and the AMF status of the parents producing the seeds. The amount of DNA methylated was positively related to seed mass. Seeds produced by females had a similar proportion of methylated DNA regardless of the AMF status of the father siring the seed. By contrast, seeds from hermaphrodites had higher DNA methylation when sired by AMF fathers. We show to the best of our knowledge for the first time, that the AMF status of fathers can affect DNA methylation in seeds and that these ch...
Source: Biology Letters - September 1, 2017 Category: Biology Authors: Varga S, Soulsbury CD Tags: Biol Lett Source Type: research

Efficacy of Topical Compound Danxiong Granules for Treatment of Dermatologic Toxicities Induced by Targeted Anticancer Therapy: A Randomized, Double-Blind, Placebo-Controlled Trial.
Authors: Tian A, Zhou A, Bi X, Hu S, Jiang Z, Zhang W, Huang Z, Shi H, Yang B, Chen W Abstract Dermatologic toxicities resulting in dose reduction or discontinuation of treatment pose challenges for targeted anticancer therapies. We conducted this randomized, double-blind, placebo-controlled trial to investigate the efficacy of topical application of Compound Danxiong Granules (CDG) for treatment of dermatologic toxicities associated with targeted anticancer therapies. One hundred and ten patients with dermatologic toxicities induced by targeted anticancer therapies were randomly assigned to CDG or placebo...
Source: Evidence-based Complementary and Alternative Medicine - August 29, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

In Vivo and In Vitro Hepatoprotective Effects of Geranium koreanum Methanolic Extract via Downregulation of MAPK/Caspase-3 Pathway.
This study aimed to investigate the protective effect and related molecular mechanism of GK on NaAsO2-induced cytotoxicity in HepG2 cells and liver damage in mice. The cytoprotective role of GK was assessed on HepG2 cells using MTT assay. Oxidative stress and lactate dehydrogenase levels were measured with ROS and LDH assay. Histopathology and serum enzymes levels were estimated. The molecular mechanism was evaluated by qPCR and immunoblotting to ensure the hepatoprotective role of GK against NaAsO2 intoxication in mice. We found cotreatment with GK significantly attenuated NaAsO2-induced cell viability loss, intracellular...
Source: Evidence-based Complementary and Alternative Medicine - August 3, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Adaptability of two accessions of Geranium macrorrhizum L. to drought stress conditions
Publication date: Available online 31 July 2017 Source:Journal of Applied Research on Medicinal and Aromatic Plants Author(s): Juliana Navarro Rocha, Jesús Burillo-Alquézar, Joaquín Aibar-Lete, Azucena González-Coloma Geranium macrorrhizum L. is a herbaceous perennial with underground stems (rhizomes) naturally found in the Balkan countries where it is known for its phytochemical properties. Despite its potential, there are no references to cultivation of this species to produce essential oil; to date only wild plants have been harvested. The purpose of this study is to compare cuttings of G. macrorrhizum taken f...
Source: Journal of Applied Research on Medicinal and Aromatic Plants - July 31, 2017 Category: Complementary Medicine Source Type: research

Geranium intoxication induces detoxification enzymes in the Japanese beetle, Popillia japonica Newman
This study shows that toxic geranium and QA induce detoxification enzyme activity, but the induced enzymes do not effectively protect P. japonica from paralysis by QA. Further investigation is required through in vitro studies to know if the enzymes induced by geranium are capable of metabolizing QA. This study highlights a rare physiological mismatch between the detoxification tool kit of a generalist and its preferred host. Graphical abstract (Source: Pesticide Biochemistry and Physiology)
Source: Pesticide Biochemistry and Physiology - July 30, 2017 Category: Biochemistry Source Type: research

Molecular recognition between potential natural inhibitors of the Keap1-Nrf2 complex.
Abstract Disrupting the Keap1-Nrf2 pathway enhances Nrf2 activity, which has been identified as an important approach for the prevention of different chronic diseases in which oxidative stress and inflammation are present, such as cancer, diabetes, Alzheimer's and Parkinson's. Based on the high potential to modulate antioxidant, anti-inflammatory and anticancer properties that the discovery of Keap1-Nrf2 protein-protein interaction inhibitors would represent, the utilization of some natural compounds has emerged as a promising strategy to identify new drugs. To gain insight into the structural and energeti...
Source: International Journal of Biological Macromolecules - July 23, 2017 Category: Biochemistry Authors: Bello M, Morales-González JA Tags: Int J Biol Macromol Source Type: research

The effects of selected phytochemicals on biofilm formed by five methicillin-resistant Staphylococcus aureus.
This study showed that TO and TC might have therapeutic potential as an inhibitory agents for use in MRSA biofilm-related infections. PMID: 28627304 [PubMed - as supplied by publisher] (Source: Natural Product Research)
Source: Natural Product Research - June 18, 2017 Category: Biochemistry Authors: Kot B, Wierzchowska K, Grużewska A, Lohinau D Tags: Nat Prod Res Source Type: research

Molecules, Vol. 22, Pages 983: Evaluation of the Antidiabetic Activity and Chemical Composition of Geranium collinum Root Extracts—Computational and Experimental Investigations
The root of Geranium collinum Steph is known in Tajik traditional medicine for its hepatoprotective, antioxidant, and anti-inflammatory therapeutic effects. The present study was conducted to evaluate of potential antidiabetic, antioxidant activities, total polyphenolic and flavonoid content from the different extracts (aqueous, aqueous-ethanolic) and individual compounds isolated of the root parts of G. collinum. The 50% aqueous-ethanolic extract possesses potent antidiabetic activity, with IC50 values of 0.10 μg/mL and 0.09 μg/mL for the enzymes protein-tyrosine phosphatase (1B PTP-1B) and α-glucosidase, respectively....
Source: Molecules - June 13, 2017 Category: Chemistry Authors: Sodik Numonov Salamet Edirs Khayrulla Bobakulov Muhammad Qureshi Khurshed Bozorov Farukh Sharopov William Setzer Haiqing Zhao Maidina Habasi Mizhgona Sharofova Haji Aisa Tags: Article Source Type: research

Aromatherapy Massage for Neuropathic Pain and Quality of Life in Diabetic Patients
ConclusionsAromatherapy massage is a simple and effective nonpharmacological nursing intervention that can be used to manage neuropathic pain and improve QoL in patients with painful neuropathy. Clinical RelevanceAromatherapy massage is a well‐tolerated, feasible, and safe nonpharmacological method that can be readily integrated into clinical settings by nursing staff. The essential oils rosemary, geranium, lavender, eucalyptus, and chamomile can be safely used by nurses in the clinical setting, if applicable. However, training and experience of nurses in aromatherapy massage is critical to achieving positive results. (S...
Source: Journal of Nursing Scholarship - June 12, 2017 Category: Nursing Authors: Zehra Gok Metin, Ayse Arikan Donmez, Nur Izgu, Leyla Ozdemir, Ismail Emre Arslan Tags: ORIGINAL MANUSCRIPT Source Type: research