Why trees are making extra nuts this year, human genetics and viral infections, and a seminal book on racism and identity
Have you noticed the trees around you lately—maybe they seem extra nutty? It turns out this is a “masting” year, when trees make more nuts, seeds, and pinecones than usual. Science Staff Writer Elizabeth Pennisi joins host Sarah Crespi to discuss the many mysteries of masting years.  Next, Producer Meagan Cantwell talks with Jean-Laurent Casanova, a professor at Rockefeller University and an investigator at the Howard Hughes Medical Institute, about his review article on why some people are more vulnerable to severe disease from viral infections. This is part of a special issue on inflammation in Science. Finally,...
Source: Science Magazine Podcast - November 25, 2021 Category: Science Authors: Science Magazine Source Type: podcasts

TWiV 830: A culture of resistance
TWiV explains that a recent report suggesting that the SARS-CoV-2 spike protein inhibits V(D)J recombination in vitro would not impact immunity after infection or vaccination, and describes the isolation of remdesivir resistant mutants in cells in culture, and the emergence of amino acid changes in the spike protein identical to those in variants of concern, in the absence of immune selection. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Click arrow to play Download TWiV 830 (67 MB .mp3, 112 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this ...
Source: This Week in Virology - MP3 Edition - November 18, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

Sea squirts teach new lessons in evolution
Spineless sea squirts shed light on vertebrate evolution, and an iodine-fuelled engine powering a satellite in space.In this episode:00:45 A story of sea squirts, ancient vertebrates and missing genesWhen a PhD student set out to study the developmental pathways of a strange sea creature, he hoped to shed light on the origins of vertebrate animals. Instead, researchers found themselves investigating a strange case of missing genes. We hear why gene loss could be a more significant factor in evolutionary processes than was previously thought.Research article: Ferrández-Roldán et al.08:17 Research HighlightsThe unusual cry...
Source: Nature Podcast - November 17, 2021 Category: Science Authors: Springer Nature Limited Source Type: podcasts

Sea squirts teach new lessons in evolution
Spineless sea squirts shed light on vertebrate evolution, and an iodine-fuelled engine powering a satellite in space.In this episode:00:45 A story of sea squirts, ancient vertebrates and missing genesWhen a PhD student set out to study the developmental pathways of a strange sea creature, he hoped to shed light on the origins of vertebrate animals. Instead, researchers found themselves investigating a strange case of missing genes. We hear why gene loss could be a more significant factor in evolutionary processes than was previously thought.Research article: Ferrández-Roldán et al.08:17 Research HighlightsThe unusual cry...
Source: Nature Podcast - November 17, 2021 Category: Science Authors: Springer Nature Limited Source Type: podcasts

TWiV 822: Viking variola variants
Rich reviews the history of smallpox and the discovery of variola viral genomes in ancient DNA from human remains throughout Northern Europe, which pushes back the earliest date of smallpox virus infection to ~600–1050 CE, overlapping the Viking Age. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Variola virus genomes from Viking era (Science) Hidden history of ancient plagues (Nature) Was smallpox a mild disease? (Science) Smallpox: Ten years gone (Am J Pub Health) Myth of ...
Source: This Week in Virology - MP3 Edition - October 28, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

New insights into endometriosis, predicting RNA folding, and the surprising career of the spirometer
News Intern  Rachel Fritts talks with host Sarah Crespi about a new way to think about endometriosis—a painful condition found in one in 10 women in which tissue that normally lines the uterus grows on the outside of the uterus and can bind to other organs. Next, Raphael Townshend, founder and CEO of Atomi c AI, talks about predicting RNA folding using deep learning—a machine learning approach that relies on very few examples and limited data. Finally, in this month's edition of our limited series on race and science, guest host and journalist Angela Saini is joined by author Lundy Braun, profe ssor of patholog...
Source: Science Magazine Podcast - August 26, 2021 Category: Science Authors: Science Tags: Scientific Community Source Type: podcasts

New insights into endometriosis, predicting RNA folding, and the surprising career of the spirometer
News Intern Rachel Fritts talks with host Sarah Crespi about a new way to think about endometriosis—a painful condition found in one in 10 women in which tissue that normally lines the uterus grows on the outside of the uterus and can bind to other organs. Next, Raphael Townshend, founder and CEO of Atomic AI, talks about predicting RNA folding using deep learning—a machine learning approach that relies on very few examples and limited data. Finally, in this month's edition of our limited series on race and science, guest host and journalist Angela Saini is joined by author Lundy Braun, professor of pathology...
Source: Science Magazine Podcast - August 26, 2021 Category: Science Authors: Science Magazine Source Type: podcasts

New insights into endometriosis, predicting RNA folding, and the surprising career of the spirometer
News Intern Rachel Fritts talks with host Sarah Crespi about a new way to think about endometriosis —a painful condition found in one in 10 women in which tissue that normally lines the uterus grows on the outside of the uterus and can bind to other organs. Next, Raphael Townshend, founder and CEO of Atomic AI, talks about predicting RNA folding using deep learning—a machine learning approach that relies on very few examples and limited data. Finally, in this month's edition of our limited series on race and science, guest host and journalist Angela Saini is joined by author Lundy Braun, professor of pathology and la...
Source: Science Magazine Podcast - August 24, 2021 Category: Science Authors: Science Tags: Scientific Community Source Type: podcasts

TWiV 796: The vary hungry spike with Paul and Theodora
Paul and Theodora return to TWiV to explain their research on determining the number of neutralizing epitopes on the SARS-CoV-2 spike that are recognized by antibodies, and engineering of a polymutant spike with twenty amino acid changes that demonstrates the high genetic barrier to escape from convalescent serum. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Guests: Paul Bieniasz and Theodora Hatiziiouannou Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode High genetic barrier for SARS-CoV-2 antibody escape (bioRxiv) Enhanced anti...
Source: This Week in Virology - MP3 Edition - August 22, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

Debating metabolically healthy obesity, delaying type 1 diabetes, and visiting bone rooms
First this week, Staff Writer Jennifer Couzin-Frankel joins host Sarah Crespi to discuss the paradox of healthy obesity. They chat about the latest research into the relationships between markers of metabolic health —such as glucose or cholesterol levels in the blood—and obesity. They aren’t as tied as you might think. Next, Colin Dayan, professor of clinical diabetes and metabolism at Cardiff University and senior clinical researcher at the Wellcome Centre for Human Genetics at the University of Oxford, joins Sarah to discuss his contribution to a special issue on type 1 diabetes. In his review, Colin and colleagues...
Source: Science Magazine Podcast - July 29, 2021 Category: Science Authors: Science Tags: Scientific Community Source Type: podcasts

Debating healthy obesity, delaying type 1 diabetes, and visiting bone rooms
First this week, Staff Writer Jennifer Couzin-Frankel joins host Sarah Crespi to discuss the paradox of metabolically healthy obesity. They chat about the latest research into the relationships between markers of metabolic health—such as glucose or cholesterol levels in the blood—and obesity. They aren’t as tied as you might think. Next, Colin Dayan, professor of clinical diabetes and metabolism at Cardiff University and senior clinical researcher at the Wellcome Centre for Human Genetics at the University of Oxford, joins Sarah to discuss his contribution to a special issue on type 1 diabetes. In his re...
Source: Science Magazine Podcast - July 29, 2021 Category: Science Authors: Science Magazine Source Type: podcasts